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National survey of the occurrence of antimicrobial agents in Australian wastewater and their socioeconomic correlates 澳大利亚废水中抗菌药物的发生及其社会经济相关性的全国调查
Pub Date : 2024-12-03 DOI: 10.1038/s44221-024-00349-9
Jinglong Li, Jake W. O’Brien, Benjamin J. Tscharke, Chang He, Katja M. Shimko, Xueting Shao, Naixiang Zhai, Jochen F. Mueller, Kevin V. Thomas
A critical approach to combatting antimicrobial resistance involves monitoring the usage of antimicrobial agents (antimicrobials). Despite the increasing per capita use of antimicrobials in Australia, surveys remain limited. Here we investigated the occurrence and use of 102 antimicrobials and their transformation products in raw wastewater collected from 50 wastewater treatment plants across Australia, encompassing ~50% of the national population. The wastewater data were subsequently correlated with catchment-matched Census data to identify population-level socioeconomic factors associated with antimicrobial use. The results showed the detection of 41 antimicrobials and 15 transformation products, covering most of the common antimicrobial groups, with 30 analytes detected at a frequency >50%. Amoxicilloic acid and cephalexin occurred at the highest concentrations and population-normalized mass loads. Correlation analysis revealed a significant association between the consumption of antimicrobials and various socioeconomic statuses, including income, education, occupation, housing, race, health condition and transport. Our study offers comprehensive insight into the patterns of antimicrobial use at the population level in Australia and highlights potential socioeconomic drivers of its use. The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.
对抗抗菌素耐药性的一个关键方法是监测抗菌素(抗菌素)的使用情况。尽管澳大利亚人均抗菌素使用量不断增加,但调查仍然有限。在这里,我们调查了102种抗菌剂及其转化产物在澳大利亚50个污水处理厂收集的原废水中的发生和使用情况,涵盖了全国50%的人口。随后将废水数据与流域匹配的普查数据相关联,以确定与抗菌药物使用相关的人口层面社会经济因素。结果显示,共检测到41种抗菌素和15种转化产物,覆盖了大多数常见的抗菌素群,其中30种分析物的检出率为50%。阿莫西酸和头孢氨苄出现在最高浓度和人群标准化的质量负荷。相关分析显示,抗菌素消费与各种社会经济状况(包括收入、教育、职业、住房、种族、健康状况和交通)之间存在显著关联。我们的研究提供了全面的洞察抗菌药物的使用模式在澳大利亚的人口水平,并强调其使用的潜在社会经济驱动因素。使用抗微生物药物可加剧抗微生物药物耐药性基因的扩散,从而危及公共卫生;评估这种风险需要适当的监控。对澳大利亚废水的广泛调查揭示了使用的抗菌剂类型与人口的社会经济地位之间的明显相关性。
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引用次数: 0
The Safe Drinking Water Act at 50 years 《安全饮用水法》颁布了50年
Pub Date : 2024-12-02 DOI: 10.1038/s44221-024-00356-w
Noah D. Hall
In its 50 years, the Safe Drinking Water Act has improved public water supplies across the United States, but it has not advanced the right to safe drinking water in America to address water inequities and injustices.
在过去的50年里,《安全饮用水法》改善了美国各地的公共供水,但它并没有提高美国的安全饮用水权利,也没有解决用水方面的不平等和不公正问题。
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引用次数: 0
Seven strategies to leverage water for peace and foster sustainable and just water management for all 利用水促进和平并促进人人享有可持续和公正的水管理的七项战略
Pub Date : 2024-11-29 DOI: 10.1038/s44221-024-00353-z
Stefan Krause, Iseult Lynch, Ankit Agarwal, Adenike Akinsemolu, Berit Arheimer, Wouter Buytaert, Rita Floyd, Annabelle Houdret, Elizabeth Saccoccia, Uwe Schneidewind, Klement Tockner, Tahmina Yasmin, David M. Hannah
Water solutions across different scales can prevent or mitigate conflict if existing obstacles to their implementation can be overcome so that water can act as catalyst to bring people and communities together to co-create collective solutions for peace.
如果能够克服现有的实施障碍,不同尺度的水解决方案可以预防或减轻冲突,从而使水成为催化剂,将人民和社区聚集在一起,共同创造促进和平的集体解决方案。
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引用次数: 0
Nanofiltration membranes with mixed-dimensional structures 混合维结构纳滤膜
Pub Date : 2024-11-29 DOI: 10.1038/s44221-024-00354-y
Dan Lu, Lin Zhang
A one-dimensional nanotubes-on-two-dimensional hierarchical nanofilm self-organized by the capillary effect within the nanopore and the interfacial polymerization reaction allows rapid aqueous nanofiltration.
通过纳米孔内的毛细效应和界面聚合反应自组织的一维纳米管-二维分层纳米膜允许快速的水纳滤。
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引用次数: 0
Interfacial self-organization of large-area mixed-dimensional polyamide membranes for rapid aqueous nanofiltration 用于快速水纳滤的大面积混维聚酰胺膜的界面自组织
Pub Date : 2024-11-29 DOI: 10.1038/s44221-024-00348-w
Si-Hua Liu, Wenxiong Shi, Wei-Song Hung, Le Shi, Bai Xue, Jingguo She, Ziping Song, Xiaolong Lu, Stephen Gray, Kueir-Rarn Lee, Chunrui Wu
Mixed-dimensional membranes are promising candidates for efficient water purification. Integrating a conventional flat two-dimensional (2D) membrane with structures of different dimensionalities is expected to create additional water transport sites. However, organizing the membrane building blocks into a mixed-dimensional hierarchy capable of facilitating rapid water transfer, while also enabling large-scale, cost-effective manufacturing, remains a significant challenge. Here we report the discovery of rapid self-organization of large-area mixed-dimensional polyamide membranes with an intriguing hierarchical structure consisting of one-dimensional nanotubes on a 2D nanofilm under room temperature using only two types of small molecules at an oil–water interface. The resulting architecture with one-dimensional nanotubes on a 2D nanofilm offers a substantially increased available area for water transport per projected area, enabling energy-efficient nanofiltration membranes with outstanding water–salt separation performance that well surpasses most state of the art membranes. Control experiments, coupled with molecular dynamic simulations, reveal that the two types of molecular monomers self-organize into a 2D nanopore network during the incipient reaction stage and then capillarity within these nanopores drives the upwards polymerization of these nanotubes. Our findings provide valuable insights into how the interplay of interfacial physical and chemical interactions organizes molecular seeds into large-scale, complex hierarchical nanostructures under ambient conditions. This opens new opportunities for developing scalable, mixed-dimensional water purification membranes. Polyamide membranes with a hierarchical structure consisting of one-dimensional nanotubes on a two-dimensional nanofilm can deliver energy-efficient nanofiltration with outstanding water–ion separation performance. This architecture provides a promising approach to the synthesis of scalable and efficient mixed-dimensional water purification membranes.
混合维膜是高效水净化的有希望的候选者。将传统的平面二维(2D)膜与不同维度的结构相结合,有望创造额外的水运场地。然而,将膜构建块组织成一个混合维度的层次结构,既能促进快速的水转移,又能实现大规模、经济高效的生产,仍然是一个重大挑战。在这里,我们报告了大面积混合维聚酰胺膜的快速自组织发现,该膜具有有趣的分层结构,在室温下由二维纳米膜上的一维纳米管组成,仅在油水界面上使用两种类型的小分子。二维纳米膜上的一维纳米管结构大大增加了每个投影面积的可用水输送面积,使节能的纳滤膜具有出色的水盐分离性能,远远超过大多数最先进的膜。对照实验和分子动力学模拟表明,两种类型的分子单体在反应初期自组织成二维纳米孔网络,然后这些纳米孔内的毛细作用驱动这些纳米管向上聚合。我们的发现为界面物理和化学相互作用如何在环境条件下将分子种子组织成大规模、复杂的分层纳米结构提供了有价值的见解。这为开发可扩展的、混合维度的水净化膜开辟了新的机会。聚酰胺膜是一种由二维纳米膜上的一维纳米管组成的分层结构,具有优异的水离子分离性能,可实现高效节能的纳滤。这种结构为合成可扩展和高效的混合维度水净化膜提供了一种有前途的方法。
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引用次数: 0
Synergetic physical damage and chemical oxidation for highly efficient and residue-free water disinfection 物理损伤和化学氧化的协同作用,实现高效无残留的水消毒
Pub Date : 2024-11-28 DOI: 10.1038/s44221-024-00344-0
Jun Zhang, Songying Qu, Ruiquan Yu, Li Ling, Wutong Chen, Lin Lin, Bing Li, Xiao-Yan Li
Waterborne pathogens, in particular, emerging antibiotic-resistant bacteria (ARB), can cause serious infectious diseases, posing a huge threat to public health. However, existing water disinfection technologies are often not only energy and chemical intensive but also inefficient at eliminating antibiotic resistance genes (ARGs). Here we show a sequential electrochemical process of ‘chemical (H2O2 pre-treatment)–physical (nanotip electroporation)–chemical (•OH injection)’ that is highly effective in inactivating ARB and removing ARGs. The bacteria are first pre-treated by H2O2 generated via two-electron water oxidation in the SnO2−x/TiO2 anode region to reduce the defences of bacterial outer walls against electroporation. Then, the ‘softened’ and ‘weakened’ bacteria are easily punctured by electroporation in the Pd-Au/TiO2 cathode region and by synchronously injected abundant •OH generated via three-electron oxygen reduction. Bacterial inclusions, including nuclear body and cytoplasm, are effectively decomposed by •OH oxidation, resulting in the destruction of the entire cell structure from the inside out. This bactericidal mechanism of synergetic physical damage and chemical oxidation inactivated >99.9999% of ARB and removed ~99% of ARGs at short retention time (~16 s), high flux (~4.5 m3 h−1 m−2) and low energy consumption (~42.4 Wh m−3) over 15 days of continuous operation. This approach may act as an alternative to meet the urgent need for efficient and residue-free water disinfection. Zhang et al. present a sequential electrochemical process that enables synergetic physical damage and chemical oxidation of antibiotic-resistant bacteria and antibiotic resistance genes, providing an efficient and residue-free water disinfection approach.
水媒病原体,特别是新出现的耐抗生素细菌(ARB),可引起严重的传染病,对公众健康构成巨大威胁。然而,现有的水消毒技术不仅往往是能源和化学密集型的,而且在消除抗生素耐药基因(ARGs)方面效率低下。在这里,我们展示了“化学(H2O2预处理)-物理(纳米尖电穿孔)-化学(•OH注射)”的顺序电化学过程,该过程在灭活ARB和去除ARGs方面非常有效。细菌首先在SnO2−x/TiO2阳极区域通过双电子水氧化产生H2O2进行预处理,以减少细菌外壁对电穿孔的防御。然后,“软化”和“弱化”的细菌很容易被Pd-Au/TiO2阴极区的电穿孔和同步注入通过三电子氧还原产生的丰富的•OH刺穿。包括核体和细胞质在内的细菌包涵体被•OH氧化有效分解,导致整个细胞结构由内而外的破坏。这种物理损伤和化学氧化协同的杀菌机制在短停留时间(~16 s)、高通量(~4.5 m3 h−1 m−2)和低能耗(~42.4 Wh m−3)下连续运行15天,灭活了99.9999%的ARB和去除了~99%的arg。这种方法可以作为一种替代方法,以满足对高效和无残留水消毒的迫切需要。Zhang等人提出了一种顺序电化学过程,可以协同物理损伤和化学氧化抗生素耐药细菌和抗生素耐药基因,提供了一种高效、无残留的水消毒方法。
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引用次数: 0
Electro-driven residual-free approach for removal of antibiotic resistance genes 电驱动无残留法去除抗生素耐药基因
Pub Date : 2024-11-28 DOI: 10.1038/s44221-024-00347-x
Wen-Wei Li, Han-Qing Yu
Current water disinfection practices still face unpredictable health risks associated with carcinogenic byproducts and bacterial resistance. Rationally synergizing electroporation and electrochemical oxidation approaches offers a promising solution.
目前的水消毒做法仍然面临着与致癌副产物和细菌耐药性有关的不可预测的健康风险。合理地协同电穿孔和电化学氧化方法是一个很有前途的解决方案。
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引用次数: 0
Curvature-induced ion docking effect in capacitive deionization 电容去离子中的曲率诱导离子对接效应
Pub Date : 2024-11-27 DOI: 10.1038/s44221-024-00340-4
Luoxing Xiang, Xingtao Xu, Yijie Liu, Han Zhang, Ruibo Xu, Chen Li, Fugui Xu, Yusuke Yamauchi, Yiyong Mai
Traditional capacitive deionization (CDI) materials usually exhibit low salt adsorption capacities due to the limitations in optimizing their specific surface area and chemical composition. Here we introduced the curvature parameter as a new variable for designing high-performance CDI electrodes. On the basis of a comprehensive surface curvature/electric field model, we found that smaller surface curvature radii may result in higher-concentration ion distributions. As a typical experimental example, bicontinuous mesoporous polypyrrole with saddle-shaped high-curvature surfaces demonstrated an enhanced ion docking effect, which provided high salt adsorption capacity values of 262.7 mg g−1 at 1.2 V and 312.5 mg g−1 at 100 mA g−1, along with an ultra-long cycling life of over 2,000 cycles. This CDI performance surpassed those of all previously reported CDI electrodes. This study provides a new design paradigm based on curvature structural engineering for next-generation CDI materials and demonstrates a promising approach for developing large-scale and sustainable high-performance CDI devices. A design principle based on the curvature parameter provides important guidance for the design of capacitive deionization electrodes.
传统的电容性去离子(CDI)材料由于在优化其比表面积和化学成分方面的限制,通常表现出较低的盐吸附能力。本文引入曲率参数作为高性能CDI电极设计的新变量。在综合表面曲率/电场模型的基础上,我们发现表面曲率半径越小,离子浓度分布越高。作为典型的实验实例,具有鞍形高曲率表面的双连续介孔聚吡咯具有增强的离子对接效应,在1.2 V和100 mA g−1下具有262.7 mg g−1和312.5 mg g−1的高盐吸附容量,并具有超过2000次的超长循环寿命。这种CDI性能超过了以前报道的所有CDI电极。该研究为下一代CDI材料提供了一种基于曲率结构工程的新设计范式,为开发大规模、可持续的高性能CDI器件提供了一条有前途的途径。基于曲率参数的设计原理为电容去离子电极的设计提供了重要的指导。
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引用次数: 0
Ion docking with a twist 别出心裁的离子对接
Pub Date : 2024-11-27 DOI: 10.1038/s44221-024-00339-x
Xiaochen Zhang, Fei Yu, Jie Ma
A curvature-induced ion docking effect can be used to enhance the ion storage capacity in capacitive deionization processes, leading to unprecedented water purification efficiency.
曲率诱导的离子对接效应可用于增强电容去离子过程中的离子存储容量,从而实现前所未有的水净化效率。
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引用次数: 0
Making production of water with desalination more sustainable 使海水淡化生产更具可持续性
Pub Date : 2024-11-18 DOI: 10.1038/s44221-024-00341-3
Vasilis Fthenakis, Zhuoran Zhang
Challenges with brine management often result in the abandonment of desalination project plans. Minimizing or eliminating brine discharges from desalination plants can enable a wider adoption of a technology that is needed as climate change stretches fresh water supplies.
盐水管理方面的挑战往往导致海水淡化项目计划的放弃。最大限度地减少或消除海水淡化厂的盐水排放,可以使这项技术得到更广泛的应用,而随着气候变化,淡水供应将更加紧张。
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引用次数: 0
期刊
Nature water
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