首页 > 最新文献

JVS-vascular science最新文献

英文 中文
Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides 利用 CD31 域 1 和 2 拟态肽为血管内支架披上内皮外衣
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100213
Jean Sénémaud MD, PhD , Charles Skarbek PhD , Belen Hernandez PhD , Ran Song PhD , Isabelle Lefevre PhD , Elisabetta Bianchi PhD , Yves Castier MD, PhD , Antonino Nicoletti PhD , Christophe Bureau PhD , Giuseppina Caligiuri MD, PhD

Objective

Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.

Methods

Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry. Human aortic EC phenotype and endothelialization assessment using parallel scratch tests were carried out using five synthetic CD31 peptides coated on 4.8-mm nitinol and CoCr flat disks and were compared with control disks. The CD31 peptide exhibiting the best results in vitro was then immobilized on clinical-grade 3 × 40-mm self-expanding nitinol and 2.5 × 20.0-mm balloon-expandable CoCr stents. Such devices were implanted in native arteries of White New Zealand rabbits, and compared with control uncoated bare metal stents (BMS) and drug-eluting stents 7 and 30 days after implantation using resin cross-sections and scanning electron microscopy (n = 2-3 per group at each time point).

Results

Membrane-distal CD31 D1 and D2 peptides exhibited a distinct capability to foster a healthy endothelial phenotype and to promote endothelialization in vitro. By day 7 after implantation, CD31 nitinol and CoCr stents were evenly covered by wholesome ECs, devoid of thromboinflammatory signs, in contrast with both BMS and drug-eluting stents. Such results were consistent until day 30.

Conclusions

Membrane-distal CD31 biomimetic peptides seem to camouflage the device surface effectively, preventing local reactions and promoting rapid and seamless endovascular integration.

目的植入血管内装置会破坏静止内皮细胞（EC）、血小板和循环白细胞之间的CD31:CD31平衡相互作用。本研究的目的是利用合成的 CD31 肽设计一种镍钛诺和钴铬（CoCr）表面和支架的内皮模拟涂层，以促进装置的内皮化和在动脉壁内的和平整合。方法利用无铜点击化学，采用三步浸涂、贻贝启发方案合成了 CD31 的 1 (D1) 和 2 (D2) 域模拟肽，并将其固定在实验性镍钛诺和 CoCr 表面。使用涂布在 4.8 毫米镍钛诺和钴铬合金平盘上的五种合成 CD31 肽，通过平行划痕试验对人体主动脉 EC 表型和内皮化进行了评估，并与对照盘进行了比较。然后，将体外效果最好的 CD31 肽固定在临床级 3 × 40 毫米自膨胀镍钛诺和 2.5 × 20.0 毫米可球囊扩张钴铬合金支架上。将这些装置植入新西兰白兔的原生动脉，并在植入 7 天和 30 天后使用树脂横截面和扫描电子显微镜与对照组无涂层裸金属支架（BMS）和药物洗脱支架进行比较（每个时间点每组 2-3 例）。植入后第 7 天，CD31 硝基镍钛诺和钴铬合金支架被健康的内皮细胞均匀覆盖，没有血栓炎症迹象，与 BMS 和药物洗脱支架形成鲜明对比。结论膜远端 CD31 生物仿生肽似乎能有效伪装装置表面，防止局部反应，促进血管内快速无缝整合。
{"title":"Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides","authors":"Jean Sénémaud MD, PhD ,&nbsp;Charles Skarbek PhD ,&nbsp;Belen Hernandez PhD ,&nbsp;Ran Song PhD ,&nbsp;Isabelle Lefevre PhD ,&nbsp;Elisabetta Bianchi PhD ,&nbsp;Yves Castier MD, PhD ,&nbsp;Antonino Nicoletti PhD ,&nbsp;Christophe Bureau PhD ,&nbsp;Giuseppina Caligiuri MD, PhD","doi":"10.1016/j.jvssci.2024.100213","DOIUrl":"10.1016/j.jvssci.2024.100213","url":null,"abstract":"<div><h3>Objective</h3><p>Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.</p></div><div><h3>Methods</h3><p>Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry. Human aortic EC phenotype and endothelialization assessment using parallel scratch tests were carried out using five synthetic CD31 peptides coated on 4.8-mm nitinol and CoCr flat disks and were compared with control disks. The CD31 peptide exhibiting the best results in vitro was then immobilized on clinical-grade 3 × 40-mm self-expanding nitinol and 2.5 × 20.0-mm balloon-expandable CoCr stents. Such devices were implanted in native arteries of White New Zealand rabbits, and compared with control uncoated bare metal stents (BMS) and drug-eluting stents 7 and 30 days after implantation using resin cross-sections and scanning electron microscopy (n = 2-3 per group at each time point).</p></div><div><h3>Results</h3><p>Membrane-distal CD31 D1 and D2 peptides exhibited a distinct capability to foster a healthy endothelial phenotype and to promote endothelialization in vitro. By day 7 after implantation, CD31 nitinol and CoCr stents were evenly covered by wholesome ECs, devoid of thromboinflammatory signs, in contrast with both BMS and drug-eluting stents. Such results were consistent until day 30.</p></div><div><h3>Conclusions</h3><p>Membrane-distal CD31 biomimetic peptides seem to camouflage the device surface effectively, preventing local reactions and promoting rapid and seamless endovascular integration.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000245/pdfft?md5=586568decde158b644a6988f3b5e2f40&pid=1-s2.0-S2666350324000245-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study 使用初步微波传感器对颈动脉病变进行体外分析，以检测易损斑块。与组织学、双相 US 和 CT 扫描仪相关。IMPACT研究（颈动脉狭窄威胁的成像和微波表型评估）。
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100182
Rania Shahbaz PhD , Etienne Charpentier MD , Maharajah Ponnaiah PhD , Frédérique Deshours PhD , Hamid Kokabi PhD , Isabelle Brochériou MD, PhD , Gilles Le Naour PhD , Alban Redheuil MD, PhD , Fabien Koskas MD, PhD , Jean-Michel Davaine MD, PhD

Objective

Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions.

Methods

We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs).

Results

VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (<60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (P = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; P < .0001).

Conclusions

We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions.

目标最佳医疗方法的进步使得确定颈动脉手术最佳候选者变得更加困难。在这方面，新的诊断方法可能会有所帮助。微波（MW）可以量化生物组织的介电特性（复相对介电常数），因此微波技术已成为区分异常组织和健康组织的一个很有前途的研究领域。我们在此评估了本实验室开发的专用 MW 传感器识别颈动脉脆弱病变的能力。术前通过超声（US）检查和计算机断层扫描血管造影术对斑块进行分析和分类，术后使用超声波传感器进行检测。组织病理学分析被用作区分易损斑块（VPs）和非易损斑块（NVPs）的金标准。结果与NVPs相比，VPs更常见于2型或3型斑块（超声检查），具有更大比例的低（60 Hounsfield单位）和中（60-130 Hounsfield单位）衰减成分（计算机断层扫描血管造影），并显示出更高的介电常数值（MW），而NVPs的情况正好相反。与 VPs 相比，NVPs 更常见于无症状斑块（P = .035）。多变量分析显示，US 检查和 MW 识别 VP 的敏感性为 77%，特异性为 76%（临界值为 -0.045；曲线下面积为 0.848；P < .0001）。还需要进一步的研究来确定 MW 识别最危险的无症状颈动脉病变的潜力。
{"title":"In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study","authors":"Rania Shahbaz PhD ,&nbsp;Etienne Charpentier MD ,&nbsp;Maharajah Ponnaiah PhD ,&nbsp;Frédérique Deshours PhD ,&nbsp;Hamid Kokabi PhD ,&nbsp;Isabelle Brochériou MD, PhD ,&nbsp;Gilles Le Naour PhD ,&nbsp;Alban Redheuil MD, PhD ,&nbsp;Fabien Koskas MD, PhD ,&nbsp;Jean-Michel Davaine MD, PhD","doi":"10.1016/j.jvssci.2023.100182","DOIUrl":"10.1016/j.jvssci.2023.100182","url":null,"abstract":"<div><h3>Objective</h3><p>Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions.</p></div><div><h3>Methods</h3><p>We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs).</p></div><div><h3>Results</h3><p>VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (&lt;60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (<em>P</em> = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; <em>P</em> &lt; .0001).</p></div><div><h3>Conclusions</h3><p>We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032300086X/pdfft?md5=afffd8fbb14ab1c4a89531bcf8ce250b&pid=1-s2.0-S266635032300086X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence: The magic 8 ball for vascular surgery 人工智能：血管外科的神奇 8 号球
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100197
Sharon C. Kiang MD, FACS
{"title":"Artificial intelligence: The magic 8 ball for vascular surgery","authors":"Sharon C. Kiang MD, FACS","doi":"10.1016/j.jvssci.2024.100197","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100197","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000087/pdfft?md5=506c99565c872936917c1c97d9bd2319&pid=1-s2.0-S2666350324000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair 针对患者的计算流模拟揭示了瓣膜和分支血管内动脉瘤修复术在主动脉瓣旁血流动力学方面的显著差异
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100183
Kenneth Tran MD , Celine Deslarzes-Dubuis MD , Sebastien DeGlise MD , Adrien Kaladji MD , Weiguang Yang PhD , Alison L. Marsden PhD , Jason T. Lee MD

Background

Endovascular aneurysm repair with four-vessel fenestrated endovascular aneurysm repair (fEVAR) or branched endovascular aneurysm repair (bEVAR) currently represent the forefront of minimally invasive complex aortic aneurysm repair. This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR.

Methods

Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. Patients in both cohorts were treated for paravisceral and extent II, II, and V thoracoabdominal aortic aneurysms. Three-dimensional finite element volume meshes were created from preoperative and postoperative computed tomography scans. Boundary conditions were adjusted for body surface area, heart rate, and blood pressure. Pulsatile flow simulations were performed with equivalent boundary conditions between preoperative and postoperative states. Postoperative changes in hemodynamic parameters were compared between the fEVAR and bEVAR groups.

Results

Patient-specific CFS was performed on 20 patients (10 bEVAR, 10 fEVAR) with a total of 80 target vessels (40 renal, 20 celiac, 20 superior mesenteric artery stents). bEVAR was associated with a decrease in renal artery peak flow rate (−5.2% vs +2.0%; P < .0001) and peak pressure (−3.4 vs +0.1%; P < .0001) compared with fEVAR. Almost all renal arteries treated with bEVAR had a reduction in renal artery perfusion (n = 19 [95%]), compared with 35% (n = 7) treated with fEVAR. There were no significant differences in celiac or superior mesenteric artery perfusion metrics (P = .10-.27) between groups. Time-averaged wall shear stress in the paravisceral aorta and branches also varied significantly depending on endograft configuration, with bEVAR associated with large postoperative increases in renal artery (+47.5 vs +13.5%; P = .002) and aortic time-averaged wall shear stress (+200.1% vs −31.3%; P = .001) compared with fEVAR. Streamline analysis revealed areas of hemodynamic abnormalities associated with branched renal grafts which adopt a U-shaped geometry, which may explain the observed differences in postoperative changes in renal perfusion between bEVAR and fEVAR.

Conclusions

bEVAR may be associated with subtle decreases in renal perfusion and a large increase in aortic wall shear stress compared with fEVAR. CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies.

Clinical Relevance

This study used patient-specific CFS to compare postoperative hemodynamic effects of four-vessel fenestrated endovascular aneurysm repair (fEVAR) and branched endovascular aneurysm repair

背景四血管腔内动脉瘤修补术（fEVAR）或分支血管腔内动脉瘤修补术（bEVAR）目前代表了微创复杂主动脉瘤修补术的前沿。本研究试图使用患者特异性计算流模拟（CFS）来评估 fEVAR 与 bEVAR 术后血流动力学效应的差异。方法回顾性地选择了两家机构的患者，他们分别接受了使用 Cook Zenith Fenestrated 平台的四血管 fEVAR 术和使用 Jotec E-xtra Design 平台的 bEVAR 术。两组患者均接受了内脏旁和 II、II 和 V 度胸腹主动脉瘤的治疗。根据术前和术后的计算机断层扫描创建了三维有限元体积网格。根据体表面积、心率和血压调整了边界条件。在术前和术后状态相同的边界条件下进行了搏动流模拟。结果对 20 位患者（10 位 bEVAR，10 位 fEVAR）共 80 根目标血管（40 根肾动脉、20 根腹腔动脉、20 根肠系膜上动脉支架）进行了患者特异性 CFS 分析。与 fEVAR 相比，bEVAR 可降低肾动脉峰值流速（-5.2% vs +2.0%；P < .0001）和峰值压力（-3.4 vs +0.1%；P < .0001）。几乎所有接受 bEVAR 治疗的肾动脉灌注都减少了（19 例 [95%]），而接受 fEVAR 治疗的比例为 35% （7 例）。各组间腹腔动脉或肠系膜上动脉灌注指标无明显差异（P = .10-.27）。内植物配置不同，腹主动脉旁和分支的时间平均壁剪应力也有显著差异，与fEVAR相比，bEVAR术后肾动脉（+47.5 vs +13.5%；P = .002）和主动脉时间平均壁剪应力（+200.1% vs -31.3%；P = .001）大幅增加。流线分析显示了与采用 U 型几何形状的分支肾移植物相关的血流动力学异常区域，这可能解释了所观察到的 bEVAR 和 fEVAR 术后肾脏灌注变化的差异。本研究使用患者特异性 CFS 比较了复杂主动脉瘤患者术后四血管腔内动脉瘤修补术（fEVAR）和分支血管腔内动脉瘤修补术（bEVAR）对血流动力学的影响。研究结果表明，与 fEVAR 相比，bEVAR 可能会导致肾动脉灌注的细微减少和主动脉壁剪应力的显著增加。这些差异与临床相关，为临床医生选择这些方法提供了启示。了解 CFS 揭示的复杂 EVAR 策略对患者特异性血流动力学的影响有助于未来的个性化治疗决策，并有可能减少主动脉瘤修复术后并发症。
{"title":"Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair","authors":"Kenneth Tran MD ,&nbsp;Celine Deslarzes-Dubuis MD ,&nbsp;Sebastien DeGlise MD ,&nbsp;Adrien Kaladji MD ,&nbsp;Weiguang Yang PhD ,&nbsp;Alison L. Marsden PhD ,&nbsp;Jason T. Lee MD","doi":"10.1016/j.jvssci.2023.100183","DOIUrl":"10.1016/j.jvssci.2023.100183","url":null,"abstract":"<div><h3>Background</h3><p>Endovascular aneurysm repair with four-vessel fenestrated endovascular aneurysm repair (fEVAR) or branched endovascular aneurysm repair (bEVAR) currently represent the forefront of minimally invasive complex aortic aneurysm repair. This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR.</p></div><div><h3>Methods</h3><p>Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. Patients in both cohorts were treated for paravisceral and extent II, II, and V thoracoabdominal aortic aneurysms. Three-dimensional finite element volume meshes were created from preoperative and postoperative computed tomography scans. Boundary conditions were adjusted for body surface area, heart rate, and blood pressure. Pulsatile flow simulations were performed with equivalent boundary conditions between preoperative and postoperative states. Postoperative changes in hemodynamic parameters were compared between the fEVAR and bEVAR groups.</p></div><div><h3>Results</h3><p>Patient-specific CFS was performed on 20 patients (10 bEVAR, 10 fEVAR) with a total of 80 target vessels (40 renal, 20 celiac, 20 superior mesenteric artery stents). bEVAR was associated with a decrease in renal artery peak flow rate (−5.2% vs +2.0%; <em>P</em> &lt; .0001) and peak pressure (−3.4 vs +0.1%; <em>P</em> &lt; .0001) compared with fEVAR. Almost all renal arteries treated with bEVAR had a reduction in renal artery perfusion (n = 19 [95%]), compared with 35% (n = 7) treated with fEVAR. There were no significant differences in celiac or superior mesenteric artery perfusion metrics (<em>P</em> = .10-.27) between groups. Time-averaged wall shear stress in the paravisceral aorta and branches also varied significantly depending on endograft configuration, with bEVAR associated with large postoperative increases in renal artery (+47.5 vs +13.5%; <em>P</em> = .002) and aortic time-averaged wall shear stress (+200.1% vs −31.3%; <em>P</em> = .001) compared with fEVAR. Streamline analysis revealed areas of hemodynamic abnormalities associated with branched renal grafts which adopt a U-shaped geometry, which may explain the observed differences in postoperative changes in renal perfusion between bEVAR and fEVAR.</p></div><div><h3>Conclusions</h3><p>bEVAR may be associated with subtle decreases in renal perfusion and a large increase in aortic wall shear stress compared with fEVAR. CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies.</p></div><div><h3>Clinical Relevance</h3><p>This study used patient-specific CFS to compare postoperative hemodynamic effects of four-vessel fenestrated endovascular aneurysm repair (fEVAR) and branched endovascular aneurysm repair ","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000871/pdfft?md5=a80815d2199cb6cf5b972868ccdb2934&pid=1-s2.0-S2666350323000871-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum detection of blood brain barrier injury in subjects with a history of stroke and transient ischemic attack 在有中风和短暂性脑缺血发作病史的受试者血清中检测血脑屏障损伤
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100206
Scott French , Juan Arias MD , Ikeoluwapo Bolakale-Rufai MD , Summan Zahra MD , Kaneez Zahra Rubab Khakwani MD , Edward J. Bedrick PhD , Geidy E. Serrano PhD , Thomas G. Beach MD, PhD , Eric Reiman MD , Craig Weinkauf MD, PhD

Objective

Stroke and transient ischemic attack may have long-term negative effects on the blood-brain barrier (BBB) and promote endothelial inflammation, both of which could increase neurodegeneration and dementia risk beyond the cell death associated with the index event.

Methods

Serum from 88 postmortem subjects in the Arizona Study of Aging and Neurodegenerative Disorders were analyzed by sandwich ELISA for specific biomarkers to investigate the effects of cerebrovascular accidents (CVAs) on BBB integrity and endothelial activation. Statistical analyses were performed using the Mann-Whitney U Test, Spearman rank correlation, and linear/logistic regressions adjusted for potential confounders; a P-value < .05 was considered significant for all analyses.

Results

Serum PDGFRẞ, a putative biomarker of BBB injury, was significantly increased in subjects with vs without a history of CVA who had similar cardiovascular risk factors (P < .01). This difference was stable after adjusting for age, hypertension, and other potential confounders in regression analysis (odds ratio, 27.02; 95% confidence interval, 2.61-411.7; P < .01). In addition, PDGFRẞ was positively associated with VCAM-1, a biomarker of endothelial inflammation (ρ = 0.42; P < .01).

Conclusions

Our data suggest that patients with stroke or transient ischemic attack have lasting changes in the BBB. Still more, this demonstrates the utility of PDGFRẞ as a serum-based biomarker of BBB physiology, a potentially powerful tool in studying the role of the BBB in various neurodegenerative diseases and COVID infection sequelae.

Clinical Relevance

Our data demonstrate the utility of serum PDGFRẞ, a putative biomarker of BBB integrity in the setting of stroke and TIA (CVA). A serum biomarker of BBB integrity could be a useful tool to detect early BBB damage and allow prospective work to study how such damage affects long-term neurodegenerative risk. Since BBB disruption occurs early in ADRD development, it could be monitored to help better understand disease progression and involvement of vascular pathways in ADRD.

亚利桑那州衰老与神经退行性疾病研究（Arizona Study of Aging and Neurodegenerative Disorders）用夹心酶联免疫吸附分析法（Sandwich ELISA）分析了88例受试者死后血清中的特定生物标记物，以研究脑血管意外（CVA）对血脑屏障（BBB）完整性和内皮活化的影响。结果血清PDGFRẞ是BBB损伤的一种假定生物标志物，在具有类似心血管风险因素的有CVA病史和无CVA病史的受试者中显著增加（P< .01）。在回归分析中对年龄、高血压和其他潜在混杂因素进行调整后，这一差异保持稳定（几率比，27.02；95% 置信区间，2.61-411.7；P < .01）。此外，PDGFRẞ 与血管内皮炎症的生物标志物 VCAM-1 呈正相关（ρ = 0.42；P <；.01）。临床相关性我们的数据证明了血清 PDGFRẞ 的实用性，它是中风和短暂性脑缺血发作（CVA）时 BBB 完整性的潜在生物标志物。BBB 完整性的血清生物标志物可作为检测早期 BBB 损伤的有用工具，并可用于研究此类损伤如何影响长期神经退行性风险的前瞻性工作。由于 BBB 破坏发生在 ADRD 发病的早期，因此对其进行监测有助于更好地了解 ADRD 的疾病进展和血管通路的参与情况。
{"title":"Serum detection of blood brain barrier injury in subjects with a history of stroke and transient ischemic attack","authors":"Scott French ,&nbsp;Juan Arias MD ,&nbsp;Ikeoluwapo Bolakale-Rufai MD ,&nbsp;Summan Zahra MD ,&nbsp;Kaneez Zahra Rubab Khakwani MD ,&nbsp;Edward J. Bedrick PhD ,&nbsp;Geidy E. Serrano PhD ,&nbsp;Thomas G. Beach MD, PhD ,&nbsp;Eric Reiman MD ,&nbsp;Craig Weinkauf MD, PhD","doi":"10.1016/j.jvssci.2024.100206","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100206","url":null,"abstract":"<div><h3>Objective</h3><p>Stroke and transient ischemic attack may have long-term negative effects on the blood-brain barrier (BBB) and promote endothelial inflammation, both of which could increase neurodegeneration and dementia risk beyond the cell death associated with the index event.</p></div><div><h3>Methods</h3><p>Serum from 88 postmortem subjects in the Arizona Study of Aging and Neurodegenerative Disorders were analyzed by sandwich ELISA for specific biomarkers to investigate the effects of cerebrovascular accidents (CVAs) on BBB integrity and endothelial activation. Statistical analyses were performed using the Mann-Whitney <em>U</em> Test, Spearman rank correlation, and linear/logistic regressions adjusted for potential confounders; a <em>P</em>-value &lt; .05 was considered significant for all analyses.</p></div><div><h3>Results</h3><p>Serum PDGFRẞ, a putative biomarker of BBB injury, was significantly increased in subjects with vs without a history of CVA who had similar cardiovascular risk factors (<em>P</em> &lt; .01). This difference was stable after adjusting for age, hypertension, and other potential confounders in regression analysis (odds ratio, 27.02; 95% confidence interval, 2.61-411.7; <em>P</em> &lt; .01). In addition, PDGFRẞ was positively associated with VCAM-1, a biomarker of endothelial inflammation (ρ = 0.42; <em>P</em> &lt; .01).</p></div><div><h3>Conclusions</h3><p>Our data suggest that patients with stroke or transient ischemic attack have lasting changes in the BBB. Still more, this demonstrates the utility of PDGFRẞ as a serum-based biomarker of BBB physiology, a potentially powerful tool in studying the role of the BBB in various neurodegenerative diseases and COVID infection sequelae.</p></div><div><h3>Clinical Relevance</h3><p>Our data demonstrate the utility of serum PDGFRẞ, a putative biomarker of BBB integrity in the setting of stroke and TIA (CVA). A serum biomarker of BBB integrity could be a useful tool to detect early BBB damage and allow prospective work to study how such damage affects long-term neurodegenerative risk. Since BBB disruption occurs early in ADRD development, it could be monitored to help better understand disease progression and involvement of vascular pathways in ADRD.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000178/pdfft?md5=2882cf384347395014f8173be3bf2f3e&pid=1-s2.0-S2666350324000178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia 6- 磷酸葡萄糖酸脱氢酶在血管平滑肌细胞表型转换和血管成形术诱导的内膜增生中的作用
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100214
Amy L. Lu , Li Yin PhD , Yitao Huang BS , Zain Husain Islam , Rohan Kanchetty , Campbell Johnston , Kaijie Zhang MD , Xiujie Xie PhD , Ki Ho Park PhD , Charles E. Chalfant PhD , Bowen Wang PhD

Background

Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP). In this study, we sought to probe whether 6PGD is aberrantly regulated in IH and contributes to VSMC phenotypic switching.

Methods

We used clinical specimens of diseased human coronary arteries with IH lesions and observed robust upregulation of 6PGD at protein level in both the medial and intimal layers in comparison with healthy arterial segments.

Results

6PGD activity and protein expression were profoundly stimulated upon platelet-derived growth factor-induced VSMC phenotypic switching. Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. Finally, we conducted a rat model of balloon angioplasty in the common carotid artery, with Pluronic hydrogel-assisted perivascular delivery of Physcion, a selective 6PGD inhibitor with poor systemic bioavailability, and observed effective mitigation of IH.

Conclusions

We contend that aberrant 6PGD expression and activity—indicative of a metabolic shift toward pentose phosphate pathway—could serve as a new disease-driving mechanism and, hence, an actionable target for the development of effective new therapies for IH and restenosis after endovascular interventions.

背景再狭窄是外周动脉疾病患者面临的一个重大挑战，通常会导致相当高的发病率，并需要反复进行干预。再狭窄发病机制的罪魁祸首是内膜增生（IH），在这种情况下，过度增殖和移行的血管平滑肌细胞（VSMC）在内膜中过度聚集。6-磷酸葡萄糖酸脱氢酶（6PGD），有时也称为 PGD，是磷酸戊糖途径（PPP）的关键酶之一。本研究试图探究 6PGD 是否在 IH 中受到异常调控并导致 VSMC 表型转换。结果 6PGD 的活性和蛋白表达在血小板衍生生长因子诱导的 VSMC 表型转换时受到显著刺激。利用功能获得（dCas9 介导的转录激活）和功能丧失（小干扰 RNA 介导的）沉默，我们能够证明 6PGD 在驱动 VSMC 过度增殖、迁移、去分化和炎症中的致病作用。最后，我们在大鼠颈总动脉中进行了球囊血管成形术模型，并在 Pluronic 水凝胶辅助下在血管周围输送 Physcion（一种全身生物利用度较低的选择性 6PGD 抑制剂），观察到 IH 得到了有效缓解。结论我们认为，6PGD 的异常表达和活性--表明新陈代谢转向磷酸戊糖途径--可作为一种新的疾病驱动机制，从而成为开发治疗 IH 和血管内介入术后再狭窄的有效新疗法的可行靶点。
{"title":"The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia","authors":"Amy L. Lu ,&nbsp;Li Yin PhD ,&nbsp;Yitao Huang BS ,&nbsp;Zain Husain Islam ,&nbsp;Rohan Kanchetty ,&nbsp;Campbell Johnston ,&nbsp;Kaijie Zhang MD ,&nbsp;Xiujie Xie PhD ,&nbsp;Ki Ho Park PhD ,&nbsp;Charles E. Chalfant PhD ,&nbsp;Bowen Wang PhD","doi":"10.1016/j.jvssci.2024.100214","DOIUrl":"10.1016/j.jvssci.2024.100214","url":null,"abstract":"<div><h3>Background</h3><p>Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP). In this study, we sought to probe whether 6PGD is aberrantly regulated in IH and contributes to VSMC phenotypic switching.</p></div><div><h3>Methods</h3><p>We used clinical specimens of diseased human coronary arteries with IH lesions and observed robust upregulation of 6PGD at protein level in both the medial and intimal layers in comparison with healthy arterial segments.</p></div><div><h3>Results</h3><p>6PGD activity and protein expression were profoundly stimulated upon platelet-derived growth factor-induced VSMC phenotypic switching. Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. Finally, we conducted a rat model of balloon angioplasty in the common carotid artery, with Pluronic hydrogel-assisted perivascular delivery of <em>Physcion</em>, a selective 6PGD inhibitor with poor systemic bioavailability, and observed effective mitigation of IH.</p></div><div><h3>Conclusions</h3><p>We contend that aberrant 6PGD expression and activity—indicative of a metabolic shift toward pentose phosphate pathway—could serve as a new disease-driving mechanism and, hence, an actionable target for the development of effective new therapies for IH and restenosis after endovascular interventions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000257/pdfft?md5=015a2d171ee9d906e05a42573e145c34&pid=1-s2.0-S2666350324000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling” [JVS–Vascular Science 2 (2021) 2 - 12] 颈动脉横断和吻合手术后的新内膜增生与去甲斑素降解和血小板衍生生长因子信号传导有关》的撤稿通知 [JVS-Vascular Science 2 (2021) 2 - 12]
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100216
Roshan J. D'Cruz MD , Valerie B. Sampson PhD , Carly A. Askinas MD , Rebecca A. Scott PhD , Karyn G. Robinson MS , Claude A. Beaty MD , Anne M. Hesek AS , Robert E. Akins PhD, FAHA
{"title":"Retraction notice to “Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling” [JVS–Vascular Science 2 (2021) 2 - 12]","authors":"Roshan J. D'Cruz MD ,&nbsp;Valerie B. Sampson PhD ,&nbsp;Carly A. Askinas MD ,&nbsp;Rebecca A. Scott PhD ,&nbsp;Karyn G. Robinson MS ,&nbsp;Claude A. Beaty MD ,&nbsp;Anne M. Hesek AS ,&nbsp;Robert E. Akins PhD, FAHA","doi":"10.1016/j.jvssci.2024.100216","DOIUrl":"10.1016/j.jvssci.2024.100216","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A surgeon-scientist's approach to improving arteriovenous fistula patency 外科医生-科学家改善动静脉瘘通畅的方法
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100207
Alan Dardik MD, PhD
{"title":"A surgeon-scientist's approach to improving arteriovenous fistula patency","authors":"Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100207","DOIUrl":"10.1016/j.jvssci.2024.100207","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032400018X/pdfft?md5=2180a3dc765c68551038549c6179d79f&pid=1-s2.0-S266635032400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms 术前动脉僵硬度对腹主动脉瘤血管内修复患者的影响
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100209
Carly Thaxton MD , Masaki Kano MD, PhD , Daniel Mendes-Pinto MD, PhD , Túlio Pinho Navarro MD, PhD , Toshiya Nishibe MD, PhD , Alan Dardik MD, PhD

Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with increased aortic stiffness after endovascular aneurysm repair (EVAR). This review provides an overview of aortic wall physiology and the contemporary understanding of aortic stiffness and its implications for patients undergoing abdominal aortic aneurysm repair. Recent data suggests that increased central arterial stiffness, estimated preoperatively using the pulse wave velocity (PWV), may predict aneurysm sac behavior after EVAR, with elevated preoperative PWV associated with less sac shrinkage, and even sac enlargement, after EVAR. With the development of several simple noninvasive methods to measure PWV, such as brachial-ankle PWV and single cuff brachial oscillometry, there may be a role for monitoring ambulatory PWV to predict outcomes after EVAR. Additionally, because aortic stiffness is associated with adverse cardiovascular outcomes, and EVAR increases aortic stiffness, assessment of aortic stiffness before aortic interventions may help to guide therapeutic decisions as well as surveillance protocols, leading to optimized patient outcomes.

动脉僵化与心血管患者的不良预后有关；僵化还可能与手术后事件有关，并被认为是主动脉瘤发病的基本机制。虽然动脉瘤开放性修复可降低主动脉僵化，但植入硬质内膜移植物与血管内动脉瘤修复（EVAR）后主动脉僵化增加有关。本综述概述了主动脉壁生理学和当代对主动脉僵硬度的理解及其对接受腹主动脉瘤修复术患者的影响。最近的数据表明，术前使用脉搏波速度（PWV）估算的中心动脉僵硬度的增加可预测 EVAR 术后动脉瘤囊的表现，术前 PWV 的升高与 EVAR 术后动脉瘤囊的缩小甚至增大有关。随着测量脉搏波速度的几种简单无创方法（如肱踝脉搏波速度和单袖带肱动脉振荡测量法）的发展，监测动态脉搏波速度可能有助于预测 EVAR 后的预后。此外，由于主动脉僵化与心血管不良预后相关，而 EVAR 会增加主动脉僵化，因此在主动脉介入前评估主动脉僵化可能有助于指导治疗决策和监测方案，从而优化患者预后。
{"title":"Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms","authors":"Carly Thaxton MD ,&nbsp;Masaki Kano MD, PhD ,&nbsp;Daniel Mendes-Pinto MD, PhD ,&nbsp;Túlio Pinho Navarro MD, PhD ,&nbsp;Toshiya Nishibe MD, PhD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100209","DOIUrl":"10.1016/j.jvssci.2024.100209","url":null,"abstract":"<div><p>Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with increased aortic stiffness after endovascular aneurysm repair (EVAR). This review provides an overview of aortic wall physiology and the contemporary understanding of aortic stiffness and its implications for patients undergoing abdominal aortic aneurysm repair. Recent data suggests that increased central arterial stiffness, estimated preoperatively using the pulse wave velocity (PWV), may predict aneurysm sac behavior after EVAR, with elevated preoperative PWV associated with less sac shrinkage, and even sac enlargement, after EVAR. With the development of several simple noninvasive methods to measure PWV, such as brachial-ankle PWV and single cuff brachial oscillometry, there may be a role for monitoring ambulatory PWV to predict outcomes after EVAR. Additionally, because aortic stiffness is associated with adverse cardiovascular outcomes, and EVAR increases aortic stiffness, assessment of aortic stiffness before aortic interventions may help to guide therapeutic decisions as well as surveillance protocols, leading to optimized patient outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000208/pdfft?md5=1cd6d8eee65627db4bd2b983b5be5f8c&pid=1-s2.0-S2666350324000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of serum vitamin D with diagnosis and growth of abdominal aortic aneurysm 血清维生素 D 与腹主动脉瘤的诊断和生长的关系
Q3 Medicine
JVS-vascular science
Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100208
Shivshankar Thanigaimani PhD , Rachel E. Neale PhD , Mary Waterhouse PhD , Joseph V. Moxon PhD , Bu B. Yeap PhD , Paul E. Norman PhD , Leon Flicker PhD , Graeme J. Hankey PhD , Jason Jenkins PhD , Frank Quigley PhD , Michael W. Clarke PhD , Jonathan Golledge MA, FRCS, FRACS

Objective

We examined the associations between 25-hydroxy vitamin D (25(OH)D3) concentration and the diagnosis and growth of abdominal aortic aneurysm (AAA).

Methods

AAA cases and healthy controls were recruited from vascular centers or the community. A subset of participants with AAA were monitored by repeat ultrasound examination to assess AAA growth. Serum 25(OH)D3 concentration was measured using a validated mass spectrometry method and categorized into guideline-recommended cut-points after deseasonalization. The associations between deseasonalized 25(OH)D3 concentration and AAA diagnosis and growth were examined using logistic regression and linear mixed effects modeling.

Results

A total of 4673 participants consisting of 873 (455 controls and 418 cases) from Queensland and 3800 (3588 controls and 212 cases) from Western Australia were recruited. For every 1 standard deviation increase in 25(OH)D3 concentration, odds of AAA diagnosis was significantly reduced in both Queensland (adjusted odds ratio: 0.81; 95% confidence interval [CI]: 0.69-0.95; P = .009) and Western Australia (adjusted odds ratio: 0.80; 95% CI: 0.68-0.94; P = .005) cohorts. A subset of 310 eligible participants with small AAA from both regions were followed for a median of 4.2 (interquartile range: 2.0-5.8) years. Compared with vitamin D sufficient participants (50 to ˂75 nmol/L), annual mean AAA growth was significantly greater in those with higher vitamin D (≥75 nmol/L) (adjusted mean difference: 0.1 mm/y, 95% CI: 0.1-0.2; P < .001).

Conclusions

High 25(OH)D3 concentration was paradoxically associated with a lower likelihood of AAA diagnosis and faster AAA growth. Further research is needed to resolve these conflicting findings.

目的我们研究了25-羟基维生素D（25(OH)D3）浓度与腹主动脉瘤（AAA）的诊断和生长之间的关系。方法从血管中心或社区招募AAA病例和健康对照组。一部分患有腹主动脉瘤的参与者通过重复超声波检查来评估腹主动脉瘤的生长情况。血清25(OH)D3浓度采用经过验证的质谱方法进行测量，并在去季节化后按指南推荐的切点进行分类。结果 共招募了 4673 名参与者，其中昆士兰州 873 人（455 名对照者和 418 名病例），西澳大利亚州 3800 人（3588 名对照者和 212 名病例）。在昆士兰州和西澳大利亚州，25（OH）D3 浓度每增加 1 个标准差，确诊 AAA 的几率就会显著降低（调整后的几率比：0.81；95% 置信区间 [CI]：0.69-0.95；P<0.05）：调整后的几率比：0.81；95% 置信区间 [CI]：0.69-0.95；P = .009）和西澳大利亚队列（调整后的几率比：0.80；95% 置信区间：0.68-0.94；P = .005）。对来自这两个地区的 310 名符合条件的小型 AAA 患者进行了中位数为 4.2 年（四分位间距：2.0-5.8）的随访。结论高浓度的25（OH）D3与较低的AAA诊断可能性和较快的AAA生长速度之间存在矛盾。要解决这些相互矛盾的发现，还需要进一步的研究。
{"title":"Association of serum vitamin D with diagnosis and growth of abdominal aortic aneurysm","authors":"Shivshankar Thanigaimani PhD ,&nbsp;Rachel E. Neale PhD ,&nbsp;Mary Waterhouse PhD ,&nbsp;Joseph V. Moxon PhD ,&nbsp;Bu B. Yeap PhD ,&nbsp;Paul E. Norman PhD ,&nbsp;Leon Flicker PhD ,&nbsp;Graeme J. Hankey PhD ,&nbsp;Jason Jenkins PhD ,&nbsp;Frank Quigley PhD ,&nbsp;Michael W. Clarke PhD ,&nbsp;Jonathan Golledge MA, FRCS, FRACS","doi":"10.1016/j.jvssci.2024.100208","DOIUrl":"10.1016/j.jvssci.2024.100208","url":null,"abstract":"<div><h3>Objective</h3><p>We examined the associations between 25-hydroxy vitamin D (25(OH)D<sub>3</sub>) concentration and the diagnosis and growth of abdominal aortic aneurysm (AAA).</p></div><div><h3>Methods</h3><p>AAA cases and healthy controls were recruited from vascular centers or the community. A subset of participants with AAA were monitored by repeat ultrasound examination to assess AAA growth. Serum 25(OH)D<sub>3</sub> concentration was measured using a validated mass spectrometry method and categorized into guideline-recommended cut-points after deseasonalization. The associations between deseasonalized 25(OH)D<sub>3</sub> concentration and AAA diagnosis and growth were examined using logistic regression and linear mixed effects modeling.</p></div><div><h3>Results</h3><p>A total of 4673 participants consisting of 873 (455 controls and 418 cases) from Queensland and 3800 (3588 controls and 212 cases) from Western Australia were recruited. For every 1 standard deviation increase in 25(OH)D<sub>3</sub> concentration, odds of AAA diagnosis was significantly reduced in both Queensland (adjusted odds ratio: 0.81; 95% confidence interval [CI]: 0.69-0.95; <em>P</em> = .009) and Western Australia (adjusted odds ratio: 0.80; 95% CI: 0.68-0.94; <em>P</em> = .005) cohorts. A subset of 310 eligible participants with small AAA from both regions were followed for a median of 4.2 (interquartile range: 2.0-5.8) years. Compared with vitamin D sufficient participants (50 to ˂75 nmol/L), annual mean AAA growth was significantly greater in those with higher vitamin D (≥75 nmol/L) (adjusted mean difference: 0.1 mm/y, 95% CI: 0.1-0.2; <em>P</em> &lt; .001).</p></div><div><h3>Conclusions</h3><p>High 25(OH)D<sub>3</sub> concentration was paradoxically associated with a lower likelihood of AAA diagnosis and faster AAA growth. Further research is needed to resolve these conflicting findings.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000191/pdfft?md5=53c6dec97c18728032cf8eccf8832233&pid=1-s2.0-S2666350324000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
JVS-vascular science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1