Nederlands tijdschrift voor tandheelkunde最新文献

Nanocarbon particles, or carbon dots, are amorphous carbon structures less than 10nm in size. Due to their unique properties, carbon dots have been investigated for various medical applications. In this dissertation research, we synthesized carbon dots from different sources, and characterized their chemical and toxic properties both in vitro and in vivo. In addition, a few potential applications of carbon dots in oral health were investigated, including a mouse model for Sj gren s syndrome. This showed that carbon dots were able to modulate the mouse s immune system, leading to a milder autoimmune response compared to that of untreated mice. Furthermore, the effects of other carbon dots on acid-induced demineralization of hydroxyapatite were investigated in vitro. These carbon dots, in combination with phytosphingosine, reduced calcium release from hydroxyapatite slices exposed to acid by 26% compared to the control group. This indicates that carbon dots promote the binding of phytosphingosine to hydroxyapatite, thereby enhancing the protective effect of phytosphingosine.

Dental personnel are exposed to noise-producing equipment, and there is evidence that this occupational exposure to noise puts dental personnel at an increased risk of developing hearing loss (noise-induced hearing loss, NIHL). A literature search identified 28 scientific publications on NIHL among dental personnel. Twenty-three studies used objective parameters for NIHL, three used subjective parameters, and two studies used a combination of objective and subjective parameters. Of the 12 studies with objective measurements that also examined a control group, eight reported significantly higher NIHL among dental personnel than in the control groups. Of the 13 studies with objective measurements without a control group, seven reported significant NIHL among dental personnel. All five studies with subjective measurements reported significant NIHL among dental personnel. These results suggest that NIHL appears to be more prevalent among dental personnel than in most control groups.

Despite measures, caries in children continues to be a problem. Caries is seen more often in young children with a low socio-economic status than in children with a high socio-economic status. The aim of this PhD research was to find ways to improve preventive oral healthcare for all children. This was achieved by collecting scientific evidence in 3 research components: targeting, effectiveness and implementation of preventive oral healthcare. Analysis of the data revealed that, despite a system fully covering oral healthcare for children, there still are disparities in children s oral health according to socio-economic status. Furthermore, 2 interventions to improve oral health in children were seen to have positive effects: a short, informative, digital video on oral care routines for parents, and doctors at child health clinics referring parents of infants to oral healthcare providers for a first appointment. Finally, the research revealed that timely visits to a dentist and collaboration between youth healthcare and oral healthcare providers can help to improve early childhood oral health.

For the special edition on the first 1,000 days of a child's development, an online readers survey was held, which was distributed to readers and other dental care providers via the NTVT website, in the journal, in the newsletter and on NTVT's social media. The aim was to gain insight into the opinion of dental care providers on the first 1,000 days of a child. The results have been processed in an infographic.

According to the Developmental Origins of Health and Disease hypothesis, the environment in which a fetus develops before birth has a profound impact on a child s long-term health. An adverse environment in the womb can lead to permanent changes in the structure and function of various organ systems, with possible negative long-term health consequences. In the Generation R Study, a longitudinal, observational cohort study in Rotterdam, these long-term effects of prenatal exposure are investigated. A few relationships were found, including between parental weight and the risk of overweight in the child, exposure to certain phthalates and the risk of obesity and early puberty in the child, and between a higher maternal serum 25(OH)D concentration during pregnancy and less caries in the child. The results enable interventions at the level of the general population, such as the Dutch government s Promising Start action programme.

In the first 1,000 days a large part of the enamel formation of the second primary molars, first permanent molars and permanent incisors takes place. If anything goes wrong during this period, this may have permanent implications for the enamel. If this occurs during the mineralization phase, it can be seen as hypomineralization of second primary molars (HSPM) and/or molar-incisor hypomineralization (MIH). The enamel of hypomineralized second primary molars and hypomineralized molar-incisors is less hard, less elastic and less beautiful. Due to a different composition of the enamel (more protein, fewer minerals) the attachment of restoration materials to hypomineralized enamel is more difficult. The aetiology of hypomineralized second primary molars and molar-incisor hypomineralization is multifactorial. Many potential aetiological factors have been investigated, but more insight still has to be gained into how different factors interact and what influence each factor has. Further longitudinal research into the possible aetiology of hypomineralized second primary molars and molar-incisor hypomineralization will be necessary to better understand how and why hypomineralization of the enamel occurs.

Every human life begins as a single, fertilized egg-cell. During the first 1,000 days of life, this cell develops into a 2-year-old toddler. More milestones are reached in this period of life than in any other. All organs are formed, the metabolism is set up, the microbiome is formed, the child learns to eat and drink, develops eating habits, food preferences, and learns to walk and talk. The environment in which these developments take place is crucial to health in later life. The established structures and systems will last for life and will thus have a life-long influence on the individual s general health. Due to the regular check-ups they carry out and their expertise in the field of preventive medicine, oral care providers can make an important contribution during this unique window of opportunity. This article summarizes why the first 1,000 days are important, and describes how oral care providers can contribute. Together with parents (to be) and children, they can build healthy habits, help prevent caries, obesity, diabetes, cardiovascular disease and other chronic disorders, and be part of building the health of present and future generations.

A healthy human being lives in symbiosis with his microbes or microbiome. The first 1,000 days of life are crucial for developing a healthy and diverse microbiome. The development of a healthy microbiome begins as early as in the womb, where the training of the fetal immune cells begins. Next, the child s microbiome is influenced by the method of delivery during the birthing process. The largest and most important phase is the postnatal period. In this last phase, the child s environment, the behaviour and lifestyle of its caregivers, and the child itself are the main determinants of developing and maintaining a healthy microbiome.

During a child s first 1,000 days, many important events take place, such as the eruption of its first tooth, taking its first bite, learning to brush its teeth and the first visits to a dental care practice. This article discusses the factors influencing a child s oral health during this crucial period. It offers oral care providers guidelines for young children s first visits. It is essential for oral care providers to be able to recognize disorders among this patient group and to treat these, when necessary. In addition, during a first visit, parents questions are answered and subjects like non-nutritive sucking, eating habits, oral hygiene and other risk factors for early childhood caries (ECC) are raised. By supporting the parents and making them aware of the importance of oral health from birth, oral care providers can play an essential role in establishing a solid foundation for a healthy future.

The correlation between breastfeeding and the development of caries in children remains unclear. Previous studies have found a correlation between prolonged breastfeeding and the risk of caries. However, the associations observed were primarily based on non-European populations, and important confounding factors, such as socio-economic position and diet, were not taken into account. The Generation R study re-examined the relationship between breastfeeding and oral health. The results of this Dutch cohort study confirmed the previously observed associations between prolonged breastfeeding and the increased risk of dental caries, even after adjustments had been made for indicators of socio-economic position, ethnic background and sugar intake. Future studies are encouraged to further explore possible explanations for the observed correlations. Healthcare professionals should be more aware of this and advise patients about the potential risk of prolonged breastfeeding on the development of caries by applying current recommendations regarding breastfeeding, oral hygiene and frequency of feeding.