Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840095
Xiaofeng Ma, Lei Zhan, Shiying Sun, Yurong Song, Qingyuan Wang, Bing Wei, Enlin Wang
Cervical cancer (CC) is the fourth most common cancer among women worldwide. Early screening is helpful for the diagnosis and precision treatment of cervical cancer. Therefore, identification of CC related protein markers is required for cervical cancer diagnosis. In this study, we found the protein arginine N-methyltransferase 5 (PRMT5) was upregulated in CC patients compared with normal tissues through analysis of data from TCGA and GTEx datasets. Immunohistochemical staining and western blot confirmed that PRMT5 was indeed increased in the CC tissues. Furthermore, PRMT5 enhanced the ability of cell clone formation through activating AKT signaling pathway. Taken together, the higher expression of PRMT5 in the CC may be act as a prognostic biomarker, which involved in carcinogenesis by excessively activating AKT signaling pathway.
{"title":"Identification of PRMT5 as a Diagnosis Biomarker for Cervical Cancer by Bioinformatics Analysis","authors":"Xiaofeng Ma, Lei Zhan, Shiying Sun, Yurong Song, Qingyuan Wang, Bing Wei, Enlin Wang","doi":"10.26502/fjwhd.2644-28840095","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840095","url":null,"abstract":"Cervical cancer (CC) is the fourth most common cancer among women worldwide. Early screening is helpful for the diagnosis and precision treatment of cervical cancer. Therefore, identification of CC related protein markers is required for cervical cancer diagnosis. In this study, we found the protein arginine N-methyltransferase 5 (PRMT5) was upregulated in CC patients compared with normal tissues through analysis of data from TCGA and GTEx datasets. Immunohistochemical staining and western blot confirmed that PRMT5 was indeed increased in the CC tissues. Furthermore, PRMT5 enhanced the ability of cell clone formation through activating AKT signaling pathway. Taken together, the higher expression of PRMT5 in the CC may be act as a prognostic biomarker, which involved in carcinogenesis by excessively activating AKT signaling pathway.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85109647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840082
Nnennaya U Opara
Women face several challenges over the course of their lives in many aspects pertaining to their phy-sical health, using the healthcare system, and the roles they play in society. Women make up over 50% of the US population and are projected to outlive men. Women are affected the most when it comes to changes in health policies because they use the healthcare system as patients (especially during childbirth), caregivers, and family representatives. In this review article, we aim to highlight and raise awareness regarding the several ways in which changes to health policies regarding abortions and breast cancer prevention, by either the Federal or State Governments, can impact women’s health in several U.S states.
{"title":"Health Policies Impacting Women’s Health: A Scoping Review","authors":"Nnennaya U Opara","doi":"10.26502/fjwhd.2644-28840082","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840082","url":null,"abstract":"Women face several challenges over the course of their lives in many aspects pertaining to their phy-sical health, using the healthcare system, and the roles they play in society. Women make up over 50% of the US population and are projected to outlive men. Women are affected the most when it comes to changes in health policies because they use the healthcare system as patients (especially during childbirth), caregivers, and family representatives. In this review article, we aim to highlight and raise awareness regarding the several ways in which changes to health policies regarding abortions and breast cancer prevention, by either the Federal or State Governments, can impact women’s health in several U.S states.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80465869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840091
Mirabel M. Vifeme, N. Gwendoline, Banlack Ernest, E. Mboh, Emmanuel Nshom, Tebeu Pierre Marie
Background: The evolution in antiretroviral treatment programs enabled HIV infected children to reach adulthood, passing through a series of sexual relationship challenges, notably early/unintended pregnancies. The risks facing young mothers are amplified for those living with HIV, who face additional vulnerabilities. This study aimed to assess the prevalence and factors associated with pregnancy among adolescents and young adults living with HIV. Methods: This was a cross-sectional study using a sequential sampling of adolescents and young adults living with HIV. Structured questionnaires were used to collect data between February and April 2022 from 238 clients in 16 HIV care and treatment sites in the Northwest Region. Data collected was cleaned and analyzed using Stata version 14.0. Results: The mean age of the 238 study participants was 18.7 years with a 26.5% prevalence of pregnancy. About 59.2% were adolescents aged 15-19 years, 90.8% single, 72.3% unemployed, while only 40.8% of those who had been exposed to sex used a pregnancy prevention method. Being an urban dweller, not schooling and having first sex between the ages 15-19 years were statistically associated with higher odds of pregnancy. Conclusion: The rate of pregnancy among adolescents and young adults living with HIV is high and mostly associated with sociodemographic factors. Setting strategies to retain youths in school, intensifying the creation of awareness on reproductive health issues, and especially counseling on pregnancy prevention methods could be options to mitigate this real-time challenge in young girls as a whole particularly those living with HIV.
背景:抗逆转录病毒治疗方案的发展使感染艾滋病毒的儿童能够长大成人，经历了一系列的性关系挑战，特别是早孕/意外怀孕。对于艾滋病毒感染者来说，年轻母亲面临的风险更大，她们面临着额外的脆弱性。本研究旨在评估感染艾滋病毒的青少年和年轻成人的流行情况及其与怀孕相关的因素。方法:这是一项横断面研究，对感染艾滋病毒的青少年和年轻人进行了连续抽样。在2022年2月至4月期间，采用结构化问卷收集西北地区16个艾滋病毒护理和治疗站点的238名客户的数据。收集的数据使用Stata version 14.0进行清理和分析。结果:238名研究参与者的平均年龄为18.7岁，怀孕率为26.5%。约59.2%为15-19岁的青少年，90.8%为单身，72.3%为失业，而有过性接触的人中只有40.8%采取了避孕措施。据统计，城市居民、未上学、15-19岁之间发生第一次性行为与较高的怀孕几率有关。结论:青少年和青壮年艾滋病病毒感染者的怀孕率较高，与社会人口因素有关。制定战略，使青年留在学校，加强对生殖健康问题的认识，特别是关于预防怀孕方法的咨询，可以作为备选办法，减轻整个年轻女孩，特别是感染艾滋病毒的女孩面临的这一实时挑战。
{"title":"Pregnancy and Associated Factors Among Adolescents and Young Adults Living with HIV in the Northwest Region of Cameroon","authors":"Mirabel M. Vifeme, N. Gwendoline, Banlack Ernest, E. Mboh, Emmanuel Nshom, Tebeu Pierre Marie","doi":"10.26502/fjwhd.2644-28840091","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840091","url":null,"abstract":"Background: The evolution in antiretroviral treatment programs enabled HIV infected children to reach adulthood, passing through a series of sexual relationship challenges, notably early/unintended pregnancies. The risks facing young mothers are amplified for those living with HIV, who face additional vulnerabilities. This study aimed to assess the prevalence and factors associated with pregnancy among adolescents and young adults living with HIV. Methods: This was a cross-sectional study using a sequential sampling of adolescents and young adults living with HIV. Structured questionnaires were used to collect data between February and April 2022 from 238 clients in 16 HIV care and treatment sites in the Northwest Region. Data collected was cleaned and analyzed using Stata version 14.0. Results: The mean age of the 238 study participants was 18.7 years with a 26.5% prevalence of pregnancy. About 59.2% were adolescents aged 15-19 years, 90.8% single, 72.3% unemployed, while only 40.8% of those who had been exposed to sex used a pregnancy prevention method. Being an urban dweller, not schooling and having first sex between the ages 15-19 years were statistically associated with higher odds of pregnancy. Conclusion: The rate of pregnancy among adolescents and young adults living with HIV is high and mostly associated with sociodemographic factors. Setting strategies to retain youths in school, intensifying the creation of awareness on reproductive health issues, and especially counseling on pregnancy prevention methods could be options to mitigate this real-time challenge in young girls as a whole particularly those living with HIV.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83399972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840092
Brittany Roberts, M. Al Jumaily, Emad Mikhail
There is a large body of literature supporting the heritable nature of endometriosis. Although there is significant evidence demonstrating the heritability of endometriosis, there is little to no evidence demonstrating the role of heritability in patients with Deep Infiltrating Endometriosis (DIE). We present a case of two 26-year-old G0 dizygotic twins with almost identical severe posterior compartment DIE who both underwent fertility sparing laparoscopic excision of DIE. This case demonstrates an almost identical presentation of DIE in dizygotic twins. Both patients had disease manifestation in their mid 20s, similar symptomatology, almost identical intraoperative findings, and the same improvement in pain following the procedure. Although this case study further contributes to the large body of literature demonstrating the heritability of endometriosis, this is the first case study demonstrating a striking resemblance of rectovaginal DIE in dizygotic twins.
{"title":"Deep Infiltrating Endometriosis in Dizygotic Twins: A Case Report and a Review of Literature","authors":"Brittany Roberts, M. Al Jumaily, Emad Mikhail","doi":"10.26502/fjwhd.2644-28840092","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840092","url":null,"abstract":"There is a large body of literature supporting the heritable nature of endometriosis. Although there is significant evidence demonstrating the heritability of endometriosis, there is little to no evidence demonstrating the role of heritability in patients with Deep Infiltrating Endometriosis (DIE). We present a case of two 26-year-old G0 dizygotic twins with almost identical severe posterior compartment DIE who both underwent fertility sparing laparoscopic excision of DIE. This case demonstrates an almost identical presentation of DIE in dizygotic twins. Both patients had disease manifestation in their mid 20s, similar symptomatology, almost identical intraoperative findings, and the same improvement in pain following the procedure. Although this case study further contributes to the large body of literature demonstrating the heritability of endometriosis, this is the first case study demonstrating a striking resemblance of rectovaginal DIE in dizygotic twins.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"538 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77450072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840098
K. Nakagawa, J. Kwak‐Kim, K. Kuroda, T. Horikawa, S. Takamizawa, M. Hisano, Yoshimitsu Kasahara, R. Sugiyama, K. Yamaguchi
Purpose: Elevated T helper 1 (Th1)/Th2 cell ratio has been associated with recurrent pregnancy losses (PRL). In this study, the clinical efficacy of tacrolimus, a calcineurin inhibitor, was investigated in women with consecutive four or more recurrent pregnancy losses (RPL) and elevated Th1/Th2 (CD4 + IFN-γ + / CD4 + IL-4 + ) cell ratio. The live-birth rate (LBR) was prospectively investigated in women with RPL who received tacrolimus treatment. Methods: A total of 100 pregnant women with PRL with elevated Th1/ Th2 cell ratios (≥10.3) were recruited from November 2013 to December 2019. Seventy-one women received tacrolimus between 1 mg and 4 mg daily (treatment group) and 29 women did not receive tacrolimus (control group). Results: In the treatment group, the LBR was 70.4% (50/71), which was significantly higher than that of the control group (48.2%, p<0.05). According to the tacrolimus doses, the treatment group was divided into three subgroups. The LBRs of women with tacrolimus 1mg, 2mg, and ≥3mg daily were 52.2%, 72.3%, and 93.3%, respectively. In women with tacrolimus ≥3mg daily, the LBR was significantly higher than women with tacrolimus 1mg daily (P<0.05). Conclusion: In conclusion, the LBR of RPL women with increased Th1/ Th2 cell ratios was significantly improved with tacrolimus treatment.
{"title":"Tacrolimus Improved Reproductive Outcomes of Women with Recurrent Pregnancy Loss (PRL) Showing Elevated T Helper 1 (Th1) /Th2 Cell Ratios","authors":"K. Nakagawa, J. Kwak‐Kim, K. Kuroda, T. Horikawa, S. Takamizawa, M. Hisano, Yoshimitsu Kasahara, R. Sugiyama, K. Yamaguchi","doi":"10.26502/fjwhd.2644-28840098","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840098","url":null,"abstract":"Purpose: Elevated T helper 1 (Th1)/Th2 cell ratio has been associated with recurrent pregnancy losses (PRL). In this study, the clinical efficacy of tacrolimus, a calcineurin inhibitor, was investigated in women with consecutive four or more recurrent pregnancy losses (RPL) and elevated Th1/Th2 (CD4 + IFN-γ + / CD4 + IL-4 + ) cell ratio. The live-birth rate (LBR) was prospectively investigated in women with RPL who received tacrolimus treatment. Methods: A total of 100 pregnant women with PRL with elevated Th1/ Th2 cell ratios (≥10.3) were recruited from November 2013 to December 2019. Seventy-one women received tacrolimus between 1 mg and 4 mg daily (treatment group) and 29 women did not receive tacrolimus (control group). Results: In the treatment group, the LBR was 70.4% (50/71), which was significantly higher than that of the control group (48.2%, p<0.05). According to the tacrolimus doses, the treatment group was divided into three subgroups. The LBRs of women with tacrolimus 1mg, 2mg, and ≥3mg daily were 52.2%, 72.3%, and 93.3%, respectively. In women with tacrolimus ≥3mg daily, the LBR was significantly higher than women with tacrolimus 1mg daily (P<0.05). Conclusion: In conclusion, the LBR of RPL women with increased Th1/ Th2 cell ratios was significantly improved with tacrolimus treatment.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87108400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840089
Rohana Bruker, Margo Harrison
Background: In Ethiopia, postpartum contraception remains underutilized. Few women receive contraceptive counseling despite the country having the highest rates of unintended pregnancies in Sub-Saharan Africa. This study characterizes the prevalence of contraceptive counseling at Mizan-Tepi University Teaching Hospital (MTUTH) and examines differences in maternal demographic, antepartum, and postpartum characteristics between women who did and did not receive contraceptive counseling. Methods: A prospective cross-sectional study was conducted in 2019 with a convenience sample of 1000 women delivering at 28 weeks or more from MTUTH. Data were collected through chart reviews and patient interviews upon admission, delivery, and discharge. Purposeful modeling was used to identify significant predictors of contraceptive counseling. Results: The prevalence of contraceptive counseling was 4.55%. Among those with contraceptive counseling data recorded, receipt of counseling was associated with parity and delivery provider (p < 0.05). Odds of receiving contraceptive counseling among women with no previous births (parity=0) were 0.83 times less likely than women who had given birth at least three times (parity=3+) (OR: 0.17; 95% CI: 0.05-0.57). Odds of receiving contraceptive counseling among women who had an integrated emergency and surgical
{"title":"Contraceptive Counseling at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia","authors":"Rohana Bruker, Margo Harrison","doi":"10.26502/fjwhd.2644-28840089","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840089","url":null,"abstract":"Background: In Ethiopia, postpartum contraception remains underutilized. Few women receive contraceptive counseling despite the country having the highest rates of unintended pregnancies in Sub-Saharan Africa. This study characterizes the prevalence of contraceptive counseling at Mizan-Tepi University Teaching Hospital (MTUTH) and examines differences in maternal demographic, antepartum, and postpartum characteristics between women who did and did not receive contraceptive counseling. Methods: A prospective cross-sectional study was conducted in 2019 with a convenience sample of 1000 women delivering at 28 weeks or more from MTUTH. Data were collected through chart reviews and patient interviews upon admission, delivery, and discharge. Purposeful modeling was used to identify significant predictors of contraceptive counseling. Results: The prevalence of contraceptive counseling was 4.55%. Among those with contraceptive counseling data recorded, receipt of counseling was associated with parity and delivery provider (p < 0.05). Odds of receiving contraceptive counseling among women with no previous births (parity=0) were 0.83 times less likely than women who had given birth at least three times (parity=3+) (OR: 0.17; 95% CI: 0.05-0.57). Odds of receiving contraceptive counseling among women who had an integrated emergency and surgical","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"194 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78034044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840087
A. Biondo, F. Murina, I. Fusco
Background: Vulvodynia is a popular disease that affects around the 15% of women. Objectives: In this study we assess the effectiveness and the safeness of a new device that uses Top Flat Magnetic Stimulation for the management of the hypertone in women with vulvodynia. Methods: PISQ-12 questionnaire for sexual function was used for the evaluation of patient’s vulvodynia improvements. Possible side effects were examined. Results: In all women examined, the mean score of PISQ-12 significantly decrease from 27,4 (SD 9.6) before treatment session to 15,5 (SD 7.9) after the last session (p < .001), showing an improvement in vulvodynia symptoms. No Side effects were observed. Conclusion: On the basis of our findings this new technology seems to be able to effectively treat the hypertone condition in vulvodynia disease.
{"title":"Treatment of Pelvic Floor Hypertonic Disorders with top Flat Magnetic Stimulation in Women with Vestibulodynia: A Pilot Study","authors":"A. Biondo, F. Murina, I. Fusco","doi":"10.26502/fjwhd.2644-28840087","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840087","url":null,"abstract":"Background: Vulvodynia is a popular disease that affects around the 15% of women. Objectives: In this study we assess the effectiveness and the safeness of a new device that uses Top Flat Magnetic Stimulation for the management of the hypertone in women with vulvodynia. Methods: PISQ-12 questionnaire for sexual function was used for the evaluation of patient’s vulvodynia improvements. Possible side effects were examined. Results: In all women examined, the mean score of PISQ-12 significantly decrease from 27,4 (SD 9.6) before treatment session to 15,5 (SD 7.9) after the last session (p < .001), showing an improvement in vulvodynia symptoms. No Side effects were observed. Conclusion: On the basis of our findings this new technology seems to be able to effectively treat the hypertone condition in vulvodynia disease.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89663693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840084
Beate Leinberger
Introduction: Psychic traumata among children, e.g. familiar violence, war, political supression or seconddary because oft he pandemic situation, are very important medical topics worldwide. Because of the lack of psychotherapists more or less anywhere, multipliers as co-therapists should be integrated. These specially trained non-professionals we call Traumahelpers (TH). In the last seven years pilot projects in German, Telangana (India), and Palestine were performed. Method: TH first learn self-stabilization techniques: Slow Paced Breathing, Somatic Universal Regulative Exercise and different techniques of Bilateral Stimulation like tapping or “lying eight”, which are near to children`s daily living experiences (e.g. swinging, drawing slopes, singing, move and run) and all derivates from the established traumatherapyconcepts. At the end the TH experience the SandplayTherapy, the nonverbal equivalent of desentizitation reprocessing. Results: In this pilot Study 15 children, aged 5 to 12 years, sectioned in two groups (one in Germany and one in Andhra Pradesh, India), diagnosed with the Depression Self Rating Scale and the Children – Impact of Event Scale had up to 10 Sandplay sessions, within three to five months. Every child had its individual TH during all the sessions. If the TH J Women’s Health Dev 2022; 5 (2): 139-151 DOI: 10.26502/fjwhd.2644-28840084 Journal of Women’s Health and Development Volume 5 No 2 – June 2022 140 observed emotion or excitation, he or she offered self-stabilization exercises which he or she performed together in a manner that the child was able to do it even alone. Conclusions: The children improved significant, comparing pre-post results and a one-year katamnesis and compared to the not yet treated multicenter controls. The concept can be easily transferred in different cultures.
{"title":"SPRINTS-Sand Play Reprocessing Integrating Nonverbal Trauma-Interventions and Self-Stabilization. A Controlled Pilot Study","authors":"Beate Leinberger","doi":"10.26502/fjwhd.2644-28840084","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840084","url":null,"abstract":"Introduction: Psychic traumata among children, e.g. familiar violence, war, political supression or seconddary because oft he pandemic situation, are very important medical topics worldwide. Because of the lack of psychotherapists more or less anywhere, multipliers as co-therapists should be integrated. These specially trained non-professionals we call Traumahelpers (TH). In the last seven years pilot projects in German, Telangana (India), and Palestine were performed. Method: TH first learn self-stabilization techniques: Slow Paced Breathing, Somatic Universal Regulative Exercise and different techniques of Bilateral Stimulation like tapping or “lying eight”, which are near to children`s daily living experiences (e.g. swinging, drawing slopes, singing, move and run) and all derivates from the established traumatherapyconcepts. At the end the TH experience the SandplayTherapy, the nonverbal equivalent of desentizitation reprocessing. Results: In this pilot Study 15 children, aged 5 to 12 years, sectioned in two groups (one in Germany and one in Andhra Pradesh, India), diagnosed with the Depression Self Rating Scale and the Children – Impact of Event Scale had up to 10 Sandplay sessions, within three to five months. Every child had its individual TH during all the sessions. If the TH J Women’s Health Dev 2022; 5 (2): 139-151 DOI: 10.26502/fjwhd.2644-28840084 Journal of Women’s Health and Development Volume 5 No 2 – June 2022 140 observed emotion or excitation, he or she offered self-stabilization exercises which he or she performed together in a manner that the child was able to do it even alone. Conclusions: The children improved significant, comparing pre-post results and a one-year katamnesis and compared to the not yet treated multicenter controls. The concept can be easily transferred in different cultures.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.26502/fjwhd.2644-28840102
Y. Shiina, M. Yamamoto, Shiori Sano, Yuta Gonai, K. Sakai
Results: In postpartum hemorrhage cases, placental site subinvolution was diagnosed. Microscopic examination of the resected uterus showed subinvoluted arteries containing large thrombi. Immunohistochemical analysis showed that extravillous trophoblasts were present within the walls of subinvoluted vessels. Failure of involution on the placental site sometimes occurs following miscarriages as well. In post-miscarriage psudoaneurysms case, the distinctive hemorrhage in this patient consisted of bleeding from various sites in the myometrium after the placental chorion had been expelled without leaving a remnant. The bleeding pattern was extremely similar to the postpartum hemorrhage described above. Though, we could not confirm extravillous trophoblasts directly because of the succes of conservative treatment, these postpartum and post-miscarriage hemorrhage were thought to have the same pathophysiology.
{"title":"Clinical Complications Induced by Placental Site Subinvolution: Secondary-Type Hemorrhage after Delivery and Pseudo Aneurysms after Non-Traumatic Delivery may be Caused by Atony Of The Uteroplacental Artery","authors":"Y. Shiina, M. Yamamoto, Shiori Sano, Yuta Gonai, K. Sakai","doi":"10.26502/fjwhd.2644-28840102","DOIUrl":"https://doi.org/10.26502/fjwhd.2644-28840102","url":null,"abstract":"Results: In postpartum hemorrhage cases, placental site subinvolution was diagnosed. Microscopic examination of the resected uterus showed subinvoluted arteries containing large thrombi. Immunohistochemical analysis showed that extravillous trophoblasts were present within the walls of subinvoluted vessels. Failure of involution on the placental site sometimes occurs following miscarriages as well. In post-miscarriage psudoaneurysms case, the distinctive hemorrhage in this patient consisted of bleeding from various sites in the myometrium after the placental chorion had been expelled without leaving a remnant. The bleeding pattern was extremely similar to the postpartum hemorrhage described above. Though, we could not confirm extravillous trophoblasts directly because of the succes of conservative treatment, these postpartum and post-miscarriage hemorrhage were thought to have the same pathophysiology.","PeriodicalId":74017,"journal":{"name":"Journal of women's health and development","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89411749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-06-20DOI: 10.26502/fjwhd.2644-28840088
Ruolin Song, Jay S Mishra, Sri Vidya Dangudubiyyam, Tracy L Baker, Jyoti J Watters, Sathish Kumar
Obstructive sleep apnea (OSA) is a chronic condition frequently observed in pregnant women. We have shown that gestational intermittent hypoxia (GIH), a hallmark of OSA, leads to sex-specific impairment in the endothelium-dependent relaxation response and an increase in blood pressure in adult male but not female rat offspring. The present study tested the hypothesis that functional ovaries normalize GIH-induced hypertensive response in female offspring. Experiments were done in female offspring of pregnant rats exposed to normoxia or GIH (FIO2 21-10.5% from gestational days 10 to 21). Ovariectomy and sham surgery were performed at 5 weeks of age. Pups born to GIH dams were significantly smaller than the controls, but they exhibited catch-up growth and were similar to controls by 5 weeks of age. Ovariectomy significantly exacerbated bodyweight gain to a similar extent in both control and GIH offspring. Marked increases in blood pressure were observed in pre-pubertal GIH offspring compared to controls; however, after puberty, blood pressure in GIH offspring progressively decreased and became normotensive at adulthood. Ovariectomy led to the maintenance of higher blood pressure in post-pubertal GIH offspring with no significant effect in controls. Vascular contractile and relaxation responses were not affected in the GIH and control offspring; however, ovariectomy selectively decreased endothelium-dependent relaxation response along with a decrease in endothelial nitric oxide synthase expression in the GIH offspring. These findings suggest that functional ovaries are crucial in protecting females against GIH-mediated endothelial dysfunction and hypertension in adulthood.
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