With the recent improvements in high-resolution mass spectrometry (HRMS), retrospective chemical analysis has been increasingly used in environmental sciences. This enables new insights into the chemical content of previously analysed samples with new data analysis methods or new information about emerging contaminants. This study aimed to conduct an in-depth investigation into the chemical content of various indoor dust samples using retrospective analysis. The samples were previously extracted using liquid-solid extraction without clean-up to increase the chemical coverage and thereafter analysed both using liquid chromatography (positive and negative ionisations) and gas chromatography coupled with high-resolution mass spectrometry. A retrospective data processing workflow was conducted in this new study by using both suspect screening analysis and non-target analysis. Among 30 dust samples from four different indoor settings, 298 compounds were tentatively identified with an identification confidence level of ≥ 3. The discussion was conducted on both individual compounds as well as their chemical compound groups and functional uses. Main detected chemical groups were plant natural products (n = 57), personal care products (n = 44), pharmaceuticals (n = 44), food additives (n = 43), plasticisers (n = 43), flame retardants (n = 43), colourants (n = 42) and pesticides (n = 31). Although some detected compounds were already reported for the same samples in our previous study, this retrospective analysis enabled the tentative identification of compounds such as polyethylene glycols, per- and polyfluoroalkyl substances, pesticides, benzotriazoles, benzothiazoles, fragrances, colourants and UV stabilizers. This study showed the usefulness of retrospective analysis on indoor dust samples to further characterise the chemical content, which can help to better estimate the exposure risks of organic contaminants to humans in the indoor environment.
{"title":"Extended characterization of the indoor dust chemical composition by retrospective suspect and non-target analysis of high resolution mass spectrometric data","authors":"Florian Dubocq, Thanh Wang","doi":"10.20517/jeea.2022.23","DOIUrl":"https://doi.org/10.20517/jeea.2022.23","url":null,"abstract":"With the recent improvements in high-resolution mass spectrometry (HRMS), retrospective chemical analysis has been increasingly used in environmental sciences. This enables new insights into the chemical content of previously analysed samples with new data analysis methods or new information about emerging contaminants. This study aimed to conduct an in-depth investigation into the chemical content of various indoor dust samples using retrospective analysis. The samples were previously extracted using liquid-solid extraction without clean-up to increase the chemical coverage and thereafter analysed both using liquid chromatography (positive and negative ionisations) and gas chromatography coupled with high-resolution mass spectrometry. A retrospective data processing workflow was conducted in this new study by using both suspect screening analysis and non-target analysis. Among 30 dust samples from four different indoor settings, 298 compounds were tentatively identified with an identification confidence level of ≥ 3. The discussion was conducted on both individual compounds as well as their chemical compound groups and functional uses. Main detected chemical groups were plant natural products (n = 57), personal care products (n = 44), pharmaceuticals (n = 44), food additives (n = 43), plasticisers (n = 43), flame retardants (n = 43), colourants (n = 42) and pesticides (n = 31). Although some detected compounds were already reported for the same samples in our previous study, this retrospective analysis enabled the tentative identification of compounds such as polyethylene glycols, per- and polyfluoroalkyl substances, pesticides, benzotriazoles, benzothiazoles, fragrances, colourants and UV stabilizers. This study showed the usefulness of retrospective analysis on indoor dust samples to further characterise the chemical content, which can help to better estimate the exposure risks of organic contaminants to humans in the indoor environment.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Assessing chemical exposure in home and personal care products (HPCPs) represents an important data need. Key challenges to the assessment are related to limited knowledge in quantifying and characterizing the weight-fraction inclusion level and functionality of chemicals in HPCPs. Publicly available tools have been developed to address these challenges, such as the Chemical and Products database (CPDat). This study aims to evaluate the relative performance of CPDat by comparing estimates of weight-fraction inclusion level and functionality to other relevant data sources. Specifically, estimates obtained from CPDat are evaluated and compared with estimates obtained from marketing analytic data, using Euromonitor Passport for 31 commonly used chemicals found in HPCPs. The results obtained from this exercise suggest relatively good agreement between each of the methods for 10 chemicals (ρ = 0.92; P-value =0.02). When considering all 31 chemical ingredients, however, the correlation observed is generally poor (ρ = 0.46; P-value = 0.1), which is attributed to differences in how the underlying data are obtained for each method. With an emphasis on obtaining data based on mining datasheets for individual products, the application of CPDat is suggested to be useful for higher tiers of assessment, with data obtained from marketing analytics providing valuable input to exposure-based screening models. The insight gained from this study can be used to help guide the appropriate use of data obtained from different sources within a tiered exposure assessment.
{"title":"Characterizing and quantifying chemical ingredient use in consumer products between two separate databases and implications for environmental and human health exposure","authors":"T. Gouin","doi":"10.20517/jeea.2022.14","DOIUrl":"https://doi.org/10.20517/jeea.2022.14","url":null,"abstract":"Assessing chemical exposure in home and personal care products (HPCPs) represents an important data need. Key challenges to the assessment are related to limited knowledge in quantifying and characterizing the weight-fraction inclusion level and functionality of chemicals in HPCPs. Publicly available tools have been developed to address these challenges, such as the Chemical and Products database (CPDat). This study aims to evaluate the relative performance of CPDat by comparing estimates of weight-fraction inclusion level and functionality to other relevant data sources. Specifically, estimates obtained from CPDat are evaluated and compared with estimates obtained from marketing analytic data, using Euromonitor Passport for 31 commonly used chemicals found in HPCPs. The results obtained from this exercise suggest relatively good agreement between each of the methods for 10 chemicals (ρ = 0.92; P-value =0.02). When considering all 31 chemical ingredients, however, the correlation observed is generally poor (ρ = 0.46; P-value = 0.1), which is attributed to differences in how the underlying data are obtained for each method. With an emphasis on obtaining data based on mining datasheets for individual products, the application of CPDat is suggested to be useful for higher tiers of assessment, with data obtained from marketing analytics providing valuable input to exposure-based screening models. The insight gained from this study can be used to help guide the appropriate use of data obtained from different sources within a tiered exposure assessment.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Poma, Shanshan Yin, B. T. Folarin, Alicia Macan Schönleben, Jasper Bombeke, J. C. Altamirano, G. Ssepuuya, D. Nakimbugwe, T. Oluseyi, A. Covaci
Pesticide use is a common practice worldwide, especially in Sub-Saharan African (SSA) countries, where ongoing agriculture intensification and the need for disease vector control make it essential. The population can thus be exposed to variable amounts of pesticides through the diet. Edible insects are a highly regarded food source in SSA. However, they are still mostly harvested from the wild, where chemical applications are not necessarily controlled, representing a major cause of concern for consumers. We investigated residues of legacy (OCPs) and current-use pesticides (CUPs) in selected edible insects commonly consumed in Uganda and Nigeria, and evaluated the eventual health risk for the adult population associated with their consumption. Targeted OCPs were < LOQ in all analysed edible insects, except for hexachlorobenzene (up to 0.87 ng/g dw), while several CUPs were present at notable levels. Cypermethrin showed the highest median concentration (17 ng/g dw), while the Nigerian cricket Brachytrupes membranaceus was the most contaminated sample, with concentrations of aldicarb, propoxur, chlorpyrifos, dichlorvos and paclobutrazol reaching 118 ng/g dw, 327 ng/g dw, 156 ng/g dw, 26 ng/dw, and 14 ng/g dw, respectively. The concentrations of pesticides were generally well below the available maximum residue levels (MRLs), and the dietary risk assessment did not indicate health threats for the adult population. However, we suggest that the monitoring of the chemical safety of edible insects in SSA should be further investigated and insects should be integrated into more extensive dietary studies.
{"title":"First insights into the occurrence of pesticide residues in edible insects from sub-Saharan African countries","authors":"Giulia Poma, Shanshan Yin, B. T. Folarin, Alicia Macan Schönleben, Jasper Bombeke, J. C. Altamirano, G. Ssepuuya, D. Nakimbugwe, T. Oluseyi, A. Covaci","doi":"10.20517/jeea.2022.25","DOIUrl":"https://doi.org/10.20517/jeea.2022.25","url":null,"abstract":"Pesticide use is a common practice worldwide, especially in Sub-Saharan African (SSA) countries, where ongoing agriculture intensification and the need for disease vector control make it essential. The population can thus be exposed to variable amounts of pesticides through the diet. Edible insects are a highly regarded food source in SSA. However, they are still mostly harvested from the wild, where chemical applications are not necessarily controlled, representing a major cause of concern for consumers. We investigated residues of legacy (OCPs) and current-use pesticides (CUPs) in selected edible insects commonly consumed in Uganda and Nigeria, and evaluated the eventual health risk for the adult population associated with their consumption. Targeted OCPs were < LOQ in all analysed edible insects, except for hexachlorobenzene (up to 0.87 ng/g dw), while several CUPs were present at notable levels. Cypermethrin showed the highest median concentration (17 ng/g dw), while the Nigerian cricket Brachytrupes membranaceus was the most contaminated sample, with concentrations of aldicarb, propoxur, chlorpyrifos, dichlorvos and paclobutrazol reaching 118 ng/g dw, 327 ng/g dw, 156 ng/g dw, 26 ng/dw, and 14 ng/g dw, respectively. The concentrations of pesticides were generally well below the available maximum residue levels (MRLs), and the dietary risk assessment did not indicate health threats for the adult population. However, we suggest that the monitoring of the chemical safety of edible insects in SSA should be further investigated and insects should be integrated into more extensive dietary studies.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noel J Aquilina, Christopher M Havel, Neal L Benowitz, Peyton Jacob
Aim: Most of the carcinogenic pollutants coming from tobacco smoking or other combustion processes tend to accumulate in settled house dust (SHD) over time. This study evaluated the load of these pollutants in smokers and non-smokers' houses from relatively fresh SHD collected in five different districts on the island of Malta.
Methods: An improved, efficient extraction method to obtain three fractions from a 200 mg of SHD was developed. It was validated for the analysis of nicotine and polycyclic aromatic hydrocarbons (PAH) by GC-MS/MS and nicotelline and TSNA by LC-MS/MS. Kruskal-Wallis H tests were used to evaluate differences across districts, while a Mann-Whitney U test was used to check differences between smokers and non-smokers' houses. Diagnostic ratios were used to evaluate the carcinogenicity of PAH in SHD in Malta.
Results: For all analytes, no statistical difference was observed across different districts, but, in smokers' houses, 97.9% of the total concentration of all target analytes found in SHD is nicotine, 0.1% is TSNA, and 2.0% is PAH. In non-smokers' houses, nicotine represents 16.8% of the load, while 0.4% and 82.8% are TSNA and PAH, respectively. The carcinogenicity of the PAH mixture in Maltese SHD, expressed as the mean benzo(a)pyrene equivalent (BaPeq) is 371 ng/g.
Conclusion: Indoor activities, ventilation practices, and infiltration of outdoor pollutants contribute to a complex SHD composition. Although the BaPeq is on the lower end of carcinogenicity, the effects of a mixture including tobacco-related potent carcinogens in SHD are largely unknown. In view of indoor, continuous exposure to SHD through several pathways, further research is warranted.
{"title":"Tobacco-specific and combustion pollutants in settled house dust in Malta.","authors":"Noel J Aquilina, Christopher M Havel, Neal L Benowitz, Peyton Jacob","doi":"10.20517/jeea.2021.09","DOIUrl":"https://doi.org/10.20517/jeea.2021.09","url":null,"abstract":"<p><strong>Aim: </strong>Most of the carcinogenic pollutants coming from tobacco smoking or other combustion processes tend to accumulate in settled house dust (SHD) over time. This study evaluated the load of these pollutants in smokers and non-smokers' houses from relatively fresh SHD collected in five different districts on the island of Malta.</p><p><strong>Methods: </strong>An improved, efficient extraction method to obtain three fractions from a 200 mg of SHD was developed. It was validated for the analysis of nicotine and polycyclic aromatic hydrocarbons (PAH) by GC-MS/MS and nicotelline and TSNA by LC-MS/MS. Kruskal-Wallis H tests were used to evaluate differences across districts, while a Mann-Whitney <i>U</i> test was used to check differences between smokers and non-smokers' houses. Diagnostic ratios were used to evaluate the carcinogenicity of PAH in SHD in Malta.</p><p><strong>Results: </strong>For all analytes, no statistical difference was observed across different districts, but, in smokers' houses, 97.9% of the total concentration of all target analytes found in SHD is nicotine, 0.1% is TSNA, and 2.0% is PAH. In non-smokers' houses, nicotine represents 16.8% of the load, while 0.4% and 82.8% are TSNA and PAH, respectively. The carcinogenicity of the PAH mixture in Maltese SHD, expressed as the mean benzo(a)pyrene equivalent (BaP<sub>eq</sub>) is 371 ng/g.</p><p><strong>Conclusion: </strong>Indoor activities, ventilation practices, and infiltration of outdoor pollutants contribute to a complex SHD composition. Although the BaP<sub>eq</sub> is on the lower end of carcinogenicity, the effects of a mixture including tobacco-related potent carcinogens in SHD are largely unknown. In view of indoor, continuous exposure to SHD through several pathways, further research is warranted.</p>","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The occurrence and behavior of dechlorane plus (DP), an additive chlorinated flame retardant, have been intensively studied since it was identified in 2006. The commercial products of DP are a mixture of two stereoisomers: syn-DP and anti-DP. Stereoselective bioaccumulation of DP isomers in biota was reported in field monitoring and laboratory experiments. This review summarizes stereoselective bioaccumulation of DP in biota samples and provides the potential mechanisms for this stereoselective bioaccumulation. Stereoselective enrichment of syn-DP was widely observed in fish, whereas selective enrichment of anti-DP was mainly found in some birds. This species-specific stereoselective enrichment of DP might reflect that two different types of DP isomer fractionation occurred in bioaccumulation between ectotherms and endotherms. Anti-DP is more readily metabolized through biotransformation in all animals. However, a preferential excretion of anti-DP in fish and syn-DP in birds was observed based on the available data. Both processes determine the DP isomer fractionation in bioaccumulation. A direct comparison in DP composition between biological samples and commercial products was conducted for most studies to determine the occurrence of stereoselective DP enrichment, which may lead to underestimating the potential stereoselective enrichment of DP in organisms. The factors which affected the DP isomer composition in organisms included the tissues or organs used, DP concentration, organisms’ trophic levels occupied, and sex. Inconsistent results were obtained considering the effects of these influence factors. The underlying cause of these inconsistent results is unclear based on present data. Further research on DP biotransformation and interactions between DP and biomacromolecule is needed.
{"title":"Species-specific dechlorane plus isomer fractionation during bioaccumulation: phenomenon and potential mechanisms","authors":"Ke-Lan Guan, Hong-Ying Liu, Xiaojun Luo","doi":"10.20517/jeea.2022.07","DOIUrl":"https://doi.org/10.20517/jeea.2022.07","url":null,"abstract":"The occurrence and behavior of dechlorane plus (DP), an additive chlorinated flame retardant, have been intensively studied since it was identified in 2006. The commercial products of DP are a mixture of two stereoisomers: syn-DP and anti-DP. Stereoselective bioaccumulation of DP isomers in biota was reported in field monitoring and laboratory experiments. This review summarizes stereoselective bioaccumulation of DP in biota samples and provides the potential mechanisms for this stereoselective bioaccumulation. Stereoselective enrichment of syn-DP was widely observed in fish, whereas selective enrichment of anti-DP was mainly found in some birds. This species-specific stereoselective enrichment of DP might reflect that two different types of DP isomer fractionation occurred in bioaccumulation between ectotherms and endotherms. Anti-DP is more readily metabolized through biotransformation in all animals. However, a preferential excretion of anti-DP in fish and syn-DP in birds was observed based on the available data. Both processes determine the DP isomer fractionation in bioaccumulation. A direct comparison in DP composition between biological samples and commercial products was conducted for most studies to determine the occurrence of stereoselective DP enrichment, which may lead to underestimating the potential stereoselective enrichment of DP in organisms. The factors which affected the DP isomer composition in organisms included the tissues or organs used, DP concentration, organisms’ trophic levels occupied, and sex. Inconsistent results were obtained considering the effects of these influence factors. The underlying cause of these inconsistent results is unclear based on present data. Further research on DP biotransformation and interactions between DP and biomacromolecule is needed.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonthinee Waiyarat, S. Boontanon, N. Boontanon, S. Harrad, M. Abdallah, D. Drage
Aim: This study investigated hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA) concentrations in indoor dust from houses, offices, and cars and estimated toddler and adult exposure to HBCDD and TBBPA through dust ingestion. Methods: The concentrations of HBCDD and TBBPA were measured in 47 indoor dust samples collected from the Bangkok metropolitan area, Thailand. All samples were analyzed for HBCDD and TBBPA using LC-MS/MS. The estimated daily intake (EDI) through dust ingestion was calculated from the median and 95th percentile concentrations of HBCDD and TBBPA. Results: HBCDD was detected in 47% of samples, and TBBPA was detected in all samples. The median concentrations of HBCDD were 6.7 ng g-1, <0.7 ng g-1, and <0.7 ng g-1 in cars, houses, and offices, respectively. The isomer composition of ∑HBCDD in dust was: α-HBCDD (40%-54%), γ-HBCDD (19%-40%), and β-HBCDD (17%-28%). In contrast, TBBPA was observed at higher concentrations, with median values of 674, 67, and 22 ng g-1 in offices, houses, and cars, respectively. Under a median exposure scenario, toddlers were exposed to 0.05 ng kg-1 bw day-1 for HBCDD and 0.25 ng kg-1 bw day-1 for TBBPA, with adults exposed to 0.01 and 0.06 ng kg-1 bw day-1 for HBCDD and TBBPA respectively. Conclusion: Concentrations of HBCDD in dust from Thai cars, homes, and offices are lower than those of TBBPA following the listing of HBCDD in the Stockholm Convention on Persistent Organic Pollutants and limited use of HBCDD in Thailand in applications such as building insulation foam. Concentrations of TBBPA in office dust significantly exceeded (P < 0.05) those in house and car dust owing to the greater number of electronic appliances and poor natural ventilation in offices. EDIs for Thai toddlers exceeded those of adults under both median and high-end exposure scenarios. However, EDIs of HBCDD and TBBPA for the general Thai population were below the corresponding oral reference dose guidelines.
目的:本研究调查了房屋、办公室和汽车室内粉尘中六溴环十二烷(HBCDD)和四溴双酚A (TBBPA)的浓度，并估计幼儿和成人通过吸入粉尘接触到六溴环十二烷和TBBPA的情况。方法:对泰国曼谷市区采集的47份室内粉尘样本进行HBCDD和TBBPA浓度测定。采用LC-MS/MS分析所有样品中HBCDD和TBBPA的含量。根据HBCDD和TBBPA的中位数和第95百分位浓度计算通过粉尘摄入估计的每日摄入量(EDI)。结果:HBCDD检出率为47%，TBBPA检出率为100%。汽车、住宅和办公室中HBCDD的中位浓度分别为6.7 ng g-1、<0.7 ng g-1和<0.7 ng g-1。∑HBCDD在粉尘中的异构体组成为:α-HBCDD(40% ~ 54%)、γ-HBCDD(19% ~ 40%)和β-HBCDD(17% ~ 28%)。相比之下，TBBPA的浓度更高，办公室、房屋和汽车中的中位数分别为674、67和22 ng g-1。在中位暴露情景下，幼儿对HBCDD和TBBPA的暴露量分别为0.05 ng kg-1 bw d -1和0.25 ng kg-1 bw d -1，成人对HBCDD和TBBPA的暴露量分别为0.01和0.06 ng kg-1 bw d -1。结论:由于《关于持久性有机污染物的斯德哥尔摩公约》将HBCDD列入名单，以及泰国在建筑保温泡沫等应用中限制使用HBCDD，泰国汽车、家庭和办公室粉尘中的HBCDD浓度低于TBBPA。由于办公室内电子设备较多，自然通风较差，办公室粉尘中TBBPA浓度显著高于室内粉尘和汽车粉尘(P < 0.05)。在中位和高端暴露情景下，泰国幼儿的edi都超过了成年人。然而，泰国一般人群的HBCDD和TBBPA的EDIs低于相应的口服参考剂量指南。
{"title":"Concentrations and human exposure to hexabromocyclododecane and tetrabromobisphenol A from the indoor environment in Bangkok metropolitan area, Thailand","authors":"Sonthinee Waiyarat, S. Boontanon, N. Boontanon, S. Harrad, M. Abdallah, D. Drage","doi":"10.20517/jeea.2022.06","DOIUrl":"https://doi.org/10.20517/jeea.2022.06","url":null,"abstract":"Aim: This study investigated hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA) concentrations in indoor dust from houses, offices, and cars and estimated toddler and adult exposure to HBCDD and TBBPA through dust ingestion. Methods: The concentrations of HBCDD and TBBPA were measured in 47 indoor dust samples collected from the Bangkok metropolitan area, Thailand. All samples were analyzed for HBCDD and TBBPA using LC-MS/MS. The estimated daily intake (EDI) through dust ingestion was calculated from the median and 95th percentile concentrations of HBCDD and TBBPA. Results: HBCDD was detected in 47% of samples, and TBBPA was detected in all samples. The median concentrations of HBCDD were 6.7 ng g-1, <0.7 ng g-1, and <0.7 ng g-1 in cars, houses, and offices, respectively. The isomer composition of ∑HBCDD in dust was: α-HBCDD (40%-54%), γ-HBCDD (19%-40%), and β-HBCDD (17%-28%). In contrast, TBBPA was observed at higher concentrations, with median values of 674, 67, and 22 ng g-1 in offices, houses, and cars, respectively. Under a median exposure scenario, toddlers were exposed to 0.05 ng kg-1 bw day-1 for HBCDD and 0.25 ng kg-1 bw day-1 for TBBPA, with adults exposed to 0.01 and 0.06 ng kg-1 bw day-1 for HBCDD and TBBPA respectively. Conclusion: Concentrations of HBCDD in dust from Thai cars, homes, and offices are lower than those of TBBPA following the listing of HBCDD in the Stockholm Convention on Persistent Organic Pollutants and limited use of HBCDD in Thailand in applications such as building insulation foam. Concentrations of TBBPA in office dust significantly exceeded (P < 0.05) those in house and car dust owing to the greater number of electronic appliances and poor natural ventilation in offices. EDIs for Thai toddlers exceeded those of adults under both median and high-end exposure scenarios. However, EDIs of HBCDD and TBBPA for the general Thai population were below the corresponding oral reference dose guidelines.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67658041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of the current study was to calculate the deposited dose rate in the human respiratory tract arising from particle number (PN) and particle mass (PM) measurements. A main objective was the investigation of deposition pattern and characteristics of the two metrics in the human respiratory tract. The dose rate was estimated for residents at a suburban background location (Chania, Greece). The total dose rate showed two peaks, one in the morning (1.6 × 109 particles/h at 7:00-8:00) and the other one at night (2.1 × 109 particles/h at 21:00-22:00), during the warm period, while the cold period showed two peaks, morning (2.0 × 109 particles/h at 9:00-10:00) and afternoon (3.6 × 109 particles/h at 18:00-19:00). The peaks during the warm period were associated with traffic emissions, whereas the peaks during the cold period were associated with both heating and traffic emissions. A higher dose rate of PN10 was found in the alveolar region while for PM10 it was found in the extrathoracic region. These findings are linked with increased contribution of ultrafine and coarse particles to PN10 (65%-78% and 54%-62% for cold and warm periods, respectively) and PM10 (63% and 55% for cold and warm periods, respectively) concentrations, respectively. The current study showed the importance to use both number and mass aerosol metrics for determining the human exposure and regional dose and their related health effects. The novelty of the current study is the simultaneous measurements of the two particles metrics and the full particle size distributions to make accurate estimates of regional deposited dose.
{"title":"Regional deposited dose in the human respiratory tract using different particulate metrics","authors":"E. Chalvatzaki, S. Chatoutsidou, M. Lazaridis","doi":"10.20517/jeea.2022.16","DOIUrl":"https://doi.org/10.20517/jeea.2022.16","url":null,"abstract":"The objective of the current study was to calculate the deposited dose rate in the human respiratory tract arising from particle number (PN) and particle mass (PM) measurements. A main objective was the investigation of deposition pattern and characteristics of the two metrics in the human respiratory tract. The dose rate was estimated for residents at a suburban background location (Chania, Greece). The total dose rate showed two peaks, one in the morning (1.6 × 109 particles/h at 7:00-8:00) and the other one at night (2.1 × 109 particles/h at 21:00-22:00), during the warm period, while the cold period showed two peaks, morning (2.0 × 109 particles/h at 9:00-10:00) and afternoon (3.6 × 109 particles/h at 18:00-19:00). The peaks during the warm period were associated with traffic emissions, whereas the peaks during the cold period were associated with both heating and traffic emissions. A higher dose rate of PN10 was found in the alveolar region while for PM10 it was found in the extrathoracic region. These findings are linked with increased contribution of ultrafine and coarse particles to PN10 (65%-78% and 54%-62% for cold and warm periods, respectively) and PM10 (63% and 55% for cold and warm periods, respectively) concentrations, respectively. The current study showed the importance to use both number and mass aerosol metrics for determining the human exposure and regional dose and their related health effects. The novelty of the current study is the simultaneous measurements of the two particles metrics and the full particle size distributions to make accurate estimates of regional deposited dose.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Olivero-Verbel, B. Johnson-Restrepo, E. Eljarrat
Concentrations of 19 organophosphate esters (OPEs) were determined in dust samples collected from house and car indoor microenvironments in three Colombian cities. ∑OPE concentrations ranged from 1.31 to 599 μg/g. Mean concentrations of dust homes were 82.6, 48.3, and 46.7 μg/g for Cartagena, Bogotá, and Medellín, respectively. The pollution inside cars was somewhat higher than in houses, with a mean value of 231 μg/g. Sixteen compounds were detected, being TPHP, DCP, TEP, and TCEP the most frequently detected. As for OPEs with higher levels in houses, we found (mean ± SD) 35.2 ± 37.1 μg/g for TDCIPP in Cartagena, 35.6 ± 80.2 μg/g for TPHP in Cartagena, 15.9 ± 31.4 μg/g for DCP in Cartagena, 35.7 ± 19.1 μg/g for TBOEP in Bogotá, 15.7 ± 14.8 μg/g for 4IPPDPP in Medellín, and 17.5 ± 22.9 μg/g for TCEP in Cartagena, while the highest OPE value found in cars was 176 ± 144 μg/g for TDCIPP. The estimated daily intake (EDI) of OPEs through dust ingestion ranged from 0.001 ng/kg bw/day for adults to 110 ng/kg bw/day for toddlers, while dermal absorption ranged from 0.02 ng/kg bw/day for adults to 42.7 ng/kg bw/day for infants. Overall, the EDIs of dust ingestion were three times greater than those of dust dermal absorption. The estimated EDIs were several orders of magnitude below the corresponding reference doses. However, the incremental lifetime cancer risk (ILCR) for TCEP ranged from 1.1 × 10-5 for infants in Bogotá to 4.3 × 10-4 for adults in Cartagena, while ILCR for TEHP ranged from 8.8 × 10-7 for infants in Bogotá to 1.1 × 10-5 for adults in Bogotá. These estimated ILCRs were higher than the safe limit value of 1 × 10-6 and showed that these populations are exposed to moderate cancer risk.
{"title":"Human exposure assessment of organophosphate esters (OPEs) through dust ingestion and dermal absorption in Colombian cities","authors":"R. Olivero-Verbel, B. Johnson-Restrepo, E. Eljarrat","doi":"10.20517/jeea.2021.08","DOIUrl":"https://doi.org/10.20517/jeea.2021.08","url":null,"abstract":"Concentrations of 19 organophosphate esters (OPEs) were determined in dust samples collected from house and car indoor microenvironments in three Colombian cities. ∑OPE concentrations ranged from 1.31 to 599 μg/g. Mean concentrations of dust homes were 82.6, 48.3, and 46.7 μg/g for Cartagena, Bogotá, and Medellín, respectively. The pollution inside cars was somewhat higher than in houses, with a mean value of 231 μg/g. Sixteen compounds were detected, being TPHP, DCP, TEP, and TCEP the most frequently detected. As for OPEs with higher levels in houses, we found (mean ± SD) 35.2 ± 37.1 μg/g for TDCIPP in Cartagena, 35.6 ± 80.2 μg/g for TPHP in Cartagena, 15.9 ± 31.4 μg/g for DCP in Cartagena, 35.7 ± 19.1 μg/g for TBOEP in Bogotá, 15.7 ± 14.8 μg/g for 4IPPDPP in Medellín, and 17.5 ± 22.9 μg/g for TCEP in Cartagena, while the highest OPE value found in cars was 176 ± 144 μg/g for TDCIPP. The estimated daily intake (EDI) of OPEs through dust ingestion ranged from 0.001 ng/kg bw/day for adults to 110 ng/kg bw/day for toddlers, while dermal absorption ranged from 0.02 ng/kg bw/day for adults to 42.7 ng/kg bw/day for infants. Overall, the EDIs of dust ingestion were three times greater than those of dust dermal absorption. The estimated EDIs were several orders of magnitude below the corresponding reference doses. However, the incremental lifetime cancer risk (ILCR) for TCEP ranged from 1.1 × 10-5 for infants in Bogotá to 4.3 × 10-4 for adults in Cartagena, while ILCR for TEHP ranged from 8.8 × 10-7 for infants in Bogotá to 1.1 × 10-5 for adults in Bogotá. These estimated ILCRs were higher than the safe limit value of 1 × 10-6 and showed that these populations are exposed to moderate cancer risk.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polychlorinated naphthalenes (PCNs) were listed as Persistent organic pollutants in the Stockholm Convention, in May 2015, because of their adverse health and environmental effects. PCNs production began in the early 1900s when they were used extensively in several consumer goods as fire retardants. However, because of their health and environmental implications, the production and use of PCNs chemicals were voluntarily banned in many countries in the 1970s and 1980s. However, PCNs are still detected in different environmental samples including air, water, sediments, soil, indoor dust, biota, consumer products, human diet, blood and serum today, as a result of their historical use and unintentional production. Thus, PCNs can be released into the environment throughout their life cycle. It becomes, therefore, crucial to monitor them in different environmental compartments. To date, about 163 reports on PCNs levels in several matrices have been published in different parts of the world. It was reported that toxic PCNs such as chloronaphthalenes 66, 67 and 73 are prevalent in most samples; thus, there is a need to continuously monitor these congeners in our environment. However, there are sparse studies related to PCNs levels, not only in consumer products, leachates and sediment samples from landfill sites in Africa but also in other matrices, leaving a huge research gap that must be prioritized. To date, only about 3 studies on PCNs have been published in Africa, bearing in mind that there is no documented evidence of any known production of PCNs in the continent. Thus, a wide research gap in PCNs studies still exists in Africa. There is an urgent need, therefore, to conduct studies and establish robust PCNs inventories in Africa. The present review examines the existing knowledge on PCNs levels and trends in Africa, and identifies research gaps that ought to be addressed so that the scale of PCNs distribution in the global environment can be known.
{"title":"A review on levels of polychlorinated naphthalenes in matrices with emphasis on knowledge and research gaps priorities in Africa","authors":"V. Nevondo, O. J. Okonkwo","doi":"10.20517/jeea.2022.02","DOIUrl":"https://doi.org/10.20517/jeea.2022.02","url":null,"abstract":"Polychlorinated naphthalenes (PCNs) were listed as Persistent organic pollutants in the Stockholm Convention, in May 2015, because of their adverse health and environmental effects. PCNs production began in the early 1900s when they were used extensively in several consumer goods as fire retardants. However, because of their health and environmental implications, the production and use of PCNs chemicals were voluntarily banned in many countries in the 1970s and 1980s. However, PCNs are still detected in different environmental samples including air, water, sediments, soil, indoor dust, biota, consumer products, human diet, blood and serum today, as a result of their historical use and unintentional production. Thus, PCNs can be released into the environment throughout their life cycle. It becomes, therefore, crucial to monitor them in different environmental compartments. To date, about 163 reports on PCNs levels in several matrices have been published in different parts of the world. It was reported that toxic PCNs such as chloronaphthalenes 66, 67 and 73 are prevalent in most samples; thus, there is a need to continuously monitor these congeners in our environment. However, there are sparse studies related to PCNs levels, not only in consumer products, leachates and sediment samples from landfill sites in Africa but also in other matrices, leaving a huge research gap that must be prioritized. To date, only about 3 studies on PCNs have been published in Africa, bearing in mind that there is no documented evidence of any known production of PCNs in the continent. Thus, a wide research gap in PCNs studies still exists in Africa. There is an urgent need, therefore, to conduct studies and establish robust PCNs inventories in Africa. The present review examines the existing knowledge on PCNs levels and trends in Africa, and identifies research gaps that ought to be addressed so that the scale of PCNs distribution in the global environment can be known.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shijie Wang, Anming Liu, Mei-ling Li, Jingxi Jin, Haodong Yuan, Jicheng Hu, Y. Wang, Jun Jin
Organophosphate ester (OPE) concentrations and distributions in 15 tree bark and 59 human hair samples from Weifang and Yantai (Shandong Province, China) were determined. The total OPE concentrations in tree bark samples from Weifang and Yantai were 16.5 ng/g-78.5 ng/g and 9.34 ng/g-98.6 ng/g dry weight (dw), respectively. The total OPE concentrations in hair samples from Weifang and Yantai were 54.2 ng/g dw-8450 ng/g dw and 7.26 ng/g dw -13,900 ng/g dw, respectively. Chlorinated OPEs were dominant in the tree bark samples from both Weifang and Yantai. Tris(2-chloroethyl)phosphate (TCEP) was the dominant OPE in the hair samples from residents of Weifang and Yantai. Attention should be paid to human exposure to TCEP, which is carcinogenic. The OPE concentrations in human hair were highest for the < 20 years age group. The OPE patterns between the two cities were similar for both tree bark and hair, but the OPE patterns in the tree bark and hair samples from the same place were significantly different. This indicates that the outdoor atmosphere may not be the main source of OPEs in human hair.
{"title":"Organophosphate esters in tree bark and human hair in Weifang and Yantai, Shandong Province, China: concentrations, profiles and sources","authors":"Shijie Wang, Anming Liu, Mei-ling Li, Jingxi Jin, Haodong Yuan, Jicheng Hu, Y. Wang, Jun Jin","doi":"10.20517/jeea.2022.01","DOIUrl":"https://doi.org/10.20517/jeea.2022.01","url":null,"abstract":"Organophosphate ester (OPE) concentrations and distributions in 15 tree bark and 59 human hair samples from Weifang and Yantai (Shandong Province, China) were determined. The total OPE concentrations in tree bark samples from Weifang and Yantai were 16.5 ng/g-78.5 ng/g and 9.34 ng/g-98.6 ng/g dry weight (dw), respectively. The total OPE concentrations in hair samples from Weifang and Yantai were 54.2 ng/g dw-8450 ng/g dw and 7.26 ng/g dw -13,900 ng/g dw, respectively. Chlorinated OPEs were dominant in the tree bark samples from both Weifang and Yantai. Tris(2-chloroethyl)phosphate (TCEP) was the dominant OPE in the hair samples from residents of Weifang and Yantai. Attention should be paid to human exposure to TCEP, which is carcinogenic. The OPE concentrations in human hair were highest for the < 20 years age group. The OPE patterns between the two cities were similar for both tree bark and hair, but the OPE patterns in the tree bark and hair samples from the same place were significantly different. This indicates that the outdoor atmosphere may not be the main source of OPEs in human hair.","PeriodicalId":73738,"journal":{"name":"Journal of environmental exposure assessment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67657944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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