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Discovering Real Men Care: The Emergent Masculinities of Stay-at-Home Husbands in Hong Kong. 发现真正的男人关怀:香港全职丈夫的新兴男性气质。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-12 DOI: 10.1177/15579883261423526
Eileen Yh Tsang

The rising phenomenon of stay-at-home husbands (SAHHs) in Hong Kong exemplifies the evolution of masculinities in Asia. The development of emergent masculinities through SAHHs is intertwined with hybrid masculinities to expand the range of visible male roles in an Asian context. The implication of SAHHs is explored through interviews conducted with 31 middle-class SAHHs and 19 wives of SAHHs in Hong Kong. Two key findings are (1) emergent masculinities via SAHHs upend conventional gendered family roles as they become the primary caregivers for their children with notable support from their breadwinner wives and (2) hybrid masculinities in blended gender roles continue to actively evolve in Hong Kong. These findings highlight how emergent masculinities are entwined with hybrid masculinities whereby SAHHs maintain some traditional gender roles and values while embracing tasks associated with child-rearing, which prioritize care, emotional expression, and domesticity. These emerging roles contribute to the literature on masculinity by highlighting Hong Kong SAHHs during the COVID-19 era. The data suggest a reframing of traditional or conventional expectations of masculinities, and through crucial support by their wives, they will continue the trend toward more dynamic gender relations.

在香港,越来越多的全职丈夫(SAHHs)现象体现了亚洲男性气质的演变。通过SAHHs产生的新兴男性气质与混合男性气质交织在一起,扩大了亚洲背景下可见男性角色的范围。本文通过对香港31位中产阶级家庭副官和19位家庭副官的妻子的访谈,探讨了家庭副官的含义。两项主要发现是:(1)透过家庭佣工而产生的男性特质颠覆了传统的性别家庭角色,因为他们在养家糊口的妻子的大力支持下,成为孩子的主要照顾者;(2)在香港,混合性别角色中的混合男性特质继续积极发展。这些发现强调了新兴的男子气概是如何与混合男子气概交织在一起的,在这种混合男子气概中,SAHHs保持了一些传统的性别角色和价值观,同时承担了与养育子女相关的任务,优先考虑照顾、情感表达和家庭生活。这些新兴角色通过突出新冠肺炎时代的香港高级卫生保健机构,为有关男性气概的文献做出了贡献。这些数据表明,对男性的传统或传统期望正在重构,通过妻子的关键支持,他们将继续朝着更有活力的两性关系发展。
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引用次数: 0
Evaluation of the Psychometric Properties for a Turkish Version of the Conformity to Masculine Norms Inventory-30. 土耳其版男性规范符合性量表的心理测量特性评价-30。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-09 DOI: 10.1177/15579883251414408
Bedia Tarsuslu, John L Oliffe, Gulgun Durat, John S Ogrodniczuk, David Kealy

Although many forms of the Conformity to Masculine Norms Inventory (CMNI) are widely used in international literature, there is yet to be a Turkish version. The CMNI-30 is an instrument consisting of 30 statements developed to measure masculinity ideologies, with statements representing different behaviors associated with masculinity. The CMNI-30 has proven reliable and valid across different languages and cultures. This study evaluated the psychometric properties of the Turkish version of the CMNI-30. Tested with 1,091 Turkish men, data were collected after content validation with the 10-factor model of the CMNI-30, indicating good construct validity. Also, convergent validity, Cronbach's alpha coefficient, item-total score analysis, and test-retest analyses were applied. Confirmatory factor analysis showed that the CMNI-30 was similar to its original structure, and all factor loadings were above 0.30. The fit indices were >0.85, and the root mean square error of approximation value was <0.05. Cronbach's alpha value was calculated as 0.871. Item-total correlations ranged between .253 and .541, and the test-retest correlation was found to be r = .344 (p < .001). Convergent validity analysis showed a significant positive relationship between CMNI-30 and Male Role Norms Scale. These findings provide preliminary evidence for the validity and reliability of the Turkish version of the CMNI-30.

虽然许多形式的男性规范符合性量表(CMNI)在国际文献中广泛使用,但尚未有一个土耳其版本。CMNI-30是一个由30个语句组成的工具,用于测量男子气概意识形态,这些语句代表与男子气概相关的不同行为。CMNI-30已被证明在不同的语言和文化中是可靠和有效的。本研究评估了土耳其版CMNI-30的心理测量特性。对1091名土耳其男性进行了测试,数据收集后使用CMNI-30的10因素模型进行内容验证,表明具有良好的结构效度。采用收敛效度分析、Cronbach’s alpha系数分析、项目总分分析和重测分析。验证性因子分析显示,CMNI-30与其原始结构相似,所有因子负荷均在0.30以上。拟合指数为>0.85,近似值的均方根误差r = 0.344 (p < 0.001)。收敛效度分析显示CMNI-30与男性角色规范量表呈显著正相关。这些发现为土耳其版CMNI-30的有效性和可靠性提供了初步证据。
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引用次数: 0
Nurses' Roles in Managing Erectile Dysfunction: A Mixed-Method Systematic Review. 护士在管理勃起功能障碍中的作用:一项混合方法的系统综述。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-09 DOI: 10.1177/15579883261426900
Hui-Chun Chen, Chieh-Yu Liu, Chun-Hou Liao

Sexual health is a fundamental aspect of overall well-being, with erectile dysfunction (ED) being one of the most prevalent sexual disorders. Nurses play a crucial role in addressing the needs of patients experiencing ED, yet their specific roles and responsibilities remain underexplored. We conducted a mixed-methods systematic review to examine the general and specific roles of registered nurses (RNs) and nurse practitioners (NPs) in caring for patients with ED. Relevant studies were identified through searches in Academic Search Complete (EBSCO), Embase, PubMed, ProQuest, Cochrane Library, and Google Scholar. Two independent researchers assessed the methodological quality of the included studies (N = 14; 12 quantitative and two qualitative) using the Joanna Briggs Institute Critical Appraisal Checklist and performed data extraction, transformation, integration, and synthesis. Five responsibilities of nursing roles in ED care were identified: (1) risk factor assessment, (2) needs clarification and/or diagnosis, (3) individual or couple education, (4) facilitation and/or provision of treatment, and (5) continuous monitoring. RNs play a fundamental role in assessing and identifying problems, promoting sexual health, educating and supporting treatment adherence, and facilitating interventions or treatments. In contrast, NPs have a distinct role in monitoring laboratory testing, diagnostics, counseling and treating patients, and collaboration with specialists. Both RNs and NPs use a multidisciplinary approach to provide care activities; RNs provide referrals for to get better services internally or externally, while NPs refer for specialists or urologists' consultations to promote comprehensive care. Findings underscore the need for enhanced education and training programs for RNs-to improve their knowledge of assessment, understanding of ED care-and for NPs-to improve knowledge of diagnosis, counseling, treatment, and patient monitoring-to ensure comprehensive and multidisciplinary ED team care.

性健康是整体健康的一个基本方面,勃起功能障碍(ED)是最普遍的性功能障碍之一。护士在满足急诊科患者的需求方面发挥着至关重要的作用,但他们的具体角色和责任仍未得到充分探讨。我们进行了一项混合方法的系统评价,以检查注册护士(RNs)和执业护士(NPs)在护理ED患者中的一般和特定角色。相关研究通过学术检索完整(EBSCO)、Embase、PubMed、ProQuest、Cochrane Library和谷歌Scholar进行检索。两名独立研究人员使用乔安娜布里格斯研究所关键评估清单评估纳入研究的方法学质量(N = 14; 12个定量和2个定性),并进行数据提取、转换、整合和综合。在急诊科护理中,护理角色的五项职责是:(1)风险因素评估;(2)需求澄清和/或诊断;(3)个人或夫妻教育;(4)促进和/或提供治疗;(5)持续监测。注册护士在评估和识别问题、促进性健康、教育和支持治疗依从性以及促进干预或治疗方面发挥着重要作用。相比之下,NPs在监测实验室检测、诊断、咨询和治疗患者以及与专家合作方面发挥着独特的作用。注册护士和新护士都采用多学科方法提供护理活动;注册护士为获得更好的内部或外部服务提供转诊,而专科医生为专科医生或泌尿科医生提供会诊,以促进综合护理。研究结果强调有必要加强对注册护士的教育和培训计划,以提高他们对评估和急诊科护理的认识,并对nps提高诊断、咨询、治疗和患者监测的知识,以确保全面和多学科的急诊科团队护理。
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引用次数: 0
Exploring the Relationship Between Diaphragmatic Ultrasound Parameters and Lipid Mediators in Chronic Obstructive Pulmonary Disease: A Case Control Study. 探讨慢性阻塞性肺疾病膈超声参数与脂质介质的关系:一项病例对照研究
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1177/15579883251396535
Warda Jelassi, Abir Hedhli, Sameh Hajtaeib, Khadija Euchi, Mohamed Kacem Ben Fraj, Sana Cheikhrouhou, Yacine Ouahchi, Meriem Mjid, Sonia Toujani, Moncef Feki, Besma Dhahri

Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disorder characterized by irreversible airflow limitation and respiratory muscle dysfunction. Bioactive lipid mediators such as prostaglandins, leukotrienes, and specialized pro-resolving mediators (SPMs) play critical roles in regulating inflammation, yet their relationship with diaphragmatic performance in COPD remains poorly understood. This case-control study investigated the association between circulating lipid mediators and diaphragmatic function in 40 male COPD patients and 40 age- and sex-matched healthy controls. All participants underwent clinical assessment, spirometry, C-reactive protein (CRP) measurement, blood sampling for lipid mediator profiling-including polyunsaturated fatty acid (PUFA)-derived metabolites-and diaphragmatic ultrasound evaluation of excursion and thickening fraction (TF). COPD patients exhibited significantly impaired diaphragmatic function and elevated pro-inflammatory lipid mediators compared with controls. Receiver operating characteristic (ROC) analysis identified Prostaglandin E2 (PGE₂) (area under the curve [AUC] = 0.826), Thromboxane B2 (TXB₂) (AUC = 0.832), and Leukotriene B4 (LTB₄) (AUC = 0.737) as strong diagnostic biomarkers for COPD. Among SPMs, RvD1 correlated positively with diaphragmatic excursion (r = .62) and TF (r = .58), Lipoxin A4 (LXA₄) correlated with Forced Expiratory Volume in one second (FEV₁) (r = .66), and Protectin DX (PDX) showed an inverse association with the COPD Assessment Test (CAT) score (r = -.54). Leukotriene E4 (LTE₄) and Leukotriene D4 (LTD₄) were negatively associated with diaphragmatic performance, while CRP levels inversely correlated with ultrasound parameters. Diaphragmatic TF demonstrated high sensitivity (90%) and specificity (92%) in predicting severe exacerbations. These findings suggest that lipid mediator imbalance contributes to diaphragmatic dysfunction in COPD and that combining lipidomic profiling with diaphragmatic ultrasound may offer a promising approach for assessing systemic inflammation and respiratory muscle performance in male COPD patients.

慢性阻塞性肺疾病(COPD)是一种进行性炎症性疾病,其特征是不可逆的气流限制和呼吸肌功能障碍。生物活性脂质介质,如前列腺素、白三烯和专门的促溶解介质(SPMs)在调节炎症中发挥关键作用,但它们与COPD患者膈功能的关系尚不清楚。本病例对照研究调查了40名男性COPD患者和40名年龄和性别匹配的健康对照者的循环脂质介质与膈功能之间的关系。所有参与者都进行了临床评估、肺活量测定、c反应蛋白(CRP)测量、血脂介质谱的血液取样——包括多不饱和脂肪酸(PUFA)衍生代谢物——以及膈超声偏移和增厚分数(TF)的评估。与对照组相比,COPD患者表现出明显的膈功能受损和促炎脂质介质升高。受试者工作特征(ROC)分析确定前列腺素E2 (PGE₂)(曲线下面积[AUC] = 0.826)、血栓素B2 (TXB₂)(AUC = 0.832)和白三烯B4 (LTB₄)(AUC = 0.737)是COPD的强诊断生物标志物。在SPMs中,RvD1与膈漂移(r = 0.62)和TF (r = 0.58)呈正相关,Lipoxin A4 (LXA₄)与1秒用力呼气量(FEV₁)相关(r = 0.66), Protectin DX (PDX)与COPD评估测试(CAT)评分呈负相关(r = - 0.54)。白三烯E4 (LTE₄)和白三烯D4 (LTD₄)与膈功能呈负相关,而CRP水平与超声参数呈负相关。膈肌TF在预测严重恶化方面表现出高灵敏度(90%)和特异性(92%)。这些发现表明,脂质介质失衡有助于COPD患者的膈功能障碍,将脂质组学分析与膈超声相结合可能为评估男性COPD患者的全身炎症和呼吸肌功能提供一种有希望的方法。
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引用次数: 0
Navigating Masculinities: An Exploration of Peer Coaching, Health Behaviors, and Mortality Risks Among Men in Tuberculosis and HIV Interventions in South Africa. 导航男子气概:探索同伴指导,健康行为,和死亡风险的男性在结核病和艾滋病干预在南非。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-13 DOI: 10.1177/15579883261430886
Kelly Rutt, Lindsey DeVos, Kuyola Gala, Thembani Njama, Mziwanbantu Fosi, Zibele Mhaleni, Joseph Daniels, Andrew Medina-Marino

South African men remain disproportionately affected by tuberculosis (TB) and HIV, with social norms around masculinity often hindering care-seeking and medication adherence. This study investigates how Coach Mpilo, a peer mentoring intervention led by men who are TB survivors or living openly with HIV, engages concepts of masculinity to improve health outcomes among men in TB/HIV care. We conducted in-depth qualitative interviews with male peer coaches implementing the Coach Mpilo intervention in Eastern Cape, Western Cape, and KwaZulu-Natal provinces. Coaches, all TB survivors and/or living with HIV, described their experiences supporting newly diagnosed men with TB/HIV. Guided by the Health, Illness, Men, and Masculinities Framework, thematic analysis identified key domains through which masculine norms and social expectations influenced health trajectories and intervention engagement. 20 participants described how men's emotional health is constrained by norms discouraging vulnerability. Participants reported that men's self-reliance and clinic avoidance impede timely care and adherence, and how provider roles, poverty, and structural barriers increase risk, often forcing men to choose work over health care. Coaches discussed hegemonic ideals among their peer clients, and that stigma delays diagnosis and worsens outcomes. Coaches described finding success by framing treatment and health-seeking as acts of strength and responsibility, and by advocating for male-centered clinic spaces and tailored support. Findings illustrate that working with, rather than against, masculine norms can motivate men to engage with TB/HIV services. Peer coaching that reimagines vulnerability as strength, while addressing both social and systemic barriers, holds promise for promoting men's health and reducing disparities in high-burden settings.

南非男性仍然不成比例地受到结核病和艾滋病毒的影响,围绕男性气质的社会规范往往阻碍了求医和服药。这项研究调查了由结核病幸存者或公开感染艾滋病毒的男性领导的同伴指导干预项目Coach Mpilo如何利用男性气概的概念来改善男性在结核病/艾滋病毒治疗中的健康结果。我们对东开普省、西开普省和夸祖鲁-纳塔尔省实施Mpilo教练干预的男性同伴教练进行了深入的定性访谈。教练,所有结核病幸存者和/或艾滋病毒感染者,描述了他们支持新诊断的结核病/艾滋病毒男性的经历。在《健康、疾病、男子和男子气概框架》的指导下,专题分析确定了男性规范和社会期望影响健康轨迹和干预参与的关键领域。20名参与者描述了男性的情绪健康如何受到不鼓励脆弱的规范的限制。与会者报告说,男子的自力更生和不愿去诊所阻碍了及时护理和坚持治疗,以及提供者的角色、贫穷和结构性障碍如何增加了风险,往往迫使男子选择工作而不是保健。教练们在他们的同龄人中讨论了霸权理想,而这种耻辱感会延迟诊断,使结果恶化。教练们将治疗和寻求健康描述为力量和责任的行为,并倡导以男性为中心的诊所空间和量身定制的支持,以此来获得成功。研究结果表明,支持而不是反对男性化规范可以激励男性参与结核病/艾滋病毒服务。同伴指导将脆弱性重新想象为力量,同时解决社会和系统障碍,有望促进男性健康并减少高负担环境中的差距。
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引用次数: 0
Paternal Alienation, Paternal Strain, Generativity, Adjustment, and Resilience (P-APGAR): A Conceptual Framework for Fathers' Perinatal Psychosocial Adjustment. 父系疏离、父系紧张、生成、适应和恢复力(P-APGAR):父亲围产期心理社会适应的概念框架。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1177/15579883261430883
Rachael E Schmitz

Paternal perinatal depression is underrecognized, and existing tools often fail to capture male-specific symptomatic expressions. Fathers experience significant psychosocial changes during the transitional period, yet clinical assessment of paternal mental health remains largely absent from routine clinical practice. This paper introduces a multi-dimensional tool called the P-APGAR. The theory-informed conceptual tool is meant to guide the assessment of fathers' perinatal adjustment, operationalizing core elements of role-based, relational, and emotional adaptation. The model adapts the logic of the traditional newborn APGAR score to a father-centered context based on Paternal Identity, Alienation, Paternal Strain, Generativity, Adjustment, and Resilience. A theoretical synthesis approach was used to integrate findings from qualitative and quantitative literature on paternal perinatal experiences using established theories of family systems, gender role strain, and transitional resilience. This fusion of nursing theory, sociological constructs, and current research shaped the development of the domains, each meant to reflect fathers' experiences of connection, stress, meaningful adaptation, and coping. This analysis includes a brief review of established instruments (BDI, CES-D, EPDS, GMDS, PHQ-9, PBQ, F-PHI, EGDS, MGMQ, MDRS, and PAPA). The P-APGAR framework provides a structured, clinically applicable approach to identifying vulnerable paternal psychosocial patterns not adequately detected by existing maternal-driven depression scales. This model offers a pragmatic structure based on grounded theories for clinical conversations, research development, and future measurement, while emphasizing fathers' relational roles, purposeful actions, and comprehensive adaptive capacities.

父亲的围产期抑郁症未得到充分认识,现有的工具往往无法捕捉到男性特有的症状表达。父亲在过渡时期经历了重大的心理社会变化,但在常规临床实践中,对父亲心理健康的临床评估在很大程度上仍然缺失。本文介绍了一种称为P-APGAR的多维工具。理论知情的概念工具旨在指导父亲围产期适应的评估,操作基于角色,关系和情感适应的核心要素。该模型将传统新生儿APGAR评分的逻辑调整到以父亲为中心的背景下,基于父亲身份、异化、父亲压力、生成、调整和弹性。本研究采用理论综合的方法,利用已建立的家庭系统、性别角色压力和过渡复原力理论,对父亲围产期经验的定性和定量文献进行整合。护理理论、社会学结构和当前研究的融合塑造了这些领域的发展,每个领域都旨在反映父亲在联系、压力、有意义的适应和应对方面的经验。本分析包括对现有仪器(BDI、CES-D、EPDS、GMDS、PHQ-9、PBQ、F-PHI、EGDS、MGMQ、MDRS和PAPA)的简要回顾。P-APGAR框架提供了一种结构化的、临床适用的方法,用于识别现有的由母亲驱动的抑郁量表无法充分检测到的脆弱的父亲心理社会模式。该模型为临床对话、研究发展和未来测量提供了基于扎根理论的实用结构,同时强调父亲的关系角色、有目的的行动和综合适应能力。
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引用次数: 0
Factors Associated With Testicular Cancer Risk Among New American Military Recruits During Wartime. 战时美国新征兵中睾丸癌风险相关因素。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-15 DOI: 10.1177/15579883261433806
D A Nelson, O T Hill, S A Skaggs, W J Brown

Testicular cancer (TCa) comprises the majority of peri/postpubertal male neoplasms and has increased in incidence. A review of the literature finds little information on short-term risks associated with mens' occupational choices. The U.S. Army includes a large population in the age range of highest TCa risk. We examined whether combat duty and occupational categories were associated with TCa in this population during a recent period of prevalent combat operations. We employed official medical, administrative and sociodemographic data on 210,483 males new to active-duty service in the U.S. Army during 2011-2014, when combat operations in Afghanistan continued apace and those in Iraq were waning. We calculated TCa diagnosis incidence rates by occupation and service time, compared predictor distributions, and devised a multivariable survival regression model. There were 44 new recruits diagnosed with TCa (period prevalence: 0.02%; incidence rate: 11.61 per 100,000 person-years). Within up to 4 years of service, the adjusted TCa diagnosis risk increased twofold for those in the infantry occupation when compared with other military occupations (p = .045) but was not associated with combat deployment. Adjusted TCa risks increased with age and White race and decreased with service time. Variation in adjusted TCa diagnosis risk by occupation was seen within 4 years following service entry. This variation could have potentially occurred due to selection effects for which we could not control, yet causative occupational exposures cannot be ruled out with our data. The results suggest the need for further research to identify causal pathways and risk mitigation strategies.

睾丸癌(TCa)占青春期前后男性肿瘤的大多数,并且发病率有所增加。回顾文献发现,与男性职业选择相关的短期风险信息很少。美国陆军中有大量人口处于TCa风险最高的年龄段。我们研究了在最近一段时间普遍的战斗行动中,战斗任务和职业类别是否与该人群的TCa有关。我们采用了2011-2014年期间美国陆军210,483名新加入现役的男性的官方医疗、行政和社会人口数据,当时阿富汗的战斗行动继续迅速进行,而伊拉克的战斗行动正在减弱。我们计算了职业和服务时间对TCa诊断的影响,比较了预测因子分布,并设计了一个多变量生存回归模型。有44名新兵被诊断为TCa(期间患病率:0.02%;发病率:11.61 / 100,000人年)。在长达4年的服役期间,与其他军事职业相比,步兵职业调整后的TCa诊断风险增加了两倍(p = 0.045),但与战斗部署无关。调整后的TCa风险随年龄和白人而增加,随服役时间而降低。调整后的TCa诊断风险在入职后的4年内随职业而变化。这种变化可能是由于我们无法控制的选择效应而潜在地发生的,但我们的数据不能排除职业性暴露的可能性。结果表明,需要进一步研究,以确定因果途径和风险缓解策略。
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引用次数: 0
Male Factors Associated With Success Following Assisted Reproduction Technology Among Infertile Couples in Ghana. 加纳不孕夫妇中辅助生殖技术成功的男性因素。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-19 DOI: 10.1177/15579883261430887
Issac Kofi Adu, Victor Boachie Owusu, Eric K Amoako, Gordon N A Attoh, Emmanuel K Asiedu, Moses Banyeh, Issah Zabsonre Alhassan, Nafiu Amidu

Assisted reproductive technologies (ARTs) are increasingly utilized in Ghana, as treatment options for couples with infertility, including male factor infertility. While extensive research has focused on female determinants of ART success, comparatively fewer studies have systematically examined the contribution of male partner characteristics beyond routine semen analysis to clinical pregnancy outcomes following ART. The paucity in research is more pronounced in Ghana. This was a cross-sectional study, conducted at the Chosen Hospital and Fertility Centre between January 2024 and March 2025. The study population comprised 198 male partners of women seeking ART services at the hospital, aged between 30 and 61 years. Baseline data were collected from the male partners before initiation of the ART procedure. The sociodemographic, anthropometric, and clinical data of the men were collected using a semi-structured questionnaire and medical records. Venous blood samples were then collected before ART and analyzed for fasting lipids, glucose, complete blood count, liver, and renal function tests. Semen samples were also collected after 3 to 7 days of abstinence and analyzed. Following the ART procedure, 126 (63.6%) of the women tested positive for pregnancy. The sociodemographic, anthropometric, hematological, biochemical, and seminal variables were compared between ART outcomes. The mean ± standard deviation of serum chloride level in mmol/L was higher in males whose partners tested negative for post-ART pregnancy compared to those who tested positive (101.3±3.5 vs 99.9±2.6, P=0.026). No significant disparities in the other variables were observed between the groups. The findings suggest that, although chloride is essential for normal spermatogenesis, high levels of serum chloride could be detrimental to sperm quality. Routine electrolyte measurements of male partners of infertile couples should be performed before ART procedure.

辅助生殖技术(ARTs)在加纳越来越多地被用作不育夫妇(包括男性因素不育)的治疗选择。虽然广泛的研究集中在ART成功的女性决定因素上,但相对较少的研究系统地检查了常规精液分析之外的男性伴侣特征对ART后临床妊娠结局的贡献。研究的匮乏在加纳更为明显。这是一项横断面研究,于2024年1月至2025年3月在选定的医院和生育中心进行。研究人群包括198名在医院寻求抗逆转录病毒治疗的女性的男性伴侣,年龄在30岁至61岁之间。在开始抗逆转录病毒治疗程序之前,从男性伴侣处收集基线数据。使用半结构化问卷和医疗记录收集男性的社会人口学、人体测量学和临床数据。在抗逆转录病毒治疗前采集静脉血样本,分析空腹血脂、血糖、全血细胞计数、肝脏和肾功能测试。禁欲3 ~ 7天后采集精液样本进行分析。接受抗逆转录病毒治疗后,126名(63.6%)妇女的妊娠检测呈阳性。社会人口学、人体测量学、血液学、生化和精液变量在ART结果之间进行比较。女性伴侣art后妊娠检测阴性的男性血清氯化物水平(mmol/L)的平均值±标准差高于阳性的男性(101.3±3.5 vs 99.9±2.6,P=0.026)。其他变量在两组间没有显著差异。研究结果表明,尽管氯化物对正常的精子形成至关重要,但高水平的血清氯化物可能对精子质量有害。不育夫妇的男性伴侣应在抗逆转录病毒治疗前进行常规电解质测量。
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引用次数: 0
The Guangsi Yulin Decoction Inhibits Oxidative Stress and Inflammation-Induced Spermatogenesis Dysfunction via the PTEN/PI3K/AKT/FoxO1 Pathway. 广四育林汤通过PTEN/PI3K/AKT/FoxO1通路抑制氧化应激和炎症诱导的精子发生功能障碍
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1177/15579883261427164
Xiangfa Lin, Junlong Feng, Haoran Chang, Hui Chen, Nianwen Huang, Kecheng Li, Maoke Chen, Haisong Li, Lu Wang, Jisheng Wang

Guangsi Yulin Decoction (GSYLD) is a traditional Chinese medicine (TCM) formula with therapeutic efficacy against spermatogenesis dysfunction. However, the underlying mechanism of the alleviation remains unclear. To investigate the effects of GSYLD on Tripterygium wilfordii polyglycolide (GTW)-induced spermatogenesis dysfunction in mice and to explore associated mechanisms, particularly its role in oxidative stress and inflammation. A total of 60 (7-8-week-old) BALB/c mice were grouped into control (NC), model (GTW), low-dose GSYLD (GSYLD-L, 0.27 g/kg/d), high-dose GSYLD (GSYLD-H, 1.08 g/kg/d), and PTEN inhibitor (1.08 g/kg/d GSYLD-H + 0.3 mg/kg PTEN inhibitor). After eight weeks, the model was validated, and semen quality was evaluated by assessing sperm vitality and concentration. Testicular tissues were analyzed by H&E staining, while Western blotting and RT-qPCR (Reverse Transcription Quantitative PCR) were used to assess the therapeutic efficacy of the GSYLD. In comparison to the GTW group, the GSYLD-H group showed a significant improvement in sperm vitality and concentration (p < .01). GSYLD upregulated PI3K, AKT, and FoxO1, while downregulating PTEN mRNA expression (p < .001). A parallel recovery was observed at the protein level. Specifically, the GSYLD-H group exhibited a significant amelioration of oxidative stress and inflammation, marked by reduced MDA, TNF-α, and IL-6 levels (p < .01) and enhanced SOD activity (p < .001) relative to the GTW group. GSYLD alleviated GTW-induced spermatogenesis dysfunction, potentially through PTEN/PI3K/AKT/FoxO1-mediated regulation of oxidative stress and inflammation.

广思育林汤是一种治疗精子发生功能障碍的中药方剂。然而,缓解的潜在机制仍不清楚。研究GSYLD对雷公藤多醇酯(GTW)诱导的小鼠精子发生功能障碍的影响,并探讨其相关机制,特别是其在氧化应激和炎症中的作用。将60只(7-8周龄)BALB/c小鼠分为对照组(NC)、模型小鼠(GTW)、低剂量GSYLD (GSYLD- l, 0.27 g/kg/d)、高剂量GSYLD (GSYLD- h, 1.08 g/kg/d)和PTEN抑制剂(GSYLD- h + 0.3 mg/kg PTEN抑制剂)。8周后,对模型进行验证,并通过评估精子活力和浓度来评估精液质量。采用H&E染色对大鼠睾丸组织进行分析,同时采用Western blotting和RT-qPCR (Reverse Transcription Quantitative PCR)方法评价GSYLD的治疗效果。与GTW组相比,GSYLD-H组精子活力和浓度显著提高(p < 0.01)。GSYLD上调PI3K、AKT和fox01,下调PTEN mRNA表达(p < 0.001)。在蛋白质水平上观察到平行恢复。具体来说,GSYLD-H组表现出氧化应激和炎症的显著改善,与GTW组相比,MDA、TNF-α和IL-6水平降低(p < 0.01), SOD活性增强(p < 0.001)。GSYLD减轻gtw诱导的精子发生功能障碍,可能是通过PTEN/PI3K/AKT/ fox01介导的氧化应激和炎症调节。
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引用次数: 0
Efficacies of Single-Dose Ceftriaxone Regimens in Treating Gonococcal Paraurethral Duct Infection in Men. 单剂量头孢曲松治疗男性淋球菌性尿道旁管感染的疗效观察。
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1177/15579883251412987
Wenge Fan, Qingsong Zhang, Mei Wei, Yuan Zhu

This study compared the efficacies of single-dose ceftriaxone therapy at doses of 250 mg, 500 mg, and 1 g for gonococcal paraurethral duct infection in men. Forty-eight men with gonococcal paraurethral duct infection were assigned to Groups A, B, and C based on their order of arrival in the clinic; each group comprised 16 patients. Groups A, B, and C received single intramuscular doses of ceftriaxone at 250 mg, 500 mg, and 1 g, respectively. The mean times to resolution of purulent discharge from the paraurethral duct were 1.87 ± 0.81 days in Group A, 1.06 ± 0.25 days in Group B, and 1.13 ± 0.34 days in Group C. The mean times to resolution of erythematous swelling at skin lesions were 4.75 ± 1.69 days in Group A, 3.44 ± 0.89 days in Group B, and 3.31 ± 1.25 days in Group C. The mean times to resolution of tenderness at skin lesions were 5.25 ± 1.00 days in Group A, 3.06 ± 0.10 days in Group B, and 2.38 ± 1.03 days in Group C. The mean times to closure of the paraurethral duct orifice were 9.88 ± 2.92 days in Group A, 6.88 ± 1.71 days in Group B, and 6.38 ± 1.86 days in Group C. The resolution times significantly differed between Group A and Groups B and C (all p < .05); however, there were no significant differences between Groups B and C (all p > .05). The study shows that all three ceftriaxone single-dose regimens effectively cured gonococcal paraurethral duct infection in men. A single 500 mg dose may represent a more suitable treatment option.

本研究比较了单剂量头孢曲松治疗男性淋球菌性尿道旁管感染的效果,剂量分别为250mg、500mg和1g。48名淋球菌性尿道旁管感染的男性根据到达诊所的先后顺序被分为A、B和C组;每组16例。A组、B组和C组分别给予单次肌肉注射头孢曲松250 mg、500 mg和1 g。平均时间分辨率的脓性分泌物从尿道旁管在A组1.87±0.81天,1.06±0.25天在B组,和1.13±0.34天在c组的平均时间分辨率红斑的肿胀的皮肤损伤在A组4.75±1.69天,3.44±0.89天在B组,和3.31±1.25天在c组的平均时间分辨率的温柔在皮肤损伤在A组5.25±1.00天,3.06±0.10天在B组,A组平均闭锁时间为9.88±2.92天,B组为6.88±1.71天,C组为6.38±1.86天,A组与B、C组的闭锁时间差异有统计学意义(p均< 0.05);B组与C组间差异无统计学意义(p < 0.05)。该研究表明,所有三种头孢曲松单剂量方案都能有效治愈男性淋球菌性尿道旁管感染。单次500毫克剂量可能是更合适的治疗选择。
{"title":"Efficacies of Single-Dose Ceftriaxone Regimens in Treating Gonococcal Paraurethral Duct Infection in Men.","authors":"Wenge Fan, Qingsong Zhang, Mei Wei, Yuan Zhu","doi":"10.1177/15579883251412987","DOIUrl":"10.1177/15579883251412987","url":null,"abstract":"<p><p>This study compared the efficacies of single-dose ceftriaxone therapy at doses of 250 mg, 500 mg, and 1 g for gonococcal paraurethral duct infection in men. Forty-eight men with gonococcal paraurethral duct infection were assigned to Groups A, B, and C based on their order of arrival in the clinic; each group comprised 16 patients. Groups A, B, and C received single intramuscular doses of ceftriaxone at 250 mg, 500 mg, and 1 g, respectively. The mean times to resolution of purulent discharge from the paraurethral duct were 1.87 ± 0.81 days in Group A, 1.06 ± 0.25 days in Group B, and 1.13 ± 0.34 days in Group C. The mean times to resolution of erythematous swelling at skin lesions were 4.75 ± 1.69 days in Group A, 3.44 ± 0.89 days in Group B, and 3.31 ± 1.25 days in Group C. The mean times to resolution of tenderness at skin lesions were 5.25 ± 1.00 days in Group A, 3.06 ± 0.10 days in Group B, and 2.38 ± 1.03 days in Group C. The mean times to closure of the paraurethral duct orifice were 9.88 ± 2.92 days in Group A, 6.88 ± 1.71 days in Group B, and 6.38 ± 1.86 days in Group C. The resolution times significantly differed between Group A and Groups B and C (all <i>p</i> < .05); however, there were no significant differences between Groups B and C (all <i>p</i> > .05). The study shows that all three ceftriaxone single-dose regimens effectively cured gonococcal paraurethral duct infection in men. A single 500 mg dose may represent a more suitable treatment option.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 1","pages":"15579883251412987"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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American Journal of Men's Health
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