Journal of AIDS and HIV research (Online)最新文献

{"title":"Assessment of renal dysfunction and associated factors among patients on Tenofovir based antiretroviral treatment at Gondar University Hospital, North West Ethiopia: Retrospective institution based cross sectional study","authors":"A. Endris, Diro Ermias, Hailu Workagegnehu, Abdu Oumer","doi":"10.5897/jahr2019.0498","DOIUrl":"https://doi.org/10.5897/jahr2019.0498","url":null,"abstract":"Tenofovir Disoproxil Fumarate a nucleotide reverse transcriptase inhibitor that was introduced as a preferred first line antiretroviral therapy in Ethiopia as of 2008. However, routine renal function assessment is recommended as it is known to cause renal failure and renal tubular dysfunction. \u0000 \u0000 To assess the practice of renal function monitoring of patients on TDF based ART regimen. The magnitude of renal dysfunction and its associated factors are also assessed. Institutional based retrospective record review was carried out to determine the magnitude of renal dysfunction and associated factors among HIV positive individuals who have been on TDF based ART regimen in Gondar university hospital. A total of 406 records were reviewed and 96.21% were found complete. From a total of 290 patients with Creatinine determination, renal dysfunction was found in 25.2%. Patients aged between 30-41years had AOR of 2.75(95%CI 1.18, 6.37), while those aged 42-53 years had AOR of 3.10 (95%CI 1.12, 8.55) as compared to those aged less than 30 years. Low body mass index (AOR 4.39(95%CI 2.24, 8.61), low CD4 (AOR 5.87(95%CI 2.73, 12.62)) were associated with increased risk of renal dysfunction. However Advanced WHO stages (stages 3 and 4), were associated with a lower incidence of renal dysfunction. About one fourth of patients who were on TDF regimen developed renal dysfunction. Twenty nine percent of participants had no renal function monitoring. Factors which influence the renal dysfunction in patients with TDF regimen in this study are age, low body mass index, low CD4 count and advanced WHO stage. \u0000 \u0000 Key words: Renal dysfunction, Tenofovir, antiretroviral therapy (ART) regimen, Gondar University Hospital","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/jahr2019.0498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44181714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the effect of anti-retroviral therapy on haematological parameters in HIV positive individuals in Zaria","authors":"M. Kayode E., O. Usiegbodi D., E Ajiboye M., S.Omonye I., N. Febut M., S. Buru A.","doi":"10.5897/JAHR2018.0467","DOIUrl":"https://doi.org/10.5897/JAHR2018.0467","url":null,"abstract":"A total of 230 patients receiving HAART for the first time and followed regularly were retained and their information gotten using a questionnaire. Of this number, 146 (63.5%) were on Stavudine + Lamivudine + Nevirapine (Regimen 1). 84(36.5%) while the remaining were on zidovudine + Lamivudine + Nevirapine (Regimen 5). The distribution was 75(32.6%) males and 155(67.4%) females. Blood was collected from each patient and analyzed (Baseline) using the Sysmex KX-21N for haematological parameters which include Haemoglobin (Hb), Packed cell volume (PCV), Total White Blood Cell count (WBC), Red blood Cell count (RBC), Platelet count, Neutrophil, Lymphocyte and Mixed count. All the values were repeated after 3 months treatment. The data were analysed using Graph pad InStat version 3. All patients had appreciable increase in CD4 levels, patients on regimen 1 had a significant increase in Hb, PCV and Lymphocyte count with P-value (<0.05). Patients on regimen 5 on the other hand had significant decrease in HB, PCV and Lymphocyte count with P-value (<0.05). In this study, haematological response is better in regimen 1 than regimen 5. \u0000 \u0000 Key words: HIV, highly active antiretroviral therapy (HAART), haematological parameters, anti-retroviral therapy, Zaria.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/JAHR2018.0467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43155284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral suppression and predictors among adolescents receiving care for HIV/AIDS in a tertiary health centre in Uyo, South-South, Nigeria","authors":"Dixon-Umo Ofonime Tony, I. Emmanuel","doi":"10.5897/jahr2020.0510","DOIUrl":"https://doi.org/10.5897/jahr2020.0510","url":null,"abstract":"Viral suppression assesses the success of HIV/AIDS treatment and can avert or reduce transmission of infection. Several factors contribute to viral suppression and may vary in different settings and age groups, hence the need to study the associated factors in different populations. The aim of the research was to study the level of viral suppression and its predictors among adolescents living with HIV (ALHIV), who knew their status, at the paediatric infectious diseases unit of a tertiary hospital in Nigeria. This was a descriptive cross-sectional study of 50 consecutive ALHIV who had full disclosure of their HIV diagnosis. There were 29 females with a female to male ratio of 1.38:1. Age range was 10 to 19 years.  Mean age was 15.06 ± 2.26 years. A pretested questionnaire was used together with information retrieved from case notes. Socio-demographic data and responses to possible factors affecting viral suppression were obtained and recorded in a proforma. Viral load ranged from <40 to 522,244 HIV RNA copies/ml of blood. Viral suppression rate was 82.00 with 22.00% in those aged 10 to 14 years and 60.00% in those between 15 and 19 years. Factors significantly associated with viral suppression were: Parents being alive (p=0.035), caregivers being on routine medications (p=0.003), missing medications (p=0.0001), number of missed doses of antiretroviral medications (p=0.001), and the current regimen of antiretroviral therapy (p=0.034). In conclusion, viral suppression is approaching UNAIDS target for 2020 and factors related to good adherence to antiretroviral regimens were significant associations. \u0000 \u0000 Key words: Viral suppression, disclosed adolescents, HIV, antiretroviral therapy.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"12 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/jahr2020.0510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41414485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of antiretroviral therapy adherence among older adolescents living with HIV in Kenya during the transition to adult care; An observational study.","authors":"Nyawira Gitahi-Kamau, Samuel Wahome, Elizabeth A Bukusi, Kenneth Ngure","doi":"10.5897/jahr2020.0513","DOIUrl":"10.5897/jahr2020.0513","url":null,"abstract":"<p><strong>Introduction: </strong>Lower levels of adherence to antiretroviral therapy (ART) among older adolescents as compared to adults are influenced by individual, psychosocial, and treatment-related factors. Successful transition of older adolescents into HIV adult care from paediatric & adolescent focused care requires an understanding of barriers to ART adherence. This study aimed at determining individual factors affecting ART adherence among older HIV positive adolescents transitioning to adult care.</p><p><strong>Methods: </strong>Between December 2018 and January 2019, we conducted a cross-sectional study among 82 perinatally infected adolescents aged 16-19 years in an HIV care and treatment clinic in Nairobi, Kenya. We used completed structured questionnaires and abstracted data from clinical charts. We performed multivariate logistic regression to identify factors independently associated >95% self-reported ART adherence (7-day recall).</p><p><strong>Results: </strong>The study participants had a median age of 17 (IQR 16,18) on ART for a median duration of 11 years (IQR 7,13). Sixty-four per cent (52) of the adolescents reported optimal adherence was of >95%, and 15% reported missing doses for three or more months. Self -reported adherence had a high correlation with viral loads of <1000 copies ml (Kappa= 0.087). Adolescents with high self-efficacy were eight times more likely to report adherence of >95% [OR 8.1, 95% CI (2.31- 28.18)]. Once a day, dosing was also independently associated with adherence [OR 1.58, 95 %CI [0.62-4.08].</p><p><strong>Conclusions: </strong>The reduction of ART pill burden and the inclusion of assessment of ART self -efficacy may contribute to transition preparedness among adolescents.</p>","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"12 2","pages":"24-33"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445519/pdf/nihms-1647928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39451467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological and clinical response to antiretroviral therapy according to baseline CD4+ T-cell count in Karamara General Hospital, Jigjiga, Ethiopia","authors":"Adugna Negussie, Walid A. Ali, Yerega Belete, Muktar Shekabdulahi","doi":"10.5897/jahr2019.0492","DOIUrl":"https://doi.org/10.5897/jahr2019.0492","url":null,"abstract":"In resource limited countries, there is scarcity of information regarding the degree of immunological and clinical recovery in remote communities with ART service. This study retrospectively assessed the degree of immune recovery by CD4 count after initiation of ART. A retrospective cohort study was conducted on adult HIV patients who have been on ART for more than one year at Karamara Hospital. All analyses were performed using SPSS software version 19.0 and findings were compared using the appropriate statistical tests. The median change from baseline to the most recent CD4 cell count was 141 cells/μl. By 5 years, the overall median CD4 cell count was 472 cells/μl while the median CD4 cell count was 401 cells/μl among patients with baseline CD4 cell counts ≤100 cells/μl, 467 cells/μl among those with baseline CD4 cell counts of 100 to 199 cells/μl, and 586 cells/μl among those with baseline CD4 cell counts equal to greater 200 cells/μl. At the end of the study, patients with higher baseline CD4 cell stratum returned to normal CD4 cell counts compared to those with the least baseline CD4 cell stratum. The findings suggest that consideration be given to initiation of ART at a CD4 cell count >350 cells/μl to achieve better immune recovery. \u0000 \u0000 Key words: Antiretroviral therapy, CD4 cell count, HIV infection.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/jahr2019.0492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44225105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of the care of HIV positive adolescents in Jos, Nigeria","authors":"E. Yiltok, Vivian Yuwa, Asabe Andrew Mshelia, H. Akhiwu, E. Ejeliogu, A. Ebonyi, P. Agaba, O. Agbaji, S. Oguche","doi":"10.5897/JAHR2019.0499","DOIUrl":"https://doi.org/10.5897/JAHR2019.0499","url":null,"abstract":"The introduction of highly active anti-retroviral therapy (HAART) to children with perinatally acquired HIV has prolonged their lifespan to adolescence and beyond. These HIV positive adolescents on care face challenges as they undertake their treatment which this study aimed to determine. The study was a cross-sectional descriptive study of challenges faced by adolescents between the ages 10 and 19 years on routine follow up at the HIV Clinic of Jos University Teaching Hospital (JUTH) over a period of six months. Ethical approval was obtained from the Health Research Ethical Committee (HREC) of JUTH and permission was also obtained from the AIDS Prevention Initiative in Nigeria (APIN) center JUTH.  Data obtained was entered into Epi Info version 7.2 and analyzed. Among the 147 subjects that were recruited, 56 (38%) were males, while females were 91(62%), M: F ratio of 1: 1.6. Of this, most were single (99%). Among the subjects, 81 (55%) were orphans, of which 53 (65%) were single orphan. Of the total patients studied, 68% lived with one or both parents, while 26% stayed with relatives and 5% lived in orphanages. Most were in school 137 (96%) and 85 (59%) were aware of their diagnosis. Discrimination was reported among 19 (13%) subjects by pupils/students, teachers, friends and/or family members, while 31 (21%) had thought of committing suicide. Among the subjects, 100 (70%) have considered stopping medication. HIV positive adolescents in our study suffer several challenges which include being orphans, discrimination and suicidal ideations. These challenges could interfere with retention in care and compliance with their antiretroviral drugs. \u0000 \u0000 Key words: Adolescents, HIV, orphaned child, social discrimination, suicidal ideation.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"11 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unprotected sexual practice and associated factors among people on anti-retro-viral therapy at public health facilities of Arba Minch town: Cross-sectional study","authors":"Zeleke Hailemariam Abebo, M. Asfaw, Alemayehu Bekele Kasahun, Aleme Mekuria Belachew, Tiglu Haile Haressa, A. Yalew","doi":"10.5897/JAHR2018.0476","DOIUrl":"https://doi.org/10.5897/JAHR2018.0476","url":null,"abstract":"Unprotected sexual practice with multiple partners is identified as the greatest risk factor for transmission of human immunodeficiency virus (HIV) in Sub Saharan Africa and it is a public health concern among people infected with HIV. However, due to the focus of HIV prevention efforts was largely on people uninfected with HIV, people on anti-retroviral therapy (ART) were not addressed by prevention strategies in Ethiopia, particularly at the study area. Thus, the aim of this study was to determine prevalence of unprotected sexual practice and associated factors among people who were on ART at Public Health facilities of Arba Minch town. Facility based cross-sectional study was undertaken on a sample of 513 patients who were on Anti-Retroviral Therapy in public Health Facilities of Arba Minch town. The study was conducted from January to March, 2014 by asking participants without any interval. Interviewer-based questionnaire was used to collect the data. Statistical package for social science (SPSS), version 20 software was used to perform descriptive and logistic regression analysis. Statistical significance was declared for predictor variables at p-value less than 0.05. Among 513 participants who were currently sexually active, 267 (52%) practiced unprotected sexual practice within 3 months prior to the study period. Monthly income of less than 500 Ethiopian birr, AOR and 95% CI were 4.69: 3.5-11.87; non specified monthly income, AOR and 95%CI were 6.74: 2.14-21.26; less than one year duration since ART started, AOR and 95%CI were 5.5:2.08-14.5;  lack of discussion about safe sex with partners, AOR and 95% CI were 7.03:4.20-11.80 and unknown  partner’s  sero-status for HIV, AOR and 95%CI were 2.76:1.16-6.53, times more likely to practice unprotected sexual practice as compared to their counterparts.   Prevalence of unprotected sexual practice was high. Low monthly income, unknown partner’s HIV sero-status, less than one year duration on anti-retro viral treatment (ART) and lack of discussion about safe sex with sexual partner were positively associated with unprotected sexual practice. Health education at different level and local media should give due attention on partners testing, open discussion about safe sex, and positive living information for recently enrolled ART patients. Income generating activities should be planned by carefully identifying those patients with low income status. \u0000 \u0000 Key words: Unprotected sexual practice, human immunodeficiency virus (HIV), anti-retro viral treatment (ART).","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"11 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42931080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mode of transmission of HIV infection among orphans and vulnerable children in some selected States \u0000in Nigeria","authors":"E. Bamgboye, P. Gado, Iyabode Olusanmi, D. Magaji, A. Atobatele, F. Iwuala, O. Ladipo","doi":"10.5897/JAHR2019.0493","DOIUrl":"https://doi.org/10.5897/JAHR2019.0493","url":null,"abstract":"Nigeria has high rate of pediatric HIV but there is a dearth of empirical data on the mode of HIV transmission. Association for Reproductive and Family Health (ARFH), with the support of USAID, is implementing a project to mitigate the impact of HIV on Orphans and Vulnerable Children (OVC) affected/infected with HIV/AIDS in Akwa-Ibom, Lagos, and Rivers states, Nigeria. The mode of HIV transmission among their OVC was examined. A retrospective study of enrolled OVC was done in the three states. HIV OVC whose mothers are HIV positive were classified under those who got HIV through vertical transmission, otherwise horizontal. The data was summarized using descriptive statistics.  Significance of association between qualitative variables and mode of transmission was determined using Chi-square test. Among the 387 OVC HIV positives who enrolled, there was a slight preponderance of males (50.6%); and about 42% were aged 10 - 17 years and 26% <5 years. Vertical mode of HIV transmission was higher (77%) in children <10 years. Horizontal transmission was highest among Akwa-ibom adolescents. In addition, age and State were significantly associated with transmission mode. A high proportion of children <10 years were infected through vertical transmission; while majority of adolescents are infected through horizontal transmission. Hence, a Swift scale-up of prevention of mother-to-child HIV transmission (PMTCT) services is recommended. Pregnant women infected with HIV need close monitoring to receive counseling as well as to get ARV prophylaxis. Also, condom demonstration should be introduced into the OVC project \u0000 \u0000 Key words: Orphans and vulnerable children (OVC), HIV, prevention of mother-to-child HIV transmission (PMTCT), vertical, horizontal, transmission.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/JAHR2019.0493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44173301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes among adolescents on antiretroviral therapy in Machakos, Kenya","authors":"D. Kimani, Simon Karanja, K. Ngure, S. Mwalili","doi":"10.5897/JAHR2019.0495","DOIUrl":"https://doi.org/10.5897/JAHR2019.0495","url":null,"abstract":"It is estimated that in 2017 there were about 1.5 million people living with Human immunodeficiency virus (HIV) in Kenya, of which 105,000 (7%) were adolescents. Adolescents have poorer antiretroviral therapy (ART) outcomes compared to adults. This study aimed to determine the treatment outcomes of adolescents on ART in Machakos County, Kenya. Adolescents on ART for at least two years from nine facilities were randomly selected in this retrospective cohort study. Data on their clinical and laboratory information at baseline and follow-up were abstracted from patient files. Descriptive analyses were used for central tendency while univariate and multivariate analysis was performed using SPSS version 16.0. A total of 182 adolescents consisting of 102 (56%) females and 80 (44%) males participated in the study. There were 54 (29.7%) young adolescents aged 12-15 years and 128 (70.3%) older adolescents (over 15 years). A total of 119 (65.4%) adolescents were retained after a mean follow-up period of 34.5 months. Almost all [180 (98.9%)] the adolescent had their weight and height documented, 143 (78.6%) had at least one viral load test, 140 (76.9%) at least one CD4 test and 164 (90.1%) had TB screening at the last visit. At first viral load test, 73% of adolescents were virally suppressed while 4.9% died in the course of follow-up. Additionally, 16.5% of adolescents were lost-to follow-up; 10.4% were transferred out, 20.3% had a treatment interruption and 6.6% were switched to second line treatment. Older adolescents had worse treatment outcomes compared to younger adolescents. They had lower retention rates; 60.2% compared to 77.8%; lower viral suppression: 70.4% compared to 75.6% and higher mortality: 6.3% compared to 1.9%. Suboptimal treatment outcomes were found despite good clinical follow-up, which were worse in the older adolescents. There is an opportunity to improve adolescent HIV treatment to meet national and global goals. \u0000 \u0000 Key words: Treatment outcomes, antiretroviral therapy, adolescents, human immunodeficiency virus (HIV), Machakos, viral suppression, Kenya.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42430218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication belief, locus of control, and adherence among patients on highly active anti retro viral therapy in Lagos, Nigeria","authors":"A. Adeniran, O. Atilola, O. OluwoleEsther, O. Fisher, Babatunde A. Odugbemi","doi":"10.5897/JAHR2019.0494","DOIUrl":"https://doi.org/10.5897/JAHR2019.0494","url":null,"abstract":"Anti-retro viral therapy (ART) is a lifelong treatment and its effectiveness depends critically both on the efficacy of the antiretroviral drugs against the virus and achieving a very high level of adherence (> 95%) to the medications. This study evaluated the relationship between medication beliefs, locus of control and adherence to ART among people living with HIV/AIDS (PLWHA) in Lagos. A cross-sectional descriptive study was conducted on 302 HIV/AIDS clients receiving Highly Active Anti-Retroviral Therapy in the outpatient ART clinics of the 3 selected public health facilities in Lagos State. Only respondents confirmed and diagnosed to be HIV positive and had met the eligibility criteria for initiating ART, and were 18 years and above on Highly Active Anti-Retroviral Therapy (HAART) for not less than a year. A total of 302 HIV positive persons on HAART completed the study. They were mostly females (n=202; 66.9%) with a mean age of 39 ± 10 years. About a third (30%; n=90) of respondents were adjudged non-adherent. Those who were adjudged adherent were significantly younger than the non-adherents (P=0.001). However, there was no significant difference in the mean score for medication beliefs (Concern or Necessity) and locus of control (Internal, Powerful Others or Chance) between those who were adjudged adherent or non-adherent. There was no direct relationship observed between the locus of control, medication beliefs and adherence to medication among patients on HAART in Lagos, Nigeria. Interventions targeting these socio-cognitive parameters may not yield a further increase in adherence. \u0000 \u0000 Key words: Locus of control, medication belief, adherence, highly active anti-retroviral therapy (HAART), HIV/AIDS.","PeriodicalId":73590,"journal":{"name":"Journal of AIDS and HIV research (Online)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5897/JAHR2019.0494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48080316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}