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Contemporary outcomes after endoscopic vein harvesting for lower extremity bypass in a multicenter subspecialty practice 多中心亚专科实践中下肢搭桥术的内窥镜静脉采集术后的当代成果
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100132

Background

Endoscopic vein harvesting (EVH) is considered the standard of care for coronary bypass procedures given the lower early morbidity from surgical wound complications. However, the use of EVH for lower extremity (LE) bypass remains controversial owing to concerns about decreased graft patency. In 2022, the BEST-CLI Trial (Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia) demonstrated patients undergoing surgical bypass with adequate great saphenous vein quality experienced a lower incidence of major adverse limb events and mortality than those who underwent endovascular repair. Despite these results, wound complications from large harvest site incisions remain a significant barrier preventing surgical bypass as being the preferred initial treatment. To mitigate wound complications, our practice has adopted EVH as the standard approach for harvesting bypass conduit. Here, we report our recent 5-year experience using EVH for LE bypass.

Methods

One hundred sixty-eight LE bypasses with EVH were evaluated from 2017 to 2022. The cohort included 14 vascular surgeons in 8 hospitals. The primary end point was 30-day surgical wound complications. Secondary end points included bypass patency, need for major amputation, 30-day morbidity and mortality, length of operation, and length of hospitalization. Wound complications were measured using Szilagyi's method, with class I characterized by erythema necessitating antibiotics, class II having drainage or superficial dehiscence, and class III threatening graft integrity and requiring surgical intervention.

Results

A total of 168 LE bypasses with EVH were performed on 166 patients. Of these, 65.48% were male with a median age of 68.4 ± 9.7 years. There were no wound complications related to saphenectomy. Surgical site infections occurred in 22 patients (13.10%). Seven patients (4.17%) had class I complications, 12 (7.14%) had class II complications, and 3 (1.79%) had class III complications. Primary patency at 30 days was 96.10% and 86.84% at 1 year). Seven patients (4.17%) required major amputation at 30 days. The 1-year amputation-free survival was 89.39%. The 30-day postoperative stroke, myocardial infarction, and death rates were 0.60%, 0.60%, and 2.38%, respectively. The median operative time was 3.30 ± 1.18 hours. The median length of hospitalization was 3.00 ± 3.56 days.

Conclusions

EVH minimizes saphenectomy wound complications without compromising patency and limb salvage rates. Older studies suggesting lower patency rates after EVH may have been limited by older technology and inexperienced operators. Whether EVH should be the standard of care for LE bypass warrants further investigation.

背景由于手术伤口并发症导致的早期发病率较低,内镜下静脉采集术(EVH)被认为是冠状动脉搭桥术的标准治疗方法。然而,由于担心移植物通畅性下降,EVH用于下肢(LE)搭桥术仍存在争议。2022 年,BEST-CLI 试验(重症肢体缺血患者最佳血管内治疗与最佳外科治疗)表明,在大隐静脉质量足够好的情况下接受外科搭桥术的患者与接受血管内修复术的患者相比,肢体重大不良事件的发生率和死亡率更低。尽管取得了这些结果,但大面积采集部位切口造成的伤口并发症仍是阻碍手术搭桥成为首选初始治疗方法的重要障碍。为了减少伤口并发症,我们采用 EVH 作为采集旁路导管的标准方法。在此,我们报告了最近5年使用EVH进行LE旁路手术的经验。方法从2017年到2022年,我们对168例使用EVH的LE旁路手术进行了评估。队列包括 8 家医院的 14 名血管外科医生。主要终点是 30 天手术伤口并发症。次要终点包括旁路通畅率、大截肢需求、30 天发病率和死亡率、手术时间和住院时间。伤口并发症采用 Szilagyi 方法进行测量,I 级为红斑,需要使用抗生素;II 级为引流或浅表裂开;III 级为威胁移植物完整性,需要手术干预。其中 65.48% 为男性,中位年龄为 68.4 ± 9.7 岁。没有出现与套管切除术相关的伤口并发症。22名患者(13.10%)发生了手术部位感染。7名患者(4.17%)出现一级并发症,12名患者(7.14%)出现二级并发症,3名患者(1.79%)出现三级并发症。30天的初次通畅率为96.10%,1年的初次通畅率为86.84%)。7名患者(4.17%)在30天内需要进行大截肢手术。1年无截肢生存率为89.39%。术后 30 天的中风、心肌梗死和死亡率分别为 0.60%、0.60% 和 2.38%。中位手术时间为(3.30 ± 1.18)小时。结论EVH最大程度地减少了鞘膜切除术伤口并发症,同时不影响通畅率和肢体挽救率。较早的研究表明,EVH术后的通畅率较低,这可能是受到较早的技术和缺乏经验的操作者的限制。EVH是否应该成为LE搭桥术的标准护理方法还需要进一步研究。
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引用次数: 0
Nonstenotic symptomatic internal carotid artery plaques: Epidemiology, pathophysiology, and treatment 无症状颈内动脉斑块:流行病学、病理生理学和治疗
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100121

Objective

Traditional views on carotid artery atherosclerosis have largely focused on the degree of stenosis as a predictor for embolic stroke. However, recent evidence highlights the significance of nonstenotic, vulnerable plaques in stroke pathophysiology. This article synthesizes current knowledge on the epidemiology, pathophysiology, and potential treatments of nonstenotic carotid plaques.

Methods

Google Scholar, PubMed, and Scopus were used to search for articles regarding “nonstenotic carotid plaques,” “embolic stroke of unknown source,” “cryptogenic stroke,” and “high-risk carotid imaging findings.” Here we conduct a narrative review of recent literature, focusing on studies published over the past decade, to understand the role of nonstenotic carotid plaques in ischemic strokes, particularly those classified as embolic strokes of unknown source. We present a representative case demonstrating these features.

Results

Nonstenotic plaques are increasingly recognized in patients with embolic strokes of unknown source, with vulnerable characteristics more prevalent on the symptomatic side. There is a higher risk of recurrent stroke in patients with these plaques, prompting reconsideration of therapeutic approaches, including the potential usefulness of carotid endarterectomy and stenting in certain cases.

Conclusions

The growing body of evidence on nonstenotic carotid plaques challenges existing paradigms in stroke management.

目的关于颈动脉粥样硬化的传统观点主要集中在将狭窄程度作为栓塞性中风的预测指标。然而,最近的证据强调了非狭窄、易损斑块在中风病理生理学中的重要性。本文综述了目前关于非狭窄性颈动脉斑块的流行病学、病理生理学和潜在治疗方法的知识。方法使用谷歌学术、PubMed 和 Scopus 搜索有关 "非狭窄性颈动脉斑块"、"来源不明的栓塞性卒中"、"隐源性卒中 "和 "高风险颈动脉成像结果 "的文章。在此,我们对最近的文献进行了叙述性回顾,重点关注过去十年间发表的研究,以了解非硬化性颈动脉斑块在缺血性脑卒中中的作用,尤其是那些被归类为来源不明的栓塞性脑卒中。结果在来源不明的栓塞性脑卒中患者中,非硬化性斑块越来越多地被发现,其易损特征在有症状的一侧更为普遍。非硬化性颈动脉斑块患者复发中风的风险较高,这促使人们重新考虑治疗方法,包括颈动脉内膜切除术和支架植入术在某些病例中的潜在作用。
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引用次数: 0
The past, present, and future of feedback in medical education 医学教育反馈的过去、现在和未来
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100116
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引用次数: 0
Adapting to declining open surgical volume in vascular surgery 适应血管外科开放手术量的下降
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100122
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引用次数: 0
Promoting diversity and inclusion in vascular surgery science: challenges and opportunities 促进血管外科科学的多样性和包容性:挑战与机遇
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100127

Lack of diversity in biomedical science and clinical medicine is well documented but persists even despite evidence to suggest that scientific discovery, generalizability of treatments, access to equitable health care, and clinical outcomes are limited without a diverse workforce. The science, technology, engineering, and mathematics workforce is severely under-represented in terms of females, under-represented minorities, and people with disabilities. Common barriers to entering science and medical fields include lack of mentorship, overt discrimination, compensation differences, and lack of early exposure. However, the lack of diversity does not end with the workforce and persists within clinical trials and databases leading to differences in health care accessibility and outcomes. Although there have been strides taken over the past several decades in improving diversity among medicine, research, and specifically vascular surgery science, the work is clearly not yet done. By increasing awareness of the problem of lack of diversity within vascular surgery, the future is bright regarding not only the vascular surgery workforce but also the patients treated within the health care system.

生物医学科学和临床医学缺乏多样性是有据可查的,尽管有证据表明,如果没有一支多元化的劳动力队伍,科学发现、治疗方法的可推广性、获得公平医疗保健的机会以及临床结果都会受到限制,但这一问题依然存在。在科学、技术、工程和数学人才队伍中,女性、代表性不足的少数民族和残疾人的比例严重不足。进入科学和医学领域的常见障碍包括缺乏导师指导、公开歧视、报酬差异以及缺乏早期接触。然而,缺乏多样性并不局限于劳动力,在临床试验和数据库中依然存在,这导致了医疗服务的可及性和结果的差异。尽管过去几十年来,医学、研究,特别是血管外科科学在提高多样性方面取得了长足进步,但这项工作显然还没有完成。通过提高人们对血管外科缺乏多样性问题的认识,不仅血管外科人才队伍,而且在医疗保健系统中接受治疗的患者都将拥有光明的未来。
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引用次数: 0
Relationship of work bullying and burnout among vascular surgeons 血管外科医生工作欺凌与职业倦怠的关系
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100106

Background

Burnout affects the quality of patient care by increasing the probability of medical errors and decreasing patient satisfaction. An environmental approach has been implemented to address burnout, recognizing that burnout can be triggered by conditions in the workplace, particularly when work bullying occurs repeatedly over an extended period of time and undermines an individual’s character, integrity, or dignity. Multiple studies have examined the prevalence of burnout among vascular surgeons, with estimates ranging from 34% to 41%. However, work bullying has not been studied as a cause of burnout. This study aimed to determine the relationship between work bullying and increased burnout rates among Mexican vascular surgeons.

Methods

This study consisted of a survey of Mexican vascular surgeons currently in practice. The Maslach Burnout Inventory was used to assess burnout, and the modified Leymann Inventory of Psychological Terrorism-60 was used to assess work bullying tactics. The study additionally aimed to identify vulnerable groups that are more susceptible to burnout, such as gender, age, working long hours, and type of practice, in order to determine if they are equally affected by work bullying.

Results

Burnout symptoms were found in 41% of the 142 completed surveys examined, with emotional exhaustion being the most common component. Positive work bullying strategies affected 32% of the population. The study demonstrated a strong association between burnout and work bullying, with work bullying victims having a greater risk of developing burnout (odds ratio = 2.9; 95% confidence interval [1.41; 5.98]; P < .01). In addition, female gender, younger generation, working more than 60 hours per week, and practicing in the public sector were also related to a greater prevalence of burnout and work bullying.

Conclusions

This study found a significant correlation between burnout and work bullying among Mexican vascular surgeons. These findings suggest that preventative measures against work bullying may reduce the incidence of burnout among this population.

背景职业倦怠会增加医疗失误的概率并降低患者满意度,从而影响患者护理的质量。由于认识到工作场所的条件可能会引发职业倦怠,尤其是当工作欺凌在较长时间内反复发生,并损害个人的人格、正直或尊严时,人们开始采用环境方法来解决职业倦怠问题。多项研究对血管外科医生的职业倦怠发生率进行了调查,估计发生率在 34% 到 41% 之间。然而,尚未将工作欺凌作为职业倦怠的原因进行研究。本研究旨在确定工作欺凌与墨西哥血管外科医生倦怠率增加之间的关系。马斯拉赫职业倦怠量表用于评估职业倦怠,改良的莱曼心理恐怖量表-60用于评估工作欺凌策略。该研究还旨在确定更容易出现职业倦怠的弱势群体,如性别、年龄、工作时间长、执业类型等,以确定他们是否同样受到工作欺凌的影响。积极的工作欺凌策略影响了 32% 的人群。研究表明,职业倦怠与工作欺凌之间存在密切联系,工作欺凌受害者出现职业倦怠的风险更高(几率比 = 2.9;95% 置信区间 [1.41; 5.98];P < .01)。此外,女性性别、年轻一代、每周工作超过 60 小时以及在公共部门执业也与职业倦怠和工作欺凌的发生率较高有关。结论这项研究发现,墨西哥血管外科医生的职业倦怠和工作欺凌之间存在显著相关性。这些研究结果表明,针对工作欺凌的预防措施可能会降低这一人群的职业倦怠发生率。
{"title":"Relationship of work bullying and burnout among vascular surgeons","authors":"","doi":"10.1016/j.jvsvi.2024.100106","DOIUrl":"10.1016/j.jvsvi.2024.100106","url":null,"abstract":"<div><h3>Background</h3><p>Burnout affects the quality of patient care by increasing the probability of medical errors and decreasing patient satisfaction. An environmental approach has been implemented to address burnout, recognizing that burnout can be triggered by conditions in the workplace, particularly when work bullying occurs repeatedly over an extended period of time and undermines an individual’s character, integrity, or dignity. Multiple studies have examined the prevalence of burnout among vascular surgeons, with estimates ranging from 34% to 41%. However, work bullying has not been studied as a cause of burnout. This study aimed to determine the relationship between work bullying and increased burnout rates among Mexican vascular surgeons.</p></div><div><h3>Methods</h3><p>This study consisted of a survey of Mexican vascular surgeons currently in practice. The Maslach Burnout Inventory was used to assess burnout, and the modified Leymann Inventory of Psychological Terrorism-60 was used to assess work bullying tactics. The study additionally aimed to identify vulnerable groups that are more susceptible to burnout, such as gender, age, working long hours, and type of practice, in order to determine if they are equally affected by work bullying.</p></div><div><h3>Results</h3><p>Burnout symptoms were found in 41% of the 142 completed surveys examined, with emotional exhaustion being the most common component. Positive work bullying strategies affected 32% of the population. The study demonstrated a strong association between burnout and work bullying, with work bullying victims having a greater risk of developing burnout (odds ratio = 2.9; 95% confidence interval [1.41; 5.98]; <em>P</em> &lt; .01). In addition, female gender, younger generation, working more than 60 hours per week, and practicing in the public sector were also related to a greater prevalence of burnout and work bullying.</p></div><div><h3>Conclusions</h3><p>This study found a significant correlation between burnout and work bullying among Mexican vascular surgeons. These findings suggest that preventative measures against work bullying may reduce the incidence of burnout among this population.</p></div>","PeriodicalId":74034,"journal":{"name":"JVS-vascular insights","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949912724000540/pdfft?md5=a18cd2d712f807cae8e1f68bf5122a78&pid=1-s2.0-S2949912724000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appraising and finding the right practice model in vascular surgery for a first or subsequent position 评估并找到合适的血管外科实践模式,担任第一或第二职位
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100099
Becoming a vascular surgeon is a long and well-defined process that results in the formation of a capable and competent surgeon that cares for patients with vascular disease in different practice settings. However, the process to find that first job or when considering a job change is not formally discussed. The aim of this paper is to provide the surgeon with a comprehensive framework to help define the ideal position, know what factors to assess, and how to go through the process from application to contract negotiation, to starting the job. Finally, if the surgeon is considering a change, this same framework can be applied, and additional considerations are also discussed.
成为一名血管外科医生是一个漫长而明确的过程,其结果是培养出一名有能力、称职的外科医生,在不同的执业环境中为血管疾病患者提供护理。然而,寻找第一份工作或考虑更换工作的过程却没有得到正式讨论。本文旨在为外科医生提供一个全面的框架,帮助他们确定理想的职位,了解需要评估的因素,以及如何完成从申请到合同谈判再到开始工作的整个过程。最后,如果外科医生正在考虑换岗,也可以采用同样的框架,同时还讨论了其他注意事项。
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引用次数: 0
A narrative review of intraoperative adjuncts and techniques to minimize radiation during complex endovascular aneurysm repair 在复杂的血管内动脉瘤修补术中尽量减少辐射的术中辅助工具和技术的叙述性回顾。
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100058
Mira T. Tanenbaum MD, Andres V. Figueroa MD, Jose Eduardo Costa Filho MD, Marilisa S. Gonzalez MD, Mirza S. Baig MD, Melissa L. Kirkwood MD, Carlos H. Timaran MD

Background

Radiation exposure is a known risk to both patients and providers during endovascular aortic aneurysm repair (EVAR). Complex EVAR procedures, such as fenestrated and branched EVAR, inherently involve longer fluoroscopy times and increased radiation doses. While adhering to the as low as reasonably achievable principles and ensuring appropriate personal protective equipment for all operating room staff remains essential, the use of intraoperative techniques and adjuncts to decrease radiation specifically during complex EVAR is necessary. This review aims to summarize intraoperative radiation reduction techniques to provide valuable insights to vascular surgeons and interventional proceduralists to enhance radiation safety during complex EVAR.

Methods

This review focused on intraoperative techniques and adjuncts that have been used to decrease intraoperative radiation exposure to patients and operators. Published and presented preclinical results, prospective and retrospective study data, and future directions are presented.

Results

We highlight several intraoperative adjuncts and techniques for reducing radiation exposure during complex EVAR including image fusion, digital zooming, intravascular ultrasound examination, Fiber Optic RealShape (FORS) technology, and robotic navigation systems. Short-term outcomes suggest that these techniques are safe, feasible, and effective and decrease radiation exposure to both patients and operators.

Conclusions

Decreasing radiation exposure during complex EVAR remains of critical importance. The presented techniques offer promising avenues for significantly decreasing radiation exposure to both patients and providers while maintaining procedural efficacy during complex EVAR.

背景在血管内主动脉瘤修补术(EVAR)中,辐射暴露对患者和医疗人员都是一个已知的风险。复杂的 EVAR 手术(如栅栏式和分支式 EVAR)本身需要更长的透视时间和更大的辐射剂量。尽管遵守 "尽可能低 "的原则并确保手术室所有工作人员都有适当的个人防护设备仍然至关重要,但在复杂的 EVAR 手术中使用术中技术和辅助设备来减少辐射也是必要的。本综述旨在总结术中减少辐射的技术,为血管外科医生和介入手术医生提供有价值的见解,以提高复杂EVAR术中的辐射安全。结果我们重点介绍了几种减少复杂EVAR术中辐射暴露的术中辅助手段和技术,包括图像融合、数字缩放、血管内超声检查、光纤实形(FORS)技术和机器人导航系统。短期结果表明,这些技术安全、可行、有效,可减少患者和操作者的辐射暴露。所介绍的技术为在复杂 EVAR 中保持手术疗效的同时大幅减少患者和术者的辐射暴露提供了很好的途径。
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引用次数: 0
Validating a 3D-printed endovascular simulator for use in training surgical residents 验证用于培训外科住院医生的 3D 打印血管内模拟器
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100069
Paarth Jain BS , Jeremy Zack BS , Lauren E. Schlegel MD , Eva Varotsis BS , Robert Pugliese PharmD , Michael Nooromid MD , Babak Abai MD

Objective

Three-dimensional (3D)-printed endovascular models can be an accessible alternative to expensive, state-of-the-art endovascular simulators but currently lack the rigorous validation needed to be dependable educational tools. This study describes the manufacture of a 3D-printed endovascular model of an aorta and determines the construct validity and preliminary content and face validity of the model.

Methods

A 3D-printed aorta was created using segmented data from a patient computerized tomography scan and a FormLabs 3B 3D printer with FormLabs Clear resin. Participants were asked to perform two tasks from a femoral access point: catheterize the contralateral common iliac artery and the superior mesenteric artery. Participants were assessed for task completion, technique, and time. Performance was compared between levels of education (medical student vs lower-year resident vs upper-year resident vs attending) and levels of endovascular experience (<5 procedures vs 6-20 procedures vs 21-100 procedures vs >100 procedures). Users completed questionnaires assessing the face and content validity of the simulator after their participation.

Results

48 participants were recruited (12 medical students, 19 lower-year residents, 13 upper-year residents, and 4 attendings). Of these, 26 participants had performed <5 procedures, 10 had performed 6 to 20 procedures, 7 had performed 21 to 100 procedures, and 5 had performed >100 real-world procedures. Neither education level nor experience level correlated with task completion. Increasing levels of training progressively increased rates of correct technique for both tasks combined (8% vs 21% vs 46% vs 75%, P = .032) and decreased cumulative time (307.3 vs 252.2 vs 185.8 vs 139 seconds, P = .005). Similarly, increased levels of experience progressively increased rates of correct technique for both tasks combined (7% vs 50% vs 71% vs 80%, for increasingly experienced groups, P < .001) and decreased cumulative completion times (276 vs 237 vs 187 vs 113 seconds, P = .003) for both tasks. Multivariate analysis showed that training level was not a predictor for time taken to complete any task, while experience level was a predictor for superior mesenteric artery cannulation time (P < .02). Participants rated the model as having somewhat realistic haptics, dissimilar “look and feel” to the operating room, and strongly believed that the model was valuable for practicing endovascular surgery.

Conclusions

These findings verify the construct validity of this endovascular simulator, as those with the most real-world experience used a correct technique more often and completed the tasks the fastest. Survey results supported the content validity of the model. Basic 3D-printed endovascular models should be considered as an affordable, readily accessible adjunct to su

目的三维(3D)打印的血管内模型可以替代昂贵的、最先进的血管内模拟器,但目前缺乏成为可靠的教育工具所需的严格验证。本研究描述了主动脉三维打印血管内模型的制作过程,并确定了模型的结构效度、初步内容效度和表面效度。方法利用患者计算机断层扫描的分段数据和使用 FormLabs Clear 树脂的 FormLabs 3B 三维打印机制作了主动脉三维打印模型。要求参与者从股骨入路点完成两项任务:导管插入对侧髂总动脉和肠系膜上动脉。对参与者的任务完成情况、技术和时间进行评估。对不同教育水平(医学生 vs 低年级住院医师 vs 高年级住院医师 vs 主治医师)和血管内治疗经验水平(5 例手术 vs 6-20 例手术 vs 21-100 例手术 vs 100 例手术)之间的表现进行了比较。结果共招募了 48 名参与者(12 名医学生、19 名低年级住院医师、13 名高年级住院医师和 4 名主治医师)。其中,26 人进行过 5 次手术,10 人进行过 6 至 20 次手术,7 人进行过 21 至 100 次手术,5 人进行过 100 次实际手术。教育水平和经验水平都与任务完成情况无关。培训水平的提高会逐渐增加两项任务的技术正确率(8% vs 21% vs 46% vs 75%,P = .032),并减少累计时间(307.3 vs 252.2 vs 185.8 vs 139 秒,P = .005)。同样,经验水平的提高会逐渐增加两项任务的技术正确率(经验越丰富的组别,正确率越高,分别为 7% vs 50% vs 71% vs 80%,P = 0.001),并减少两项任务的累计完成时间(276 vs 237 vs 187 vs 113 秒,P = 0.003)。多变量分析表明,培训水平并不能预测完成任何任务所需的时间,而经验水平则能预测肠系膜上动脉插管时间(P < .02)。参与者认为该模型的触觉有些逼真,"外观和感觉 "与手术室不同,并坚信该模型对练习血管内手术很有价值。调查结果支持了模型的内容效度。基本的 3D 打印血管内模型应被视为一种经济实惠、易于获取的外科教育辅助工具。
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引用次数: 0
Representation of female vascular surgeons in national clinical trial leadership: analysis of trends over 20 years 女血管外科医生在国家临床试验领导层中的代表性:20 年来的趋势分析
Pub Date : 2024-01-01 DOI: 10.1016/j.jvsvi.2024.100077
Valentyna Kostiuk BA , Carly Thaxton MD , Sarah A. Loh MD, MS , Jonathan A. Cardella MD , Alan Dardik MD, PhD , Britt H. Tonnessen MD

Female vascular surgeons constitute 15% of the workforce. Despite an increased pipeline of female vascular surgeons, representation in leadership positions nationally has not maintained pace. We hypothesized that female vascular surgeons are underrepresented as leaders of clinical trials in the United States for several vascular conditions germane to our specialty. Clinical trials registered in the United States were reviewed using the ClinicalTrials.gov website for several index vascular conditions: abdominal aortic aneurysm, carotid artery disease, hemodialysis access, venous thrombectomy and stenting, and peripheral arterial disease. The specialty and presenting gender of national and site principal investigators were recorded. The gender distribution was compared for trials led by vascular surgeons and nonvascular surgeon physicians. A subgroup analysis was performed for solo and group investigators, intervention types, sponsorship sources, and professional affiliation. Temporal trends were examined to evaluate the relationship between the duration of board certification and clinical trial leadership involvement. For all conditions, female vascular surgeons represent 10.3% and 7.8% of national and site principal investigators, respectively. A significantly lower proportion of female investigators were included in national vascular surgeon-led trials compared with nonvascular surgeon-led trials (10.3% vs 19.9%; P = .006). However, site investigators had a lower, but similar, proportion of women in both groups (7.8% vs 7.9%; P = .89). A significantly lower proportion of female vascular surgeons led clinical trials focused on interventions vs noninterventions (6% vs 11%; P = .02). There was a trend toward fewer female vascular surgeons conducting industry-sponsored trials for group (8% vs 11%; P = .3) and solo (5% vs 12%; P = .1) investigator-led trials. A similar proportion of female investigators had both academic and nonacademic affiliations (15% vs 16%; P = .83). Of 109 individual vascular surgeon investigators who were board certified between 1983 and 2003, 6 were women (5.5%) compared with 24 women (28.6%) of 84 investigators who had received board certification between 2004 and 2023. Finally, female vascular surgeon investigators started leading clinical trials sooner after board certification compared with male investigators (mean, 5.5 years vs 10.9 years; P = .0009). The representation of female leaders in vascular clinical trials lags behind that of male leaders, although this trend has improved over time. However, a percentage of women in vascular surgery are successful in leading clinical trials early in their career, suggesting the importance of strong sponsorship and allyship. Furthermore, it is a call to action to our leaders and our industry partners to “lift the curtain” on the pathway to clinical trial leadership.

女性血管外科医生占从业人员总数的 15%。尽管女性血管外科医生的人数在不断增加,但在全国范围内担任领导职务的人数却没有跟上步伐。我们假设,在美国,女性血管外科医生在与本专业相关的几种血管疾病的临床试验中担任领导职务的人数不足。我们使用ClinicalTrials.gov网站对在美国注册的临床试验进行了审查,这些临床试验涉及几种指数血管疾病:腹主动脉瘤、颈动脉疾病、血液透析通路、静脉血栓切除术和支架植入术以及外周动脉疾病。记录了国家和研究机构主要研究人员的专业和性别。比较了由血管外科医生和非血管外科医生领导的试验的性别分布情况。对单独和集体研究者、干预类型、赞助来源和专业隶属关系进行了分组分析。对时间趋势进行了研究,以评估获得委员会认证的时间与参与临床试验领导工作之间的关系。在所有情况下,女性血管外科医生分别占全国和研究机构主要研究者的 10.3% 和 7.8%。与非血管外科医生领导的试验相比,女性研究者参与国家血管外科医生领导的试验的比例明显较低(10.3% vs 19.9%;P = .006)。然而,在两组试验中,现场研究人员中女性所占比例较低,但相近(7.8% vs 7.9%; P = .89)。女性血管外科医生领导的干预性临床试验与非干预性临床试验的比例明显较低(6% vs 11%; P = .02)。在研究者领导的集体试验(8% vs 11%;P = .3)和单独试验(5% vs 12%;P = .1)中,开展行业赞助试验的女性血管外科医生呈减少趋势。同时拥有学术和非学术背景的女性研究者比例相似(15% vs 16%; P = .83)。在1983年至2003年间获得委员会认证的109名血管外科医生研究人员中,有6名女性(5.5%),而在2004年至2023年间获得委员会认证的84名研究人员中,有24名女性(28.6%)。最后,与男性研究人员相比,女性血管外科医生研究人员在获得委员会认证后更早开始领导临床试验(平均 5.5 年 vs 10.9 年;P = 0.0009)。女性领导者在血管临床试验中的代表性落后于男性领导者,尽管随着时间的推移,这一趋势有所改善。不过,在血管外科领域,有一定比例的女性在其职业生涯早期就成功领导了临床试验,这表明强有力的赞助和同盟关系非常重要。此外,该报告还呼吁我们的领导者和行业合作伙伴采取行动,"揭开 "通往临床试验领导者之路的 "帷幕"。
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JVS-vascular insights
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