Journal of women's health and development最新文献

{"title":"The Clinical Study on Short-Term Efficacy of Pelvic Magnetic Stimulation Combined with Pelvic Muscle Biofeedback on Female Idiopathic Overactive Bladder.","authors":"Liu Xiaofang,&nbsp;Lin Fang,&nbsp;Luo Shuang,&nbsp;L U Zongjie,&nbsp;H E Quanjiang,&nbsp;M U Yan,&nbsp;Peng Qiao","doi":"10.26502/fjwhd.2644-288400105","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400105","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the short-term efficacy of pelvic magnetic stimulation combined with pelvic muscle biofeedback on female Idiopathic Overactive Bladder (IOAB).</p><p><strong>Methods: </strong>96 cases of IOAB females were randomly divided into control group (magnetic stimulation treatment n=48) and observation group (magnetic stimulation with biofeedback n=48). All the patients were dealt with the sacralneuromagnetic stimulation (once, qod), with 5 times in total. Then the patients in observation group were processed with biofeedback (10 times). Overactive Bladder Symptom Score (OABSS), Patients Perception Bladder Condition (PPBC) and Incontinence Quality of Life Scale (I-QOL) were evaluated as the indexes.</p><p><strong>Results: </strong>The effective rate of control group and observation group respectively were 89.58% and 93.75%. There were significant differences (P=0.67). The OABSS and PPBC of two groups were decreased, I-QOL were increased after treatment (P<0.05). Difference was statistically significant in OABSS three months after treatment between the two groups (P=0.00).The recurrence rate of three months after treatment of the two groups were 18.75% and 6.38% (P=0.04).</p><p><strong>Conclusions: </strong>Both magnetic stimulation alone and magnetic stimulation with biofeedback were effective and safe in female patients with IOAB. Magnetic stimulation with biofeedback may reduce the recurrence rate and continue to improve the symptoms in a certain extent.</p>","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Ovarian Cancer Survival using Machine Learning: A Population-Based Study","authors":"M. Akazawa, K. Hashimoto","doi":"10.26502/fjwhd.2644-288400109","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400109","url":null,"abstract":"","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72947879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Pattern and Clinical Significance of E2F Transcription Factors in Skin Cutaneous Melanoma","authors":"Liuchang Tan","doi":"10.26502/fjwhd.2644-288400104","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400104","url":null,"abstract":"","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87261214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitating Healing for Black Women Experiencing Gendered Racism and Traumatic Stress: The Moderation of Psychosocial Resources","authors":"Tiffany R Williams, Christy L. Erving, Whitney Frierson, Fanchen Gao, Jeffery E Bass, Reniece Martin, Taeja Mitchell","doi":"10.26502/fjwhd.2644-288400110","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400110","url":null,"abstract":"Black women must navigate a tumultuous sociopolitical terrain while simultaneously managing their psychological health. Experiences of gendered racism increase Black women’s vulnerability to psychological distress. Gendered racial microaggressions, a specific type of microaggression, account for the intricate ways racism and sexism intersect. The association between Black women’s experiences of gendered racial microaggressions and traumatic stress was investigated among 201 Black female-identified undergraduate and graduate students attending a Historically Black College or University. Whether psychosocial resources (i.e., resilience, social support, mastery, self-esteem) moderated the linkage between gendered racial microaggressions and traumatic stress was also examined. Gendered racial microaggressions were positively associated with traumatic stress. The microaggression Assumptions of Beauty and Sexual Objectification was the most strongly associated with traumatic stress, followed by Angry Black Woman. Resilience and mastery were protective factors, reducing the influence of gendered racial microaggressions on traumatic stress. In addition, high levels of social support reduced the impact of Assumptions of Beauty and Sexual Objectification on traumatic stress. To foster healing and posttraumatic growth for Black women, psychologists must decolonize their understanding and treatment of mental illness. Practice and research implications are discussed.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136302025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Fatty Acid Metabolism and Transport in a Rat Model of Gestational Diabetes Mellitus.","authors":"Jay S Mishra,&nbsp;Sathish Kumar","doi":"10.26502/fjwhd.2644-288400108","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400108","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) is a form of heightened insulin resistance triggered during gestation. This study examines how insulin resistance alters placental long-chain polyunsaturated fatty acid (LCPUFA) transport and metabolism in a rat model of lean GDM. Pregnant Sprague Dawley rats were administered with S961, an insulin receptor antagonist (30 nmol/kg s.c. daily), or vehicle from gestational day (GD) 7 to 20. Daily maternal body weight, food, and water intake were measured. Blood pressure assessment and glucose tolerance test were done on GD20. Fetal plasma and placenta were collected on GD20 and processed for fatty acid measurement using LC-mass spectrometry. The expression of fatty acid metabolism-related genes in the placenta was assessed using RT² Profiler PCR arrays. The results were validated by qRT-PCR. Blockade of insulin receptors with S961 in pregnant rats resulted in glucose intolerance with increased fasting glucose and insulin levels. Maternal body weight gain and food and water intake were not affected; however, S961 significantly increased maternal blood pressure and heart rate. The placenta n3 and n6 LCPUFA concentrations were significantly decreased by 8% and 11%, respectively, but their levels in the fetal plasma were increased by 15% and 4%. RT2 profiler arrays revealed that placental expressions of 10 genes related to fatty acid β-oxidation (Acaa1a, Acadm, Acot2, Acox2, Acsbg1, Acsl4, Acsm5, Cpt1b, Eci2, Ehhadh) and 3 genes related to fatty acid transport pathway (Fabp2, Fabp3, Slc27a3) were significantly upregulated. In summary, lack of insulin action increased the expression of genes related to placental fatty acid β-oxidation and transport with an increased transfer of LCPUFA to the fetus. The increased lipid levels routed toward the fetus may lead to fat adiposity and later-life metabolic dysfunction.</p>","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246410/pdf/nihms-1899830.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9991424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Principal Component Analysis of Nursing Students’ Satisfaction with Blended E-learning following the Covid-19 Pandemic","authors":"N. Tayyib, F. Alsolami, HI Asfour, P. Ramaih, EE Ahmed, I. Nomani, GM Lindsay","doi":"10.26502/fjwhd.2644-288400107","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400107","url":null,"abstract":"","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75229456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis , Management of Polycystic ovarian syndrome","authors":"HendAbdelbary Ibrahim Aly","doi":"10.26502/fjwhd.2644-288400106","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-288400106","url":null,"abstract":"","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84783851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Client Knowledge and Demand on Service Provision from Antenatal to Postnatal Care - An Implementation Science Design","authors":"Chancy Mauluka, Isabel Kazanga Chiumia, L. Maliwichi, W. Stones","doi":"10.26502/fjwhd.2644-28840101","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840101","url":null,"abstract":"Background: In low resource countries suboptimal clinical care has been identified a contributor to maternal and infant mortality. This study aimed to test the impact of a community intervention promoting client demand on provision of care during ANC, labour and the first postnatal contact (PNC). Methods: This was implementation science research in Kasungu district of Malawi using a quasi-experimental design with an intervention site where mothers were exposed to a package of interventions aiming to improve knowledge and demand. The results were compared with a site where there was no intervention in the same district. The intervention included checklists for mothers, posters and a Radio Distance Learning (RDL) program. The study used mixed methods (qualitative and quantitative). A total of 1040 mothers participated in individual interviews. Sixteen Focus Group Discussions (FGDs) were conducted with 128 mothers and 8 Key Informant Interviews were conducted with health workers. Health passports were used to check service provision at both comparison and intervention sites. In addition, mothers’ checklists were used at the intervention site to verify service provision. Quantitative data were processed in Stata 16.0 using binomial regression and two-sample proportion tests. NVivo 12 was used to process qualitative data for thematic analysis through coding and merging or creation of new codes. Results: At the intervention site there a 21.9% mean increase in knowledge of demandable services in ANC (43.3% to 56.1%, p<0.001,), intrapartum services for the mother (20.6%, 41.8% to 62.6%, p=0.003,) and the neonatal services before discharge (17.5%, 47% to 64.5%, p=0.0039). For PNC, changes were non-significant. Overall, women at the intervention site were 50% more likely than women at the comparison site to demand a service in the continuum of care (RR = 1.5). Actual service provision was increased at the intervention sites across all elements of the continuum, including laboratory testing, clinical examination of mothers and newborns and provision of essential interventions such as oxytocin for prevention of postpartum haemorrhage, chlorhexidine for umbilical cord care and vitamin K. Conclusion: The intervention positively contributed to increased knowledge on care practices, attitudes towards demand, actual demand for care practices, services provision and service satisfaction.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84894419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncogenic HPV Infection Dysregulates Histone H3 Clipping","authors":"Jorge SANDOVAL-BASILIO, Sofia L. Alcaraz-Estrada","doi":"10.26502/fjwhd.2644-28840093","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840093","url":null,"abstract":", Abstract During infection by various pathogens, there is an accumulation of epigenetic alterations that lead to changes in gene expression or viral reactivation. Oncogenic Human Papillomavirus (HPV) dysregulate various epigenetic mechanisms. Impaired histone H3 clipping constitutes an epigenetic mechanism in cervical cancer. However, if the impaired H3 clipping occurred as a primary effect of the HPV infection or if is a consequence of cervical carcinogenesis due to the high number of alterations is unknown. Using human cervical samples with negative pathology to cancer, but positive and negative to oncogenic HPV, we were able to identify that H3 clipping was low in the positive oncogenic HPV cervix compared to the negative oncogenic HPV cervix. These results suggest that low H3 clipping previously observed in cervical cancer may be a primary effect of oncogenic HPV infection.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85534899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Uterine Gene Expression in Lean and Obese Mice Following Maternal Oxytocin","authors":"S. Soni, P. K. Chatterjee, Frances F. Hsieh, Xiangying Xue, N. Kohn, Swati Madankumar, B. Rochelson, Christine N Metz","doi":"10.26502/fjwhd.2644-28840090","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840090","url":null,"abstract":"Background: Obese women exhibit higher rates of failed labor inductions with oxytocin. To investigate the mechanisms underlying parturition dysfunction in obese populations, we examined the changes in uterine gene expression profiles in lean and obese mice at term, with and without maternal oxytocin administration. Methods: Female C57BL/6 mice were fed either a high-fat or regular-lean diet for 6 weeks prior to conception and throughout pregnancy. At term, dams were given saline or oxytocin, with a second group of obese mice receiving high-dose oxytocin. Six hours later, uterine gene expression for 30 select transcripts associated with parturition (e.g. gap junctions, relaxation/contractility pathways, and oxytocin signaling) and obesity were analyzed by quantitative real time PCR. Results: Lean and obese uteri, at baseline, showed differential gene expression patterns at term. Oxytocin significantly altered the expression of numerous myometrial transcripts associated with parturition (gap junctions, relaxation/contractility pathways, and oxytocin signaling). The expression of numerous oxytocin-responsive genes depended on the dams’ body masses (lean vs. obese), with either blunted effects or no effects of oxytocin observed in obese mice vs. lean mice. Additionally, high-dose oxytocin did not consistently regulate parturition-related gene expression in obese uteri. In summary, gene expression patterns significantly differed in lean vs. obese uteri at term in the presence and absence of maternal oxytocin. Lean uteri were more responsive to oxytocin than obese uteri, even at higher doses of oxytocin. Conclusions: These findings support that blunted oxytocin responsiveness in obese uteri may contribute to obesity-related labor dysfunction.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85880484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}