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Tacrolimus Improved Reproductive Outcomes of Women with Recurrent Pregnancy Loss (PRL) Showing Elevated T Helper 1 (Th1) /Th2 Cell Ratios 他克莫司改善复发性妊娠丢失(PRL)妇女的生殖结局,显示T辅助1 (Th1) /Th2细胞比率升高
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840098
K. Nakagawa, J. Kwak‐Kim, K. Kuroda, T. Horikawa, S. Takamizawa, M. Hisano, Yoshimitsu Kasahara, R. Sugiyama, K. Yamaguchi
Purpose: Elevated T helper 1 (Th1)/Th2 cell ratio has been associated with recurrent pregnancy losses (PRL). In this study, the clinical efficacy of tacrolimus, a calcineurin inhibitor, was investigated in women with consecutive four or more recurrent pregnancy losses (RPL) and elevated Th1/Th2 (CD4 + IFN-γ + / CD4 + IL-4 + ) cell ratio. The live-birth rate (LBR) was prospectively investigated in women with RPL who received tacrolimus treatment. Methods: A total of 100 pregnant women with PRL with elevated Th1/ Th2 cell ratios (≥10.3) were recruited from November 2013 to December 2019. Seventy-one women received tacrolimus between 1 mg and 4 mg daily (treatment group) and 29 women did not receive tacrolimus (control group). Results: In the treatment group, the LBR was 70.4% (50/71), which was significantly higher than that of the control group (48.2%, p<0.05). According to the tacrolimus doses, the treatment group was divided into three subgroups. The LBRs of women with tacrolimus 1mg, 2mg, and ≥3mg daily were 52.2%, 72.3%, and 93.3%, respectively. In women with tacrolimus ≥3mg daily, the LBR was significantly higher than women with tacrolimus 1mg daily (P<0.05). Conclusion: In conclusion, the LBR of RPL women with increased Th1/ Th2 cell ratios was significantly improved with tacrolimus treatment.
目的:升高的辅助性T细胞1 (Th1)/Th2细胞比例与复发性妊娠丢失(PRL)有关。在这项研究中,研究了钙调神经磷酸酶抑制剂他克莫司(tacrolimus)在连续四次或以上复发性妊娠丢失(RPL)和Th1/Th2 (CD4 + IFN-γ + / CD4 + IL-4 +)细胞比例升高的妇女中的临床疗效。对接受他克莫司治疗的RPL妇女的活产率(LBR)进行前瞻性调查。方法:从2013年11月至2019年12月共招募100例Th1/ Th2细胞比值升高(≥10.3)的PRL孕妇。71名妇女每天服用他克莫司1毫克至4毫克(治疗组),29名妇女不服用他克莫司(对照组)。结果:治疗组LBR为70.4%(50/71),显著高于对照组48.2% (p<0.05)。根据他克莫司剂量将治疗组分为3个亚组。每日服用他克莫司1mg、2mg和≥3mg的女性lbr分别为52.2%、72.3%和93.3%。他克莫司≥3mg /天的女性LBR显著高于他克莫司1mg /天的女性(P<0.05)。结论:他克莫司治疗后,Th1/ Th2细胞比值增高的RPL患者LBR明显改善。
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引用次数: 0
Contraceptive Counseling at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia 埃塞俄比亚西南部Mizan-Tepi大学教学医院的避孕咨询
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840089
Rohana Bruker, Margo Harrison
Background: In Ethiopia, postpartum contraception remains underutilized. Few women receive contraceptive counseling despite the country having the highest rates of unintended pregnancies in Sub-Saharan Africa. This study characterizes the prevalence of contraceptive counseling at Mizan-Tepi University Teaching Hospital (MTUTH) and examines differences in maternal demographic, antepartum, and postpartum characteristics between women who did and did not receive contraceptive counseling. Methods: A prospective cross-sectional study was conducted in 2019 with a convenience sample of 1000 women delivering at 28 weeks or more from MTUTH. Data were collected through chart reviews and patient interviews upon admission, delivery, and discharge. Purposeful modeling was used to identify significant predictors of contraceptive counseling. Results: The prevalence of contraceptive counseling was 4.55%. Among those with contraceptive counseling data recorded, receipt of counseling was associated with parity and delivery provider (p < 0.05). Odds of receiving contraceptive counseling among women with no previous births (parity=0) were 0.83 times less likely than women who had given birth at least three times (parity=3+) (OR: 0.17; 95% CI: 0.05-0.57). Odds of receiving contraceptive counseling among women who had an integrated emergency and surgical
背景:在埃塞俄比亚,产后避孕仍然没有得到充分利用。尽管该国意外怀孕率在撒哈拉以南非洲地区最高,但很少有妇女接受避孕咨询。本研究描述了Mizan-Tepi大学教学医院(MTUTH)避孕咨询的流行程度,并检查了接受和未接受避孕咨询的妇女在产妇人口统计学、产前和产后特征方面的差异。方法:2019年进行了一项前瞻性横断面研究,方便样本为1000名28周或以上从MTUTH分娩的妇女。数据收集通过病历回顾和患者在入院、分娩和出院时的访谈。有目的的模型被用来确定避孕咨询的重要预测因素。结果:避孕咨询使用率为4.55%。在有避孕咨询记录的患者中,接受咨询与胎次和分娩提供者相关(p < 0.05)。没有生育过(胎次=0)的妇女接受避孕咨询的几率比至少生育过三次(胎次=3+)的妇女低0.83倍(OR: 0.17;95% ci: 0.05-0.57)。综合急诊和外科手术的妇女接受避孕咨询的几率
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引用次数: 0
Treatment of Pelvic Floor Hypertonic Disorders with top Flat Magnetic Stimulation in Women with Vestibulodynia: A Pilot Study 前庭痛症女性盆底高渗疾病的治疗:一项初步研究
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840087
A. Biondo, F. Murina, I. Fusco
Background: Vulvodynia is a popular disease that affects around the 15% of women. Objectives: In this study we assess the effectiveness and the safeness of a new device that uses Top Flat Magnetic Stimulation for the management of the hypertone in women with vulvodynia. Methods: PISQ-12 questionnaire for sexual function was used for the evaluation of patient’s vulvodynia improvements. Possible side effects were examined. Results: In all women examined, the mean score of PISQ-12 significantly decrease from 27,4 (SD 9.6) before treatment session to 15,5 (SD 7.9) after the last session (p < .001), showing an improvement in vulvodynia symptoms. No Side effects were observed. Conclusion: On the basis of our findings this new technology seems to be able to effectively treat the hypertone condition in vulvodynia disease.
背景:外阴痛是一种常见病,影响约15%的女性。目的:在本研究中,我们评估了一种新的装置的有效性和安全性,该装置使用顶部平面磁刺激来管理女性外阴痛的高张力。方法:采用PISQ-12性功能问卷对患者外阴痛改善情况进行评价。检查了可能的副作用。结果:在所有接受检查的女性中,PISQ-12的平均得分从治疗前的27.4分(SD 9.6)显著下降到最后一次治疗后的15.5分(SD 7.9) (p < 0.001),表明外阴痛症状有所改善。未观察到任何副作用。结论:根据我们的研究结果,这种新技术似乎可以有效地治疗外阴痛疾病的高张力状况。
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引用次数: 3
SPRINTS-Sand Play Reprocessing Integrating Nonverbal Trauma-Interventions and Self-Stabilization. A Controlled Pilot Study 短跑-沙游戏再加工整合非语言创伤干预和自我稳定。对照试验研究
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840084
Beate Leinberger
Introduction: Psychic traumata among children, e.g. familiar violence, war, political supression or seconddary because oft he pandemic situation, are very important medical topics worldwide. Because of the lack of psychotherapists more or less anywhere, multipliers as co-therapists should be integrated. These specially trained non-professionals we call Traumahelpers (TH). In the last seven years pilot projects in German, Telangana (India), and Palestine were performed. Method: TH first learn self-stabilization techniques: Slow Paced Breathing, Somatic Universal Regulative Exercise and different techniques of Bilateral Stimulation like tapping or “lying eight”, which are near to children`s daily living experiences (e.g. swinging, drawing slopes, singing, move and run) and all derivates from the established traumatherapyconcepts. At the end the TH experience the SandplayTherapy, the nonverbal equivalent of desentizitation reprocessing. Results: In this pilot Study 15 children, aged 5 to 12 years, sectioned in two groups (one in Germany and one in Andhra Pradesh, India), diagnosed with the Depression Self Rating Scale and the Children – Impact of Event Scale had up to 10 Sandplay sessions, within three to five months. Every child had its individual TH during all the sessions. If the TH J Women’s Health Dev 2022; 5 (2): 139-151 DOI: 10.26502/fjwhd.2644-28840084 Journal of Women’s Health and Development Volume 5 No 2 – June 2022 140 observed emotion or excitation, he or she offered self-stabilization exercises which he or she performed together in a manner that the child was able to do it even alone. Conclusions: The children improved significant, comparing pre-post results and a one-year katamnesis and compared to the not yet treated multicenter controls. The concept can be easily transferred in different cultures.
儿童的心理创伤,如熟悉的暴力、战争、政治压迫或因流行病而继发的心理创伤,是世界范围内非常重要的医学课题。由于任何地方或多或少都缺乏心理治疗师,因此应该整合乘数师作为共同治疗师。这些经过特殊训练的非专业人员,我们称之为创伤帮助者(TH)。在过去七年中,在德国、特伦甘纳(印度)和巴勒斯坦实施了试点项目。方法:首先学习自我稳定技术:慢节奏呼吸、躯体通用调节练习、拍打或“卧八”等不同的双侧刺激技术,这些技术接近儿童的日常生活经验(如秋千、划坡、唱歌、移动、跑步),都源自已建立的创伤治疗概念。最后,他们会经历“沙盘疗法”,这是一种非语言的“脱感再加工”。结果:在这项试点研究中,15名5至12岁的儿童被分为两组(一组在德国,一组在印度安得拉邦),他们被诊断患有抑郁症自评量表和儿童-事件影响量表,在三到五个月内进行了多达10次的沙盘游戏。在所有的疗程中,每个孩子都有自己的TH。《中华人民共和国妇女健康发展纲要2022》;5 (2): 139-151 DOI: 10.26502/fjwhd。《妇女健康与发展杂志》第5卷第2期- 2022年6月140观察到情绪或兴奋,他或她提供自我稳定练习,他或她以一种孩子即使独自也能做的方式进行。结论:与未治疗的多中心对照相比,与治疗前后的结果和一年的卡遗忘相比,儿童有了显著改善。这个概念很容易在不同的文化中传播。
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引用次数: 0
Clinical Complications Induced by Placental Site Subinvolution: Secondary-Type Hemorrhage after Delivery and Pseudo Aneurysms after Non-Traumatic Delivery may be Caused by Atony Of The Uteroplacental Artery 胎盘部位亚内陷引起的临床并发症:子宫胎盘动脉张力不全可能引起分娩后继发性出血和非外伤性分娩后假性动脉瘤
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840102
Y. Shiina, M. Yamamoto, Shiori Sano, Yuta Gonai, K. Sakai
Results: In postpartum hemorrhage cases, placental site subinvolution was diagnosed. Microscopic examination of the resected uterus showed subinvoluted arteries containing large thrombi. Immunohistochemical analysis showed that extravillous trophoblasts were present within the walls of subinvoluted vessels. Failure of involution on the placental site sometimes occurs following miscarriages as well. In post-miscarriage psudoaneurysms case, the distinctive hemorrhage in this patient consisted of bleeding from various sites in the myometrium after the placental chorion had been expelled without leaving a remnant. The bleeding pattern was extremely similar to the postpartum hemorrhage described above. Though, we could not confirm extravillous trophoblasts directly because of the succes of conservative treatment, these postpartum and post-miscarriage hemorrhage were thought to have the same pathophysiology.
结果:产后出血患者可诊断为胎盘部位亚退化。切除子宫的显微镜检查显示动脉近缠绕,含有大血栓。免疫组化分析显示,上皮外滋养细胞存在于亚缠绕血管壁内。胎盘部位复旧失败有时也发生在流产后。在一例流产后的假性动脉瘤病例中,该患者的独特出血包括胎盘绒毛膜被排出后,子宫肌层的各个部位出血而没有留下残留物。出血模式与上述产后出血极为相似。虽然由于保守治疗的成功,我们不能直接确认外滋养细胞,但这些产后出血和流产后出血被认为具有相同的病理生理。
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引用次数: 0
Gestational Intermittent Hypoxia Programs Hypertensive Response in Female Rat Offspring: Impact of Ovaries. 妊娠期间歇性缺氧程序对雌性大鼠后代高血压反应:卵巢的影响。
Pub Date : 2022-01-01 Epub Date: 2022-06-20 DOI: 10.26502/fjwhd.2644-28840088
Ruolin Song, Jay S Mishra, Sri Vidya Dangudubiyyam, Tracy L Baker, Jyoti J Watters, Sathish Kumar

Obstructive sleep apnea (OSA) is a chronic condition frequently observed in pregnant women. We have shown that gestational intermittent hypoxia (GIH), a hallmark of OSA, leads to sex-specific impairment in the endothelium-dependent relaxation response and an increase in blood pressure in adult male but not female rat offspring. The present study tested the hypothesis that functional ovaries normalize GIH-induced hypertensive response in female offspring. Experiments were done in female offspring of pregnant rats exposed to normoxia or GIH (FIO2 21-10.5% from gestational days 10 to 21). Ovariectomy and sham surgery were performed at 5 weeks of age. Pups born to GIH dams were significantly smaller than the controls, but they exhibited catch-up growth and were similar to controls by 5 weeks of age. Ovariectomy significantly exacerbated bodyweight gain to a similar extent in both control and GIH offspring. Marked increases in blood pressure were observed in pre-pubertal GIH offspring compared to controls; however, after puberty, blood pressure in GIH offspring progressively decreased and became normotensive at adulthood. Ovariectomy led to the maintenance of higher blood pressure in post-pubertal GIH offspring with no significant effect in controls. Vascular contractile and relaxation responses were not affected in the GIH and control offspring; however, ovariectomy selectively decreased endothelium-dependent relaxation response along with a decrease in endothelial nitric oxide synthase expression in the GIH offspring. These findings suggest that functional ovaries are crucial in protecting females against GIH-mediated endothelial dysfunction and hypertension in adulthood.

阻塞性睡眠呼吸暂停(OSA)是一种常见于孕妇的慢性疾病。我们已经证明,妊娠期间歇性缺氧(GIH)是OSA的一个标志,会导致成年雄性大鼠后代的内皮依赖性松弛反应的性别特异性损伤和血压升高,而雌性大鼠后代则不会。本研究验证了卵巢功能正常的假说,即在雌性后代中,gih诱导的高血压反应正常。实验在妊娠第10 ~ 21天暴露于常氧或GIH (FIO2 21 ~ 10.5%)的怀孕大鼠雌性后代中进行。在5周龄时进行卵巢切除和假手术。出生在GIH水坝的幼崽明显小于对照组,但它们在5周龄时表现出追赶性生长,与对照组相似。卵巢切除术显著加重了对照组和GIH后代的体重增加,其程度相似。与对照组相比,在青春期前的GIH后代中观察到血压明显升高;然而,青春期后,GIH后代的血压逐渐下降,并在成年时变为正常。卵巢切除术导致青春期后GIH后代维持较高血压,而对照组无显著影响。血管收缩和舒张反应在GIH和对照后代中不受影响;然而,卵巢切除术选择性地降低了GIH后代内皮依赖性松弛反应以及内皮型一氧化氮合酶表达的降低。这些发现表明,卵巢功能在保护女性免受gih介导的内皮功能障碍和成年期高血压的影响方面至关重要。
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引用次数: 0
Effective Tumor Control Following Re-Irradiation Combined with Superficial Hyperthermia of Inoperable, Locally Recurrent Breast Cancers 再照射联合浅表热疗对不能手术的局部复发乳腺癌的有效肿瘤控制
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840076
Notter Markus, Thomsen Ar, Vaupel P
Inoperable, locally Recurrent Breast Cancer (LRBC) in previously irradiated regions is a challenging disease to manage. Superficial Hyperthermia (sHT) in combination with Re-Irradiation (re-RT) offers an effective local tumor control with a total re-RT dose of 20 Gy. The low toxicity enables the application of repeated re-irradiations, especially in recurrent lymphangiosis carcinomatosa. This technology can also be applied with other superficial tumor types, e.g., in primary or radiation-associated angiosarcoma or skin metastasis.
不能手术,局部复发乳腺癌(LRBC)在以前的放疗区域是一个具有挑战性的疾病管理。浅表热疗(sHT)联合再照射(re-RT)提供了有效的局部肿瘤控制,总再照射剂量为20 Gy。低毒性使反复再照射的应用,特别是在复发性淋巴管病癌。该技术也可以应用于其他浅表肿瘤类型,例如原发性或辐射相关血管肉瘤或皮肤转移。
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引用次数: 0
Surviving Tactics of Medical Interns Countering Long Working Hours: A Systematic Review 医疗实习生应对长时间工作的生存策略:系统回顾
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840096
Shamaila Manzoor, Idrees Anwar, Aisha Rafi
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引用次数: 0
Gynaecological Health of Women Attending Hospital in Oil City of Port Harcourt in the Niger Delta Region of Nigeria 尼日利亚尼日尔三角洲地区哈科特港油城住院妇女的妇科健康
Pub Date : 2022-01-01 DOI: 10.26502/fjwhd.2644-28840080
Felix M Onyije, Ajuluchukwu Azubuike Ngokere, Aloysius Ebi Ligha, Godwin Ovie Avwioro, O. Mgbere
Introduction: Increasingly, residents of the Niger Delta region of Nigeria are reporting health impacts that they believe are linked to environmental pollutions from oil and gas activities. Hence, the objective of this study was to assess the gynaecological health of women in the Oil City of Port Harcourt in the Niger Delta Region of Nigeria. Methods: Data used for this study (n=697) were obtained from the Rivers State University Teaching Hospital (RSUTH) in Port Harcourt, Nigeria. The J Women’s Health Dev 2022; 5 (1): 097-108 DOI: 10.26502/fjwhd.2644-28840080 Journal of Women’s Health and Development Volume 5 No 1 – March 2022 98 patients had partial or total hysterectomy or diagnosed of gynaecological lesion. Data obtained were subjected to both descriptive and inferential statistics using SAS 9.4 version (SAS Institute, Cary, NC, USA). Results: The distribution of the gynaecological lesions differed significantly (p<0.001) by year of diagnosis, developmental stage, age category and types of lesion. Leiomyoma was the highest number of lesions identified (56.0%, n=390), followed by ovarian cyst (10.0%, n=70) and retained product of conception (8.0%, n=56). Women of age group 30-39 years and 40-49 years had the highest number of lesions during the study period with a range of 2171% and 17-34 %, respectively. Conclusion: The prevalence and characteristics of gynaecological lesions in our study sample point to the potential public health consequences, and strong need for creation of awareness campaigns and general health assessment in the Niger Delta region of Nigeria.
导言:尼日利亚尼日尔三角洲地区的居民越来越多地报告他们认为与石油和天然气活动造成的环境污染有关的健康影响。因此,本研究的目的是评估尼日利亚尼日尔三角洲地区石油城市哈科特港妇女的妇科健康状况。方法:本研究使用的数据(n=697)来自尼日利亚哈科特港的河流州立大学教学医院(RSUTH)。《妇女健康发展2022》;[5] (1): 097-108 DOI: 10.26502/fjwhd.]妇女健康与发展杂志第5卷第1期- 2022年3月98例患者部分或全部切除子宫或诊断为妇科病变。使用SAS 9.4版本(SAS Institute, Cary, NC, USA)对获得的数据进行描述性和推断性统计。结果:妇科病变在诊断年份、发育阶段、年龄分型、病变类型上的分布差异有统计学意义(p<0.001)。发现的病变最多的是平滑肌瘤(56.0%,n=390),其次是卵巢囊肿(10.0%,n=70)和受孕产物残留(8.0%,n=56)。30-39岁和40-49岁的女性在研究期间的病变数量最多,分别为2171%和17- 34%。结论:在我们的研究样本中,妇科病变的患病率和特征表明了潜在的公共卫生后果,以及在尼日利亚尼日尔三角洲地区开展宣传运动和一般健康评估的强烈需要。
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引用次数: 0
Risk Factors and Referral Rates for Urinary Tract Infection in Pregnant Mothers of Southwest Guatemala. 危地马拉西南部孕妇尿路感染的危险因素和转诊率。
Pub Date : 2021-12-01 Epub Date: 2021-10-09
Michael Miller, Molly Lamb, Claudia Rivera, Saskia Bunge Montes, Andrea Jimenez-Zambrano, Antonio Bolanos, Edwin Asturias, Stephen Berman, Margo S Harrison
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引用次数: 0
期刊
Journal of women's health and development
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