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A qualitative investigation of interventionalists’ views and experiences on clinical decision-making in claudication 介入医师对跛行临床决策的看法与经验之质性调查
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100327
Chloé A. Powell MD, MS , Lauren A. Szczygiel PhD , Mary E. Byrnes PhD, MUP , Nicholas H. Osborne MD, MS

Background

Claudication, pain with walking, is a common presentation of peripheral artery disease, which can significantly impact quality of life. Recent appropriate use criteria from the Society of Vascular Surgery provide a framework for management, particularly considerations for revascularization; however, consensus on the indications for revascularization remain elusive. This study seeks to understand the interventionalist perspective on decision making around intermittent claudication.

Methods

Semi-structured interviews were conducted with 30 interventionalists including interventional cardiologists, interventional radiologists, and vascular surgeons. Transcripts were iteratively analyzed through steps informed by inductive thematic analysis.

Results

Three key thematic patterns were identified regarding interventionalists’ perspectives on management, particularly procedural intervention, for patients with claudication: (1) periprocedural risk for complications and long-term durability of interventions for claudication was a persistent consideration in decision making; (2) despite the risks, there were opportunities to improve the patient’s quality of life, in other words, there were “good reasons” to be risky; (3) interventionalists’ expectations of the patient regarding adherence to medical management and indication influence providers’ decisions to pursue intervention.

Conclusions

Although there are recommendations to guide an interventionalists’ decision-making to pursue revascularization for a patient with claudication, in practice, there is heterogeneity in the factors that influence the decision to intervene. Interventionalists contend with not only the risks of a procedure but must interpret patients’ treatment goals and subjectivity of symptoms when determining benefit of revascularization. Interventionalists’ value judgements are frequently incorporated into the decision-making process, which may introduce bias. As such, there are opportunities to improve shared decision-making.
跛行,即行走疼痛,是外周动脉疾病的常见表现,可显著影响生活质量。最近来自血管外科学会的适当使用标准为管理提供了框架,特别是考虑到血运重建;然而,对于血运重建术的适应症的共识仍然难以捉摸。本研究旨在了解间歇性跛行决策的干预主义观点。方法采用半结构化访谈法对30名介入医师进行访谈,包括介入心脏科医师、介入放射科医师和血管外科医师。通过归纳主题分析的步骤对转录本进行迭代分析。结果干预医师对跛行患者的管理观点,特别是手术干预的观点,有三个关键的主题模式:(1)跛行患者的围手术期并发症风险和干预的长期持久性是决策中持续考虑的因素;(2)尽管存在风险,但仍有机会改善患者的生活质量,换句话说,有“充分的理由”去冒险;(3)介入医师对患者对医疗管理依从性和适应证的期望影响提供者进行干预的决定。结论虽然有一些建议可以指导介入医师对跛行患者进行血运重建术的决策,但在实践中,影响介入决策的因素存在异质性。介入医师不仅要应对手术的风险,而且在确定血运重建的益处时,还必须解释患者的治疗目标和症状的主观性。干预主义者的价值判断经常被纳入决策过程,这可能会引入偏见。因此,有机会改善共同决策。
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引用次数: 0
Outcomes of supra-versus infra-renal clamping in elective open aortic aneurysm repair in a tertiary vascular center 肾上与肾下夹持在三级血管中心择期开放性主动脉瘤修复中的效果
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100322
Daniel Becker MD , Ahmed Ali MD , Anja Lehmann MD , Christian Zielasek MD , Michel J. Bosiers MD , Juerg Schmidli MD , Drosos Kotelis MD , Vladimir Makaloski MD

Objective

Juxtarenal abdominal aortic aneurysms (AAAs), pose a greater surgical challenge than infrarenal AAAs and often require suprarenal aortic clamping during open repair. This study aims to assess the impact of suprarenal vs infrarenal clamping on short- and long-term renal outcomes, mortality, and reintervention rates.

Methods

A retrospective cohort analysis was conducted on 1250 patients undergoing open AAA repair between 2000 and 2020 at a tertiary vascular center. Patients were stratified into suprarenal and infrarenal clamping groups. Outcomes included 30-day mortality, major adverse events, acute kidney injury, new-onset dialysis, chronic kidney disease (CKD), long-term mortality, and reintervention. Propensity score matching and multivariate analysis were used to adjust for confounders.

Results

Of the cohort, 492 underwent suprarenal and 758 infrarenal clamping. The suprarenal group experienced higher 30-day major adverse events (20.9% vs 16.2%; P = .036), acute kidney injury (37.6% vs 22.0%; P < .001), and new-onset dialysis (4.5% vs 1.8%; P = .009). At a median follow-up of 8.6 years, CKD incidence was significantly higher in the suprarenal group (28.5% vs 21.1%; P = .004), as was all-cause mortality (41.3% vs 32.4%; P < .001). We found no difference in reintervention rates between groups. In the propensity-matched cohort, CKD remained significantly more common with suprarenal clamping (P < .001), whereas differences in mortality were not statistically significant.

Conclusions

Suprarenal clamping during open AAA repair is associated with increased postoperative renal complications and long-term CKD and mortality, despite similar reintervention and short-term mortality rates. These findings support the need for individualized surgical planning.
目的肾旁腹主动脉瘤(AAAs)的手术难度大于肾下动脉瘤(AAAs),在开放修复时通常需要肾上主动脉夹闭。本研究旨在评估肾上与肾下夹持对短期和长期肾脏预后、死亡率和再干预率的影响。方法回顾性队列分析2000 ~ 2020年在某三级血管中心行AAA开放性修复术的1250例患者。将患者分为肾上夹组和肾下夹组。结果包括30天死亡率、主要不良事件、急性肾损伤、新发透析、慢性肾病(CKD)、长期死亡率和再干预。倾向评分匹配和多变量分析用于调整混杂因素。结果492例接受了肾上夹持术,758例接受了肾下夹持术。肾上治疗组30天主要不良事件发生率(20.9% vs 16.2%; P = 0.036)、急性肾损伤发生率(37.6% vs 22.0%; P < 0.001)和新发透析发生率(4.5% vs 1.8%; P = 0.009)较高。在8.6年的中位随访中,肾上动脉组的CKD发病率明显更高(28.5% vs 21.1%; P = 0.004),全因死亡率也明显更高(41.3% vs 32.4%; P < 0.001)。我们发现两组之间的再干预率没有差异。在倾向匹配的队列中,肾上夹持的CKD仍然明显更常见(P < .001),而死亡率的差异无统计学意义。结论:尽管再干预和短期死亡率相似,但开放AAA修复期间肾上夹持与术后肾脏并发症、长期CKD和死亡率增加有关。这些发现支持了个体化手术计划的必要性。
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引用次数: 0
The lasting value of single-center experiences 单中心体验的持久价值
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100333
Mauricio Gonzalez-Urquijo MD, PhD, Francisco Valdes MD
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引用次数: 0
Incidence, risk factors, and short-term outcomes of groin infections after femoral bovine patch angioplasty and concomitant procedures 牛股补片血管成形术及伴随手术后腹股沟感染的发生率、危险因素和短期预后
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100338
Ryan Lee BA , Rajbir Singh DO , Calogero DiMaggio DO , Sharvil Sheth MD , Maggie Lin MD

Objective

Bovine pericardial patches are widely used in femoral artery reconstruction following femoral endarterectomy due to presumed resistance to infection compared with prosthetic materials, but literature on the management of groin infection in the setting of femoral endarterectomy (FEA) with bovine patch angioplasty remains limited. This study aims to evaluate risk factors for groin infection and need for bovine patch explant (BPE).

Methods

This is a single-center, retrospective, case-control study of all consecutive groins undergoing FEA with bovine patch angioplasty between January 2020 through July 2024. Risk factors for groin infection and BPE were assessed in a multivariate model. Secondary outcomes included wound infection bacteriology, 30-day mortality, and 1-year amputation rates for groin infections with and without BPE.

Results

A total of 313 groins from 288 patients underwent FEA with bovine patch angioplasty, 60 of whom (19.2%) developed groin infections. Of these groin infections, 20 were deep infections (33.3%). Risk factors for groin infection on multivariate analysis included diabetes mellitus (relative risk [RR], 1.67; P = .043) and overweight body mass index (RR, 1.04; P = .024). Patients developing groin infections were less likely to be current smokers (RR, 0.52; P = .038). All deep groin infections were managed with washout with negative pressure wound therapy. BPE was performed in nine of 20 patients (45%) with deep infections, and none of the superficial infections. BPE was pursued in all patients developing pseudoaneurysm, and patch preservation was successful in all patients with seromas. On multivariate analysis, female gender was associated with increased risk of BPE (RR, 7.87; P = .047). Hypertension was associated with decreased risk of BPE (RR, 0.11; P = .005), as was current smoking status (RR, 0.13; P = .039). None of the other comorbidities, indications for FEA, and concomitant procedures increased risk of BPE in our study. Wound culture bacteriology did not significantly differ between patients managed with and without BPE. Compared with patch preservation, BPE was associated with significantly higher 1-year amputation rate (33.3% vs 5.9%; P = .011) and higher 30-day mortality rates (22.2% vs 3.9%; P = .045).

Conclusions

Bovine patch preservation is reasonable for patients with superficial groin infections and postoperative seroma. Patch preservation is reasonable in select patients with deep groin infections, although a lower threshold for patch explant is necessary. Female gender and deep infection are associated with a higher rate of patch explant. Groin infection bacteriology did not alter risk of BPE. Patch explant is associated with a high perioperative mortality rate and 1-year major limb loss.
目的:与假体材料相比,牛心包补片被广泛应用于股动脉内膜切除术后的股动脉重建,因为牛心包补片被认为具有抗感染的能力,但关于股动脉内膜切除术(FEA)合并牛补片血管成形术中腹股沟感染的处理的文献仍然有限。本研究的目的是评估腹股沟感染的危险因素和牛斑块外植体(BPE)的需求。方法:这是一项单中心、回顾性、病例对照研究,研究对象为2020年1月至2024年7月期间所有连续接受FEA和牛贴片血管成形术的腹股沟。在多变量模型中评估腹股沟感染和BPE的危险因素。次要结局包括伤口感染细菌学,30天死亡率,腹股沟感染1年截肢率,有无BPE。结果288例患者行FEA合并牛贴片血管成形术,共313个腹股沟,其中60例(19.2%)发生腹股沟感染。腹股沟感染中深部感染20例(33.3%)。多因素分析腹股沟感染的危险因素包括糖尿病(相对危险度[RR], 1.67; P = 0.043)和超重体重指数(RR, 1.04; P = 0.024)。发生腹股沟感染的患者不太可能是当前吸烟者(RR, 0.52; P = 0.038)。所有深腹股沟感染均采用负压伤口冲洗治疗。20例深部感染患者中有9例(45%)行BPE,无一例浅表感染。所有假性动脉瘤患者都进行了BPE治疗,所有血清瘤患者的贴片保存都很成功。在多因素分析中,女性与BPE风险增加相关(RR, 7.87; P = 0.047)。高血压与BPE风险降低相关(RR, 0.11; P = 0.005),吸烟状况与BPE风险降低相关(RR, 0.13; P = 0.039)。在我们的研究中,没有其他合并症、FEA适应症和伴随手术增加BPE的风险。伤口培养细菌学在接受和不接受BPE治疗的患者之间没有显著差异。与补片保存相比,BPE与更高的1年截肢率(33.3% vs 5.9%, P = 0.011)和更高的30天死亡率(22.2% vs 3.9%, P = 0.045)相关。结论对腹股沟浅表感染及术后血肿患者行牛补片保存是合理的。对于深腹股沟感染的患者,膜片保留是合理的,尽管膜片移植的门槛较低是必要的。女性和深部感染与较高的斑块外植体发生率相关。腹股沟感染细菌学没有改变BPE的风险。膜片外植体与高围手术期死亡率和1年主要肢体丧失相关。
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引用次数: 0
Aortic remodeling predicts long-term survival and freedom from reintervention after thoracic endovascular aortic repair for chronic type B aortic dissection including residual type A dissection 主动脉重塑预测慢性B型主动脉夹层(包括残留的A型夹层)胸腔血管内主动脉修复术后的长期生存和免于再干预
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100352
Sadanari Sawaki MD, PhD , Mika Kumagai MA , Kazuki Nomura MD , Shogo Maeda MD , Riku Kato MD , Tsubasa Yazawa MD , Masayoshi Tokoro MD, PhD , Ayumi Shintani MPH, PhD , Toshiaki Ito MD, PhD

Background

The optimal timing for thoracic endovascular aortic repair in chronic type B aortic dissection is controversial, largely because the long-term impact of aortic remodeling on clinical outcomes remains unclear. This study investigates the prognostic value of aortic remodeling and identifies its key determinants.

Methods

In a retrospective analysis of 95 patients treated with thoracic endovascular aortic repair for chronic type B aortic dissection, we defined aortic remodeling as a ≥5 mm decrease in aortic diameter. We then assessed its association with 5-year survival and freedom from reintervention and identified preoperative predictors for its occurrence.

Results

Achieving aortic remodeling was associated with a dramatic improvement in long-term outcomes. Patients in the remodeling group (n = 57) had the estimated 5-year survival rate of 98.0%, compared with 80.0% in the non-remodeling group (n = 38; P = .003). Freedom from reintervention was also substantially higher at 91.3% in the remodeling group vs 50.0% in the non-remodeling group (P < .0001). This favorable remodeling was most likely to occur in patients treated sooner after the initial dissection (median, 12 months vs 78 months; P < .001) and in those with a smaller preoperative aortic diameter at the diaphragmatic level (median, 34 mm vs 42 mm; P < .001).

Conclusions

Favorable aortic remodeling is a strong and independent predictor of long-term survival and freedom from reintervention after thoracic endovascular aortic repair for chronic type B aortic dissection. These findings suggest that intervening earlier in the chronic phase, before substantial aortic dilatation develops, may be beneficial for improving clinical outcomes.
背景:慢性B型主动脉夹层的胸腔内主动脉修复的最佳时机存在争议,主要是因为主动脉重构对临床结果的长期影响尚不清楚。本研究探讨了主动脉重塑的预后价值,并确定了其关键决定因素。方法回顾性分析95例慢性B型主动脉夹层行胸腔血管内主动脉修复术的患者,将主动脉重构定义为主动脉直径减小≥5mm。然后,我们评估了其与5年生存率和免于再干预的相关性,并确定了其发生的术前预测因素。结果实现主动脉重塑与长期预后的显著改善相关。重塑组患者(n = 57)的5年生存率为98.0%,而非重塑组患者的5年生存率为80.0% (n = 38; P = 0.003)。再干预自由度在重塑组也明显更高,为91.3%,而非重塑组为50.0% (P < .0001)。这种有利的重构最有可能发生在初次剥离后不久接受治疗的患者(中位数,12个月vs 78个月;P < .001)和术前膈水平主动脉直径较小的患者(中位数,34 mm vs 42 mm; P < .001)。结论良好的主动脉重构是慢性B型主动脉夹层胸廓血管内主动脉修复术后长期生存和免于再干预的一个强有力的独立预测因素。这些发现表明,在主动脉扩张发展之前,在慢性期早期进行干预可能有利于改善临床结果。
{"title":"Aortic remodeling predicts long-term survival and freedom from reintervention after thoracic endovascular aortic repair for chronic type B aortic dissection including residual type A dissection","authors":"Sadanari Sawaki MD, PhD ,&nbsp;Mika Kumagai MA ,&nbsp;Kazuki Nomura MD ,&nbsp;Shogo Maeda MD ,&nbsp;Riku Kato MD ,&nbsp;Tsubasa Yazawa MD ,&nbsp;Masayoshi Tokoro MD, PhD ,&nbsp;Ayumi Shintani MPH, PhD ,&nbsp;Toshiaki Ito MD, PhD","doi":"10.1016/j.jvsvi.2025.100352","DOIUrl":"10.1016/j.jvsvi.2025.100352","url":null,"abstract":"<div><h3>Background</h3><div>The optimal timing for thoracic endovascular aortic repair in chronic type B aortic dissection is controversial, largely because the long-term impact of aortic remodeling on clinical outcomes remains unclear. This study investigates the prognostic value of aortic remodeling and identifies its key determinants.</div></div><div><h3>Methods</h3><div>In a retrospective analysis of 95 patients treated with thoracic endovascular aortic repair for chronic type B aortic dissection, we defined aortic remodeling as a ≥5 mm decrease in aortic diameter. We then assessed its association with 5-year survival and freedom from reintervention and identified preoperative predictors for its occurrence.</div></div><div><h3>Results</h3><div>Achieving aortic remodeling was associated with a dramatic improvement in long-term outcomes. Patients in the remodeling group (n = 57) had the estimated 5-year survival rate of 98.0%, compared with 80.0% in the non-remodeling group (n = 38; <em>P</em> = .003). Freedom from reintervention was also substantially higher at 91.3% in the remodeling group vs 50.0% in the non-remodeling group (<em>P</em> &lt; .0001). This favorable remodeling was most likely to occur in patients treated sooner after the initial dissection (median, 12 months vs 78 months; <em>P</em> &lt; .001) and in those with a smaller preoperative aortic diameter at the diaphragmatic level (median, 34 mm vs 42 mm; <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Favorable aortic remodeling is a strong and independent predictor of long-term survival and freedom from reintervention after thoracic endovascular aortic repair for chronic type B aortic dissection. These findings suggest that intervening earlier in the chronic phase, before substantial aortic dilatation develops, may be beneficial for improving clinical outcomes.</div></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":"4 ","pages":"Article 100352"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopsychosocial predictors of long-term major amputation following peripheral vascular intervention in chronic limb-threatening ischemia using a machine learning algorithm approach 使用机器学习算法的外周血管介入治疗慢性肢体缺血后长期截肢的生物心理社会预测因素
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100348
Golsa Joodi MD , Gaëlle Romain PhD , Jacob Cleman MD , Iliana Hurtado Rendon MD , Rabih Tabet MD , Lindsey Scierka MD, MPH , Mufti Mushfiqur Rahman MD, MPH , Aseem Vashist MD , Eman Mubarak MD , Christiany Tapia MD , Kim G. Smolderen PhD , Carlos Mena-Hurtado MD

Background

Patients with chronic limb-threatening ischemia (CLTI) remain at high risk of major amputation following revascularization. Although traditional clinical risk factors are well-established, the role of biopsychosocial factors in amputation risk remains unclear. This study aimed to identify the most important biopsychosocial clinical factors that predict the 3-year risk of major amputation following peripheral vascular intervention (PVI).

Methods

Patients who underwent PVI for CLTI between January 2017 and December 2018 were identified from the PVI module of the Vascular Quality Initiative, which is linked to Medicare outcomes data. We evaluated 63 pre-procedural variables, including peripheral arterial disease (PAD)/CLTI-related, demographic, functional, and behavioral characteristics. A random survival forest algorithm accounting for the competing risk of death (RSF-CR) was developed to rank pre-procedural variables based on their importance in predicting the 3-year major amputation risk. The relative importance [RI] of each predictor was calculated using the Breiman-Cutler importance approach. A sensitivity analysis was conducted using the minimal depth approach, which measures the importance of each variable in the decision-making process. We assessed the RSF-CR’s accuracy and discriminative ability using the out-of-bag error rate and the Harrell C-index, respectively.

Results

A total of 7848 patients with CLTI were included (mean age, 76.5 ± 7.6 years; 57.2% male; 77.9% White). At 3-year follow-up, 40.9% died, and 13.8% underwent major amputation. A non-null RI was calculated for 52 of 63 preprocedural variables. Advanced chronic kidney disease (stage 5) was the most important predictor of 3-year major amputation risk (RI = 100%), followed by below-the-knee disease, prior major amputation, and diabetes (RI = 78%, 71%, and 57%, respectively). Beyond these medical history and PAD/CLTI-related factors, the key demographic, functional status, and behavioral factors were female sex, ambulation with wheelchair, and pain (RI = 28%, 28%, and 3%, respectively). Model demonstrated good performance (out-of-bag error rate = 32.7%; C-index = 0.67).

Conclusions

Long-term limb outcomes are affected by a multitude of factors including traditional cardiovascular risk factors as well as functional and behavioral patient characteristics. A multidimensional risk assessment framework, incorporating both traditional clinical and biopsychosocial factors, is essential to shared decision-making and delivery of individualized care with multidisciplinary involvement.
背景:慢性肢体威胁性缺血(CLTI)患者在血管重建术后仍有较高的截肢风险。虽然传统的临床危险因素已经确立,但生物心理社会因素在截肢危险中的作用仍不清楚。本研究旨在确定预测外周血管干预(PVI)后3年主要截肢风险的最重要的生物心理社会临床因素。方法从血管质量倡议的PVI模块中确定2017年1月至2018年12月期间因CLTI接受PVI的患者,该模块与医疗保险结果数据相关。我们评估了63个手术前变量,包括外周动脉疾病(PAD)/ clti相关、人口统计学、功能和行为特征。采用随机生存森林算法计算竞争死亡风险(RSF-CR),根据预测3年主要截肢风险的重要性对程序前变量进行排序。每个预测因子的相对重要性(RI)采用Breiman-Cutler重要性法计算。使用最小深度方法进行敏感性分析,该方法测量决策过程中每个变量的重要性。我们分别用袋外错误率和Harrell c指数来评估RSF-CR的准确性和判别能力。结果共纳入7848例CLTI患者,平均年龄76.5±7.6岁,男性占57.2%,白人占77.9%。在3年的随访中,40.9%的患者死亡,13.8%的患者接受了大面积截肢。计算了63个术前变量中的52个的非空RI。晚期慢性肾脏疾病(5期)是3年主要截肢风险的最重要预测因子(RI = 100%),其次是膝关节以下疾病、既往主要截肢和糖尿病(RI分别= 78%、71%和57%)。除了这些病史和PAD/ clti相关因素外,关键的人口统计学、功能状态和行为因素是女性、轮椅行走和疼痛(RI分别为28%、28%和3%)。模型表现出良好的性能(出袋错误率= 32.7%,C-index = 0.67)。结论长期肢体预后受多种因素影响,包括传统的心血管危险因素以及患者的功能和行为特征。一个多维风险评估框架,结合传统的临床和生物心理社会因素,对于共同决策和提供多学科参与的个性化护理至关重要。
{"title":"Biopsychosocial predictors of long-term major amputation following peripheral vascular intervention in chronic limb-threatening ischemia using a machine learning algorithm approach","authors":"Golsa Joodi MD ,&nbsp;Gaëlle Romain PhD ,&nbsp;Jacob Cleman MD ,&nbsp;Iliana Hurtado Rendon MD ,&nbsp;Rabih Tabet MD ,&nbsp;Lindsey Scierka MD, MPH ,&nbsp;Mufti Mushfiqur Rahman MD, MPH ,&nbsp;Aseem Vashist MD ,&nbsp;Eman Mubarak MD ,&nbsp;Christiany Tapia MD ,&nbsp;Kim G. Smolderen PhD ,&nbsp;Carlos Mena-Hurtado MD","doi":"10.1016/j.jvsvi.2025.100348","DOIUrl":"10.1016/j.jvsvi.2025.100348","url":null,"abstract":"<div><h3>Background</h3><div>Patients with chronic limb-threatening ischemia (CLTI) remain at high risk of major amputation following revascularization. Although traditional clinical risk factors are well-established, the role of biopsychosocial factors in amputation risk remains unclear. This study aimed to identify the most important biopsychosocial clinical factors that predict the 3-year risk of major amputation following peripheral vascular intervention (PVI).</div></div><div><h3>Methods</h3><div>Patients who underwent PVI for CLTI between January 2017 and December 2018 were identified from the PVI module of the Vascular Quality Initiative, which is linked to Medicare outcomes data. We evaluated 63 pre-procedural variables, including peripheral arterial disease (PAD)/CLTI-related, demographic, functional, and behavioral characteristics. A random survival forest algorithm accounting for the competing risk of death (RSF-CR) was developed to rank pre-procedural variables based on their importance in predicting the 3-year major amputation risk. The relative importance [RI] of each predictor was calculated using the Breiman-Cutler importance approach. A sensitivity analysis was conducted using the minimal depth approach, which measures the importance of each variable in the decision-making process. We assessed the RSF-CR’s accuracy and discriminative ability using the out-of-bag error rate and the Harrell C-index, respectively.</div></div><div><h3>Results</h3><div>A total of 7848 patients with CLTI were included (mean age, 76.5 ± 7.6 years; 57.2% male; 77.9% White). At 3-year follow-up, 40.9% died, and 13.8% underwent major amputation. A non-null RI was calculated for 52 of 63 preprocedural variables. Advanced chronic kidney disease (stage 5) was the most important predictor of 3-year major amputation risk (RI = 100%), followed by below-the-knee disease, prior major amputation, and diabetes (RI = 78%, 71%, and 57%, respectively). Beyond these medical history and PAD/CLTI-related factors, the key demographic, functional status, and behavioral factors were female sex, ambulation with wheelchair, and pain (RI = 28%, 28%, and 3%, respectively). Model demonstrated good performance (out-of-bag error rate = 32.7%; C-index = 0.67).</div></div><div><h3>Conclusions</h3><div>Long-term limb outcomes are affected by a multitude of factors including traditional cardiovascular risk factors as well as functional and behavioral patient characteristics. A multidimensional risk assessment framework, incorporating both traditional clinical and biopsychosocial factors, is essential to shared decision-making and delivery of individualized care with multidisciplinary involvement.</div></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":"4 ","pages":"Article 100348"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular surgery training in Brazil: Gaps and opportunities 巴西血管外科培训:差距与机遇
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100334
Mauricio Gonzalez-Urquijo MD, PhD, Lara Lopes MD
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引用次数: 0
Exploring the awareness of artificial intelligence among vascular surgeons in the Middle East 探索中东地区血管外科医生对人工智能的认知
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100347
Yalnaz Mohasin MB, BCh, BaO , Ali Mohamed Omar Mohamed MB, BCh , Jamal Hashem MB, BCh, BaO , Martin Maresch MD

Background

Artificial intelligence (AI) and machine learning (ML) are transforming health care, with significant potential to enhance diagnosis, prognosis, and treatment. In vascular surgery, AI/ML has demonstrated promise not only in predicting outcomes and aiding imaging diagnostics but also in optimizing patient selection and procedural planning. However, clinical adoption remains limited, necessitating an understanding of clinician perspectives to identify facilitators and barriers. This study aims to assess the knowledge, attitudes, and perceptions of vascular surgeons in the Middle East regarding AI/ML, identify key barriers and facilitators for adoption, and explore their clinical applicability in vascular surgery.

Methods

A survey was conducted among vascular surgeons practicing in Bahrain, Egypt, Kuwait, Jordan, Oman, Saudi Arabia, Syria, and the United Arab Emirates to assess their demographics, knowledge, attitudes, and perceptions regarding AI/ML.The survey explored self-assessed knowledge, formal training in AI, perceived applications, confidence in integrating AI/ML tools, and concerns regarding errors, bias, and ethical implications. A total of 65 vascular surgeons participated in the survey, with a response rate of 16.5%.

Results

Respondents (median age, 41 years; mean age, 43.9 years) were predominantly male (70%), with 45% having less than 10 years of practice experience. Although most (44%) rated their AI/ML knowledge as “fair,” 90% reported no formal training in AI, indicating a substantial knowledge gap. Despite this, 74% expressed moderate to high excitement about AI/ML, with 61% believing it could significantly or extremely improve patient outcomes. The primary areas of interest included image analysis, clinical decision support, and patient selection. Concerns centered on errors leading to patient harm (47%) and data security/privacy issues (42%), and 67% of clinicians reported moderate to high levels of ethical concern.

Conclusions

Middle Eastern vascular surgeons acknowledge the potential of AI/ML to improve patient care but face significant barriers to adoption, including limited knowledge, training deficits in AI, and ethical concerns. Addressing these challenges through targeted education, transparent AI/ML tools, and ethical oversight is critical for successful integration into clinical practice. These findings highlight the need for tailored strategies to bridge the gap between AI/ML innovation and its practical utility in vascular surgery.
人工智能(AI)和机器学习(ML)正在改变医疗保健,在增强诊断、预后和治疗方面具有巨大潜力。在血管手术中,人工智能/机器学习不仅在预测结果和辅助成像诊断方面表现出色,而且在优化患者选择和手术计划方面也表现出色。然而,临床采用仍然有限,需要了解临床医生的观点,以确定促进因素和障碍。本研究旨在评估中东地区血管外科医生对AI/ML的知识、态度和看法,确定采用AI/ML的主要障碍和促进因素,并探讨其在血管手术中的临床适用性。方法对在巴林、埃及、科威特、约旦、阿曼、沙特阿拉伯、叙利亚和阿拉伯联合酋长国执业的血管外科医生进行调查,评估他们的人口统计、知识、态度和对AI/ML的看法。该调查探讨了自我评估的知识、人工智能的正式培训、感知应用、集成人工智能/机器学习工具的信心,以及对错误、偏见和道德影响的担忧。共有65名血管外科医生参与调查,回复率为16.5%。结果调查对象中位年龄41岁,平均年龄43.9岁,以男性为主(70%),其中45%执业经验不足10年。尽管大多数人(44%)认为他们的人工智能/机器学习知识“一般”,但90%的人表示没有接受过人工智能方面的正式培训,这表明知识差距很大。尽管如此,74%的人对AI/ML表示中度至高度兴奋,61%的人认为它可以显著或极大地改善患者的治疗效果。主要研究领域包括图像分析、临床决策支持和患者选择。担忧集中在导致患者伤害的错误(47%)和数据安全/隐私问题(42%)上,67%的临床医生报告了中度至高度的道德担忧。中东血管外科医生承认人工智能/机器学习在改善患者护理方面的潜力,但在采用人工智能方面面临重大障碍,包括知识有限、人工智能培训不足和伦理问题。通过有针对性的教育、透明的人工智能/机器学习工具和道德监督来应对这些挑战,对于成功融入临床实践至关重要。这些发现突出了定制策略的必要性,以弥合人工智能/机器学习创新与其在血管手术中的实际应用之间的差距。
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引用次数: 0
Comparison of patient outcomes following endovascular vs surgical management of infrainguinal autogenous bypass stenosis 腹股沟下自体旁路狭窄的血管内治疗与手术治疗的比较
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100341
Meghan McGillivray MD , Ningzhi Gu MD , Mark Tatangelo PhD, MBA, BA , Jason Faulds MD, MHSc, FRCSC , Jonathan Misskey MD, MHPE, FRCSC

Objective

The aim of this study was to evaluate outcomes of open vs endovascular intervention for infrainguinal bypass stenosis.

Methods

A single-institution retrospective review of infrainguinal bypass stenosis cases from January 1, 2010, to December 31, 2020, was conducted. Data collected included index bypass operation, lesion characteristics, reintervention, and patient outcomes.

Results

Of the 146 patients included, 40% underwent open intervention, whereas 60% underwent endovascular intervention. There were no significant differences between the index bypasses of each cohort with respect to inflow, outflow, conduit, or primary patency. The severity of stenotic lesions in open and endovascular cohorts was >70% severity on duplex ultrasound in 76% and 78% of patients, respectively (P = .02). Lesion location was not significantly different between cohorts with 48% proximal, 27% distal, 8% midgraft, 3% venovenostomy, and 14% multiple stenotic lesions. There was no significant difference in primary revision patency in open vs endovascular intervention (1109 vs 809 days; P = .09). The average number of repeat interventions was not significantly different (0.47 vs 0.58 times; P = .48); however, the average cumulative hospital length of stay was significantly shorter for patients who underwent endovascular intervention (8.21 vs 5.22 days; P = .02). During the study period, a comparable portion of patients in open and endovascular cohorts went on to have failed bypass grafts (17% vs 18%) with no significant difference in the total time to graft failure in these subgroups (860 vs 1144 days; P = .47). There were no significant differences in major adverse limb events (12% vs 8%; P = .59) or mortality (47% vs 40%; P = .52).

Conclusions

Open and endovascular interventions for infrainguinal bypass stenosis showed no significant differences in primary revision patency, graft failure rates, major adverse limb events, or mortality. Endovascular intervention was associated with shorter cumulative hospital stays for reintervention.
目的评价腹股沟下旁路狭窄的切开与血管内介入治疗的效果。方法对2010年1月1日至2020年12月31日的腹股沟下旁路狭窄病例进行单机构回顾性分析。收集的数据包括心脏绕道手术、病变特征、再介入和患者预后。结果146例患者中,40%接受了开放介入治疗,60%接受了血管内介入治疗。每个队列在流入、流出、导管或原发性通畅方面的指数绕道没有显著差异。双工超声显示,开放组和血管内组狭窄病变严重程度分别为76%和78% (P = 0.02)。病变位置在近端48%、远端27%、中端8%、静脉造口3%和多发性狭窄病变14%的队列之间无显著差异。开放与血管内干预的初次翻修通畅无显著差异(1109天vs 809天;P = .09)。平均重复干预次数差异无统计学意义(0.47 vs 0.58次,P = 0.48);然而,接受血管内介入治疗的患者平均累计住院时间明显缩短(8.21天vs 5.22天;P = 0.02)。在研究期间,开放和血管内队列中相当一部分患者继续进行旁路移植失败(17%对18%),这些亚组中移植物失败的总时间无显著差异(860天对1144天;P = 0.47)。两组在主要肢体不良事件(12% vs 8%, P = 0.59)或死亡率(47% vs 40%, P = 0.52)方面无显著差异。结论对腹股沟下旁路狭窄进行开放和血管内介入治疗在初次翻修通畅、移植物失败率、主要肢体不良事件和死亡率方面无显著差异。血管内干预与再干预累积住院时间缩短相关。
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引用次数: 0
Retrograde tibiopedal access as an alternative procedural technique for genicular artery embolization 胫瓣逆行入路作为膝动脉栓塞的替代手术技术
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100339
Nishanth Konduru, Anton Hnatov BS, Siddhartha Rao MD

Objective

The aim of this study is to assess the feasibility, safety, and technical outcomes of genicular artery embolization (GAE) performed via retrograde tibiopedal access.

Materials and Methods

GAE was performed in 357 patients utilizing tibiopedal access. Patient eligibility was determined through a comprehensive clinical evaluation and radiographic imaging. Embolic agents were delivered through a microcatheter to the targeted arteries by an interventional cardiologist with an additional 1 year of fellowship training in endovascular medicine and certification from the American Board of Vascular Medicine. Technical success was defined as successful embolization of at least two genicular arteries, with subsequent resolution of arterial blush. Peri and post-procedural data and complications related to the access site were assessed.

Results

Technical success was obtained in 96.6% of cases. Patient ages ranged from 38 to 98 years, with body mass index ranging from 18.01 to 63.23 kg/m2. Across this study cohort, 3.7 ± 1.0 genicular arteries were embolized, with a mean procedure time of 51.3 ± 13.0 minutes. Procedure time was measured from initial injection of lidocaine to application of hemostatic device. Results also show 25% improvement in average procedure duration after 50 cases, suggesting a brief learning curve for GAE. Post-procedural complications occurred in 4.5% of cases (n = 16) and were associated only with minor, transient side effects.

Conclusions

GAE via tibiopedal access offers a viable alternative to the conventional femoral approach reported in recent literature. In this study, retrograde access consistently enabled successful completion of GAE without notable discrepancies in treatment efficacy or safety. This approach resulted in a high technical success rate with no significant complications. Study findings support the potential for widespread adoption of the retrograde approach for treating osteoarthritis with GAE, particularly in patients in whom an antegrade approach may pose a higher risk of complications.
目的:本研究的目的是评估通过逆行胫趾通道进行膝动脉栓塞(GAE)的可行性、安全性和技术结果。材料与方法对357例采用双趾通道的患者进行gae手术。通过全面的临床评估和放射成像来确定患者的资格。栓塞剂通过微导管输送到目标动脉,由具有额外1年血管内医学研究员培训并获得美国血管医学委员会认证的介入心脏病专家进行。技术上的成功被定义为成功栓塞至少两条膝动脉,随后动脉红肿的解决。评估术中及术后资料及与入路部位相关的并发症。结果手术成功率为96.6%。患者年龄38 ~ 98岁,体重指数18.01 ~ 63.23 kg/m2。在整个研究队列中,3.7±1.0根膝动脉被栓塞,平均手术时间为51.3±13.0分钟。测量从首次注射利多卡因到使用止血装置的时间。结果还显示,50例术后平均手术时间改善了25%,表明GAE的学习曲线很短。术后并发症发生率为4.5% (n = 16),且仅伴有轻微、短暂的副作用。结论在最近的文献报道中,经双趾入路的gae为传统的股骨入路提供了一种可行的选择。在这项研究中,逆行通路始终如一地使GAE成功完成,在治疗疗效或安全性方面没有显着差异。该方法技术成功率高,无明显并发症。研究结果支持广泛采用逆行入路治疗GAE骨关节炎的潜力,特别是在逆行入路可能导致并发症风险较高的患者中。
{"title":"Retrograde tibiopedal access as an alternative procedural technique for genicular artery embolization","authors":"Nishanth Konduru,&nbsp;Anton Hnatov BS,&nbsp;Siddhartha Rao MD","doi":"10.1016/j.jvsvi.2025.100339","DOIUrl":"10.1016/j.jvsvi.2025.100339","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to assess the feasibility, safety, and technical outcomes of genicular artery embolization (GAE) performed via retrograde tibiopedal access.</div></div><div><h3>Materials and Methods</h3><div>GAE was performed in 357 patients utilizing tibiopedal access. Patient eligibility was determined through a comprehensive clinical evaluation and radiographic imaging. Embolic agents were delivered through a microcatheter to the targeted arteries by an interventional cardiologist with an additional 1 year of fellowship training in endovascular medicine and certification from the American Board of Vascular Medicine. Technical success was defined as successful embolization of at least two genicular arteries, with subsequent resolution of arterial blush. Peri and post-procedural data and complications related to the access site were assessed.</div></div><div><h3>Results</h3><div>Technical success was obtained in 96.6% of cases. Patient ages ranged from 38 to 98 years, with body mass index ranging from 18.01 to 63.23 kg/m<sup>2</sup>. Across this study cohort, 3.7 ± 1.0 genicular arteries were embolized, with a mean procedure time of 51.3 ± 13.0 minutes. Procedure time was measured from initial injection of lidocaine to application of hemostatic device. Results also show 25% improvement in average procedure duration after 50 cases, suggesting a brief learning curve for GAE. Post-procedural complications occurred in 4.5% of cases (n = 16) and were associated only with minor, transient side effects.</div></div><div><h3>Conclusions</h3><div>GAE via tibiopedal access offers a viable alternative to the conventional femoral approach reported in recent literature. In this study, retrograde access consistently enabled successful completion of GAE without notable discrepancies in treatment efficacy or safety. This approach resulted in a high technical success rate with no significant complications. Study findings support the potential for widespread adoption of the retrograde approach for treating osteoarthritis with GAE, particularly in patients in whom an antegrade approach may pose a higher risk of complications.</div></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":"4 ","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
JVS-vascular insights
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