Aging occurs in response to many triggers, including cellular senescence, telomere attrition, DNA damage, organelle stress, oncogene activation and stem cell dysfunction [1]. Among these, the aged stem cell per sec can exhibit various aging hallmarks, such as increased DNA damage, dysregulated mitochondrial function, and less efficient protein recycling. Aged stem cell is a prime factor that undermines organismal homeostasis, which can facilitate numerous pathologies including cancer, neuropathy, sarcopenia and immunopathy [2].
{"title":"Dysregulated circadian clock and aged stem cell: An inflammatory crosstalk?","authors":"Dan Li, Yuting Tan","doi":"10.15761/jts.1000438","DOIUrl":"https://doi.org/10.15761/jts.1000438","url":null,"abstract":"Aging occurs in response to many triggers, including cellular senescence, telomere attrition, DNA damage, organelle stress, oncogene activation and stem cell dysfunction [1]. Among these, the aged stem cell per sec can exhibit various aging hallmarks, such as increased DNA damage, dysregulated mitochondrial function, and less efficient protein recycling. Aged stem cell is a prime factor that undermines organismal homeostasis, which can facilitate numerous pathologies including cancer, neuropathy, sarcopenia and immunopathy [2].","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67493369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic hallmarks of cancer cells as targets for integrative therapies","authors":"J. Ionescu, A. Constantinescu","doi":"10.15761/JTS.1000390","DOIUrl":"https://doi.org/10.15761/JTS.1000390","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67491268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Laurent, Jeanne-Pascale Simon, N. Hirt-Burri, W. Raffoul, L. Applegate, A. D. B. Roessingh
1Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland 2Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland 3Unit of Legal Affairs, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland 4Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, CH-8057 Zurich, Switzerland 5Oxford Suzhou Center for Advanced Research, Science and Technology Co. Ltd., Oxford University, Suzhou 215000, PRC 6Pediatric Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland
{"title":"GMP-grade allogeneic musculoskeletal primary progenitor cell types: Standardized candidates for general or pharmacopeial monograph elaboration","authors":"A. Laurent, Jeanne-Pascale Simon, N. Hirt-Burri, W. Raffoul, L. Applegate, A. D. B. Roessingh","doi":"10.15761/jts.1000406","DOIUrl":"https://doi.org/10.15761/jts.1000406","url":null,"abstract":"1Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland 2Plastic, Reconstructive and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland 3Unit of Legal Affairs, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland 4Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, CH-8057 Zurich, Switzerland 5Oxford Suzhou Center for Advanced Research, Science and Technology Co. Ltd., Oxford University, Suzhou 215000, PRC 6Pediatric Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Vogel, P. Boehme, R. Wakili, Katharina Boden, T. Reimer, P. Sandner, Jörg Hüser, W. Dinh, H. Truebel, T. Mondritzki
aminobutyric with reduced ventricular diastolic ventricular Millimeters Magnetic tomography; blood Standard natriuretic Abstract Background: The influence of initial propofol on cardiac hemodynamics in patients suffering from heart failure (HF) is insufficiently understood and contradicting opinions are existing. Nevertheless, propofol is often used in HF patients if etomidate is contraindicated. The development of novel telemetry sensors allows the assessment of intracardiac pressure signals in conscious animals and thus the investigation of anesthesia induction. Here, we investigated the hemodynamic effects of propofol in healthy dogs in comparison to dogs affected with HF. Methods: Telemetry sensors and pacemaker were implanted in six male beagle dogs. After wound healing, the pacemaker was programmed to 220 bpm and later to 180 bpm to induce and maintain heart failure. At baseline conditions (before pacing) and at several time points (Day 14, 28 and 42) during HF progression all animals were anesthetized with 5 mg/kg propofol i.v. Hemodynamic measurements were done to assess the effects of propofol during anesthesia induction Results: After induction with propofol, we observed a significant (p<0.001) increase in heart rate (HR) for all groups (healthy: +63 ± 53 bpm, 14d: +48 ± 23 bpm, 28d: +45 ± 20 bpm, 42d: +51 ± 28 bpm in peak) compared to individual baseline values. In addition, blood pressure (BP) increased in all HF groups (in average +17.4 ± 1.4 mmHg, p<0.05), while this effect was not present under healthy conditions. We further observed a trend towards an increase in left ventricular contractility (+dP/ dtmax) by +621.1 ± 157.0 mmHg/s (averaged peak data) in all groups. Conclusions: In dogs affected with heart failure, initial anesthesia with propofol resulted in an increase in heart rate and blood pressure, whereas no cardio depressive adverse effects could be observed on HF-relevant parameters. Therefore, propofol might be an alternative for short term anesthesia in HF patients. Nevertheless, further animal and human studies are needed to evaluate if these data can be translated into the clinical setting.
{"title":"Telemetric hemodynamic assessment during anesthesia induction with propofol in experimental heart failure","authors":"Julia Vogel, P. Boehme, R. Wakili, Katharina Boden, T. Reimer, P. Sandner, Jörg Hüser, W. Dinh, H. Truebel, T. Mondritzki","doi":"10.15761/jts.1000408","DOIUrl":"https://doi.org/10.15761/jts.1000408","url":null,"abstract":"aminobutyric with reduced ventricular diastolic ventricular Millimeters Magnetic tomography; blood Standard natriuretic Abstract Background: The influence of initial propofol on cardiac hemodynamics in patients suffering from heart failure (HF) is insufficiently understood and contradicting opinions are existing. Nevertheless, propofol is often used in HF patients if etomidate is contraindicated. The development of novel telemetry sensors allows the assessment of intracardiac pressure signals in conscious animals and thus the investigation of anesthesia induction. Here, we investigated the hemodynamic effects of propofol in healthy dogs in comparison to dogs affected with HF. Methods: Telemetry sensors and pacemaker were implanted in six male beagle dogs. After wound healing, the pacemaker was programmed to 220 bpm and later to 180 bpm to induce and maintain heart failure. At baseline conditions (before pacing) and at several time points (Day 14, 28 and 42) during HF progression all animals were anesthetized with 5 mg/kg propofol i.v. Hemodynamic measurements were done to assess the effects of propofol during anesthesia induction Results: After induction with propofol, we observed a significant (p<0.001) increase in heart rate (HR) for all groups (healthy: +63 ± 53 bpm, 14d: +48 ± 23 bpm, 28d: +45 ± 20 bpm, 42d: +51 ± 28 bpm in peak) compared to individual baseline values. In addition, blood pressure (BP) increased in all HF groups (in average +17.4 ± 1.4 mmHg, p<0.05), while this effect was not present under healthy conditions. We further observed a trend towards an increase in left ventricular contractility (+dP/ dtmax) by +621.1 ± 157.0 mmHg/s (averaged peak data) in all groups. Conclusions: In dogs affected with heart failure, initial anesthesia with propofol resulted in an increase in heart rate and blood pressure, whereas no cardio depressive adverse effects could be observed on HF-relevant parameters. Therefore, propofol might be an alternative for short term anesthesia in HF patients. Nevertheless, further animal and human studies are needed to evaluate if these data can be translated into the clinical setting.","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guo Zhongwei, Duan Xin, W. Lijuan, Zheng Jisheng, Lu Longxi
{"title":"Virtual reality hypnosis improves sleep quality of first-line medical staff responding to COVID-19","authors":"Guo Zhongwei, Duan Xin, W. Lijuan, Zheng Jisheng, Lu Longxi","doi":"10.15761/jts.1000410","DOIUrl":"https://doi.org/10.15761/jts.1000410","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Zeitani, S. Kuçi, A. Ibrahimi, Antonio Pellegrino, E. Likaj
{"title":"LVAD driveline infection: Pump cable relocation in two stage surgical strategy and preventive partial driveline replacement","authors":"J. Zeitani, S. Kuçi, A. Ibrahimi, Antonio Pellegrino, E. Likaj","doi":"10.15761/jts.1000442","DOIUrl":"https://doi.org/10.15761/jts.1000442","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67494178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Codina, O. Altisent, Ignasi Guasch-Arriaga, E. Santiago‐Vacas, J. Lupón, A. Bayés‐Genís
{"title":"Late CardioMEMS migration: Coughing spells as a cause of concern","authors":"P. Codina, O. Altisent, Ignasi Guasch-Arriaga, E. Santiago‐Vacas, J. Lupón, A. Bayés‐Genís","doi":"10.15761/jts.1000443","DOIUrl":"https://doi.org/10.15761/jts.1000443","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67495398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bortolussi Carlo, Portale Teresa Rosanna, Costa Salvatore Domenico, Meli Gaetano Alfio, Allocco Roberto, Di Stefano Biagio
Anatomical variants of the hepatic arteries are often leaved out in anatomical atlases and university corse, even if represented in on the of gallbladder left cystic
肝动脉的解剖变异在解剖图集和大学病历中经常被遗漏，即使在胆囊左囊中也有表现
{"title":"Aberrant left hepatic artery from the gastroduodenal artery with no cystic branch: Case report and review of literature","authors":"Bortolussi Carlo, Portale Teresa Rosanna, Costa Salvatore Domenico, Meli Gaetano Alfio, Allocco Roberto, Di Stefano Biagio","doi":"10.15761/jts.1000420","DOIUrl":"https://doi.org/10.15761/jts.1000420","url":null,"abstract":"Anatomical variants of the hepatic arteries are often leaved out in anatomical atlases and university corse, even if represented in on the of gallbladder left cystic","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67493016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Annunziata, A. Coppola, M. Lanza, Francecsa Simioli, P. Imitazione, N. Pepe, V. Maddaloni, L. Atripaldi, G. Fiorentino
The insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene, previously described in association with adult respiratory distress syndrome, may play a key role in lung injury in patients with SARS-COV2. In this paper we describe 26 patients with severe respiratory failure related to COVID-19 pneumonia that underwent genetic screening for ACE polymorphisms.
{"title":"ACE DD polymorphism in severe COVID-19","authors":"A. Annunziata, A. Coppola, M. Lanza, Francecsa Simioli, P. Imitazione, N. Pepe, V. Maddaloni, L. Atripaldi, G. Fiorentino","doi":"10.15761/JTS.1000396","DOIUrl":"https://doi.org/10.15761/JTS.1000396","url":null,"abstract":"The insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene, previously described in association with adult respiratory distress syndrome, may play a key role in lung injury in patients with SARS-COV2. In this paper we describe 26 patients with severe respiratory failure related to COVID-19 pneumonia that underwent genetic screening for ACE polymorphisms.","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67491811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Nozaki, Keitaro Nakamoto, Y. Sasaki, M. Masutani
{"title":"Effect of parp inhibitor, 3-aminobenzamide on p53 stabilization after DNA damage","authors":"T. Nozaki, Keitaro Nakamoto, Y. Sasaki, M. Masutani","doi":"10.15761/jts.1000434","DOIUrl":"https://doi.org/10.15761/jts.1000434","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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