Objective
Carotid endarterectomy (CEA) for symptomatic carotid artery stenosis treatment is recommended within the first 2 weeks from index event. Despite this indication for treatment being well-accepted and demonstrated appropriate for the reduction of stroke recurrence, the treatment in the first 48 hours from the index event is debated in the literature, considering the high risk of complications and the reduction of stroke recurrence by modern medical therapies. The aim of the present study was to review the rate of stroke recurrence in the first 48 hours after the index event according to the type of preoperative symptoms.
Methods
A systematic review and meta-analysis, registered on PROSPERO (CRD420250656373), was performed according to the PRISMA recommendations searching in three databases (Embase, PubMed, and Cochrane Database) studies on recurrence of stroke within 48 hours from the index event in patients with symptomatic carotid artery stenosis. Observational studies and studies evaluating the rate of recurrence event in the waiting time of CEA were considered. The rate of stroke in the first 48 hours from the index event, was evaluated by the Der Simonian-Laird weights of random effects model.
Results
Four studies, comprising a total of 2224 patients, were included in the meta-analysis. Three studies had a prospective, one of which was randomized and one was retrospective. Heterogeneity among studies was low. The overall stroke rate at 48 hours from the index event was 2.6% (95% confidence interval [CI], 1.5%-4.8%; P = .001). The risk of stroke within 48 hours varied significantly based on the type of index event: 0.6% (95% CI, 0.3%-6%), for amaurosis fugax (AF), 3.5% (95% CI, 1.3%-9.1%) for transient ischemic attack (TIA), and 1.3% (95% CI, 0.3%-6%) for stroke. Hypertension, diabetes, smoking, recent year of enrolment, and male gender were significant (P < .05) moderators affecting stroke risk after TIA, whereas no moderators influenced outcomes after AF or stroke as the index event.
Conclusions
Few studies have investigated stroke recurrence within the first 48 hours after an index event. The pooled stroke rate was relatively low, particularly for patients who experienced AF (0.6%) or stroke (1.3%) as the index event, raising questions about the necessity for urgent CEA in these cases. However, for patients with TIA as the index event, the risk of stroke within the first 48 hours appears to be significant, suggesting that urgent intervention may be warranted.
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