J. Liesse Iyamba, Cyprien Mbundu Lukukula, Joseph Welo Unya, Benjamin Kodondi Ngbandani, Edouard Bissingou, Musomoni Mabankama, Nelson Nsiata Ngoma, Thierry Mukendi Kajinga, Blaise Mabamu Maya, Aline Diza Lubonga, N. Takaisi-Kikuni
of infections is compromised worldwide by that are resistant to multiple antibiotics [2]. Infections caused by multidrug-resistant organisms (MDROs) are associated with Abstract Background: Gram-negative and Gram-positive microorganisms are responsible for both community and hospital acquired infections. The increase, emergence, and spread of antimicrobial resistance among bacteria are the most important health problems worldwide. One of the mechanisms of resistance used by bacteria is biofilm formation. The aim of this study was to investigate the antibiotic resistance pattern and the biofilm formation ability of Staphylococcus aureus and Enterobacteriaceae isolates. Methods : A total of 18 Staphylococcus aureus and 60 Enterobacteriaceae clinical isolates were collected from patients with urinary and surgical site infections in Hôpital Biamba Marie Mutombo and Saint Joseph Hospital. The antibiotic susceptibility profile of the isolates were determined by disk-diffusion method. Microtiter plate method was used to assess the ability of bacteria strains to produce and to form un biofilm. Results : The majority of S. aureus and Enterobacteriacea clinical isolates were highly resistant to the majority of antibiotics and biofilm producers. S. aureus strains were 100 % resistant to ampicillin-sulbactam, piperacillin-tazobactam, vancomycin, amoxicillin-clavulanic acid, levofloxacin, and aztreonam. E. coli, Enterobacter sp. , Citrobacter sp., and Serratia sp. were 100 % resistant to
在世界范围内，对多种抗生素具有耐药性的感染受到损害。摘要背景:革兰氏阴性和革兰氏阳性微生物是社区和医院获得性感染的主要原因。细菌中抗菌素耐药性的增加、出现和传播是全世界最重要的健康问题。细菌产生耐药性的机制之一是生物膜的形成。本研究的目的是研究金黄色葡萄球菌和肠杆菌科分离株的抗生素耐药模式和生物膜形成能力。方法:收集Hôpital Biamba Marie Mutombo和圣约瑟夫医院泌尿系和外科部位感染患者中金黄色葡萄球菌18株和肠杆菌科临床分离株。采用纸片扩散法测定菌株的药敏谱。采用微滴板法评价菌株产生和形成非生物膜的能力。结果:大多数金黄色葡萄球菌和肠杆菌临床分离株对大多数抗生素和生物膜生产者具有高度耐药性。金黄色葡萄球菌对氨苄西林-舒巴坦、哌拉西林-他唑巴坦、万古霉素、阿莫西林-克拉维酸、左氧氟沙星和氨曲南耐药100%。大肠杆菌、肠杆菌、柠檬酸杆菌和沙雷氏菌对
{"title":"Antibiotic Resistance Pattern and Biofilm Formation of Staphylococcus and Enterobacteriaceae Isolates from Clinical Samples of Patients with Urinary Tract and Surgical Site Infections in Kinshasa, Democratic Republic of Congo","authors":"J. Liesse Iyamba, Cyprien Mbundu Lukukula, Joseph Welo Unya, Benjamin Kodondi Ngbandani, Edouard Bissingou, Musomoni Mabankama, Nelson Nsiata Ngoma, Thierry Mukendi Kajinga, Blaise Mabamu Maya, Aline Diza Lubonga, N. Takaisi-Kikuni","doi":"10.26502/fjppr.061","DOIUrl":"https://doi.org/10.26502/fjppr.061","url":null,"abstract":"of infections is compromised worldwide by that are resistant to multiple antibiotics [2]. Infections caused by multidrug-resistant organisms (MDROs) are associated with Abstract Background: Gram-negative and Gram-positive microorganisms are responsible for both community and hospital acquired infections. The increase, emergence, and spread of antimicrobial resistance among bacteria are the most important health problems worldwide. One of the mechanisms of resistance used by bacteria is biofilm formation. The aim of this study was to investigate the antibiotic resistance pattern and the biofilm formation ability of Staphylococcus aureus and Enterobacteriaceae isolates. Methods : A total of 18 Staphylococcus aureus and 60 Enterobacteriaceae clinical isolates were collected from patients with urinary and surgical site infections in Hôpital Biamba Marie Mutombo and Saint Joseph Hospital. The antibiotic susceptibility profile of the isolates were determined by disk-diffusion method. Microtiter plate method was used to assess the ability of bacteria strains to produce and to form un biofilm. Results : The majority of S. aureus and Enterobacteriacea clinical isolates were highly resistant to the majority of antibiotics and biofilm producers. S. aureus strains were 100 % resistant to ampicillin-sulbactam, piperacillin-tazobactam, vancomycin, amoxicillin-clavulanic acid, levofloxacin, and aztreonam. E. coli, Enterobacter sp. , Citrobacter sp., and Serratia sp. were 100 % resistant to","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Accidental dislodgement of tubes/catheters from patients’ bodies is frequent in healthcare; making it a crucial patient safety management issue. Additionally, the number of patients needing catheter management at home has increased with the rise in aging patients. Pain or stress from directly inserting a tube/catheter into the body causes accidental dislodgement. However, quantitative measurements have not yet been developed to evaluate patients’ stress resulting from dislodgement fear. Aim: This study aimed to develop a psychological stress scale for patients using tubes/catheters at home (PSS-CP) and evaluate its reliability and validity. Materials and Methods: The questionnaire was developed through interviews with 10 patients using tubes/catheters at home. Reliability was examined using the test-retest method and Cronbach’s α. J Pharm Pharmacol Res 2022; 6 (1): 1-14 DOI: 10.26502/fjppr.047 Journal of Pharmacy and Pharmacology Research Vol. 6 No. 1 March 2022. 2 Factorial and criterion-related validity were examined using exploratory factor analysis and the 12-item General Health Questionnaire, respectively. Results: The PSS-CP comprised 16 items across four factors: “anxiety about catheter dislodgement while moving or in the toilet,” “anxiety about tube dislodgement when resting or lying down,” “anxiety about tube dislodgement while dressing/undressing,” and “anxiety about tube dislodgement while bathing.” Criterion-related validity was significantly correlated with general anxiety (r = 0.71, p < 0.01) and pain/discomfort (r = 0.364, p < 0.05). The retest method showed a highly significant correlation (r = 0.791, p < 0.01), with Cronbach’s α > .90. Conclusions: A scale to measure psychological stress among catheterized home healthcare patients was developed and its reliability and validity demonstrated.
背景:在医疗保健中，管道/导管从患者体内意外脱出是常见的;这是一个至关重要的患者安全管理问题。此外，随着老年患者的增加，需要在家中进行导管管理的患者数量也在增加。直接将导管插入体内的疼痛或压力会导致意外的脱位。然而，定量测量尚未开发，以评估患者的压力造成的移位恐惧。目的:编制一套家庭留置管患者心理压力量表(PSS-CP)，并对其信效度进行评价。材料与方法:通过对10例在家使用导管的患者进行访谈，编制问卷。信度采用重测法和Cronbach’s α进行检验。[J]中国医药科学，2012;6 (1): 1-14 DOI: 10.26502/fjppr.047《药学与药理学研究》第6卷第1期，2022年3月。2采用探索性因子分析和12项一般健康问卷，分别检验因子效度和标准相关效度。结果:PSS-CP包括16个项目，分为4个因素:“移动或上厕所时对导管拔出的焦虑”、“休息或躺下时对导管拔出的焦虑”、“穿/脱衣服时对导管拔出的焦虑”和“洗澡时对导管拔出的焦虑”。标准相关效度与一般焦虑(r = 0.71, p < 0.01)和疼痛/不适(r = 0.364, p < 0.05)显著相关。重测法显示相关性极显著(r = 0.791, p < 0.01)， Cronbach 's α > .90。结论:编制了一套家庭护理病人心理应激量表，并证明了量表的信度和效度。
{"title":"Development and Assessment of the Reliability and Validity of a Psychological Stress Scale for Catheterized Home Healthcare Patients","authors":"Toshihide Ito, Ryoichi Ichihashi, Kouichi Tanabe, Tomomi Umemura, Masakazu Uemura, Yoshimasa Nagao","doi":"10.26502/jppr.0047","DOIUrl":"https://doi.org/10.26502/jppr.0047","url":null,"abstract":"Background: Accidental dislodgement of tubes/catheters from patients’ bodies is frequent in healthcare; making it a crucial patient safety management issue. Additionally, the number of patients needing catheter management at home has increased with the rise in aging patients. Pain or stress from directly inserting a tube/catheter into the body causes accidental dislodgement. However, quantitative measurements have not yet been developed to evaluate patients’ stress resulting from dislodgement fear. Aim: This study aimed to develop a psychological stress scale for patients using tubes/catheters at home (PSS-CP) and evaluate its reliability and validity. Materials and Methods: The questionnaire was developed through interviews with 10 patients using tubes/catheters at home. Reliability was examined using the test-retest method and Cronbach’s α. J Pharm Pharmacol Res 2022; 6 (1): 1-14 DOI: 10.26502/fjppr.047 Journal of Pharmacy and Pharmacology Research Vol. 6 No. 1 March 2022. 2 Factorial and criterion-related validity were examined using exploratory factor analysis and the 12-item General Health Questionnaire, respectively. Results: The PSS-CP comprised 16 items across four factors: “anxiety about catheter dislodgement while moving or in the toilet,” “anxiety about tube dislodgement when resting or lying down,” “anxiety about tube dislodgement while dressing/undressing,” and “anxiety about tube dislodgement while bathing.” Criterion-related validity was significantly correlated with general anxiety (r = 0.71, p < 0.01) and pain/discomfort (r = 0.364, p < 0.05). The retest method showed a highly significant correlation (r = 0.791, p < 0.01), with Cronbach’s α > .90. Conclusions: A scale to measure psychological stress among catheterized home healthcare patients was developed and its reliability and validity demonstrated.","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69351355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Common symptoms associated with fibromyalgia are chronic widespread pain, fatigue, sleep disturbances, depression, and cognitive dysfunction. Cryotherapy, which is commonly used in sports medicine, is used to alleviate pain and inflammation by exposing the body to cold temperatures maintained at -110°C and below. Recent evidence has shown that cryotherapy has a potential beneficial role in treating fibromyalgia. This review summarizes the unknown etiology of fibromyalgia, first-line treatment options for fibromyalgia, and how cryotherapy can be effective in reducing fibromyalgia symptoms. Cryotherapy might be useful adjunctive treatment but further research is still needed with larger sample sizes.
{"title":"Cryotherapy as Adjunct Treatment for Fibromyalgia","authors":"Jobin Puthuparampil, Shaker A. Mousa","doi":"10.26502/fjppr.051","DOIUrl":"https://doi.org/10.26502/fjppr.051","url":null,"abstract":"Common symptoms associated with fibromyalgia are chronic widespread pain, fatigue, sleep disturbances, depression, and cognitive dysfunction. Cryotherapy, which is commonly used in sports medicine, is used to alleviate pain and inflammation by exposing the body to cold temperatures maintained at -110°C and below. Recent evidence has shown that cryotherapy has a potential beneficial role in treating fibromyalgia. This review summarizes the unknown etiology of fibromyalgia, first-line treatment options for fibromyalgia, and how cryotherapy can be effective in reducing fibromyalgia symptoms. Cryotherapy might be useful adjunctive treatment but further research is still needed with larger sample sizes.","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Abdalla, Zhongli Niu, B. Sun, X. Jiang, Meifang Zhu
To develop biotinylated pH-responsive glycopolymers and investigate their performances as anticancer drug delivery nanocarriers, bromide-terminated biotin was synthesized and then used to initiate the polymerization of D-gluconamido ethyl methacrylate (GAMA) and 2-(diethylamino)ethyl methacrylate (DEA) monomers via atom transfer radical polymerization (ATRP). Two biotinylated pH-responsive copolymers with similar degree polymerization (DP) chain segments, Biotin-P(GAMA- b -DEA) and Biotin-P(GAMA- co -DEA), were prepared by block or random architectures, respectively. The chemical compositions and self-assembly behavior of glycopolymers were characterized. The results show that the block glycopolymer self- assembles in water medium into core-shell structure assembly containing PGAMA shell and PDEA core with the 28 nm in diameter, while the random glycopolymer remains water-soluble state above pH 7.4. Both glycopolymers possess the loading ability of the BTZ with encapsulation efficiency (EE %) and loading capacity (LC %) of 83.7% and 8.4%, 78.7% and 7.9%, and the release behavior was kept at low constants with 20% and 26% cumulative amount even after 24 hours at pH 7.4, respectively. The study is expected to give the light to the development of new intelligent drug carrier system with excellent biological compatibility.
为了开发生物素化的ph响应型糖共聚物并研究其作为抗癌药物纳米载体的性能，合成了溴端生物素，然后通过原子转移自由基聚合(ATRP)引发d -氨基甲基丙烯酸乙酯(GAMA)和2-(二乙胺)甲基丙烯酸乙酯(DEA)单体的聚合。采用嵌段和随机结构分别制备了两种具有相似聚合度(DP)链段的生物素化ph响应共聚物Biotin-P(GAMA- b - dea)和Biotin-P(GAMA- co - dea)。表征了糖共聚物的化学组成和自组装行为。结果表明，嵌段共聚物在水介质中自组装成含有PGAMA壳和PDEA核的核壳结构，直径为28 nm，而无规嵌段共聚物在pH 7.4以上仍保持水溶性。两种糖共聚物均具有BTZ的负载能力，包封效率(EE %)和负载量(LC %)分别为83.7%和8.4%、78.7%和7.9%，且在pH 7.4条件下，24 h的累积释放量分别保持在20%和26%的低常数。该研究有望为开发具有优异生物相容性的新型智能药物载体体系提供参考。
{"title":"Preparation of Developing Biotinylated PH-Responsive Glycopolymers as Delivery Nanocarriers for Controlling Release of Bortezomib","authors":"I. Abdalla, Zhongli Niu, B. Sun, X. Jiang, Meifang Zhu","doi":"10.26502/fjppr.054","DOIUrl":"https://doi.org/10.26502/fjppr.054","url":null,"abstract":"To develop biotinylated pH-responsive glycopolymers and investigate their performances as anticancer drug delivery nanocarriers, bromide-terminated biotin was synthesized and then used to initiate the polymerization of D-gluconamido ethyl methacrylate (GAMA) and 2-(diethylamino)ethyl methacrylate (DEA) monomers via atom transfer radical polymerization (ATRP). Two biotinylated pH-responsive copolymers with similar degree polymerization (DP) chain segments, Biotin-P(GAMA- b -DEA) and Biotin-P(GAMA- co -DEA), were prepared by block or random architectures, respectively. The chemical compositions and self-assembly behavior of glycopolymers were characterized. The results show that the block glycopolymer self- assembles in water medium into core-shell structure assembly containing PGAMA shell and PDEA core with the 28 nm in diameter, while the random glycopolymer remains water-soluble state above pH 7.4. Both glycopolymers possess the loading ability of the BTZ with encapsulation efficiency (EE %) and loading capacity (LC %) of 83.7% and 8.4%, 78.7% and 7.9%, and the release behavior was kept at low constants with 20% and 26% cumulative amount even after 24 hours at pH 7.4, respectively. The study is expected to give the light to the development of new intelligent drug carrier system with excellent biological compatibility.","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nardeen Perko, Tewodros D. Kebede, Shaker A. Mousa
Malaria is an infectious disease caused by the Plasmodium parasite, which is carried by the Anopheles mosquito. Among
疟疾是一种由疟原虫引起的传染病，由按蚊携带。在
{"title":"Current and future directions in the prevention and treatment of Malaria","authors":"Nardeen Perko, Tewodros D. Kebede, Shaker A. Mousa","doi":"10.26502/fjppr.058","DOIUrl":"https://doi.org/10.26502/fjppr.058","url":null,"abstract":"Malaria is an infectious disease caused by the Plasmodium parasite, which is carried by the Anopheles mosquito. Among","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-25DOI: 10.22541/au.162460492.29738849/v1
J. Dow, G. Trevitt, E. Bone, K. Haque, L. Nastoupil
Aims: KA2237, an oral, potent and selective, inhibitor of the PI3K β and δ isoforms, was evaluated for safety, tolerability and pharmacokinetics (PK) in patients with B-cell lymphoma. KA2237 is metabolised by CYP3A4/5 but also demonstrated mechanism-based inhibition (MBI) of CYP3A4/5. An MBI mechanistic dynamic model was used to predict drug accumulation after repeat dosing of KA2237. This model, along with clinical safety data, was used to guide safe dose escalation. Methods: An open-label, single arm, dose escalation study was carried out in patients, dosed orally with KA2237 at 50, 100, 200 and 400 mg once daily. Complete plasma profiles were obtained on Day 1 and Day 14 of dosing and pre-dose (Cmin) samples were obtained on Days 2-7. The MBI model was validated and used to calculate drug levels and predict potential drug accumulation during dose escalation. Results: KA2237 elimination half-life was around 20-30 h, compatible with once daily dosing regimens. The accumulation of KA2237 was around 4-fold after the highest dose of 400 mg and around 3-fold after administration of 200 mg, which is considered the maximum tolerated dose (MTD). The MBI model accurately predicted this accumulation. Conclusions: Drugs that demonstrate MBI and potential auto-inhibition can be successfully developed, provided that models are developed to assess the extent of accumulation prior to the start of FIH clinical studies. This, along with the close monitoring of drug levels and clinical safety data can be used to guide dose escalation and lead to the safe conduct of clinical studies.
{"title":"Pharmacokinetics of KA2237, a novel selective inhibitor of PI3K-β and PI3K-δ, in patients: A first-in-human study using PK modelling to predict drug concentrations during dose escalation","authors":"J. Dow, G. Trevitt, E. Bone, K. Haque, L. Nastoupil","doi":"10.22541/au.162460492.29738849/v1","DOIUrl":"https://doi.org/10.22541/au.162460492.29738849/v1","url":null,"abstract":"Aims: KA2237, an oral, potent and selective, inhibitor of the PI3K β and\u0000δ isoforms, was evaluated for safety, tolerability and pharmacokinetics\u0000(PK) in patients with B-cell lymphoma. KA2237 is metabolised by CYP3A4/5\u0000but also demonstrated mechanism-based inhibition (MBI) of CYP3A4/5. An\u0000MBI mechanistic dynamic model was used to predict drug accumulation\u0000after repeat dosing of KA2237. This model, along with clinical safety\u0000data, was used to guide safe dose escalation. Methods: An open-label,\u0000single arm, dose escalation study was carried out in patients, dosed\u0000orally with KA2237 at 50, 100, 200 and 400 mg once daily. Complete\u0000plasma profiles were obtained on Day 1 and Day 14 of dosing and pre-dose\u0000(Cmin) samples were obtained on Days 2-7. The MBI model was validated\u0000and used to calculate drug levels and predict potential drug\u0000accumulation during dose escalation. Results: KA2237 elimination\u0000half-life was around 20-30 h, compatible with once daily dosing\u0000regimens. The accumulation of KA2237 was around 4-fold after the highest\u0000dose of 400 mg and around 3-fold after administration of 200 mg, which\u0000is considered the maximum tolerated dose (MTD). The MBI model accurately\u0000predicted this accumulation. Conclusions: Drugs that demonstrate MBI and\u0000potential auto-inhibition can be successfully developed, provided that\u0000models are developed to assess the extent of accumulation prior to the\u0000start of FIH clinical studies. This, along with the close monitoring of\u0000drug levels and clinical safety data can be used to guide dose\u0000escalation and lead to the safe conduct of clinical studies.","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44248180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Walaa Albenayan, N. Alruwaili, J. Pauli, A. King, M. Migliore, Iman Zaghloul
{"title":"Development and Validation of a Gliadin Induced Intestinal Enteropathy Rat Model of Non-Celiac Gluten Sensitivity","authors":"Walaa Albenayan, N. Alruwaili, J. Pauli, A. King, M. Migliore, Iman Zaghloul","doi":"10.26502/fjppr.045","DOIUrl":"https://doi.org/10.26502/fjppr.045","url":null,"abstract":"","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rigorous peer-review is the main part in building the corner-stone of high-quality academic publishing. The editorial team greatly appreciates the authors, reviewers who contributed their knowledge and expertise to the journal’s editorial process over the past 12 months. In 2020, a total of 15 were published in the journal with a median time to first decision of 15 days and a median time to publication of 20 days. The editorial office would like to express their sincere gratitude to the following authors, reviewers and editors for their cooperation and dedication in 2020:
{"title":"Acknowledgement to Authors, Reviewers and Editors of Journal of Pharmacy and Pharmacology Research in 2020.","authors":"Fortune Journals","doi":"10.26502/jppr.0044","DOIUrl":"https://doi.org/10.26502/jppr.0044","url":null,"abstract":"Rigorous peer-review is the main part in building the corner-stone of high-quality academic publishing. The editorial team greatly appreciates the authors, reviewers who contributed their knowledge and expertise to the journal’s editorial process over the past 12 months. In 2020, a total of 15 were published in the journal with a median time to first decision of 15 days and a median time to publication of 20 days. The editorial office would like to express their sincere gratitude to the following authors, reviewers and editors for their cooperation and dedication in 2020:","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69351346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth Chinedu Ugoeze, Princewill Chukwuebuka Aja, N. Nwachukwu, Bruno Chukwuemeka Chinko, J. Egwurugwu, Kennedy Emeka Oluigbo
Background: Wound is one of the health indispositions with undesirable socio-economic impacts on the victim and those around them. Crude aqueous extract of Azadirachta indica leaves (AEAIL) retains verified potentials for wound healing. Developing the AEAIL into a topical aqueous cream could enhance its value in wound treatment. Aim: The aim of this study was to formulate aqueous topical creams containing various concentrations of AEAIL as bioactive ingredients, evaluate their stability and wound healing activities in male Wistar rats using hydroxyproline (HXP) as a biochemical marker. Materials and methods: Creams containing 1.0, 1.5, 2.0 and 3.0 % w/w of AEAIL were prepared, evaluating their stability up to 14 days and assessing their wound healing activities in male Wistar rats using DMSO, cholesterol and distilled water as controls. Results: All the batches of creams were stable in colour, pH, viscosity, etc. and exhibited wound healing actions with the animals treated with the cream containing 1.5 % w/w of AEAIL demonstrating the highest tissue HXP level (p > 0.05). The tissue HXP levels in the animals treated with DMSO, cholesterol and distilled water were lower than those of the test creams (p < 0.05). There was significant marginal differences in percentage difference of their HXP level compared to those of the test creams (p < 0.05). Conclusion: The aqueous extract of Azadirachta indica leaves formulated as aqueous cream was stable and retained its wound healing activities. This new formula could therefore be used in the treatment of body injuries.
{"title":"Evaluation of the Wound healing Potentials of Aqueous Topical creams Containing Aqueous extract of Azadirachta indica leaves as Bioactive Ingredient","authors":"Kenneth Chinedu Ugoeze, Princewill Chukwuebuka Aja, N. Nwachukwu, Bruno Chukwuemeka Chinko, J. Egwurugwu, Kennedy Emeka Oluigbo","doi":"10.26502/FJPPR.041","DOIUrl":"https://doi.org/10.26502/FJPPR.041","url":null,"abstract":"Background: Wound is one of the health indispositions with undesirable socio-economic impacts on the victim and those around them. Crude aqueous extract of Azadirachta indica leaves (AEAIL) retains verified potentials for wound healing. Developing the AEAIL into a topical aqueous cream could enhance its value in wound treatment. Aim: The aim of this study was to formulate aqueous topical creams containing various concentrations of AEAIL as bioactive ingredients, evaluate their stability and wound healing activities in male Wistar rats using hydroxyproline (HXP) as a biochemical marker. Materials and methods: Creams containing 1.0, 1.5, 2.0 and 3.0 % w/w of AEAIL were prepared, evaluating their stability up to 14 days and assessing their wound healing activities in male Wistar rats using DMSO, cholesterol and distilled water as controls. Results: All the batches of creams were stable in colour, pH, viscosity, etc. and exhibited wound healing actions with the animals treated with the cream containing 1.5 % w/w of AEAIL demonstrating the highest tissue HXP level (p > 0.05). The tissue HXP levels in the animals treated with DMSO, cholesterol and distilled water were lower than those of the test creams (p < 0.05). There was significant marginal differences in percentage difference of their HXP level compared to those of the test creams (p < 0.05). Conclusion: The aqueous extract of Azadirachta indica leaves formulated as aqueous cream was stable and retained its wound healing activities. This new formula could therefore be used in the treatment of body injuries.","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acknowledgement to Authors, Reviewers and Editors of Journal of Pharmacy and Pharmacology Research in 2019.","authors":"Fortune Journals","doi":"10.26502/jppr.0043","DOIUrl":"https://doi.org/10.26502/jppr.0043","url":null,"abstract":"","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69351283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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