JVS-vascular science最新文献

{"title":"Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling","authors":"Calvin Chao MD ,&nbsp;Caitlyn Dang BS ,&nbsp;Nidhi Reddy BA ,&nbsp;Sara Alharbi MS ,&nbsp;Jimmy Doan ,&nbsp;Akashraj Karthikeyan ,&nbsp;Brandon Applewhite PhD ,&nbsp;Bin Jiang PhD","doi":"10.1016/j.jvssci.2024.100202","DOIUrl":"10.1016/j.jvssci.2024.100202","url":null,"abstract":"<div><h3>Objective</h3><p>Sympathetic innervation plays a pivotal role in regulating cardiovascular health, and its dysregulation is implicated in a wide spectrum of cardiovascular diseases. This study seeks to evaluate the impact of denervation of the abdominal aorta on its morphology and wall homeostasis.</p></div><div><h3>Methods</h3><p>Male and female Sprague-Dawley rats (N = 12), aged 3 months, underwent midline laparotomy for infrarenal aorta exposure. Chemical denervation was induced via a one-time topical application of 10% phenol (n = 6), whereas sham controls received phosphate-buffered saline (n = 6). Animals were allowed to recover and subsequently were sacrificed after 6 months for analysis encompassing morphology, histology, and immunohistochemistry.</p></div><div><h3>Results</h3><p>At 6 months post-treatment, abdominal aortas subjected to phenol denervation still exhibited a significant reduction in nerve fiber density compared with sham controls. Denervated aortas demonstrated reduced intima-media thickness, increased elastin fragmentation, decreased expression of vascular smooth muscle proteins (α-SMA and MYH11), and elevated adventitial vascular density. Sex-stratified analyses revealed additional dimorphic responses, particularly in aortic collagen and medial cellular density in female animals.</p></div><div><h3>Conclusions</h3><p>Single-timepoint phenol-based chemical denervation induces alterations in abdominal aortic morphology and vascular remodeling over a 6-month period. These findings underscore the potential of the sympathetic nervous system as a therapeutic target for aortic pathologies.</p></div><div><h3>Clinical Relevance</h3><p>Aortic remodeling remains an important consideration in the pathogenesis of aortic disease, including occlusive, aneurysmal, and dissection disease states. The paucity of medical therapies for the treatment of aortic disease has driven considerable interest in elucidating the pathogenesis of these conditions; new therapeutic targets are critically needed. Here, we show significant remodeling after phenol-induced denervation with morphologic, histologic, and immunohistochemical features. Future investigations should integrate sympathetic dysfunction as a potential driver of pathologic aortic wall changes with additional consideration of the sympathetic nervous system as a therapeutic target.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000130/pdfft?md5=a268668ec326d9c73541b8e91aa1791d&pid=1-s2.0-S2666350324000130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140401435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenascin-C in Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics","authors":"Luis Gonzalez,&nbsp;Weichang Zhang,&nbsp;Yuichi Ohashi,&nbsp;Roberto Vazquez-Padron,&nbsp;Alan Dardik","doi":"10.1016/j.jvssci.2024.100254","DOIUrl":"10.1016/j.jvssci.2024.100254","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Genetic and Lifestyle Risk Factors With Incident Peripheral Artery Disease: A Prospective Cohort Study","authors":"Shuai Yuan,&nbsp;Yuhao Sun,&nbsp;Jie Chen,&nbsp;Pranav Sharma,&nbsp;Michael G. Levin,&nbsp;Susanna Larsson,&nbsp;Scott M. Damrauer","doi":"10.1016/j.jvssci.2024.100258","DOIUrl":"10.1016/j.jvssci.2024.100258","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of the ETS Transcription Factor ERG Disrupts Fate-defining Programs in the Aortic Endothelium and Promotes Expansion of Endothelial Lineage Cells in Atherosclerotic Plaque","authors":"Steven R. Botts,&nbsp;Kristen Schulz,&nbsp;Corey A. Scipione,&nbsp;Sneha Raju,&nbsp;Leandro C. Breda,&nbsp;Kamalben Prajapati,&nbsp;Kai Yu,&nbsp;Aniqa Khan,&nbsp;Chanele K. Polenz,&nbsp;Sharon J. Hyduk,&nbsp;Joshua D. Wythe,&nbsp;Clint S. Robbins,&nbsp;Myron I. Cybulsky,&nbsp;Jason E. Fish,&nbsp;Kathryn L. Howe","doi":"10.1016/j.jvssci.2024.100239","DOIUrl":"10.1016/j.jvssci.2024.100239","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoleamine 2,3-dioxygenase-Mediated Tryptophan Catabolism Limits Experimental Abdominal Aortic Aneurysms","authors":"Baohui Xu,&nbsp;Gang Li,&nbsp;Hongping Deng,&nbsp;Yankui Li,&nbsp;Fanru Shen,&nbsp;Makoto Samura,&nbsp;Philip S. Tsao,&nbsp;Ronald L. Dalman","doi":"10.1016/j.jvssci.2024.100248","DOIUrl":"10.1016/j.jvssci.2024.100248","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Limb Revascularization With Synthetic Probiotics","authors":"John Vlahos,&nbsp;Molly Ratner,&nbsp;Tetsuhiro Harimoto,&nbsp;Ariadne Zias,&nbsp;Cristobal Rivera,&nbsp;Yogi Pratama,&nbsp;Karan Garg,&nbsp;Tal Danido,&nbsp;Bhama Ramkhelawon","doi":"10.1016/j.jvssci.2024.100231","DOIUrl":"10.1016/j.jvssci.2024.100231","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Bio-Hybrid Endovascular Stent-Graft That Enables Immunosuppression Free Islet Cell Transplantation","authors":"Brandon T. Gaston,&nbsp;Varun Singh,&nbsp;Anil Kharga,&nbsp;Kevin Deng,&nbsp;Kang Mi Lee,&nbsp;Marc Succi,&nbsp;Anahita Dua,&nbsp;James F. Markmann","doi":"10.1016/j.jvssci.2024.100264","DOIUrl":"10.1016/j.jvssci.2024.100264","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Forces Can Promote SGK-1-dependent Expression of Pathologic Matrix Markers","authors":"Christian Barksdale,&nbsp;Jonah Silverman,&nbsp;Ethan Fannin,&nbsp;Ryan Gedney,&nbsp;Victoria Mattia,&nbsp;Mario Figueroa,&nbsp;Ying Xiong,&nbsp;Rupak Mukherjee,&nbsp;Jeffrey A. Jones,&nbsp;Jean Marie Ruddy","doi":"10.1016/j.jvssci.2024.100255","DOIUrl":"10.1016/j.jvssci.2024.100255","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo-1 Expression Decreases Under Disturbed Flow Model of Femoral Atherosclerosis","authors":"Gloriani Sanchez,&nbsp;Fujie Zhao,&nbsp;Levi Wood,&nbsp;Luke P. Brewster","doi":"10.1016/j.jvssci.2024.100261","DOIUrl":"10.1016/j.jvssci.2024.100261","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecularly Fabricated Non-thrombogenic Small Diameter Vascular Graft","authors":"Nitisha Mehrotra,&nbsp;Aparna Adumbumkulath,&nbsp;Paul Kim,&nbsp;Suran Somawardana,&nbsp;Kirti Mhatre,&nbsp;Aladdein Mattar,&nbsp;Abdelmotagaly Elgalad,&nbsp;Nilson Salas,&nbsp;Ramyar Gilani,&nbsp;Crystal Shin,&nbsp;Ghanashyam Acharya,&nbsp;Pulickel M. Ajayan","doi":"10.1016/j.jvssci.2024.100267","DOIUrl":"10.1016/j.jvssci.2024.100267","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100267"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}