首页 > 最新文献

Journal of ageing and longevity最新文献

英文 中文
Planning for Aging and Frailty: A Qualitative Study on Older Adults’ Perceptions, Facilitators, and Barriers 老龄化和脆弱性规划:老年人认知、促进者和障碍的定性研究
Pub Date : 2023-02-02 DOI: 10.3390/jal3010006
Erica Frechman, Harleah G. Buck, M. Dietrich, B. Rhoten, A. Davis, Cathy A. Maxwell
Aging is often accompanied by health events that may disrupt older adults’ desires to age in place. Understanding older adults’ perceptions of planning for their aging process was a priority to identify how planning behaviors occur. Our study explored how people perceive the concept of planning for aging and frailty, and identified the facilitators and barriers involved in the planning process. Using conventional qualitative content analysis, we used the data from semi-structured interviews of twenty community-dwelling older adults aged 50–80 years old. Demographic information was obtained, followed by the participant interviews. Seventeen code categories surfaced including six categories in the perception domain (i.e., internal, external, and future-oriented), seven categories in the facilitators domain (i.e., internal, external, and systems), and four categories in the barriers domain (i.e., internal, and systems). The emergent categories included understanding one’s perception of planning through a holistic lens, the importance of experiences with self/others as facilitators, and the physical/cognitive/emotional factors that serve as barriers within a larger sphere of societal influence. Planning for aging and frailty is an innovative concept that normalizes the aging process and promotes planning through an awareness of aging across the life-course domains. Future research is warranted for intervention development to help older adults recognize and actively plan for aging and to address the barriers involved.
衰老通常伴随着健康事件,这些事件可能会破坏老年人就地衰老的愿望。了解老年人对衰老过程规划的看法是确定规划行为如何发生的首要任务。我们的研究探讨了人们如何看待衰老和虚弱的规划概念,并确定了规划过程中涉及的推动者和障碍。使用传统的定性内容分析,我们使用了20名50-80岁社区老年人的半结构化访谈数据。获得人口统计信息,然后对参与者进行访谈。17个代码类别浮出水面,包括感知领域的6个类别(即内部、外部和面向未来),促进者领域的7个类别(如内部、外部、系统),以及障碍领域的4个类别(例如内部和系统)。新兴类别包括通过整体视角理解一个人对计划的看法,将自我/他人作为促进者的经历的重要性,以及在更大的社会影响范围内作为障碍的身体/认知/情感因素。针对衰老和虚弱的规划是一个创新概念,它使衰老过程正常化,并通过对整个生命过程领域的衰老意识来促进规划。未来的研究需要制定干预措施,以帮助老年人认识到并积极规划老龄化,并解决相关障碍。
{"title":"Planning for Aging and Frailty: A Qualitative Study on Older Adults’ Perceptions, Facilitators, and Barriers","authors":"Erica Frechman, Harleah G. Buck, M. Dietrich, B. Rhoten, A. Davis, Cathy A. Maxwell","doi":"10.3390/jal3010006","DOIUrl":"https://doi.org/10.3390/jal3010006","url":null,"abstract":"Aging is often accompanied by health events that may disrupt older adults’ desires to age in place. Understanding older adults’ perceptions of planning for their aging process was a priority to identify how planning behaviors occur. Our study explored how people perceive the concept of planning for aging and frailty, and identified the facilitators and barriers involved in the planning process. Using conventional qualitative content analysis, we used the data from semi-structured interviews of twenty community-dwelling older adults aged 50–80 years old. Demographic information was obtained, followed by the participant interviews. Seventeen code categories surfaced including six categories in the perception domain (i.e., internal, external, and future-oriented), seven categories in the facilitators domain (i.e., internal, external, and systems), and four categories in the barriers domain (i.e., internal, and systems). The emergent categories included understanding one’s perception of planning through a holistic lens, the importance of experiences with self/others as facilitators, and the physical/cognitive/emotional factors that serve as barriers within a larger sphere of societal influence. Planning for aging and frailty is an innovative concept that normalizes the aging process and promotes planning through an awareness of aging across the life-course domains. Future research is warranted for intervention development to help older adults recognize and actively plan for aging and to address the barriers involved.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45971956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Families’ Use of Digital Technology Can Be a Tool for Reducing Loneliness and Improving Food Intake among Older Adults 家庭对数字技术的使用如何成为老年人减少孤独感和改善食物摄入量的工具
Pub Date : 2023-01-25 DOI: 10.3390/jal3010004
I. S. Grini, Ø. Ueland
The purpose of this study was to explore how a technical solution implemented among older adults and connected with an app supervised by an app administrator can reduce loneliness, prevent malnutrition, and inspire social eating and networking. In October 2020, a survey was distributed to 3500 administrators of the one-button computer communication tool Komp. Komp consists of a screen placed with older adults and an app used by the administrator of the tool. The survey addresses aspects that can provide new insights into how older adults can use digital solutions as a link to family and external networks. The study results show that due to COVID-19, 65% of respondents said they used Komp more frequently than before, but only 5% of current use was associated with eating meals together. However, 54% of the app administrators indicated that this could be a good future activity. Furthermore, 88% thought Komp could contribute to more socializing through shared meals. This study elicited almost 1650 constructive comments on experience, use, and recommendations. The study results show that digital solutions can be a link between older adults and their families and external network. Such tools can address needs connected to loneliness, social isolation, and food intake.
这项研究的目的是探索在老年人中实施的技术解决方案,并与应用程序管理员监督的应用程序连接,如何减少孤独感,防止营养不良,并激发社交饮食和社交网络。2020年10月,一项调查被分发给了一键式计算机通信工具Komp的3500名管理员。Komp由一个放置老年人的屏幕和一个由该工具管理员使用的应用程序组成。该调查涉及的方面可以为老年人如何使用数字解决方案作为与家庭和外部网络的联系提供新的见解。研究结果显示,由于新冠肺炎,65%的受访者表示他们比以前更频繁地使用Komp,但目前只有5%的人与一起吃饭有关。然而,54%的应用程序管理员表示,这可能是一项很好的未来活动。此外,88%的人认为Komp可以通过共享用餐来促进更多的社交活动。这项研究引发了近1650条关于经验、使用和建议的建设性意见。研究结果表明,数字解决方案可以成为老年人及其家庭和外部网络之间的纽带。这些工具可以满足与孤独、社交孤立和食物摄入相关的需求。
{"title":"How Families’ Use of Digital Technology Can Be a Tool for Reducing Loneliness and Improving Food Intake among Older Adults","authors":"I. S. Grini, Ø. Ueland","doi":"10.3390/jal3010004","DOIUrl":"https://doi.org/10.3390/jal3010004","url":null,"abstract":"The purpose of this study was to explore how a technical solution implemented among older adults and connected with an app supervised by an app administrator can reduce loneliness, prevent malnutrition, and inspire social eating and networking. In October 2020, a survey was distributed to 3500 administrators of the one-button computer communication tool Komp. Komp consists of a screen placed with older adults and an app used by the administrator of the tool. The survey addresses aspects that can provide new insights into how older adults can use digital solutions as a link to family and external networks. The study results show that due to COVID-19, 65% of respondents said they used Komp more frequently than before, but only 5% of current use was associated with eating meals together. However, 54% of the app administrators indicated that this could be a good future activity. Furthermore, 88% thought Komp could contribute to more socializing through shared meals. This study elicited almost 1650 constructive comments on experience, use, and recommendations. The study results show that digital solutions can be a link between older adults and their families and external network. Such tools can address needs connected to loneliness, social isolation, and food intake.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46890844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between Malnutrition Risk Factors and Physical Function in Community-Dwelling Adults ≥80 Years ≥80岁社区居民营养不良危险因素与身体功能的关系
Pub Date : 2023-01-06 DOI: 10.3390/jal3010003
S. F. Buhl, P. Ø. Olsen, T. Thilsing, P. Caserotti
Malnutrition is associated with accelerated loss of physical function in old adults, but the assessment of malnutrition in primary prevention is challenging. This study aimed to investigate if malnutrition risk factors; poor appetite, dysphagia, and poor dental state, were associated with reduced physical function in community-dwelling adults ≥80 years. The study is based on data from two cross-sectional studies. Physical function was assessed by the Short Physical Performance Battery (score ≤ 9 indicate reduced physical function) and poor appetite, dysphagia and poor dental status was assessed by single questions. A total of 900 participants were included (age 85.1 ± 3.7 years; 60.9% females; 62.8% had reduced physical function). Participants with reduced physical function were older, had a higher BMI, more polypharmacy, more falls, and lower quality of life. Poor appetite was reported by 10.8% and associated with reduced physical function (adjusted-OR 1.93, 95%CI 1.18–3.15). No association was identified between dysphagia, poor dental state and reduced physical function (adjusted-OR 0.96, 95%CI 0.53–1.75 and adjusted-OR 0.99, 95%CI 0.41–2.35, respectively). The assessment of appetite during primary preventive strategies was feasible and may offer an opportunity for identification of very old community-dwelling adults at risk of reduced physical function.
营养不良与老年人身体功能的加速丧失有关,但初级预防中营养不良的评估具有挑战性。本研究旨在探讨营养不良的危险因素;在≥80岁的社区居民中,食欲不振、吞咽困难和牙齿状况不佳与身体功能下降有关。这项研究基于两项横断面研究的数据。采用短体能测试(Short Physical Performance Battery)评估身体机能(得分≤9分表示身体机能下降),单题评估食欲不佳、吞咽困难和牙齿状况不佳。共纳入900名受试者(年龄85.1±3.7岁;60.9%的女性;62.8%身体机能下降)。身体功能下降的参与者年龄较大,身体质量指数较高,多种药物较多,摔倒较多,生活质量较低。10.8%的患者报告食欲不振,并伴有身体机能下降(调整比值比1.93,95%可信区间1.18-3.15)。吞咽困难、牙齿状况不佳和身体功能下降之间没有关联(调整后的or分别为0.96,95%CI 0.53-1.75和0.99,95%CI 0.41-2.35)。在初级预防策略期间对食欲进行评估是可行的,并可能为识别有身体功能下降风险的社区老年成年人提供机会。
{"title":"Association between Malnutrition Risk Factors and Physical Function in Community-Dwelling Adults ≥80 Years","authors":"S. F. Buhl, P. Ø. Olsen, T. Thilsing, P. Caserotti","doi":"10.3390/jal3010003","DOIUrl":"https://doi.org/10.3390/jal3010003","url":null,"abstract":"Malnutrition is associated with accelerated loss of physical function in old adults, but the assessment of malnutrition in primary prevention is challenging. This study aimed to investigate if malnutrition risk factors; poor appetite, dysphagia, and poor dental state, were associated with reduced physical function in community-dwelling adults ≥80 years. The study is based on data from two cross-sectional studies. Physical function was assessed by the Short Physical Performance Battery (score ≤ 9 indicate reduced physical function) and poor appetite, dysphagia and poor dental status was assessed by single questions. A total of 900 participants were included (age 85.1 ± 3.7 years; 60.9% females; 62.8% had reduced physical function). Participants with reduced physical function were older, had a higher BMI, more polypharmacy, more falls, and lower quality of life. Poor appetite was reported by 10.8% and associated with reduced physical function (adjusted-OR 1.93, 95%CI 1.18–3.15). No association was identified between dysphagia, poor dental state and reduced physical function (adjusted-OR 0.96, 95%CI 0.53–1.75 and adjusted-OR 0.99, 95%CI 0.41–2.35, respectively). The assessment of appetite during primary preventive strategies was feasible and may offer an opportunity for identification of very old community-dwelling adults at risk of reduced physical function.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47394443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Arbiters of Time: The Experience of Adults Aging with Spinal Cord Injury. 时间的仲裁者:脊髓损伤的成年人衰老的经验
Pub Date : 2023-01-01 DOI: 10.3390/jal3010005
Lisa Reber, Nasya S W Tan, Michelle A Meade, Martin Forchheimer, Denise G Tate, Philippa Clarke

Time is a fundamental component of our lives. It is both objective, a structure outside of ourselves, and subjective, an element that is relative to the life we live and how we experience it. The disabled body must come to terms with time to understand the future impact of the injury and its progression, as well as how the injury will impose a new more accelerated aging process in the body, resulting in a compressed lifespan. The body also challenges time's control of the body. This paper extends the literature on the study of time to the experience of adults aging with a spinal cord injury (SCI). Drawing from interviews conducted with adults with long-term SCI, it examines how their narratives about aging and the proactive management of their lives reflect their orientation toward and anticipation of the future. Recognizing that the spoken word often carries a multiplicity of meanings, it considers what participants' words might imply about their engagement with time. The results of this study show that the process of aging is characterized by uncertainty and the expectations of functional and health decline, requiring a sense of urgency and vigilance in the face of the uncertain course of aging with SCI. Participants understood that their lifespan was compressed due to the physiological impact of accelerated aging. Knowledge of this compression made time a scarce resource. Yet, despite it being the arbiters of their futures, so too were they the arbiters of time.

时间是我们生活的基本组成部分。它既是客观的,是我们自己之外的一种结构,也是主观的,是一种与我们生活和体验方式相关的因素。残疾的身体必须接受时间,以了解损伤的未来影响及其进展,以及损伤将如何在身体中施加一个新的、加速的衰老过程,从而缩短寿命。身体也挑战时间对身体的控制。本文将时间研究的文献扩展到成年脊髓损伤(SCI)患者的经验。根据对长期SCI患者的采访,研究了他们对衰老的叙述和对生活的积极管理如何反映他们对未来的取向和预期。认识到口语通常具有多种含义,它考虑了参与者的话语对他们与时间的接触可能意味着什么。本研究结果表明,衰老过程具有不确定性以及对功能和健康下降的预期,需要在面对SCI衰老过程的不确定性时有紧迫感和警惕性。参与者明白,由于加速衰老的生理影响,他们的寿命被缩短了。对这种压缩的了解使时间成为稀缺资源。然而,尽管它是他们未来的仲裁者,但他们也是时间的仲裁器。
{"title":"Arbiters of Time: The Experience of Adults Aging with Spinal Cord Injury.","authors":"Lisa Reber, Nasya S W Tan, Michelle A Meade, Martin Forchheimer, Denise G Tate, Philippa Clarke","doi":"10.3390/jal3010005","DOIUrl":"10.3390/jal3010005","url":null,"abstract":"<p><p>Time is a fundamental component of our lives. It is both objective, a structure outside of ourselves, and subjective, an element that is relative to the life we live and how we experience it. The disabled body must come to terms with time to understand the future impact of the injury and its progression, as well as how the injury will impose a new more accelerated aging process in the body, resulting in a compressed lifespan. The body also challenges time's control of the body. This paper extends the literature on the study of time to the experience of adults aging with a spinal cord injury (SCI). Drawing from interviews conducted with adults with long-term SCI, it examines how their narratives about aging and the proactive management of their lives reflect their orientation toward and anticipation of the future. Recognizing that the spoken word often carries a multiplicity of meanings, it considers what participants' words might imply about their engagement with time. The results of this study show that the process of aging is characterized by uncertainty and the expectations of functional and health decline, requiring a sense of urgency and vigilance in the face of the uncertain course of aging with SCI. Participants understood that their lifespan was compressed due to the physiological impact of accelerated aging. Knowledge of this compression made time a scarce resource. Yet, despite it being the arbiters of their futures, so too were they the arbiters of time.</p>","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48135999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative Study on Important Elements of Life for Japanese and Thai Older Adults 日本和泰国老年人重要生活要素的定性研究
Pub Date : 2022-12-30 DOI: 10.3390/jal3010002
Nobuko Shimizu, Takako Yamada, Nobuyuki Honda, Miyako Mochizuki, Mayumi Kato, Noboru Hasegawa, H. Sethabouppha, N. Suwankruhasn, Chalinee Suvanayos
Previous studies have demonstrated relationships between religiosity, physical and mental health-related outcomes, and healthy collective longevity. This qualitative study investigated the elements of pleasure and fulfillment in older adults living in the super-aged society of Japan and the rapidly super-aging society of Thailand. Semi-structured interviews were conducted with 14 older adults—seven from Japan, and seven from Thailand, covering five topics: (1) pleasures in daily life; (2) purpose in daily life; (3) thoughts about aging; (4) things they do actively for their health; and (5) things they worry about. Data were analyzed using the Steps for Coding and Theorization method. Japanese older adults mostly engaged in individually accomplished pleasures, whereas Thai older adults aimed to experience pleasures involving others. Thai older adults viewed aging as a natural phenomenon and stressed the importance of self-regulation. The Japanese participants, however, focused on activities that would avoid the burden of long-term care, maintain their current lifestyle, and help with self-improvement and lifetime learning. Although Thai older adults derived pleasure and fulfillment from being helpful toward others, Japanese older adults’ narratives indicated that they tended to worry about others. Differences between the two countries’ lifestyles, environments, beliefs, and religious contexts explain the differences in the mechanisms by which Japanese and Thai older adults experience joy, fulfillment, and purpose in life. These results suggest ways to improve quality of life, extend healthy life expectancy, and prevent cognitive decline in older adults thriving in aging societies.
先前的研究已经证明了宗教信仰、身心健康结果和健康的集体寿命之间的关系。这项定性研究调查了生活在日本老龄化社会和泰国快速老龄化社会的老年人的快乐和成就感要素。对14名老年人进行了半结构化访谈,其中7名来自日本,7名来自泰国,涵盖五个主题:(1)日常生活中的乐趣;(2) 日常生活目的;(3) 老龄化思想;(4) 他们为健康积极做的事情;以及(5)他们担心的事情。使用编码步骤和理论化方法对数据进行分析。日本的老年人大多从事个人完成的快乐,而泰国的老年人则致力于体验与他人有关的快乐。泰国老年人认为老龄化是一种自然现象,并强调自我调节的重要性。然而,日本参与者专注于避免长期护理负担、保持当前生活方式、帮助自我提升和终身学习的活动。尽管泰国老年人从帮助他人中获得快乐和满足感,但日本老年人的叙述表明,他们倾向于担心他人。两国生活方式、环境、信仰和宗教背景的差异解释了日本和泰国老年人体验快乐、成就感和人生目标的机制的差异。这些结果提出了提高生活质量、延长健康预期寿命和防止老龄化社会中老年人认知能力下降的方法。
{"title":"Qualitative Study on Important Elements of Life for Japanese and Thai Older Adults","authors":"Nobuko Shimizu, Takako Yamada, Nobuyuki Honda, Miyako Mochizuki, Mayumi Kato, Noboru Hasegawa, H. Sethabouppha, N. Suwankruhasn, Chalinee Suvanayos","doi":"10.3390/jal3010002","DOIUrl":"https://doi.org/10.3390/jal3010002","url":null,"abstract":"Previous studies have demonstrated relationships between religiosity, physical and mental health-related outcomes, and healthy collective longevity. This qualitative study investigated the elements of pleasure and fulfillment in older adults living in the super-aged society of Japan and the rapidly super-aging society of Thailand. Semi-structured interviews were conducted with 14 older adults—seven from Japan, and seven from Thailand, covering five topics: (1) pleasures in daily life; (2) purpose in daily life; (3) thoughts about aging; (4) things they do actively for their health; and (5) things they worry about. Data were analyzed using the Steps for Coding and Theorization method. Japanese older adults mostly engaged in individually accomplished pleasures, whereas Thai older adults aimed to experience pleasures involving others. Thai older adults viewed aging as a natural phenomenon and stressed the importance of self-regulation. The Japanese participants, however, focused on activities that would avoid the burden of long-term care, maintain their current lifestyle, and help with self-improvement and lifetime learning. Although Thai older adults derived pleasure and fulfillment from being helpful toward others, Japanese older adults’ narratives indicated that they tended to worry about others. Differences between the two countries’ lifestyles, environments, beliefs, and religious contexts explain the differences in the mechanisms by which Japanese and Thai older adults experience joy, fulfillment, and purpose in life. These results suggest ways to improve quality of life, extend healthy life expectancy, and prevent cognitive decline in older adults thriving in aging societies.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47945486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Higher Frequencies of T-Cells Expressing NK-Cell Markers and Chemokine Receptors in Parkinson’s Disease 帕金森病中表达nk细胞标记物和趋化因子受体的t细胞频率较高
Pub Date : 2022-12-22 DOI: 10.3390/jal3010001
D. Goldeck, C. Schulte, M. C. Teixeira dos Santos, Dieter Scheller, Lilly Öttinger, G. Pawelec, Christian Deuschle, D. Berg, A. Nogueira da Costa, W. Maetzler
Immune cells are thought to be involved in a destructive cycle of sterile cerebral inflammatory responses in neurodegenerative diseases such as Parkinson’s Disease (PD). Despite their peripheral origin, immune cells may enter the CNS due to impaired blood–brain barrier function and may potentially contribute to neuronal damage. Hence, specific characteristics of peripherally activated immune cells could help in understanding neurodegeneration in PD and could potentially serve as accessible disease markers. To investigate immune cell activation status, the expression of receptors for cell surface molecules CD161, NKG2A, NKG2C and NKG2D as well as chemokine receptors CCR6, CXCR2, CXCR3 and CCR5 associated with neurodegenerative diseases was investigated. The frequencies of peripheral CD8+ T-cells expressing the inhibitory and activating receptors NKG2A and NKG2C, and the activating receptor NKG2D were higher in PD patients than in healthy matched controls. The frequencies of NKG2C+CD8− cells were also higher, whereas the frequencies of CD161+ cells were not significantly different. Of the chemokine receptor-expressing cells, only the proportion of CD4−CD56+CCR5+ T-cells was higher in PD patients than in the controls. These observations support the hypothesis that an imbalance in the activation state of T-cells plays a role in the pathological processes of PD and suggest that peripheral blood immune cell phenotypes could be specific early markers for inflammation in PD.
免疫细胞被认为参与了神经退行性疾病如帕金森病(PD)的无菌脑炎症反应的破坏性循环。尽管免疫细胞起源于外周,但由于血脑屏障功能受损,免疫细胞可能进入中枢神经系统,并可能导致神经元损伤。因此,外周活化免疫细胞的特定特征可能有助于理解PD的神经退行性变,并可能作为可获得的疾病标志物。为了研究免疫细胞激活状态,我们研究了细胞表面分子CD161、NKG2A、NKG2C和NKG2D受体以及趋化因子受体CCR6、CXCR2、CXCR3和CCR5与神经退行性疾病相关的表达。PD患者外周血CD8+ t细胞表达抑制和激活受体NKG2A和NKG2C以及激活受体NKG2D的频率高于健康匹配对照组。NKG2C+CD8−细胞的频率也较高,而CD161+细胞的频率无显著差异。在趋化因子受体表达细胞中,PD患者中只有CD4−CD56+CCR5+ t细胞的比例高于对照组。这些观察结果支持了t细胞激活状态失衡在PD病理过程中发挥作用的假设,并提示外周血免疫细胞表型可能是PD炎症的特异性早期标志物。
{"title":"Higher Frequencies of T-Cells Expressing NK-Cell Markers and Chemokine Receptors in Parkinson’s Disease","authors":"D. Goldeck, C. Schulte, M. C. Teixeira dos Santos, Dieter Scheller, Lilly Öttinger, G. Pawelec, Christian Deuschle, D. Berg, A. Nogueira da Costa, W. Maetzler","doi":"10.3390/jal3010001","DOIUrl":"https://doi.org/10.3390/jal3010001","url":null,"abstract":"Immune cells are thought to be involved in a destructive cycle of sterile cerebral inflammatory responses in neurodegenerative diseases such as Parkinson’s Disease (PD). Despite their peripheral origin, immune cells may enter the CNS due to impaired blood–brain barrier function and may potentially contribute to neuronal damage. Hence, specific characteristics of peripherally activated immune cells could help in understanding neurodegeneration in PD and could potentially serve as accessible disease markers. To investigate immune cell activation status, the expression of receptors for cell surface molecules CD161, NKG2A, NKG2C and NKG2D as well as chemokine receptors CCR6, CXCR2, CXCR3 and CCR5 associated with neurodegenerative diseases was investigated. The frequencies of peripheral CD8+ T-cells expressing the inhibitory and activating receptors NKG2A and NKG2C, and the activating receptor NKG2D were higher in PD patients than in healthy matched controls. The frequencies of NKG2C+CD8− cells were also higher, whereas the frequencies of CD161+ cells were not significantly different. Of the chemokine receptor-expressing cells, only the proportion of CD4−CD56+CCR5+ T-cells was higher in PD patients than in the controls. These observations support the hypothesis that an imbalance in the activation state of T-cells plays a role in the pathological processes of PD and suggest that peripheral blood immune cell phenotypes could be specific early markers for inflammation in PD.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70126256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Associated with Annual Influenza Vaccination Uptake in U.S. Older Adults from 2019 to 2020 2019年至2020年美国老年人每年接种流感疫苗的相关因素
Pub Date : 2022-12-17 DOI: 10.3390/jal2040028
Margaret Anne Lovier, R. Wong
Annual influenza vaccination is important for older adults to prevent morbidity and mortality from seasonal influenza. Although the United States has had limited success in increasing influenza vaccination, the rise of the COVID-19 pandemic in 2020 may have changed older adults’ approach to vaccination. The objective of this study is to determine factors associated with influenza vaccination in 2019 and 2020 and compare their degree of associations across the two years. Data from the 2019 and 2020 National Health Interview Survey, a nationally representative cross-sectional interview, were collected for variables relating to annual influenza vaccination and possible associated factors. Data were analyzed using chi-square tests and multiple logistic regression. The results show that never having received a vaccination for pneumonia increased the odds of receiving an influenza vaccination by 6.79–7.80 times. Recent specialist care for eye or oral health significantly increased the odds of receiving an influenza vaccination. Being a smoker, identifying as African American, and considering oneself to have excellent overall health were associated with significantly lower odds of receiving a vaccination. Although self-reported feelings of anxiety were not associated with vaccination in 2019, they increased the odds in 2020. Overall, influenza vaccination in older adults may be tied to reliable healthcare access and perceived susceptibility to infectious respiratory diseases.
每年接种流感疫苗对老年人预防季节性流感的发病率和死亡率很重要。尽管美国在增加流感疫苗接种方面取得的成功有限,但2020年新冠肺炎大流行的兴起可能改变了老年人的疫苗接种方法。本研究的目的是确定2019年和2020年与流感疫苗接种相关的因素,并比较这两年的关联程度。收集了2019年和2020年全国健康访谈调查的数据,该调查是一项具有全国代表性的横断面访谈,涉及与年度流感疫苗接种相关的变量和可能的相关因素。使用卡方检验和多元逻辑回归对数据进行分析。结果显示,从未接种过肺炎疫苗的人接种流感疫苗的几率增加了6.79-7.80倍。最近对眼睛或口腔健康的专业护理显著增加了接种流感疫苗的几率。吸烟者、非裔美国人以及认为自己整体健康状况良好,接种疫苗的几率显著降低。尽管2019年自我报告的焦虑感与疫苗接种无关,但在2020年,焦虑感增加了几率。总的来说,老年人接种流感疫苗可能与可靠的医疗服务和对传染性呼吸道疾病的易感性有关。
{"title":"Factors Associated with Annual Influenza Vaccination Uptake in U.S. Older Adults from 2019 to 2020","authors":"Margaret Anne Lovier, R. Wong","doi":"10.3390/jal2040028","DOIUrl":"https://doi.org/10.3390/jal2040028","url":null,"abstract":"Annual influenza vaccination is important for older adults to prevent morbidity and mortality from seasonal influenza. Although the United States has had limited success in increasing influenza vaccination, the rise of the COVID-19 pandemic in 2020 may have changed older adults’ approach to vaccination. The objective of this study is to determine factors associated with influenza vaccination in 2019 and 2020 and compare their degree of associations across the two years. Data from the 2019 and 2020 National Health Interview Survey, a nationally representative cross-sectional interview, were collected for variables relating to annual influenza vaccination and possible associated factors. Data were analyzed using chi-square tests and multiple logistic regression. The results show that never having received a vaccination for pneumonia increased the odds of receiving an influenza vaccination by 6.79–7.80 times. Recent specialist care for eye or oral health significantly increased the odds of receiving an influenza vaccination. Being a smoker, identifying as African American, and considering oneself to have excellent overall health were associated with significantly lower odds of receiving a vaccination. Although self-reported feelings of anxiety were not associated with vaccination in 2019, they increased the odds in 2020. Overall, influenza vaccination in older adults may be tied to reliable healthcare access and perceived susceptibility to infectious respiratory diseases.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44593612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare Professionals’ Perspectives on the Outgoing Geriatric Team: A Qualitative Explorative Study 医疗保健专业人员对即将离职的老年团队的看法:一项质的探索性研究
Pub Date : 2022-12-09 DOI: 10.3390/jal2040026
Sanne Have Beck, D. Nielsen
The need for communication and collaboration increases when an older patient is discharged from the hospital, as the transition of care is complex for older patients living with multiple concurrent diseases. An intervention: The outgoing geriatric team was developed and initiated to address these patients’ complex needs. The outgoing geriatric team aimed to collaborate with healthcare professionals at a skilled nursing facility. This study explored how the intervention was experienced by the healthcare professionals from both the outgoing geriatric team and the skilled nursing facility. The study employed a qualitative explorative design using semi-structured interviews. Fourteen healthcare professionals participated in the interviews. Data were analyzed using Braun and Clark’s thematic analysis. Three themes emerged: (1) The need for personal contact and communication; (2) the need for competent care and sensitive observation; and (3) the need for clarification of responsibilities. The study emphasized the importance of meeting face-to-face during cross-sectoral collaboration when treating and caring for patients with complex care needs.
当老年患者出院时,沟通和协作的需求会增加,因为患有多种并发疾病的老年患者的护理过渡很复杂。干预措施:成立并启动了即将离任的老年医学团队,以解决这些患者的复杂需求。即将离任的老年医学团队旨在与专业护理机构的医疗保健专业人员合作。本研究探讨了即将离职的老年医学团队和熟练护理机构的医疗保健专业人员如何体验干预。该研究采用了半结构化访谈的定性探索性设计。14名医疗保健专业人员参加了访谈。数据采用Braun和Clark的主题分析法进行分析。出现了三个主题:(1)个人接触和交流的必要性;(2) 需要有能力的护理和敏感的观察;(3)需要澄清责任。该研究强调了在治疗和照顾有复杂护理需求的患者时,在跨部门合作期间面对面会面的重要性。
{"title":"Healthcare Professionals’ Perspectives on the Outgoing Geriatric Team: A Qualitative Explorative Study","authors":"Sanne Have Beck, D. Nielsen","doi":"10.3390/jal2040026","DOIUrl":"https://doi.org/10.3390/jal2040026","url":null,"abstract":"The need for communication and collaboration increases when an older patient is discharged from the hospital, as the transition of care is complex for older patients living with multiple concurrent diseases. An intervention: The outgoing geriatric team was developed and initiated to address these patients’ complex needs. The outgoing geriatric team aimed to collaborate with healthcare professionals at a skilled nursing facility. This study explored how the intervention was experienced by the healthcare professionals from both the outgoing geriatric team and the skilled nursing facility. The study employed a qualitative explorative design using semi-structured interviews. Fourteen healthcare professionals participated in the interviews. Data were analyzed using Braun and Clark’s thematic analysis. Three themes emerged: (1) The need for personal contact and communication; (2) the need for competent care and sensitive observation; and (3) the need for clarification of responsibilities. The study emphasized the importance of meeting face-to-face during cross-sectoral collaboration when treating and caring for patients with complex care needs.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45645784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Socio-Cultural Factors Influencing the Perception and Management of Meningitis among Older Patients and Their Caregivers 影响老年患者及其护理人员对脑膜炎认知和管理的社会文化因素
Pub Date : 2022-12-02 DOI: 10.3390/jal2040025
K. Mahmoud, M. Issah, Darlingtina K Esiaka
Limited studies have investigated the socio-cultural factors influencing the management and control of Meningococcal Meningitis among older adults in Northern Nigeria. This study explored the lived experiences of older individuals with Meningococcal Meningitis and relationships with their caregivers in the Kaiama Local Government Area of Kwara State, Nigeria. Twenty (20) Meningococcal Meningitis patients aged 65+, their caregivers, and three (3) traditional healers were purposely selected for in-depth interviews. Results show that some older adults believed that their health conditions were caused by supernatural forces, thereby influencing the scope and type of care they receive. For such participants, traditional treatment options are fundamental for addressing the root causes of their ailment. Few participants mentioned that their health conditions were caused by excessive heat in their community and were more likely to consider biomedical treatments as the most effective for diagnosing, treating, and managing the ailment. Additionally, Meningococcal Meningitis might have caused physical, cognitive, and psychological frailties and impairments among the older patients, compelling family caregivers to support the older adult patients in their homes. We discuss the need for a policy that would benefit both those who care for older adults and the older adults themselves.
有限的研究调查了影响尼日利亚北部老年人脑膜炎管理和控制的社会文化因素。本研究探讨了尼日利亚夸拉州凯亚马地方政府区老年脑膜炎球菌脑膜炎患者的生活经历及其与护理人员的关系。有意选择二十(20)名年龄在65岁以上的脑膜炎球菌脑膜炎患者、他们的护理人员和三(3)名传统治疗师进行深入访谈。结果显示,一些老年人认为他们的健康状况是由超自然力量引起的,从而影响了他们接受护理的范围和类型。对于这些参与者来说,传统的治疗方案对于解决他们疾病的根本原因至关重要。很少有参与者提到他们的健康状况是由社区过热引起的,他们更有可能认为生物医学治疗是诊断、治疗和管理疾病的最有效方法。此外,脑膜炎球菌脑膜炎可能会导致老年患者的身体、认知和心理脆弱和损伤,迫使家庭护理人员在家中支持老年患者。我们讨论了制定一项既有利于照顾老年人又有利于老年人自身的政策的必要性。
{"title":"Socio-Cultural Factors Influencing the Perception and Management of Meningitis among Older Patients and Their Caregivers","authors":"K. Mahmoud, M. Issah, Darlingtina K Esiaka","doi":"10.3390/jal2040025","DOIUrl":"https://doi.org/10.3390/jal2040025","url":null,"abstract":"Limited studies have investigated the socio-cultural factors influencing the management and control of Meningococcal Meningitis among older adults in Northern Nigeria. This study explored the lived experiences of older individuals with Meningococcal Meningitis and relationships with their caregivers in the Kaiama Local Government Area of Kwara State, Nigeria. Twenty (20) Meningococcal Meningitis patients aged 65+, their caregivers, and three (3) traditional healers were purposely selected for in-depth interviews. Results show that some older adults believed that their health conditions were caused by supernatural forces, thereby influencing the scope and type of care they receive. For such participants, traditional treatment options are fundamental for addressing the root causes of their ailment. Few participants mentioned that their health conditions were caused by excessive heat in their community and were more likely to consider biomedical treatments as the most effective for diagnosing, treating, and managing the ailment. Additionally, Meningococcal Meningitis might have caused physical, cognitive, and psychological frailties and impairments among the older patients, compelling family caregivers to support the older adult patients in their homes. We discuss the need for a policy that would benefit both those who care for older adults and the older adults themselves.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47573539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loneliness in Posttraumatic Stress Disorder: A Neglected Factor in Accelerated Aging? 创伤后应激障碍中的孤独感:加速衰老的一个被忽视的因素?
Pub Date : 2022-12-01 Epub Date: 2022-12-09 DOI: 10.3390/jal2040027
Barton W Palmer, Mariam A Hussain, James B Lohr

Prior research suggests that people with Posttraumatic Stress Disorder (PTSD) may experience a form of accelerated biological aging. In other populations, loneliness has been shown to elevate risk for many of the same components of accelerated biological aging, and other deleterious outcomes, as seen in people with PTSD. Although standard diagnostic criteria for PTSD include "feelings of detachment or estrangement from others", the relationship of such feelings to the concept of loneliness remains uncertain, in par potentially due to a failure to distinguish between loneliness versus objective social isolation. In order to catalyze wider research attention to loneliness in PTSD, and the potential contribution to accelerated biological aging, the present paper provides three components: (1) a conceptual overview of the relevant constructs and potential interrelationships, (2) a review of the limited extant empirical literature, and (3) suggested directions for future research. The existing empirical literature is too small to support many definitive conclusions, but there is evidence of an association between loneliness and symptoms of PTSD. The nature of this association may be complex, and the causal direction(s) uncertain. Guided by the conceptual overview and review of existing literature, we also highlight key areas for further research. The ultimate goal of this line of work is to elucidate mechanisms underlying any link between loneliness and accelerated aging in PTSD, and to develop, validate, and refine prevention and treatment efforts.

先前的研究表明,创伤后应激障碍(PTSD)患者可能会经历某种形式的生物加速衰老。在其他人群中,与创伤后应激障碍患者一样,孤独也会增加生物加速衰老的许多因素和其他有害结果的风险。虽然创伤后应激障碍的标准诊断标准包括 "脱离或疏远他人的感觉",但这种感觉与孤独概念之间的关系仍不确定,部分原因可能是未能区分孤独与客观的社会隔离。为了促使研究人员更广泛地关注创伤后应激障碍中的孤独感,以及它对加速生物衰老的潜在作用,本文提供了三个组成部分:(1)对相关概念和潜在相互关系的概念性概述;(2)对有限的现有实证文献的回顾;(3)对未来研究方向的建议。现有的实证文献数量太少,无法支持许多明确的结论,但有证据表明孤独与创伤后应激障碍症状之间存在关联。这种关联的性质可能很复杂,因果方向也不确定。在概念概述和现有文献回顾的指导下,我们还强调了有待于进一步研究的关键领域。这项工作的最终目标是阐明创伤后应激障碍患者的孤独感与加速衰老之间的关联机制,并开发、验证和完善预防和治疗工作。
{"title":"Loneliness in Posttraumatic Stress Disorder: A Neglected Factor in Accelerated Aging?","authors":"Barton W Palmer, Mariam A Hussain, James B Lohr","doi":"10.3390/jal2040027","DOIUrl":"10.3390/jal2040027","url":null,"abstract":"<p><p>Prior research suggests that people with Posttraumatic Stress Disorder (PTSD) may experience a form of accelerated biological aging. In other populations, loneliness has been shown to elevate risk for many of the same components of accelerated biological aging, and other deleterious outcomes, as seen in people with PTSD. Although standard diagnostic criteria for PTSD include \"feelings of detachment or estrangement from others\", the relationship of such feelings to the concept of loneliness remains uncertain, in par potentially due to a failure to distinguish between loneliness versus objective social isolation. In order to catalyze wider research attention to loneliness in PTSD, and the potential contribution to accelerated biological aging, the present paper provides three components: (1) a conceptual overview of the relevant constructs and potential interrelationships, (2) a review of the limited extant empirical literature, and (3) suggested directions for future research. The existing empirical literature is too small to support many definitive conclusions, but there is evidence of an association between loneliness and symptoms of PTSD. The nature of this association may be complex, and the causal direction(s) uncertain. Guided by the conceptual overview and review of existing literature, we also highlight key areas for further research. The ultimate goal of this line of work is to elucidate mechanisms underlying any link between loneliness and accelerated aging in PTSD, and to develop, validate, and refine prevention and treatment efforts.</p>","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"2 4","pages":"326-339"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10795929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of ageing and longevity
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1