American Journal of Men's Health最新文献

Prostate cancer is the leading male cancer in sub-Saharan Africa, with 74,878 (17.4%) new cases and 32,390 (11.6%) deaths in 2022. In Togo, the total number of prostate cancers was 726 in 2021. Screening methods are readily available in Togo. However, prostate cancer is still detected at a late stage. This study aimed to determine the factors associated with adherence to prostate cancer screening among retired men in Togo, 2023, using the Health Belief Model. A national descriptive and analytical exploratory cross-sectional study was carried out from March 1 to May 31, 2023. A total of 288 retirees were included. Overall, 54.9% of retirees perceived their vulnerability to prostate cancer, 54.9% perceived its severity, 52.4% perceived barriers to screening, 50.3% perceived benefits from screening, 53.1% perceived their self-efficacy for screening, and 55.2% perceived cues to action. A total of 83% of retirees agreed to undergo prostate cancer screening. The absence of a history of chronic pathology (adjust odds ratio [aOR] = 3.0, 95% CI [1.4, 6.2], p = .010), frequency of annual medical consultation (aOR = 0.3, 95% CI [0.1, 0.8], p = .020), perceived obstacles (aOR = 0.4, 95% CI [0.2, 0.9], p = .029) and perceived cues to action (aOR = 5.1, 95% CI [1.9, 15.1], p = .002) are significantly associated with adherence to prostate cancer screening. This study reported a high level of adherence to prostate cancer screening among retirees. It demonstrated that the absence of a history of chronic pathology, frequency of annual medical consultation, perceived barriers, and perceived incentive to action were significantly associated with adherence to prostate cancer screening.

Sexual violence robs victims of their autonomy and rights to consent. While myths and gender stereotypes allow the narrative that men cannot be victims thrive, stigma has contributed to the silence and invisibility of male victims of sexual violence. This descriptive, cross-sectional study aimed to assess the knowledge, attitude, and prevalence of male sexual violence among male undergraduates in a tertiary institution in Lagos, Nigeria. A multistage sampling method was used to recruit 400 respondents for this study. Data were collected using interviewer-administered semi-structured questionnaires. The data were analyzed using IBM Statistical Package for Social Sciences Version 26. Chi-Square test was used to test for association between categorical variables and a statistical significance level of 5% (p < .05) was set. The mean age of the respondents was 22.7 ± 4.10 years. Most (75%) had good knowledge about sexual violence and 98% had positive attitudes regarding male sexual violence. Thirteen percent, 16%, and 10% of the respondents reported being victims of child sexual abuse, sexual harassment, and sexual assault, respectively. Violence experienced in childhood was found to be a predisposing factor for re-victimization in adulthood (p value of .000). A multi-sectoral approach to curb sexual violence is recommended.

This review employs bibliometric methods to map the evolving landscape of prostate cancer endocrine therapy research over the past 15 years. Through analysis of 961 articles from the Web of Science Core Collection, we identified key trends in therapeutic innovation and clinical translation. The United States emerged as the dominant contributor (34.96% of publications), with Harvard University and the University of California System leading institutional output. Three paradigm shifts emerged: early stage research focused on optimizing androgen deprivation therapy (ADT) efficacy (2008-2013), followed by castration-resistant prostate cancer (CRPC) drug development (2014-2016), and recent emphasis on combination therapies and molecular targeting (2017-2023). The top 50 most cited papers confirmed that keyword clusters directly corresponded to pivotal trials, including TAMPEDE (NCT00268476) and PROSPER (NCT02003924). The translational science spectrum model revealed that 68% of current clinical applications originated from basic research on androgen receptor variants. Emerging frontiers include prostate-specific membrane antigen-targeted radioligand therapy and immunotherapy-ADT synergies. This synthesis provides clinicians with an evidence-based roadmap to navigate therapeutic advancements while highlighting the critical need for international collaboration in addressing persistent challenges such as treatment resistance.

Non-obstructive azoospermia (NOA) is a condition of testicular failure caused by various factors. To retrieve sperm in NOA patients, microdissection testicular sperm extraction (micro-TESE) is a highly effective technique. The present study aimed to evaluate successful sperm retrieval (SSR) in NOA patients across different etiologies in the Iranian population to identify predictive factors. This retrospective analysis included 566 NOA patients undergoing micro-TESE from 2018 to 2023, with 58 histories of Cryptorchidism, 40 Klinefelter syndrome (KS), 6 Y chromosomal microdeletions (YCMDs), 6 histories of chemotherapy, 5 mumps orchitis, and 451 patients with idiopathic reasons. The overall SSR was 43.2%, with a significantly lower SSR in the KS group (p = .012). Patients with higher average ages tended to have higher SSR rates, especially in the idiopathic group. Hormone levels differed among the groups, with higher follicle-stimulating hormone and luteinizing hormone levels in the YCMDs group, higher testosterone levels in the idiopathic and Cryptorchidism groups, and higher prolactin levels in the KS group. There were no significant differences in other clinical characteristics between the SSR and sperm retrieval failure groups, except for a positive relationship between prolactin levels and SSR rates in the KS group (r = .45, p = .003). Our data underscores that underlying etiology and genetic background may reveal more valuable predictive value than age, hormone levels, and testicular volume. This finding suggests that no patient with NOA should be deprived of micro-TESE based on candidate predictors of SSR presented to date.

Sexual dysfunction, which is increasingly recognized as a cause of male infertility, may be influenced by environmental factors such as phthalic acid diesters (phthalates) and prenatal androgen exposure. This study aimed to investigate the association between male sexual function and recent exposure to phthalates and prenatal testosterone. The cross-sectional study included 177 males seeking fertility treatment. The index-to-ring-finger length ratio (2D:4D) was calculated as a measure of prenatal androgen exposure. To evaluate recent phthalate exposure, urinary concentrations of seven phthalate metabolites were measured. Their associations with International Index of Erectile Function (IIEF) scores were analyzed using generalized linear models. One standard deviation increase of mono-methyl phthalate was negatively associated with IIEF domains A (erectile function; exponentiated coefficient, 0.95; exponentiated 95% confidence interval, CI, [0.91, 0.98]) and D (intercourse satisfaction; exponentiated coefficient, 0.91; exponentiated [0.85, 0.97]). While mono-butyl phthalate was positively associated with domain A, mono-ethyl phthalate, monobenzyl phthalate, and the molar sum of di (2-ethylhexyl) phthalate metabolites showed no significant association with IIEF domain scores. When the serum testosterone concentration was included as an exposure variable, the overall association between urinary phthalates and IIEF domain scores remained similar. The left- and right-hand 2D:4D ratios did not show significant associations with any IIEF domain scores. Recent phthalate exposure may affect male sexual function by decreasing testosterone levels and other potential mechanisms.

Testicular cancer (TCa) can precipitate ongoing psychosocial/physical morbidity post-treatment, despite high rates of cure. We conducted a systematic review to synthesise three decades of primary qualitative research on health-related quality of life (HRQoL) to inform the design of supportive care pathways. We queried MEDLINE/PubMed, PsycINFO, CINAHL, and Web of Science for all qualitative studies published up to 26 October 2022 examining issues relevant to HRQoL in post-treatment TCa patients. Two independent reviewers appraised included studies for methodological quality using established guidance for evidence-based public health policy and analysed findings via thematic synthesis. Studies were analytically weighted by study quality. Studies were evaluated using GRADE-CERQual to produce confidence levels in findings. We included 18 studies, comprising 387 participants. Seven studies were graded high quality, eight medium quality, and three low quality. Emergent analytical themes were: (a) Residual psychological injury; (b) Information deficits and unnecessary anxiety; (c) Thwarted life trajectory; (d) Social disruption; (e) Undermined youth; (f) Health service abandonment; (g) Long-term sexual problems; and (h) Maladaptive coping and post-traumatic stress. All findings were deemed 'high confidence', except theme (g), which was of 'moderate confidence'. A limitation of the review was the relative dominance of Anglophone countries in the included studies. Some men treated for TCa are at risk of a range of post-treatment HRQoL issues, particularly psychosocial issues. Some individuals may be more at risk than others, based on specific personality traits, access to accurate and complete information about treatment recovery, and individual coping responses.

This study explores aspects that men consider when deciding whether to participate in a prostate cancer screening program and how the information in the invitation letter contributed to their decision. Semi-structured interviews were conducted with 50- to 62-year-old men invited by letter to a population-based prostate cancer screening program. Data from transcribed interviews were analyzed using qualitative content analysis using manifest and indicative approaches. Eighteen men were interviewed, 10 whom chose to be tested, and 8 who declined screening. The information in the invitation letter was not decisive for whether men chose to be tested or not. The aspects that the men valued in their personal decision to participate or refrain from screening were categorized as (a) the expectation that authorities should take responsibility and provide guidance; (b) fear, which was described as both a driving force and a barrier; (c) reliance upon intuition combined with seeking social and emotional support; (d) the perception of one's own risk of being affected. Men who relied on risk assessment mentioned difficulties in evaluating the information about the potential disadvantages of screening. Our findings suggest that the intention of informed decision-making for prostate cancer screening is difficult to fully realize. Further research is needed to understand how the individual decision-making process is influenced by factors such as assessment of personal risk, perception of advantages and disadvantages, and cultural background, and to optimize the information to the invited men.

Infertility affects 17% of the global population, yet fertility awareness remains low, particularly among younger individuals and men. This study assessed fertility awareness and attitudes toward infertility prevention among French adults of childbearing age, focusing on gender differences. Conducted via social media from March to May 2023, the survey included 322 participants aged 18-43 who had not consulted assisted reproduction centers. Most respondents were women (84%), under 33 (59%), from high socio-professional backgrounds (58%), in relationships (78%), and childless (59%). Significant gender differences emerged regarding desired ages for having a first (women: 30.7 ± 3.5 years vs. men: 32.8 ± 3.8 years; p = .06) and last child (women: 36.7 ± 3.6 years vs. men: 39.8 ± 4.5 years; p = .001). Only 55.8% of men correctly identified the female fertility window, compared to 64.1% of women (p = .023). Men also showed lower awareness of the timing of female fertility decline (p = .043) and underestimated the prevalence of assisted reproductive technologies among heterosexual couples (p = .001). In addition, men were less likely to discuss fertility with their doctor (15.4% vs. 35.9%; p = .004) or express interest in infertility prevention consultations (53.9% vs. 60.8%; p = .048). These findings suggest a gender gap in fertility awareness, with men generally less informed and engaged in reproductive health discussions. While the small sample size limits generalizability, the results underscore the need for targeted educational efforts to improve fertility knowledge and encourage proactive reproductive health behaviors across genders.

Spirometry-induced bronchoconstriction (SIB) refers to the paradoxical narrowing of the airways triggered by deep inhalation (DI) during spirometry testing. This response is atypical but can occur in subjects with heightened airway sensitivity, such as those with asthma. The present case report described a male patient who developed SBI in response to DI during spirometric maneuvers. A 34-year-old male patient with personal (i.e., rhinitis) and family allergy consulted our pulmonary department for recurrent wheezing dyspnea associated with exertional dyspnea level 2 according to the modified Medical Research Council dyspnea scale. Asthma diagnosis was suspected and a spirometry test was required. During five consecutive spirometric efforts, the patient developed a SIB with forced expiratory volume in one second (FEV₁) decreases (in mL and % of initial value [%_Initial]) of 50 mL (1%_Initial), 270 mL (8%_Initial), 480 mL (14%_Initial), and 600 mL (18%_Initial), respectively. Following the spirometry tests, the patient presented symptoms such as wheezing, shortness of breath, and chest tightness. The bronchodilator test (i.e., 400 µg of short-acting bronchodilator) was clinically significant with an increase of FEV₁ by 1,260 mL (40%_Predicted) (FEV₁ passed from 2.80 L [65%_Predicted] to 4.06 L [95%_Predicted]). An alleviation of symptoms was noted, which supports the diagnosis of SIB. Clinicians should exercise caution when asking asthmatic patients to repeatedly perform DI for spirometry testing.