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A comparison between augmented reality and traditional in-person teaching for vascular anastomotic surgical skills training 血管吻合手术技能培训中的增强现实与传统面授教学比较
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2023.100032

Background

Augmented reality (AR) superimposes computer-generated content to a real-world environment through multitudinous devices, and is used across multiple training fora. Its use in vascular surgery education is yet to be formally investigated. The aim is to assess feasibility and effectiveness of remote teaching of vascular anastomosis skills enhanced by AR in the form of the HoloLens2 Head-Mounted Display technology with traditional in-person skills teaching. A remote trainer used video, gestures and images superimposed over participants' field of vision via the HoloLens2 to teach the skills.

Methods

Twenty-eight participants underwent a preassessment performing an end-to-end vascular anastomosis on an artificial vessel. They were allocated randomly to an AR or in-person group, and underwent two teaching sessions. Individuals were asked to complete a postsession feedback form and assessment (video recorded and anonymized). The videos were marked by two blinded, independent assessors using the Objective Structured Assessment of Technical Skills (OSATS) scoring.

Results

There was an overall improvement in both cohorts in OSATS score after the intervention by +7.083 in the in-person group and +8.275 in the AR. Independent t test was performed and a P value of .422 was obtained, indicating no statistically significant difference in the change in OSATS scores when comparing the skills teaching received in-person with that through AR.

Conclusions

Remote teaching enhanced by AR is feasible and effective for the teaching of vascular surgical anastomosis skills and noninferior to in-person teaching. There is scope for development of the use of AR in vascular surgical skills training.

背景增强现实(AR)通过多种设备将计算机生成的内容叠加到真实世界的环境中,被广泛应用于多个培训领域。其在血管外科教育中的应用尚待正式研究。本研究旨在评估通过 HoloLens2 头戴式显示器技术形式的 AR 增强的血管吻合术技能远程教学与传统的面对面技能教学的可行性和有效性。远程培训师通过 HoloLens2 在学员视野中叠加视频、手势和图像来教授技能。方法28 名学员在人工血管上进行端到端血管吻合术前评估。他们被随机分配到AR组或面对面组,并接受了两节教学课程。他们被要求完成课后反馈表和评估(录像并匿名)。视频由两名盲人独立评估员使用技术技能客观结构化评估(OSATS)评分法进行评分。结果干预后,两组学员的 OSATS 评分均有整体提高,面授组提高了 7.083 分,AR 组提高了 8.275 分。进行了独立 t 检验,P 值为 0.422,表明当面教学与通过 AR 进行的技能教学相比,OSATS 分数的变化没有显著的统计学差异。在血管外科技能培训中使用 AR 还有很大的发展空间。
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引用次数: 0
Identifying disruptive publications and changing paradigms in vascular surgery 识别血管外科的颠覆性出版物和变革范式
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2023.100036
Eric Sung BA , Joel L. Ramirez MD , Adan Z. Becerra PhD , Emanuel Jaramillo MD , Warren J. Gasper MD , Peter Schneider MD , Michael S. Conte MD , James C. Iannuzzi MD, MPH

Objective

A novel disruption index (DI) designed to measure impact of scientific research has been developed. However, the DI metric has not yet been applied to vascular surgery peer-reviewed publications. We hypothesized that vascular surgery-specific disruptive articles would increase over time with the advent of new surgical and technological advancements.

Methods

The Journal of Vascular Surgery was queried from its inception in 1984 to 2014 to identify the top 100 most disruptive publications. The DI ranges from −1 to 1, where negative scores represent developmental and positive scores indicate disruptive publications. Most impactful papers were identified and defined as being in both the 100 most cited and disruptive lists of publications.

Results

When the top 100 most cited publications were categorized by vascular disease, aortic research was the most frequently highly cited publication (42%). Low correlation was found between DI and citation, controlling for time after publication (R2 = 0.0096; P = .78). Among the 100 most disruptive papers, publications discussing the field of vascular surgery as a unique subspecialty were the most common category of publication (24%). Narrowing down the 100 most disruptive publications with 50 or more citations (n = 30), aortic (37%) and venous (20%) publications were the most common. Among this group of publications, aortic papers were most disruptive between 1993 to 1997, and venous papers were most disruptive in the more recent years between 2001 to 2005. Eight papers were identified as being most disruptive and included topics of publication of aortic (n = 4), venous (n = 2), carotid (n = 1), and endovascular (n = 1) research, with an average DI of 0.14 and citation count between 174 and 712.

Conclusions

This is the first application of the DI to the field of vascular surgery. Although citation count is a vital metric, there remains limitations in its ability to measure impact. DI should be used in conjunction with citation count to provide a holistic analysis of publication impact. Additionally, the DI can identify shifting paradigms and innovations unique to vascular surgery and help guide education on impactful studies.

目标 一项旨在衡量科学研究影响力的新型干扰指数(DI)已经开发出来。然而,该指数尚未应用于血管外科同行评审出版物。我们假设,随着新的外科手术和技术进步的出现,血管外科特有的破坏性文章会随着时间的推移而增加。方法对《血管外科杂志》从1984年创刊到2014年进行了查询,以确定前100篇最具破坏性的出版物。DI从-1到1不等,负分代表发展性,正分代表颠覆性。结果当按血管疾病对被引用次数最多的前 100 篇出版物进行分类时,主动脉研究是被引用次数最多的出版物(42%)。在控制发表时间后,发现DI与引用之间的相关性较低(R2 = 0.0096; P = .78)。在100篇最具破坏性的论文中,讨论血管外科作为一个独特的亚专科的论文是最常见的一类论文(24%)。将引用次数达到或超过 50 次的 100 篇最具破坏性的论文(n = 30)范围缩小,主动脉(37%)和静脉(20%)论文最为常见。在这组论文中,1993 年至 1997 年间的主动脉论文最具破坏性,2001 年至 2005 年间的静脉论文最具破坏性。八篇论文被确定为最具破坏性,包括主动脉(4 篇)、静脉(2 篇)、颈动脉(1 篇)和血管内(1 篇)研究的发表主题,平均 DI 为 0.14,引用次数在 174 到 712 之间。虽然引用次数是一项重要指标,但其衡量影响力的能力仍有局限性。应该将《文献综述》与引用次数结合起来使用,以全面分析出版物的影响力。此外,DI 还能发现血管外科特有的范式和创新的转变,并帮助指导有影响力研究的教育。
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引用次数: 0
Manifestations of human atherosclerosis across vascular beds 跨血管床的人体动脉粥样硬化表现
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100089
Daniel G. Jovin BS , Bauer E. Sumpio MD, PhD , Daniel M. Greif MD

Objective

Atherosclerosis underlies the most common etiologies of mortality worldwide, resulting in nearly 10 million deaths annually. In atherosclerosis, inflammation, metabolic factors, and hemodynamics cause the accumulation of extracellular lipids and the formation of plaques in the tunica intima of specific arteries. Atherosclerotic plaques primarily form in the coronary and carotid arteries, the aorta, and the peripheral arteries of the lower extremities. Although a common conceptual model of atherogenesis across these arteries has evolved over decades, there is a limited understanding of the important differences in regional atherosclerotic disease.

Methods

This review summarizes clinical studies, meta-analyses, and case reports to compare and contrast the impact, risk, plaque features, and clinical management of carotid, coronary, and femoral atherosclerosis in humans.

Results

Common risk factors, such as smoking and diabetes, influence disease risk differently across vascular beds. In addition, biological variables demonstrate a region-specific relationship with disease as peripheral atherosclerosis is most heritable, and male sex increases the risk of coronary and carotid, but not peripheral artery disease. The pathology of atherosclerotic lesions also varies between vascular territories. Specifically, carotid plaques are primarily lipid rich, whereas coronary plaques more commonly include fibrotic components with lipid-rich features, and femoral plaques are predominantly fibrocalcific. Clinically, interventional outcomes are worst in the carotid arteries and response to medical therapies, particularly statins, is not consistent across diseased regions, even within individual patients.

Conclusions

Atherosclerosis manifests in site-specific ways with regional differences in susceptibility and treatment response. Despite advances in the scientific understanding and clinical management of atherosclerosis, little is known about the mechanisms determining vessel-specific disease patterns and risk. Further research is needed urgently to delineate factors controlling plaque initiation and progression specific to vascular beds.

目标动脉粥样硬化是导致全球死亡的最常见病因,每年造成近 1 千万人死亡。在动脉粥样硬化中,炎症、代谢因素和血液动力学导致细胞外脂质堆积,并在特定动脉的内膜形成斑块。动脉粥样硬化斑块主要形成于冠状动脉、颈动脉、主动脉和下肢外周动脉。本综述总结了临床研究、荟萃分析和病例报告,对人体颈动脉、冠状动脉和股动脉粥样硬化的影响、风险、斑块特征和临床管理进行了比较和对比。结果 吸烟和糖尿病等常见风险因素对不同血管床的疾病风险影响不同。此外,生物变量与疾病的关系因地区而异,外周动脉粥样硬化的遗传性最强,男性会增加冠状动脉和颈动脉的患病风险,但不会增加外周动脉的患病风险。动脉粥样硬化病变的病理也因血管区域而异。具体来说,颈动脉斑块主要富含脂质,而冠状动脉斑块更常见的是富含脂质的纤维化成分,股动脉斑块主要是纤维钙化。在临床上,颈动脉的介入治疗效果最差,而且不同病变区域对药物治疗,尤其是他汀类药物的反应并不一致,甚至在单个患者中也是如此。尽管对动脉粥样硬化的科学认识和临床治疗取得了进展,但人们对决定血管特异性疾病模式和风险的机制知之甚少。亟需开展进一步的研究,以确定控制特定血管床斑块形成和发展的因素。
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引用次数: 0
Increasing early career surgeon engagement in the Society for Vascular Surgery: a report of the Society’s Young Surgeons Section Steering Committee 提高早期职业外科医生对血管外科学会的参与度:学会年轻外科医生分会指导委员会报告
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100085
Chelsea Dorsey MD , Rana O. Afifi MD , Edward Arous D , Saideep Bose MD , Nathan Droz MD , Laura M. Drudi MD , Michael M. McNally MD , Nicolas J. Mouawad MD, MPH, MBA , Leigh Ann O’Banion MD , Carlos Pineda MD , Christine Shokrzadeh MD , M. Libby Weaver MD , Gregory A. Magee MD , Edward Gifford MD

When examining the United States surgical workforce, a shortage of approximately 30,000 surgeons is predicted by 2030. This shortage is attributed to the increasing surgical needs of the nation’s aging population and the increased rate of retirement in the surgeon workforce. As such, the surgeon workforce will rely on Millennials and Generation Z to grow and expand their role in health care. To address these changes, the Society for Vascular Surgery (SVS) established the Young Surgeons Section (YSS) in 2022 after formal approval by the Society’s Executive Board. The YSS Steering Committee set forth in 2022 with an initial charge focused on identifying the needs of this demographic, beginning to develop educational content focused on early career surgeons, providing and advocating for leadership opportunities within the SVS, and assisting the Society in its membership recruitment efforts. The goal of this report is to provide the context under which the YSS was started, outline the major accomplishments of the Section over its first 2 years, and to begin to discuss the needed next steps for the SVS to ensure continued engagement.

在对美国外科医师队伍进行考察时,预计到 2030 年,美国将短缺约 30,000 名外科医生。造成这一短缺的原因是,美国老龄化人口对外科手术的需求不断增加,以及外科医生队伍退休率的上升。因此,外科医生队伍将依靠 "千禧一代 "和 "Z 世代 "来发展壮大,并扩大他们在医疗保健领域的作用。为了应对这些变化,血管外科学会(SVS)在获得学会执行委员会的正式批准后,于 2022 年成立了青年外科医生分会(YSS)。青年外科医生分会指导委员会于 2022 年成立,最初的工作重点是确定这一群体的需求,开始开发以职业生涯早期外科医生为重点的教育内容,提供并倡导 SVS 内部的领导机会,并协助学会招募会员。本报告的目的是介绍青年外科医生分会成立的背景,概述分会成立两年来取得的主要成就,并开始讨论 SVS 下一步需要采取的措施,以确保分会的持续参与。
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引用次数: 0
Inferring acute economic aspects of endovascular deep vein thrombosis management from a literature-based comparative cohort analysis 从基于文献的队列比较分析中推断血管内深静脉血栓治疗的急性经济意义
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100117

Objective

This study was an inferential analysis aimed to estimate 30-day episode care costs associated with four contemporary endovascular therapies indicated for the treatment of deep vein thrombosis (DVT).

Methods

Source data were extracted from a systematic literature review of publications that reported outcomes after DVT intervention with mechanical thrombectomy (MT), aspiration thrombectomy with capital equipment (AT), ultrasound-facilitated catheter-directed thrombolysis (US-CDT), and rheolytic thrombectomy (RT). Case reports or series with fewer than 10 subjects, interim or subanalyses, and pediatric patients were excluded. Total episode care costs were defined as the sum of device and therapeutic costs, acute care costs, and contingent costs (ie, comprised bleeding, acute kidney injury, and readmissions) through 30 days.

Results

Through July 2023, 45 studies representing 2581 patients informed the analysis. The total episode cost per patient was estimated at $10,682, $14,073, $16,177, and $19,669 for MT, AT, US-CDT, RT, respectively. Device costs constituted the largest component of total episode costs at $8228, $9105, $5883, and $8862, respectively. Thrombolytic medications were a more significant driver of cost for US-CDT ($2982) and RT ($2412), relative to MT ($22) and AT ($931). Acute care costs included primary and adjunctive procedure suites, hospital stay, and intensive care unit monitoring and were estimated at $1723, $2875, $4014, and $4416, respectively. Contingent costs were estimated at $709, $1163, $3298, and $3980, respectively.

Conclusions

Endovascular strategies for the treatment of acute DVT that avoided thrombolytics saw shortened length of stay, reduced the need for intensive care unit level care, and minimized postprocedure bleeding and 30-day readmissions. These factors favored MT with the lowest episode costs.

目的本研究是一项推论性分析,旨在估算与四种用于治疗深静脉血栓形成(DVT)的现代血管内疗法相关的 30 天医疗费用。方法从系统性文献综述中提取源数据,这些文献报道了使用机械血栓切除术(MT)、使用资本设备抽吸血栓切除术(AT)、超声引导导管溶栓术(US-CDT)和流变溶栓术(RT)进行深静脉血栓干预后的结果。受试者少于 10 人的病例报告或系列研究、中期分析或子分析以及儿科患者均被排除在外。总治疗费用定义为设备和治疗费用、急性期治疗费用以及30天内的或有费用(即包括出血、急性肾损伤和再入院)之和。据估计,MT、AT、US-CDT 和 RT 每名患者的总治疗成本分别为 10,682 美元、14,073 美元、16,177 美元和 19,669 美元。设备费用是总治疗费用的最大组成部分,分别为 8228 美元、9105 美元、5883 美元和 8862 美元。相对于 MT(22 美元)和 AT(931 美元),溶栓药物对 US-CDT (2982 美元)和 RT(2412 美元)成本的影响更大。急性护理成本包括主要和辅助手术套间、住院和重症监护室监测,估计分别为 1723 美元、2875 美元、4014 美元和 4416 美元。结论避免使用溶栓药物的急性深静脉血栓形成血管内治疗策略缩短了住院时间,减少了对重症监护室级别护理的需求,并最大限度地减少了术后出血和30天再入院率。这些因素使得 MT 的治疗成本最低。
{"title":"Inferring acute economic aspects of endovascular deep vein thrombosis management from a literature-based comparative cohort analysis","authors":"","doi":"10.1016/j.jvsvi.2024.100117","DOIUrl":"10.1016/j.jvsvi.2024.100117","url":null,"abstract":"<div><h3>Objective</h3><p>This study was an inferential analysis aimed to estimate 30-day episode care costs associated with four contemporary endovascular therapies indicated for the treatment of deep vein thrombosis (DVT).</p></div><div><h3>Methods</h3><p>Source data were extracted from a systematic literature review of publications that reported outcomes after DVT intervention with mechanical thrombectomy (MT), aspiration thrombectomy with capital equipment (AT), ultrasound-facilitated catheter-directed thrombolysis (US-CDT), and rheolytic thrombectomy (RT). Case reports or series with fewer than 10 subjects, interim or subanalyses, and pediatric patients were excluded. Total episode care costs were defined as the sum of device and therapeutic costs, acute care costs, and contingent costs (ie, comprised bleeding, acute kidney injury, and readmissions) through 30 days.</p></div><div><h3>Results</h3><p>Through July 2023, 45 studies representing 2581 patients informed the analysis. The total episode cost per patient was estimated at $10,682, $14,073, $16,177, and $19,669 for MT, AT, US-CDT, RT, respectively. Device costs constituted the largest component of total episode costs at $8228, $9105, $5883, and $8862, respectively. Thrombolytic medications were a more significant driver of cost for US-CDT ($2982) and RT ($2412), relative to MT ($22) and AT ($931). Acute care costs included primary and adjunctive procedure suites, hospital stay, and intensive care unit monitoring and were estimated at $1723, $2875, $4014, and $4416, respectively. Contingent costs were estimated at $709, $1163, $3298, and $3980, respectively.</p></div><div><h3>Conclusions</h3><p>Endovascular strategies for the treatment of acute DVT that avoided thrombolytics saw shortened length of stay, reduced the need for intensive care unit level care, and minimized postprocedure bleeding and 30-day readmissions. These factors favored MT with the lowest episode costs.</p></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949912724000655/pdfft?md5=a5d363b2e8d6c85ce394d0a5a9df3eca&pid=1-s2.0-S2949912724000655-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current status of brain monitoring during carotid endarterectomy 颈动脉内膜切除术期间脑部监测的现状
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100060

Objective

This narrative review aims to analyze the role and efficacy of different methods of intraoperative neuro-monitoring during carotid endarterectomy.

Methods

Articles were collected from online databases, searching ‘carotid endarterectomy,’ intraoperative neuro monitoring,’ and ‘intraoperative neurological monitoring,” from 1999 to 2023.

Results

The search for an optimal intraoperative neuromonitoring technique during carotid endarterectomy is complex and still debated. Regional anesthesia, specifically ultrasound-guided cervical blocks, has become increasingly popular due to its ability to examine the awake patient. Additionally, reports suggest that regional anesthesia leads to shorter operative times, shorter postoperative stays, and less need for shunting. The primary limitations are patient compliance, particularly in cases of claustrophobia, and complications that make it difficult to access the patient’s airway. Currently, there is no definitive evidence favoring one anesthetic technique over another. Other monitoring techniques, such as electroencephalogram, cannot detect ischemia in the subcortical lobe or silent brain strokes caused by micro-embolisms. Although bispectral index is a potential tool, it may lead to false positives due to impaired cerebral perfusion during clamping. Stump pressure measurement is a direct indicator of perfusion pressure across the circle of Willis. However, the critical threshold of “adequate” perfusion is still debated. Near-infrared spectroscopy (NIRS) is a user-friendly, low-cost, noninvasive, and portable method with easily interpretable results. The critical cutoff to detect cerebral ischemia differs among market available NIRS devices; despite high negative predictive value, NIRS is still affected by a low positive predictive value. The available data on the use of routine shunting from randomized controlled trials is limited, and further studies are warranted.

Conclusions

Currently available intraoperative neuro-monitoring techniques for patients undergoing carotid endarterectomy have different uses and limitations, and a conclusive judgement cannot be reached. Future randomized studies and large real-world registries might shed light on this debated topic.

方法从在线数据库中收集文章,搜索 "颈动脉内膜剥脱术"、"术中神经监测 "和 "术中神经监测",搜索时间从 1999 年到 2023 年。结果在颈动脉内膜剥脱术中寻找最佳术中神经监测技术是一项复杂的工作,目前仍存在争议。区域麻醉,特别是超声引导下的颈椎阻滞,因其能对清醒患者进行检查而越来越受欢迎。此外,有报告显示区域麻醉可缩短手术时间、缩短术后住院时间并减少分流需求。主要的局限性在于患者的依从性,尤其是幽闭恐惧症患者,以及难以进入患者气道的并发症。目前,还没有确切的证据表明一种麻醉技术优于另一种。脑电图等其他监测技术无法检测到皮层下叶的缺血或由微栓子引起的无声脑卒中。虽然双谱指数是一种潜在的工具,但它可能会因钳夹时脑灌注受损而导致假阳性。残端压力测量是威利斯圈灌注压力的直接指标。然而,"充分 "灌注的临界阈值仍存在争议。近红外光谱(NIRS)是一种用户友好型、低成本、无创、便携的方法,其结果易于解释。市场上现有的近红外设备检测脑缺血的临界值各不相同;尽管近红外预测值较高,但仍受阳性预测值较低的影响。结论目前针对颈动脉内膜剥脱术患者的术中神经监测技术有不同的用途和局限性,无法得出结论。未来的随机研究和大型真实世界登记可能会对这一争论不休的话题有所启示。
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引用次数: 0
Branding yourself through social media in vascular surgery 在血管外科领域通过社交媒体打造自己的品牌
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100131

Background

Social media is a powerful tool for vascular surgeons to showcase their expertise, share their research, and network with peers and patients. However, it also requires careful consideration of ethical and professional standards and effective strategies to create and disseminate engaging content.

Objective

This article provides practical tips and recommendations for vascular surgeons who want to use social media to build their personal and professional brands. We draw on the Journal of Vascular Surgery social media guidelines, which offer best practices for the vascular surgery community based on the latest evidence and experience. We cover social media branding, choosing the right platforms, crafting your message, engaging with the audience, managing conflicts and controversies, and measuring impact and outcomes. We also provide examples of vascular surgery organizations and hashtags. By following these guidelines, vascular surgeons can leverage social media to enhance their reputation, reach, and influence in vascular surgery.

背景社交媒体是血管外科医生展示专业知识、分享研究成果以及与同行和患者建立联系的有力工具。本文为希望使用社交媒体打造个人和专业品牌的血管外科医生提供实用技巧和建议。我们借鉴了《血管外科杂志》的社交媒体指南,该指南根据最新证据和经验为血管外科界提供了最佳实践。我们的内容包括社交媒体品牌建设、选择合适的平台、精心设计信息、与受众互动、处理冲突和争议以及衡量影响和成果。我们还提供了血管外科组织和标签的范例。遵循这些指导原则,血管外科医生可以利用社交媒体提高他们在血管外科领域的声誉、覆盖面和影响力。
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引用次数: 0
Carotid plaque characteristics in the CREST-2 trial CREST-2试验中的颈动脉斑块特征
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100134
<div><h3>Background</h3><div>The modest stroke prevention from surgery for asymptomatic carotid disease has prompted a search for predictors that may improve risk stratification beyond luminal stenosis. Plaque disruption and atheroembolization are associated with unique anatomical and histological changes. The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) collects information on duplex ultrasound (DUS) plaque biomarkers with the goal of evaluating their relationship to the periprocedural and long-term risks of stroke. In this study, we examine the reliability with which carotid plaque features can be measured from DUS images, and report baseline carotid DUS-derived stenosis and plaque features using semiautomated digital image analysis of patients enrolled in CREST-2.</div></div><div><h3>Methods</h3><div>We studied the first 503 patients in CREST-2. Patients underwent standardized carotid DUS evaluation pre-enrollment. B-Mode images were scaled linearly to normalize brightness. Plaques were outlined manually. Dedicated software automatically measured the longitudinal sectional area (mm<sup>2</sup>), grayscale median (GSM), Gray-Weale classification, and tissue composition (mm<sup>2</sup>) of intraplaque hemorrhage (IPH), lipid, fibrous tissue, muscle, and calcium. We present the mean, standard deviation, median, interquartile range, minimum and maximum range, and proportions of carotid peak systolic velocities (PSVs) and plaque morphological features. We tested for autocorrelation among plaque features and computed the proportion of potentially unstable plaques in the cohort. Reliability of the image analysis techniques was tested in 100 patients using Bland-Altman plots and intraclass and interclass correlation coefficients.</div></div><div><h3>Results</h3><div>Most patients were male (58.4%), older (mean age of 69.3 years), White (87.5%), and had a PSV of ≥230 cm/s (98.6%); the 1.4% with a PSV of <230 cm/s were enrolled based on catheter angiography. Plaques in this study were large; the mean longitudinal sectional area was 62 ± 37 mm<sup>2</sup> (range, 6.2–256.5 mm<sup>2</sup>). The mean GSM was 58 ± 30 (unitless) (range, 0–168) and Gray-Weale classification was 3.5 ± 0.9 (range, 1–5). The mean areas of tissue types were IPH 5.3 ± 8.9 mm<sup>2</sup>, lipid 9.3 ± 8.6 mm<sup>2</sup>, fibrous tissue 10 ± 10 mm<sup>2</sup>, muscle 17 ± 12 mm<sup>2</sup>, and calcium 1.6 ± 4.1 mm<sup>2</sup>. The PSV of patients showed poor correlation with plaque features. The proportion of plaques with a GSM of ≤35 was 22.8%, IPH of ≥5 mm<sup>2</sup> was 30.0%, and a lipid-rich necrotic core of ≥40% was 3.0% of the cohort. Plaque measurements could be performed with high reliability with good interobserver and intraobserver correlations.</div></div><div><h3>Conclusions</h3><div>Site-generated, core laboratory-interpreted ultrasound examination provides a reliable way of characterizing carotid plaque morphol
背景无症状颈动脉疾病手术对中风的预防作用不大,这促使人们寻找可改善管腔狭窄以外风险分层的预测因素。斑块破坏和动脉粥样栓塞与独特的解剖学和组织学变化有关。无症状颈动脉狭窄的颈动脉血管重建和医疗管理试验(CREST-2)收集了有关双工超声(DUS)斑块生物标志物的信息,目的是评估它们与围手术期和长期卒中风险的关系。在本研究中,我们研究了从 DUS 图像测量颈动脉斑块特征的可靠性,并使用半自动数字图像分析报告了 CREST-2 患者的颈动脉 DUS 衍生狭窄和斑块特征基线。患者在入组前接受了标准化颈动脉 DUS 评估。对 B 型图像进行线性缩放,使亮度正常化。手动勾画斑块轮廓。专用软件自动测量纵切面积(mm2)、灰度中值(GSM)、格雷-韦尔分类以及斑块内出血(IPH)、脂质、纤维组织、肌肉和钙的组织成分(mm2)。我们列出了颈动脉收缩峰值速度(PSV)和斑块形态特征的平均值、标准差、中位数、四分位数间范围、最小和最大范围以及比例。我们检测了斑块特征之间的自相关性,并计算了队列中潜在不稳定斑块的比例。结果大多数患者为男性(58.4%)、老年人(平均年龄 69.3 岁)、白人(87.5%),PSV ≥230 cm/s(98.6%);PSV 为 <230 cm/s 的 1.4% 患者是根据导管血管造影术入选的。本研究中的斑块面积较大;平均纵切面积为 62 ± 37 平方毫米(范围为 6.2-256.5 平方毫米)。平均 GSM 为 58 ± 30(无单位)(范围为 0-168),Gray-Weale 分级为 3.5 ± 0.9(范围为 1-5)。组织类型的平均面积为:IPH 5.3 ± 8.9 mm2,脂质 9.3 ± 8.6 mm2,纤维组织 10 ± 10 mm2,肌肉 17 ± 12 mm2,钙质 1.6 ± 4.1 mm2。患者的 PSV 与斑块特征的相关性较差。斑块GSM≤35的比例为22.8%,IPH≥5平方毫米的比例为30.0%,富脂坏死核心≥40%的比例为3.0%。斑块测量的可靠性很高,观察者间和观察者内相关性良好。结论在许多CREST-2研究机构进行的研究中,现场生成、核心实验室解释的超声检查是描述颈动脉斑块形态特征的可靠方法。在CREST-2中随机抽取的首批患者尽管造成了高度狭窄,但斑块特征却存在异质性。试验完成后,将有机会评估斑块异质性是否与血管重建和医疗管理的反应相互影响。
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引用次数: 0
Physician-industry relationships in vascular surgery 血管外科的医生与行业关系
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100079
Interactions between industry and physicians are important in any specialty, but perhaps nowhere more so than in Vascular Surgery. Our field is a highly technological one, and there can be significant mutual benefit when vascular surgeons and our industry partners work together including better device development, improved dissemination of knowledge, and alternative revenue streams. There is, however, potential for inappropriate and unethical behavior. Here we discuss the types of potential relationships, as well as their benefits and risks, and processes for disclosure and reporting.
行业与医生之间的互动在任何专业领域都很重要,但在血管外科领域可能更为重要。我们的领域是一个技术含量很高的领域,血管外科医生和我们的行业合作伙伴携手合作,可以为双方带来巨大的利益,包括更好的设备开发、更好的知识传播和替代收入来源。但是,也有可能出现不当和不道德的行为。在此,我们将讨论潜在关系的类型、其益处和风险,以及披露和报告流程。
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引用次数: 0
Noninvasive optical methods to assess tissue perfusion in patients with peripheral arterial disease and diabetes mellitus: A scoping review and discussion 评估外周动脉疾病和糖尿病患者组织灌注的无创光学方法:范围综述与讨论
Pub Date : 2023-11-17 DOI: 10.1016/j.jvsvi.2023.100034
Manal Ahmad MBBch, BaO, MRCS, MMedSc, PGCMedEd, MAcadMEd , Kirtan Patel BSc, MBBS, MRCS, PGCMedEd , Alun Huw Davies MA, DM, DSc, FRCS, FHEA, FEBVS, FACPh , Joseph Shalhoub BSc, MBBS, FHEA, PhD, Med, FRCS, FEBVS

Background

The global incidence of peripheral arterial disease (PAD) is 10.5 million individuals annually. There are 113 million people affected globally, which can result in limb loss. PAD is often part of a greater set of comorbidities, including diabetes mellitus (DM), chronic kidney disease, coronary artery disease and obesity. Diabetic foot ulceration is a debilitating complication of DM that occurs owing to a combination of neuropathy, PAD, and structural biomechanical changes. Poor tissue perfusion in the context of microangiopathy can result in impaired wound healing and eventual limb loss. The combination of diabetic foot ulceration and PAD can be burdensome socially, psychologically and economically, for patients and health systems. It is, therefore, imperative to be able to identify and continuously monitor high-risk patients to aid in the prevention, monitoring, and management of these conditions in a noninvasive, easily accessible and cost-effective manner. We sought to evaluate the current evidence relating to noninvasive optical tissue perfusion assessment modalities available and their use in patients with PAD and individuals with DM. We also aimed to collate how each assessment modality worked, and its advantages and disadvantages.

Methods

A systematic literature search was conducted of the Embase and Medline (via the Ovid interface), PubMed, and Google Scholar databases for articles relating to PAD in individuals with DM. Articles were reviewed by two independent reviewers. Findings were collated for each method of tissue perfusion.

Results

In the final review, 35 articles met criteria for inclusion. The modalities discussed included photoplethysmography, spatial frequency domain imaging, hyperspectral imaging, laser Doppler, laser speckle flowgraphy, near infrared spectroscopy, thermography, photoacoustic imaging, and indocyanine green.

Conclusions

Several modalities are available for the noninvasive monitoring of tissue perfusion in individuals with DM and PAD that show promise. Their clinical applicability is an area of ongoing research.

背景外周动脉疾病(PAD)的全球发病率为每年 1,050 万人。全球有 1.13 亿人受到影响,可能导致肢体缺失。PAD 通常是糖尿病(DM)、慢性肾病、冠状动脉疾病和肥胖症等多种并发症的一部分。糖尿病足溃疡是一种使人衰弱的糖尿病并发症,是神经病变、PAD 和生物力学结构变化共同作用的结果。微血管病变导致的组织灌注不良会影响伤口愈合,最终导致肢体缺失。糖尿病足溃疡和 PAD 的结合会给患者和医疗系统带来沉重的社会、心理和经济负担。因此,当务之急是能够识别并持续监测高危患者,以非侵入性、易于获取和经济有效的方式帮助预防、监测和管理这些病症。我们试图评估与现有无创光学组织灌注评估方法有关的现有证据,以及这些方法在并发动脉粥样硬化症患者和糖尿病患者中的应用。我们还旨在整理每种评估方式的工作原理及其优缺点。方法在 Embase 和 Medline(通过 Ovid 界面)、PubMed 和 Google Scholar 数据库中进行了系统的文献检索,以查找与糖尿病患者 PAD 相关的文章。文章由两名独立审稿人进行审阅。结果在最终审查中,有 35 篇文章符合纳入标准。讨论的方式包括光电血压计、空间频域成像、高光谱成像、激光多普勒、激光斑点血流成像、近红外光谱、热成像、光声成像和吲哚青绿。它们的临床适用性是一个正在研究的领域。
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引用次数: 0
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JVS-vascular insights
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