JVS-vascular science最新文献

英文中文

Indoleamine 2,3-dioxygenase-Mediated Tryptophan Catabolism Limits Experimental Abdominal Aortic Aneurysms

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100248

Baohui Xu, Gang Li, Hongping Deng, Yankui Li, Fanru Shen, Makoto Samura, Philip S. Tsao, Ronald L. Dalman

引用次数: 0

Harnessing Limb Revascularization With Synthetic Probiotics

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100231

John Vlahos, Molly Ratner, Tetsuhiro Harimoto, Ariadne Zias, Cristobal Rivera, Yogi Pratama, Karan Garg, Tal Danido, Bhama Ramkhelawon

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Tenascin-C in Arteriovenous Fistula Failure: Unraveling Venous Remodeling Dynamics

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100254

Luis Gonzalez, Weichang Zhang, Yuichi Ohashi, Roberto Vazquez-Padron, Alan Dardik

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Associations of Genetic and Lifestyle Risk Factors With Incident Peripheral Artery Disease: A Prospective Cohort Study

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100258

Shuai Yuan, Yuhao Sun, Jie Chen, Pranav Sharma, Michael G. Levin, Susanna Larsson, Scott M. Damrauer

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Loss of the ETS Transcription Factor ERG Disrupts Fate-defining Programs in the Aortic Endothelium and Promotes Expansion of Endothelial Lineage Cells in Atherosclerotic Plaque

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100239

Steven R. Botts, Kristen Schulz, Corey A. Scipione, Sneha Raju, Leandro C. Breda, Kamalben Prajapati, Kai Yu, Aniqa Khan, Chanele K. Polenz, Sharon J. Hyduk, Joshua D. Wythe, Clint S. Robbins, Myron I. Cybulsky, Jason E. Fish, Kathryn L. Howe

引用次数: 0

Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides 利用 CD31 域 1 和 2 拟态肽为血管内支架披上内皮外衣

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100213

Jean Sénémaud MD, PhD , Charles Skarbek PhD , Belen Hernandez PhD , Ran Song PhD , Isabelle Lefevre PhD , Elisabetta Bianchi PhD , Yves Castier MD, PhD , Antonino Nicoletti PhD , Christophe Bureau PhD , Giuseppina Caligiuri MD, PhD

Objective

Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.

Methods

Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry. Human aortic EC phenotype and endothelialization assessment using parallel scratch tests were carried out using five synthetic CD31 peptides coated on 4.8-mm nitinol and CoCr flat disks and were compared with control disks. The CD31 peptide exhibiting the best results in vitro was then immobilized on clinical-grade 3 × 40-mm self-expanding nitinol and 2.5 × 20.0-mm balloon-expandable CoCr stents. Such devices were implanted in native arteries of White New Zealand rabbits, and compared with control uncoated bare metal stents (BMS) and drug-eluting stents 7 and 30 days after implantation using resin cross-sections and scanning electron microscopy (n = 2-3 per group at each time point).

Results

Membrane-distal CD31 D1 and D2 peptides exhibited a distinct capability to foster a healthy endothelial phenotype and to promote endothelialization in vitro. By day 7 after implantation, CD31 nitinol and CoCr stents were evenly covered by wholesome ECs, devoid of thromboinflammatory signs, in contrast with both BMS and drug-eluting stents. Such results were consistent until day 30.

Conclusions

Membrane-distal CD31 biomimetic peptides seem to camouflage the device surface effectively, preventing local reactions and promoting rapid and seamless endovascular integration.

目的植入血管内装置会破坏静止内皮细胞（EC）、血小板和循环白细胞之间的CD31:CD31平衡相互作用。本研究的目的是利用合成的 CD31 肽设计一种镍钛诺和钴铬（CoCr）表面和支架的内皮模拟涂层，以促进装置的内皮化和在动脉壁内的和平整合。方法利用无铜点击化学，采用三步浸涂、贻贝启发方案合成了 CD31 的 1 (D1) 和 2 (D2) 域模拟肽，并将其固定在实验性镍钛诺和 CoCr 表面。使用涂布在 4.8 毫米镍钛诺和钴铬合金平盘上的五种合成 CD31 肽，通过平行划痕试验对人体主动脉 EC 表型和内皮化进行了评估，并与对照盘进行了比较。然后，将体外效果最好的 CD31 肽固定在临床级 3 × 40 毫米自膨胀镍钛诺和 2.5 × 20.0 毫米可球囊扩张钴铬合金支架上。将这些装置植入新西兰白兔的原生动脉，并在植入 7 天和 30 天后使用树脂横截面和扫描电子显微镜与对照组无涂层裸金属支架（BMS）和药物洗脱支架进行比较（每个时间点每组 2-3 例）。植入后第 7 天，CD31 硝基镍钛诺和钴铬合金支架被健康的内皮细胞均匀覆盖，没有血栓炎症迹象，与 BMS 和药物洗脱支架形成鲜明对比。结论膜远端 CD31 生物仿生肽似乎能有效伪装装置表面，防止局部反应，促进血管内快速无缝整合。

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引用次数: 0

In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study 使用初步微波传感器对颈动脉病变进行体外分析，以检测易损斑块。与组织学、双相 US 和 CT 扫描仪相关。IMPACT研究（颈动脉狭窄威胁的成像和微波表型评估）。

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100182

Rania Shahbaz PhD , Etienne Charpentier MD , Maharajah Ponnaiah PhD , Frédérique Deshours PhD , Hamid Kokabi PhD , Isabelle Brochériou MD, PhD , Gilles Le Naour PhD , Alban Redheuil MD, PhD , Fabien Koskas MD, PhD , Jean-Michel Davaine MD, PhD

Objective

Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions.

Methods

We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs).

Results

VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (<60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (P = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; P < .0001).

Conclusions

We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions.

目标最佳医疗方法的进步使得确定颈动脉手术最佳候选者变得更加困难。在这方面，新的诊断方法可能会有所帮助。微波（MW）可以量化生物组织的介电特性（复相对介电常数），因此微波技术已成为区分异常组织和健康组织的一个很有前途的研究领域。我们在此评估了本实验室开发的专用 MW 传感器识别颈动脉脆弱病变的能力。术前通过超声（US）检查和计算机断层扫描血管造影术对斑块进行分析和分类，术后使用超声波传感器进行检测。组织病理学分析被用作区分易损斑块（VPs）和非易损斑块（NVPs）的金标准。结果与NVPs相比，VPs更常见于2型或3型斑块（超声检查），具有更大比例的低（60 Hounsfield单位）和中（60-130 Hounsfield单位）衰减成分（计算机断层扫描血管造影），并显示出更高的介电常数值（MW），而NVPs的情况正好相反。与 VPs 相比，NVPs 更常见于无症状斑块（P = .035）。多变量分析显示，US 检查和 MW 识别 VP 的敏感性为 77%，特异性为 76%（临界值为 -0.045；曲线下面积为 0.848；P < .0001）。还需要进一步的研究来确定 MW 识别最危险的无症状颈动脉病变的潜力。

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引用次数: 0

Artificial intelligence: The magic 8 ball for vascular surgery 人工智能：血管外科的神奇 8 号球

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100197

Sharon C. Kiang MD, FACS

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Unveiling Sex-Based Differences in Plaque Histology in Patients With End-Stage Peripheral Arterial Disease

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100225

Madeline Drake, Fouzul Kansul, Judit Csore, Deborah Vela, Trisha Roy

引用次数: 0

Events of Interest

Q3 Medicine

JVS-vascular science

Pub Date : 2024-01-01 DOI: 10.1016/S2666-3503(24)00087-7

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