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A systematic review and meta-analysis of risk of stroke within 48 hours after an index symptomatic carotid event 颈动脉症状性事件后48小时内卒中风险的系统回顾和荟萃分析
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100296
Rodolfo Pini MD, PhD, FEBVS , Gianluca Faggioli MD , Marcello Lodato MD , Eleonora Acquisti MD , Federica Campana MD , Betty Shiti MD , Enrico Gallitto MD, PhD, FEBVS , Paolo Spath MD, PhD , Emiliano Chisci MD, PhD , Mauro Gargiulo MD, PhD

Objective

Carotid endarterectomy (CEA) for symptomatic carotid artery stenosis treatment is recommended within the first 2 weeks from index event. Despite this indication for treatment being well-accepted and demonstrated appropriate for the reduction of stroke recurrence, the treatment in the first 48 hours from the index event is debated in the literature, considering the high risk of complications and the reduction of stroke recurrence by modern medical therapies. The aim of the present study was to review the rate of stroke recurrence in the first 48 hours after the index event according to the type of preoperative symptoms.

Methods

A systematic review and meta-analysis, registered on PROSPERO (CRD420250656373), was performed according to the PRISMA recommendations searching in three databases (Embase, PubMed, and Cochrane Database) studies on recurrence of stroke within 48 hours from the index event in patients with symptomatic carotid artery stenosis. Observational studies and studies evaluating the rate of recurrence event in the waiting time of CEA were considered. The rate of stroke in the first 48 hours from the index event, was evaluated by the Der Simonian-Laird weights of random effects model.

Results

Four studies, comprising a total of 2224 patients, were included in the meta-analysis. Three studies had a prospective, one of which was randomized and one was retrospective. Heterogeneity among studies was low. The overall stroke rate at 48 hours from the index event was 2.6% (95% confidence interval [CI], 1.5%-4.8%; P = .001). The risk of stroke within 48 hours varied significantly based on the type of index event: 0.6% (95% CI, 0.3%-6%), for amaurosis fugax (AF), 3.5% (95% CI, 1.3%-9.1%) for transient ischemic attack (TIA), and 1.3% (95% CI, 0.3%-6%) for stroke. Hypertension, diabetes, smoking, recent year of enrolment, and male gender were significant (P < .05) moderators affecting stroke risk after TIA, whereas no moderators influenced outcomes after AF or stroke as the index event.

Conclusions

Few studies have investigated stroke recurrence within the first 48 hours after an index event. The pooled stroke rate was relatively low, particularly for patients who experienced AF (0.6%) or stroke (1.3%) as the index event, raising questions about the necessity for urgent CEA in these cases. However, for patients with TIA as the index event, the risk of stroke within the first 48 hours appears to be significant, suggesting that urgent intervention may be warranted.
目的建议在症状性颈动脉狭窄发生后2周内行颈动脉内膜切除术(CEA)治疗。尽管这一治疗指征被广泛接受,并被证明适合减少卒中复发,但考虑到现代医学治疗的并发症高风险和卒中复发的减少,文献中对指数事件发生后48小时内的治疗存在争议。本研究的目的是根据术前症状的类型,回顾指标事件发生后48小时内卒中复发率。方法根据PRISMA推荐检索三个数据库(Embase、PubMed和Cochrane数据库),对症状性颈动脉狭窄患者发生指数事件后48小时内卒中复发情况进行系统评价和荟萃分析,注册于PROSPERO (CRD420250656373)。观察性研究和评估CEA等待时间内复发率的研究被考虑在内。从指数事件开始的前48小时内的中风率,通过随机效应模型的Der Simonian-Laird权重来评估。结果荟萃分析纳入了4项研究,共计2224例患者。三项研究是前瞻性的,其中一项是随机的,另一项是回顾性的。研究间异质性较低。指数事件发生后48小时的总卒中发生率为2.6%(95%可信区间[CI], 1.5%-4.8%; P = .001)。48小时内卒中的风险根据指标事件的类型有显著差异:黑朦(AF)为0.6% (95% CI, 0.3%-6%),短暂性脑缺血发作(TIA)为3.5% (95% CI, 1.3%- 6%),卒中为1.3% (95% CI, 0.3%-6%)。高血压、糖尿病、吸烟、最近入组年份和男性性别是影响TIA后卒中风险的显著调节因素(P < 0.05),而房颤或卒中作为指标事件后没有调节因素影响预后。结论:很少有研究调查指数事件后48小时内卒中复发。合并卒中发生率相对较低,特别是以房颤(0.6%)或卒中(1.3%)为指标事件的患者,这引发了对这些病例是否需要紧急CEA的质疑。然而,对于TIA为指标事件的患者,头48小时内卒中的风险似乎是显著的,这表明可能需要紧急干预。
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引用次数: 0
Comparison of patient outcomes following endovascular vs surgical management of infrainguinal autogenous bypass stenosis 腹股沟下自体旁路狭窄的血管内治疗与手术治疗的比较
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100341
Meghan McGillivray MD , Ningzhi Gu MD , Mark Tatangelo PhD, MBA, BA , Jason Faulds MD, MHSc, FRCSC , Jonathan Misskey MD, MHPE, FRCSC

Objective

The aim of this study was to evaluate outcomes of open vs endovascular intervention for infrainguinal bypass stenosis.

Methods

A single-institution retrospective review of infrainguinal bypass stenosis cases from January 1, 2010, to December 31, 2020, was conducted. Data collected included index bypass operation, lesion characteristics, reintervention, and patient outcomes.

Results

Of the 146 patients included, 40% underwent open intervention, whereas 60% underwent endovascular intervention. There were no significant differences between the index bypasses of each cohort with respect to inflow, outflow, conduit, or primary patency. The severity of stenotic lesions in open and endovascular cohorts was >70% severity on duplex ultrasound in 76% and 78% of patients, respectively (P = .02). Lesion location was not significantly different between cohorts with 48% proximal, 27% distal, 8% midgraft, 3% venovenostomy, and 14% multiple stenotic lesions. There was no significant difference in primary revision patency in open vs endovascular intervention (1109 vs 809 days; P = .09). The average number of repeat interventions was not significantly different (0.47 vs 0.58 times; P = .48); however, the average cumulative hospital length of stay was significantly shorter for patients who underwent endovascular intervention (8.21 vs 5.22 days; P = .02). During the study period, a comparable portion of patients in open and endovascular cohorts went on to have failed bypass grafts (17% vs 18%) with no significant difference in the total time to graft failure in these subgroups (860 vs 1144 days; P = .47). There were no significant differences in major adverse limb events (12% vs 8%; P = .59) or mortality (47% vs 40%; P = .52).

Conclusions

Open and endovascular interventions for infrainguinal bypass stenosis showed no significant differences in primary revision patency, graft failure rates, major adverse limb events, or mortality. Endovascular intervention was associated with shorter cumulative hospital stays for reintervention.
目的评价腹股沟下旁路狭窄的切开与血管内介入治疗的效果。方法对2010年1月1日至2020年12月31日的腹股沟下旁路狭窄病例进行单机构回顾性分析。收集的数据包括心脏绕道手术、病变特征、再介入和患者预后。结果146例患者中,40%接受了开放介入治疗,60%接受了血管内介入治疗。每个队列在流入、流出、导管或原发性通畅方面的指数绕道没有显著差异。双工超声显示,开放组和血管内组狭窄病变严重程度分别为76%和78% (P = 0.02)。病变位置在近端48%、远端27%、中端8%、静脉造口3%和多发性狭窄病变14%的队列之间无显著差异。开放与血管内干预的初次翻修通畅无显著差异(1109天vs 809天;P = .09)。平均重复干预次数差异无统计学意义(0.47 vs 0.58次,P = 0.48);然而,接受血管内介入治疗的患者平均累计住院时间明显缩短(8.21天vs 5.22天;P = 0.02)。在研究期间,开放和血管内队列中相当一部分患者继续进行旁路移植失败(17%对18%),这些亚组中移植物失败的总时间无显著差异(860天对1144天;P = 0.47)。两组在主要肢体不良事件(12% vs 8%, P = 0.59)或死亡率(47% vs 40%, P = 0.52)方面无显著差异。结论对腹股沟下旁路狭窄进行开放和血管内介入治疗在初次翻修通畅、移植物失败率、主要肢体不良事件和死亡率方面无显著差异。血管内干预与再干预累积住院时间缩短相关。
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引用次数: 0
The business of vascular surgery 血管外科血管外科的业务
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100303
Krishna Jain MD, FACS
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引用次数: 0
Retrograde tibiopedal access as an alternative procedural technique for genicular artery embolization 胫瓣逆行入路作为膝动脉栓塞的替代手术技术
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100339
Nishanth Konduru, Anton Hnatov BS, Siddhartha Rao MD

Objective

The aim of this study is to assess the feasibility, safety, and technical outcomes of genicular artery embolization (GAE) performed via retrograde tibiopedal access.

Materials and Methods

GAE was performed in 357 patients utilizing tibiopedal access. Patient eligibility was determined through a comprehensive clinical evaluation and radiographic imaging. Embolic agents were delivered through a microcatheter to the targeted arteries by an interventional cardiologist with an additional 1 year of fellowship training in endovascular medicine and certification from the American Board of Vascular Medicine. Technical success was defined as successful embolization of at least two genicular arteries, with subsequent resolution of arterial blush. Peri and post-procedural data and complications related to the access site were assessed.

Results

Technical success was obtained in 96.6% of cases. Patient ages ranged from 38 to 98 years, with body mass index ranging from 18.01 to 63.23 kg/m2. Across this study cohort, 3.7 ± 1.0 genicular arteries were embolized, with a mean procedure time of 51.3 ± 13.0 minutes. Procedure time was measured from initial injection of lidocaine to application of hemostatic device. Results also show 25% improvement in average procedure duration after 50 cases, suggesting a brief learning curve for GAE. Post-procedural complications occurred in 4.5% of cases (n = 16) and were associated only with minor, transient side effects.

Conclusions

GAE via tibiopedal access offers a viable alternative to the conventional femoral approach reported in recent literature. In this study, retrograde access consistently enabled successful completion of GAE without notable discrepancies in treatment efficacy or safety. This approach resulted in a high technical success rate with no significant complications. Study findings support the potential for widespread adoption of the retrograde approach for treating osteoarthritis with GAE, particularly in patients in whom an antegrade approach may pose a higher risk of complications.
目的:本研究的目的是评估通过逆行胫趾通道进行膝动脉栓塞(GAE)的可行性、安全性和技术结果。材料与方法对357例采用双趾通道的患者进行gae手术。通过全面的临床评估和放射成像来确定患者的资格。栓塞剂通过微导管输送到目标动脉,由具有额外1年血管内医学研究员培训并获得美国血管医学委员会认证的介入心脏病专家进行。技术上的成功被定义为成功栓塞至少两条膝动脉,随后动脉红肿的解决。评估术中及术后资料及与入路部位相关的并发症。结果手术成功率为96.6%。患者年龄38 ~ 98岁,体重指数18.01 ~ 63.23 kg/m2。在整个研究队列中,3.7±1.0根膝动脉被栓塞,平均手术时间为51.3±13.0分钟。测量从首次注射利多卡因到使用止血装置的时间。结果还显示,50例术后平均手术时间改善了25%,表明GAE的学习曲线很短。术后并发症发生率为4.5% (n = 16),且仅伴有轻微、短暂的副作用。结论在最近的文献报道中,经双趾入路的gae为传统的股骨入路提供了一种可行的选择。在这项研究中,逆行通路始终如一地使GAE成功完成,在治疗疗效或安全性方面没有显着差异。该方法技术成功率高,无明显并发症。研究结果支持广泛采用逆行入路治疗GAE骨关节炎的潜力,特别是在逆行入路可能导致并发症风险较高的患者中。
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引用次数: 0
Real-world outcomes of above-knee amputation: Investigating the impact of peripheral arterial disease 膝上截肢的实际结果:外周动脉疾病的影响
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2026.100353
Micah Thomas BS , Aaron Ebeweber MS , Maham Rahimi MD, PhD

Objective

Above-knee amputation (AKA), or transfemoral amputation, represents a highly morbid surgical procedure, typically performed in patients with irreversible limb compromise due to peripheral arterial disease, diabetes, trauma, or malignancy. Despite prior declines, U.S. incidence of AKA has risen 4% annually since 2012, paralleling an aging population and evolving comorbid risk profiles. Given its profound functional, psychosocial, and systemic implications, a contemporary understanding of real-world outcomes is essential. This study evaluated demographic characteristics, preoperative comorbidities, and postoperative complications of patients undergoing AKA using the TriNetX global health research network, comparing large-scale patient data with published literature to identify gaps between controlled research and clinical practice.

Methods

A retrospective cohort analysis was performed using deidentified electronic health records within TriNetX, identifying approximately 23,000 patients who underwent AKA via Current Procedural Terminology codes 27590, 27594, and 27596. Demographics, preoperative comorbidities, and postoperative outcomes—including stroke, myocardial infarction, infection, venous thromboembolism, contralateral limb amputation, and mortality—were assessed longitudinally and compared with systematically reviewed literature cohorts (n = 56-2879 patients). Statistical comparisons were conducted using two-proportion z tests (P < .05).

Results

TriNetX patients were younger (70 vs 75 years) and more often male (61.3% vs 47.4%) than literature cohorts. Compared with literature, TriNetX showed higher rates of chronic kidney disease (39% vs 23.9%) and end-stage renal disease (16% vs 12.9%) but lower rates of smoking, stroke, congestive heart failure, and diabetes. Major postoperative complications accumulated progressively: stroke (11.6%), myocardial infarction (14.1%), deep vein thrombosis (6.6%), pulmonary embolism (6.1%), and contralateral limb amputation (54.2%) by 11 years. All-cause mortality reached 19.9% at 1 year and 34.6% at 20 years.

Conclusions

AKA represents a sentinel event signaling advanced systemic vascular disease and high long-term morbidity and mortality. TriNetX data reveal substantial cerebrovascular, cardiovascular, and contralateral limb complications exceeding prior reports. These findings support multidisciplinary postamputation pathways emphasizing cardiovascular risk reduction, thromboembolic prophylaxis, wound management, and proactive contralateral limb surveillance to improve survival and quality of life.
目的:膝上截肢(AKA)或经股截肢是一种高度病态的外科手术,通常用于因外周动脉疾病、糖尿病、创伤或恶性肿瘤导致的不可逆肢体损害患者。尽管之前有所下降,但自2012年以来,美国的AKA发病率每年上升4%,与人口老龄化和不断变化的合并症风险概况相一致。鉴于其深刻的功能、社会心理和系统影响,对现实世界结果的当代理解至关重要。本研究利用TriNetX全球健康研究网络评估了接受AKA患者的人口统计学特征、术前合并症和术后并发症,并将大规模患者数据与已发表的文献进行比较,以确定对照研究与临床实践之间的差距。方法使用TriNetX内未识别的电子健康记录进行回顾性队列分析,通过现行程序术语代码27590、27594和27596确定约23,000名接受AKA的患者。人口统计学、术前合并症和术后结局(包括卒中、心肌梗死、感染、静脉血栓栓塞、对侧肢体截肢和死亡率)进行纵向评估,并与系统回顾的文献队列(n = 56-2879例患者)进行比较。采用双比例z检验进行统计学比较(P < 0.05)。结果与文献组相比,strinetx组患者更年轻(70岁vs 75岁),男性居多(61.3% vs 47.4%)。与文献相比,TriNetX显示慢性肾病(39% vs 23.9%)和终末期肾病(16% vs 12.9%)的发生率较高,但吸烟、中风、充血性心力衰竭和糖尿病的发生率较低。术后主要并发症逐渐累积:中风(11.6%)、心肌梗死(14.1%)、深静脉血栓形成(6.6%)、肺栓塞(6.1%)和对侧截肢(54.2%)。1年时全因死亡率为19.9%,20年时为34.6%。结论:saka是一个前哨事件,预示着晚期全身性血管疾病和高长期发病率和死亡率。TriNetX数据显示大量脑血管、心血管和对侧肢体并发症超过先前的报道。这些发现支持多学科截肢后途径,强调心血管风险降低、血栓栓塞预防、伤口管理和主动对侧肢体监测,以提高生存率和生活质量。
{"title":"Real-world outcomes of above-knee amputation: Investigating the impact of peripheral arterial disease","authors":"Micah Thomas BS ,&nbsp;Aaron Ebeweber MS ,&nbsp;Maham Rahimi MD, PhD","doi":"10.1016/j.jvsvi.2026.100353","DOIUrl":"10.1016/j.jvsvi.2026.100353","url":null,"abstract":"<div><h3>Objective</h3><div>Above-knee amputation (AKA), or transfemoral amputation, represents a highly morbid surgical procedure, typically performed in patients with irreversible limb compromise due to peripheral arterial disease, diabetes, trauma, or malignancy. Despite prior declines, U.S. incidence of AKA has risen 4% annually since 2012, paralleling an aging population and evolving comorbid risk profiles. Given its profound functional, psychosocial, and systemic implications, a contemporary understanding of real-world outcomes is essential. This study evaluated demographic characteristics, preoperative comorbidities, and postoperative complications of patients undergoing AKA using the TriNetX global health research network, comparing large-scale patient data with published literature to identify gaps between controlled research and clinical practice.</div></div><div><h3>Methods</h3><div>A retrospective cohort analysis was performed using deidentified electronic health records within TriNetX, identifying approximately 23,000 patients who underwent AKA via Current Procedural Terminology codes 27590, 27594, and 27596. Demographics, preoperative comorbidities, and postoperative outcomes—including stroke, myocardial infarction, infection, venous thromboembolism, contralateral limb amputation, and mortality—were assessed longitudinally and compared with systematically reviewed literature cohorts (n = 56-2879 patients). Statistical comparisons were conducted using two-proportion <em>z</em> tests (<em>P</em> &lt; .05).</div></div><div><h3>Results</h3><div>TriNetX patients were younger (70 vs 75 years) and more often male (61.3% vs 47.4%) than literature cohorts. Compared with literature, TriNetX showed higher rates of chronic kidney disease (39% vs 23.9%) and end-stage renal disease (16% vs 12.9%) but lower rates of smoking, stroke, congestive heart failure, and diabetes. Major postoperative complications accumulated progressively: stroke (11.6%), myocardial infarction (14.1%), deep vein thrombosis (6.6%), pulmonary embolism (6.1%), and contralateral limb amputation (54.2%) by 11 years. All-cause mortality reached 19.9% at 1 year and 34.6% at 20 years.</div></div><div><h3>Conclusions</h3><div>AKA represents a sentinel event signaling advanced systemic vascular disease and high long-term morbidity and mortality. TriNetX data reveal substantial cerebrovascular, cardiovascular, and contralateral limb complications exceeding prior reports. These findings support multidisciplinary postamputation pathways emphasizing cardiovascular risk reduction, thromboembolic prophylaxis, wound management, and proactive contralateral limb surveillance to improve survival and quality of life.</div></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":"4 ","pages":"Article 100353"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved maturation of two-stage over single-stage basilic vein transposition for first-time hemodialysis access creation: A multilevel model 两期比单期基底静脉转位在首次血液透析通路创建中的成熟程度提高:一个多层次模型
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100345
Max Zhu MD, Joel Kruger MD, Joshua T. Geiger MD, MS, Irina Kanzafarova MD, Jose Aldana MD, Adam Doyle MD, Doran S. Mix MD, Michael C. Stoner MD, Karina A. Newhall MD, MS

Objective

Successful brachiobasilic arteriovenous fistula (BBAVF) creation can be performed in single or two stages, with evidence supporting either approach. Although surgeon and practice pattern often influence surgical approach, little is known about the role of practice patterns in maturation and reintervention-free fistula survival.

Methods

We conducted a retrospective study using the Vascular Quality Initiative from 2011 to 2022, including patients undergoing BBAVF procedures for first-time hemodialysis access with at least 4 weeks of follow-up. The primary outcome was fistula maturation. Our analysis incorporated a multilevel model, clustering by surgeon effects. Secondary analysis examined 1-year freedom from the composite outcome of access reintervention, fistula abandonment, or death, using Cox proportional hazards modeling and Kaplan-Meier survival analysis. Likelihood ratio testing was used to analyze model fit.

Results

Among 6417 patients, 1347 (21%) underwent single-stage and 5043 (79%) underwent two-stage BBAVF creation. Overall maturation was 60.6%. On univariable analysis, two-stage fistulas had higher maturation (62.3% vs 54.3%, P < .001) and 1-year reintervention-free fistula survival (50.5% vs 47.9%, P = .008). Multilevel adjusted analysis demonstrated that two-stage procedures were associated with higher maturation rates (odds ratio: 1.4, 95% confidence interval: 1.1-1.6, P = .001) and lower 1-year composite reintervention, abandonment, or death risk (hazard ratio: 0.88, 95% confidence interval: 0.8-0.98, P = .018). Clustering by surgeon random effects significantly improved model fit for maturation rate (likelihood ratio: 66.9, P < .001) and 1-year reintervention, abandonment, or death (likelihood ratio: 4774.7, P < .001).

Conclusions

Two-stage BBAVF creation was associated with superior maturation and 1-year reintervention-free fistula survival, even after adjusting for surgeon practice patterns. With other patient factors equal, a two-stage approach should be considered for first-time BBAVF creation.
目的成功的肱基底动静脉瘘(bbbavf)的形成可以分单期或两期进行,并有证据支持这两种方法。尽管外科医生和实践模式经常影响手术入路,但实践模式在成熟和无再干预瘘管存活中的作用知之甚少。方法:采用血管质量倡议(Vascular Quality Initiative)于2011年至2022年进行了一项回顾性研究,包括首次接受BBAVF手术进行血液透析的患者,随访时间至少4周。主要结果为瘘管成熟。我们的分析纳入了一个多层模型,根据外科医生的影响进行聚类。二级分析采用Cox比例风险模型和Kaplan-Meier生存分析,检查了1年无通路再干预、瘘管放弃或死亡的复合结局。采用似然比检验分析模型拟合。结果在6417例患者中,1347例(21%)接受单期治疗,5043例(79%)接受两期治疗。总体成熟度为60.6%。在单变量分析中,两期瘘管具有更高的成熟度(62.3% vs 54.3%, P < 001)和1年无再干预瘘管生存率(50.5% vs 47.9%, P = 0.008)。多水平调整分析表明,两阶段手术与较高的成熟率(优势比:1.4,95%可信区间:1.1-1.6,P = 0.001)和较低的1年复合再干预、放弃或死亡风险相关(风险比:0.88,95%可信区间:0.8-0.98,P = 0.018)。外科医生随机效应聚类显著改善了成熟率(似然比:66.9,P < 0.001)和1年后再干预、放弃或死亡(似然比:4774.7,P < 0.001)的模型拟合。结论:即使在调整了外科医生的实践模式后,两期bbbavf的形成与更高的成熟度和1年无再干预瘘管存活相关。在其他患者因素相同的情况下,应考虑采用两阶段方法治疗首次bbbavf。
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引用次数: 0
Analysis of physician-modified endograft utilization using online databases and social media 利用在线数据库和社交媒体分析医师改良内移植物的使用情况
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100314
Rob Tatum MD , Michael Nooromid MD , Paul DiMuzio MD , Babak Abai MD

Background

To characterize the present landscape of physician-modified endograft (PMEG) use and the impact of an institution's investigational device exemption (IDE) status on endograft use by analyzing publication trends and social media coverage.

Methods

We used the social media platform X and three online bibliographic databases to perform a keyword search using the following terms: PMEG, physician-modified endograft, and laser fenestration. Data extracted from X and online articles included authorship, IDE protocol status, pertinent clinical outcome measures, and others. An internet search was performed to determine which institutions offered revascularization with a custom-made device within an IDE protocol and which institutions were performing PMEGs without an IDE. Data were compared using standard methods.

Results

Our search identified 177 X posts and 315 published articles between 2017 and 2024. We found that 61% (109/177) of X post authors were male, and the most frequently mentioned device was Cook (n = 21) followed by Gore (n = 12) and AFX (n = 2). There were 306 articles published in peer-reviewed journals, and 217 articles described at least 10 procedures. An IDE was mentioned in 3.9% of X posts (7/177). Sixty-seven percent of posts (119/177) mentioned a thoracoabdominal repair compared with 18% (32/177) mentioning arches and 15% (26/177) not indicating repair type. Of the 74 posts mentioning the number of branch grafts, 35% (26/74) were three-branch, and 65% (48/74) were four-branch repairs. Of the X posts, 64% (114/177) were related to procedural technique followed by 20% meeting presentations (34/177), 14% education (n = 24), and 2% mentorship (n = 5). The most frequently observed complication was endoleak (n = 8), followed by aneurysmal degeneration (n = 3) and stent migration (n = 1). Among published articles, most institutions were academic (n = 236) and urban (n = 209). Of the 274 articles for which author training history was available, most institutions were in the United States (n = 238) and urban (n = 211). The most frequently reported outcome was endoleak (n = 249), followed by need for reintervention (n = 199), stent migration (n = 57), and aneurysmal degeneration (n = 41). Only 31% of institutions (97/315) had an IDE; the remaining 69% (218/315) were performing PMEGs without an IDE. Of the 144 articles indicating commercial device use, Cook was the most frequently reported platform (n = 97) followed by Gore (n = 47).

Conclusions

PMEG has become a broadly used treatment option for patients with complex thoracoabdominal aortic disease at non-IDE centers. A less restrictive regulatory environment may expand patient access to custom-made devices without sacrificing patient safety standards. Collaboration is needed between vascular surgeons, device manufacturers, and lawmakers to achieve this goal.
通过分析出版趋势和社交媒体报道,描述医生改良内移植物(PMEG)使用的现状,以及一个机构的研究器械豁免(IDE)状态对内移植物使用的影响。方法利用社交媒体平台X和3个在线文献数据库进行关键词检索:PMEG、医师改良内移植物和激光开窗。从X和在线文章中提取的数据包括作者身份、IDE协议状态、相关临床结果测量等。通过互联网搜索,确定哪些机构在IDE协议下使用定制设备进行血运重建,哪些机构在没有IDE的情况下进行pmeg。采用标准方法对数据进行比较。结果在2017年至2024年期间,我们检索了177x篇帖子和315篇发表的文章。我们发现61%(109/177)的X篇文章作者是男性,最常被提及的设备是Cook (n = 21),其次是Gore (n = 12)和AFX (n = 2)。在同行评议的期刊上发表了306篇文章,其中217篇文章描述了至少10种治疗方法。在X个帖子中有3.9%(7/177)提到了IDE。67%的帖子(119/177)提到胸腹修复,18%(32/177)提到弓,15%(26/177)没有指出修复类型。在74篇提到树枝移植数量的文章中,35%(26/74)为三支修复,65%(48/74)为四支修复。在X个帖子中,64%(114/177)与程序技术相关,其次是20%的会议演讲(34/177),14%的教育(n = 24)和2%的指导(n = 5)。最常见的并发症是内漏(n = 8),其次是动脉瘤变性(n = 3)和支架移位(n = 1)。在发表的文章中,大多数机构是学术机构(236篇)和城市机构(209篇)。在有作者培训历史的274篇文章中,大多数机构在美国(238)和城市(211)。最常见的报道结果是内漏(n = 249),其次是需要再干预(n = 199),支架移位(n = 57)和动脉瘤变性(n = 41)。只有31%的机构(97/315)拥有IDE;其余69%(218/315)在没有IDE的情况下执行pmeg。在144篇关于商业设备使用的文章中,Cook是最常被报道的平台(n = 97),其次是Gore (n = 47)。结论spmeg已成为非ide中心复杂胸腹主动脉疾病患者广泛使用的治疗选择。限制较少的监管环境可以在不牺牲患者安全标准的情况下扩大患者使用定制设备的机会。为了实现这一目标,血管外科医生、设备制造商和立法者之间需要合作。
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引用次数: 0
Impact of body fat quality on long-term survival following endovascular repair for abdominal aortic aneurysms 体脂质量对腹主动脉瘤血管内修复术后长期生存的影响
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100323
Hirotsugu Ozawa MD, PhD, Takao Ohki MD, PhD, Kota Shukuzawa MD, PhD, Daisuke Yamagishi MD, Takehiro Suzuki MD, Ryo Nishide MD, Kentaro Kasa MD, Makiko Omori MD, Soichiro Fukushima MD

Objective

The aim of this study was to evaluate the impact of body fat quality and quantity on long-term survival following endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs).

Methods

A single-center, retrospective cohort study was performed on 237 patients who underwent primary EVAR for AAAs from 2016 to 2019. Fat quality was assessed by measuring the Hounsfield units (HUs) of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) at the level of the third lumbar vertebra on preoperative noncontrast computed tomography. Fat quantity was assessed by measuring the area (cm2) of SAT and VAT at the level of the umbilicus. Hazard ratios for all-cause mortality were calculated for each variable using univariate and multivariate analysis.

Results

This study included 237 patients with a mean age of 76.8 years, of whom 33 were female. The median body mass index was 23.4 kg/m2 (interquartile range, 21.6-26.0 kg/m2), and 226 patients (95.3%) were classified as nonobese. During the median follow-up period of 72 months, there were 107 all-cause deaths. In univariate analysis, overall survival was significantly lower in patients with higher SAT or VAT density or larger SAT or VAT area among body fat-related parameters. In a multivariate analysis, SAT density was an independent risk factor for all-cause mortality following EVAR (SAT density: hazard ratio, 1.02; 95% confidence interval, 1.01-1.03; P = .007), along with other variables including age, sarcopenia, osteoporosis, and aneurysm diameter.

Conclusions

Patients with higher SAT density showed increased all-cause mortality following EVAR. This finding suggests that fat quality, rather than fat quantity, may be more closely associated with long-term survival in post-EVAR patients.
目的探讨体脂肪质量和数量对腹主动脉瘤(AAAs)血管内动脉瘤修复(EVAR)术后长期生存的影响。方法采用单中心、回顾性队列研究方法,对2016 - 2019年237例AAAs患者进行原发性EVAR。通过术前非对比计算机断层扫描测量第三腰椎水平皮下脂肪组织(SAT)和内脏脂肪组织(VAT)的Hounsfield单位(HUs)来评估脂肪质量。通过测量脐部水平SAT和VAT的面积(cm2)来评估脂肪量。使用单因素和多因素分析计算每个变量的全因死亡率风险比。结果237例患者,平均年龄76.8岁,其中女性33例。中位体重指数为23.4 kg/m2(四分位数范围为21.6 ~ 26.0 kg/m2), 226例(95.3%)为非肥胖。在中位随访72个月期间,有107例全因死亡。在单因素分析中,在体脂相关参数中,SAT或VAT密度较高或SAT或VAT面积较大的患者的总生存率显著降低。在多变量分析中,SAT密度是EVAR后全因死亡率的独立危险因素(SAT密度:危险比1.02;95%可信区间1.01-1.03;P = .007),其他变量包括年龄、肌肉减少症、骨质疏松症和动脉瘤直径。结论高SAT密度患者EVAR后全因死亡率增高。这一发现表明,脂肪质量,而不是脂肪数量,可能与evar后患者的长期生存更密切相关。
{"title":"Impact of body fat quality on long-term survival following endovascular repair for abdominal aortic aneurysms","authors":"Hirotsugu Ozawa MD, PhD,&nbsp;Takao Ohki MD, PhD,&nbsp;Kota Shukuzawa MD, PhD,&nbsp;Daisuke Yamagishi MD,&nbsp;Takehiro Suzuki MD,&nbsp;Ryo Nishide MD,&nbsp;Kentaro Kasa MD,&nbsp;Makiko Omori MD,&nbsp;Soichiro Fukushima MD","doi":"10.1016/j.jvsvi.2025.100323","DOIUrl":"10.1016/j.jvsvi.2025.100323","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to evaluate the impact of body fat quality and quantity on long-term survival following endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs).</div></div><div><h3>Methods</h3><div>A single-center, retrospective cohort study was performed on 237 patients who underwent primary EVAR for AAAs from 2016 to 2019. Fat quality was assessed by measuring the Hounsfield units (HUs) of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) at the level of the third lumbar vertebra on preoperative noncontrast computed tomography. Fat quantity was assessed by measuring the area (cm<sup>2</sup>) of SAT and VAT at the level of the umbilicus. Hazard ratios for all-cause mortality were calculated for each variable using univariate and multivariate analysis.</div></div><div><h3>Results</h3><div>This study included 237 patients with a mean age of 76.8 years, of whom 33 were female. The median body mass index was 23.4 kg/m<sup>2</sup> (interquartile range, 21.6-26.0 kg/m<sup>2</sup>), and 226 patients (95.3%) were classified as nonobese. During the median follow-up period of 72 months, there were 107 all-cause deaths. In univariate analysis, overall survival was significantly lower in patients with higher SAT or VAT density or larger SAT or VAT area among body fat-related parameters. In a multivariate analysis, SAT density was an independent risk factor for all-cause mortality following EVAR (SAT density: hazard ratio, 1.02; 95% confidence interval, 1.01-1.03; <em>P</em> = .007), along with other variables including age, sarcopenia, osteoporosis, and aneurysm diameter.</div></div><div><h3>Conclusions</h3><div>Patients with higher SAT density showed increased all-cause mortality following EVAR. This finding suggests that fat quality, rather than fat quantity, may be more closely associated with long-term survival in post-EVAR patients.</div></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":"4 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Office-based lab mesenteric angiography is safe for low- and moderate-risk patients 基于办公室的实验室肠系膜血管造影对中低危患者是安全的
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100331
John Fang DO, Niteesh Sundaram MD, Omer Riaz MD, Thomas Lee MD, Kevin James MD

Objective

There has been a significant shift of vascular care and intervention from the inpatient to the outpatient setting. The office-based laboratory (OBL) is an increasingly adopted treatment model following the 2008 payor reimbursement modifications for outpatient vascular intervention by the Centers for Medicare and Medicaid Services. Reports on this phenomenon largely focus on the financial effects, with a paucity of safety and outcomes data associated with this treatment setting. In this study, we examine treatment outcomes of elective mesenteric angiograms performed at an OBL, and factors affecting patient selection for safe outpatient intervention.

Methods

A retrospective study was performed of adult patients treated with diagnostic or interventional mesenteric angiography at a single OBL over 9 years. Patient and treatment variables were abstracted from outpatient and inpatient medical records. Primary outcomes of interest were 30-day adverse events (30D A/E) reported with the Clavien-Dindo (CD) classification system. Technical success was examined as a secondary outcome.

Results

Between September 2015 and February 2024, 80 patients underwent 115 mesenteric angiograms by seven vascular surgeons. Patients were 73 years old on average (standard deviation, 9.3 years; range, 44-89 years), predominantly female (53 of 80 patients), predominantly low risk (97 of 115 angiograms were performed on patients with Society for Vascular Surgery and the American Association for Vascular Surgery Medical Comorbidity Score <2), with a mean body mass index of 25.9 kg/m2 (range, 14.1-50.6 kg/m2; standard deviation, 6 kg/m2). The overall incidence of 30D A/Es was 6.1% (7 of 115), with a 5.2% 30D rate of morbidity (6 of 115), and 0.9% 30D rate of mortality (1 of 115). Six of seven cases with 30D A/Es were CD grade 3 or greater. An univariable comparison of mesenteric angiograms resulting in a 30D A/E with those without demonstrated no significant differences in mean age, race distribution, mean body mass index, preoperative Society for Vascular Surgery/American Association for Vascular Surgery Medical Comorbidity Score, smoking history, history of malignancy, use of antithrombotic medications, history of prior mesenteric stents, or whether the procedure was performed for reintervention. On multivariable regression, technical failure was a significant predictor for complications CD 3 or greater (odds ratio, 6.36; 95% confidence interval, 1.1-37.4; P = .04) when correcting for interoperator variability.

Conclusions

Variable complexity mesenteric angiography for primary and repeat intervention is safely performed at an OBL on selected low- and moderate-risk patients. Further study of anatomic and patient selection factors predicting technical failure is required.
目的血管护理和干预已经从住院到门诊有了显著的转变。在2008年医疗保险和医疗补助服务中心对门诊血管干预进行付款人报销修改后,办公室实验室(OBL)越来越多地采用治疗模式。关于这一现象的报告主要集中在经济影响上,缺乏与这种治疗环境相关的安全性和结果数据。在这项研究中,我们检查了选择性肠系膜血管造影在OBL进行的治疗结果,以及影响患者选择安全门诊干预的因素。方法回顾性分析9年来在单一OBL行诊断性或介入性肠系膜血管造影治疗的成年患者。从门诊和住院病历中提取患者和治疗变量。主要研究结果是Clavien-Dindo (CD)分类系统报告的30天不良事件(30D A/E)。技术上的成功是次要的结果。结果2015年9月至2024年2月,7位血管外科医生对80例患者进行了115次肠系膜造影。患者平均年龄73岁(标准差:9.3岁;范围:44-89岁),以女性为主(80例患者中53例),以低危为主(115例血管造影患者中有97例接受血管外科学会和美国血管外科协会医学共病评分<;2),平均体重指数25.9 kg/m2(范围:14.1-50.6 kg/m2;标准差:6 kg/m2)。30D A/ e总发病率为6.1% (7 / 115),30D发病率为5.2% (6 / 115),30D死亡率为0.9%(1 / 115)。7例30D A/ e中有6例为CD 3级或以上。单变量比较导致30D a /E的肠系膜血管造影与没有30D a /E的肠系膜血管造影在平均年龄、种族分布、平均体重指数、术前血管外科学会/美国血管外科协会医学合并症评分、吸烟史、恶性肿瘤史、抗血栓药物的使用、既往肠系膜支架史或手术是否为再干预方面没有显著差异。在多变量回归中,当校正操作者间的可变性时,技术故障是并发症CD 3或以上的显著预测因子(优势比6.36;95%置信区间1.1-37.4;P = 0.04)。结论可变复杂性肠系膜血管造影用于初次和重复干预是安全的,可在OBL对选定的中低风险患者进行。需要进一步研究预测技术失败的解剖和患者选择因素。
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引用次数: 0
Robot-assisted carotid stenting: Precision, ergonomics, and the next frontier in vascular surgery 机器人辅助颈动脉支架置入术:精确性、人体工程学和血管外科的下一个前沿
Pub Date : 2026-01-01 DOI: 10.1016/j.jvsvi.2025.100346
Clark J. Zeebregts MD, PhD , Emiel W.M. Huistra MD , Tomas Baltrunas MD, PhD , Alan B. Lumsden MD
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引用次数: 0
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JVS-vascular insights
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