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Men's Mental Health Matters: The Impact of Traditional Masculinity Norms on Men's Willingness to Seek Mental Health Support; a Systematic Review of Literature. 男性心理健康问题:传统男子气概规范对男性心理健康支持意愿的影响文献系统综述
IF 2.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-05-27 DOI: 10.1177/15579883251321670
Leshata Winter Mokhwelepa, Gsakani Olivia Sumbane

Men's mental health is a focus area for improving population health worldwide. Traditional masculine norms among men have been reported to make them more susceptible to mental health issues. This study aims to review existing literature on how traditional masculinity norms influence men's willingness to seek mental health support. This review followed stages of systematic review. The review search was initiated in February 2024. The search process was conducted on electronic databases such as PubMed, PsycINFO, Science Direct, and Google Scholar to identify relevant studies published in English between 2000 and 2024. The search terms included "traditional masculinity norms," "men's mental health," "help-seeking behavior," and "barriers to mental health care." Studies were selected based on their relevance to the topic. The inclusion criteria were studies focusing on adult men and examining the relationship between traditional masculinity norms and mental health help-seeking behaviors. Exclusion criteria included studies focusing on children, adolescents, or women and nonempirical articles. Data extraction covered study details, design, population characteristics, and key findings. This study included 47 relevant studies. Two key themes emerged, namely: masculinity and mental health (impact on mental health); and barriers to seeking help. Traditional masculinity norms significantly deter men from seeking mental health support, highlighting the need for culturally sensitive interventions that address these barriers.

男性心理健康是改善全球人口健康的一个重点领域。据报道,男性的传统男性化规范使他们更容易受到心理健康问题的影响。本研究旨在回顾传统男性规范如何影响男性寻求心理健康支持意愿的现有文献。本综述遵循了系统综述的各个阶段。评审搜索于2024年2月启动。检索过程在PubMed、PsycINFO、Science Direct和谷歌Scholar等电子数据库中进行,以确定2000年至2024年间发表的相关英文研究。搜索词包括“传统的男子气概规范”、“男性心理健康”、“寻求帮助的行为”和“心理健康护理的障碍”。研究是根据它们与主题的相关性来选择的。纳入标准以成年男性为研究对象,考察传统男性气质规范与心理健康求助行为之间的关系。排除标准包括关注儿童、青少年或妇女的研究和非经验性文章。数据提取包括研究细节、设计、人口特征和主要发现。本研究纳入47项相关研究。出现了两个关键主题,即:男子气概与心理健康(对心理健康的影响);以及寻求帮助的障碍。传统的男子气概规范极大地阻碍了男子寻求心理健康支持,突出表明需要采取具有文化敏感性的干预措施来解决这些障碍。
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引用次数: 0
Exploring the Vision of an Equitable Prostate Cancer Care Delivery System: Perspectives of Black Men in Charleston, South Carolina. 探索一个公平的前列腺癌护理提供系统的愿景:黑人在查尔斯顿,南卡罗来纳州的观点。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-06-26 DOI: 10.1177/15579883251336798
Sherrie Flynt Wallington, Kris Bennett, Marvella E Ford, Lee Moultrie, Melanie Slan, Reginald D Tucker-Seeley

Prostate cancer presents a pressing public health challenge in the United States and disproportionately affects Black men. Despite efforts to address these disparities, equitable access to timely diagnosis and optimal treatment remains elusive for many Black men. Using focus group discussions, the researchers aimed to understand what constitutes equitable cancer care and identify tools needed by Black men for equitable navigation of prostate cancer care. Through a community-engaged qualitative design, 29 Black males aged 40 to 75 participated in virtual and in-person focus groups in August 2023. Data analysis employed NVivo qualitative software and an inductive thematic approach. Three overarching themes emerged: general prostate knowledge, barriers and experiences, and preferred communication channels. Participants discussed their understanding of prostate cancer, barriers to screening, experiences with healthcare delivery, and trusted information sources. Findings revealed nuanced differences between groups but emphasized the importance of clear communication, respect, and community support in cancer care. The researchers' future recommendations include developing educational programs, addressing systemic barriers, providing early education on prostate cancer risk, implementing training for providers, creating support groups, and revisiting national guidelines for Black men. The study provides valuable insights into the experiences and needs of Black men when accessing equitable prostate cancer care that are essential for addressing disparities in cancer outcomes.

前列腺癌在美国是一个紧迫的公共卫生挑战,对黑人男性的影响尤为严重。尽管努力解决这些差异,公平获得及时诊断和最佳治疗仍然是许多黑人男子难以捉摸。通过焦点小组讨论,研究人员旨在了解什么是公平的癌症治疗,并确定黑人男性在前列腺癌治疗中公平导航所需的工具。通过社区参与的定性设计,29名40至75岁的黑人男性于2023年8月参加了虚拟和面对面的焦点小组。数据分析采用NVivo定性软件和归纳专题方法。三个主要的主题出现了:前列腺的一般知识,障碍和经验,首选的沟通渠道。参与者讨论了他们对前列腺癌的理解、筛查的障碍、医疗保健服务的经验和可信赖的信息来源。研究结果揭示了各组之间的细微差异,但强调了明确沟通、尊重和社区支持在癌症治疗中的重要性。研究人员未来的建议包括制定教育计划,解决系统障碍,提供前列腺癌风险的早期教育,对提供者进行培训,创建支持小组,以及重新审视黑人男性的国家指导方针。该研究为黑人男性在获得公平的前列腺癌治疗时的经历和需求提供了宝贵的见解,这对于解决癌症结果的差异至关重要。
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引用次数: 0
Violent Firearm Injury and Homelessness: Examining the Experiences of Black Men Participating in Hospital-Based Violence Intervention Programs. 暴力枪支伤害和无家可归:检查黑人男性参与医院暴力干预计划的经验。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-06-23 DOI: 10.1177/15579883251343966
William Wical, Lea Marineau, Nazsa Baker, Bethany Strong, Nakita Lovelady, Joseph B Richardson

Both experiencing homelessness and having survived a violent firearm injury are well-known risk factors for being a victim of violence. Despite there being significant racial disparities in these factors, there is no qualitative research examining the experiences of Black men who survive a gunshot wound and were homeless after their injury. Drawing on over a year of ethnographic research at the two busiest hospital-based violence intervention programs in the state of Maryland, this research centers the experiences of violently injured homeless Black men to understand how to best support their health, healing, and social goals. Emergent themes from the research included the significant need for housing after injury, challenges with healing while homeless, and difficult experiences with housing institutions. The findings suggest that additional supportive care services for Black men who survive gunshot wounds are needed to increase access to safe and stable housing.

众所周知,无家可归和遭受过枪支暴力伤害都是成为暴力受害者的风险因素。尽管在这些因素上存在着显著的种族差异,但目前还没有对黑人枪伤幸存者和受伤后无家可归者的经历进行定性研究。在马里兰州两个最繁忙的医院暴力干预项目中进行了一年多的人种学研究,本研究以暴力受伤的无家可归的黑人男性的经历为中心,了解如何最好地支持他们的健康、康复和社会目标。研究中出现的主题包括受伤后对住房的巨大需求,无家可归时的康复挑战,以及与住房机构的困难经历。研究结果表明,需要为枪伤幸存的黑人提供额外的支持性护理服务,以增加获得安全和稳定住房的机会。
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引用次数: 0
Understanding Drivers of Prostate Cancer Screening in Mexican-Origin Men Along the U.S./Mexico Border Region. 了解美国/墨西哥边境地区墨西哥裔男性前列腺癌筛查的驱动因素
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-06-23 DOI: 10.1177/15579883251343956
Adriana Maldonado, Julio C Loya, Edgar A Villavicencio, Rogelio Torres, Edward Sanchez, Erik Luzanilla, Tomas Garcia, Luis Vazquez, Richard M Hoffman, Emma Torres, David O Garcia

The U.S. Preventive Services Task Force recommends individualized decision making about prostate cancer screening for men between 55 and 69 years of age. Compared to non-Hispanic Whites, Hispanic men are less likely to report having had a prostate-specific antigen test. While these differences have been attributed to individual- and system-level barriers in early detection and screening of prostate cancer (PCa), less is known about Mexican-origin men perceptions of barriers to PCa screening. Using a community-based participatory research approach, we conducted semistructured interviews (5 men with PCa history; 15 men without PCa history) to characterize Mexican-origin men's knowledge, beliefs, attitudes, and experiences with PCa screening in Yuma County, Arizona. Mexican-origin men viewed genetic predisposition as the main driver of PCa, yet participants highly endorsed PCa screening as reflected by the high rates of PCa screening in our study sample. Further, men spoke to how PCa is a taboo subject among Mexican-origin men and how getting screened for it is often perceived as a threat to their manhood. Finally, Mexican-origin men identified a variety of system-level barriers to PCa screening including lack of health insurance, elevated medical costs, and lack of transportation. The study findings add to an emerging body of literature on determinants of PCa screening among Mexican-origin men. The results of this study have significant implications for public health as they underscore the need for multifaceted interventions that target both individual behaviors and broader social influences to increase PCa screening rates among Mexican-origin men.

美国预防服务工作组建议55岁至69岁的男性在前列腺癌筛查方面做出个性化的决定。与非西班牙裔白人相比,西班牙裔男性报告进行前列腺特异性抗原检测的可能性较小。虽然这些差异归因于前列腺癌(PCa)早期检测和筛查中的个体和系统层面的障碍,但对墨西哥裔男性对前列腺癌筛查障碍的看法知之甚少。采用基于社区的参与性研究方法,我们进行了半结构化访谈(5名有前列腺癌病史的男性;15名没有前列腺癌病史的男性),以表征亚利桑那州尤马县墨西哥裔男性对前列腺癌筛查的知识、信仰、态度和经历。墨西哥裔男性认为遗传易感性是前列腺癌的主要驱动因素,但参与者高度支持前列腺癌筛查,这反映在我们研究样本中的高前列腺癌筛查率。此外,男性还谈到,在墨西哥裔男性中,前列腺癌是一个禁忌话题,接受前列腺癌筛查通常被视为对他们男子气概的威胁。最后,墨西哥裔男性确定了前列腺癌筛查的各种系统层面障碍,包括缺乏健康保险、医疗费用升高和缺乏交通。该研究结果增加了对墨西哥裔男性前列腺癌筛查决定因素的新兴文献。这项研究的结果对公共卫生具有重要意义,因为它们强调需要针对个人行为和更广泛的社会影响进行多方面的干预,以提高墨西哥裔男性的前列腺癌筛查率。
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引用次数: 0
Addressing Mental Health Stigma and the Challenges Faced by Sexual Minority Men: Insights from the Philippines. 解决性少数群体男性面临的心理健康耻辱和挑战:来自菲律宾的见解。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1177/15579883251338694
Rowalt Alibudbud
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引用次数: 0
Engaging Young Dads in the Discussion of Family Health: Results from a Preliminary Study. 让年轻父亲参与家庭健康的讨论:初步研究的结果。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-05-28 DOI: 10.1177/15579883251336485
Sierra X Vaughn, Levi Funches, Melanie Smith, Jamichael Fann, Hannah L Maxey

Inclusion of fathers in research and initiatives related to maternal and infant health outcomes is limited, though fathers' involvement with their families has been associated with positive family health outcomes. Engagement of fathers must be done with an understanding of how men view health and fatherhood. This study explores if and how fatherhood influences men's health perceptions and health care-seeking behaviors. This observational study utilized a mixed-method approach to collect data from fathers who were either expecting or had a child under 12 months old. Fathers were invited to complete an electronic survey, and eligible fathers were invited to participate in a focus group discussion. Focus group questions covered four topic areas, and responses were qualitatively analyzed and themed by these topics. Out of 73 eligible fathers who completed the electronic survey, 13 participated in the focus groups. Physical health and mental health were mentioned more often, along with prioritizing healthy routines and habits, and self-improvement were predominant. Fathers also highlighted being positive role models and being committed to their partners. When discussing personal experiences in fatherhood, fathers focused on their family's health over their own. Fatherhood is a rewarding and challenging time that brings many changes to men's lives. This study demonstrates how men's health habits may change because of fatherhood. This evidence can inform how targeted programs can empower men to ensure their highest well-being while optimizing their family's health.

将父亲纳入与孕产妇和婴儿健康结果有关的研究和倡议的情况有限,尽管父亲与家庭的参与与积极的家庭健康结果有关。父亲的参与必须在了解男性如何看待健康和父亲身份的情况下进行。本研究探讨父亲身份是否以及如何影响男性的健康观念和寻求医疗保健的行为。这项观察性研究采用混合方法,从怀孕或有12个月以下孩子的父亲那里收集数据。父亲们被邀请完成一份电子调查,合格的父亲被邀请参加焦点小组讨论。焦点小组问题涵盖四个主题领域,并根据这些主题对回答进行定性分析和主题化。在完成电子调查的73名合格父亲中,有13人参加了焦点小组。身体健康和心理健康被提到的频率更高,同时优先考虑健康的日常生活和习惯,自我改善占主导地位。父亲们还强调要成为积极的榜样,对伴侣忠诚。在讨论个人的父亲经历时,父亲们更关注家庭的健康,而不是自己的健康。做父亲是一段有益而又充满挑战的时期,它给男人的生活带来了许多变化。这项研究表明,男性的健康习惯可能会因为成为父亲而改变。这一证据可以告诉我们,有针对性的方案如何使男性能够确保他们的最高福祉,同时优化他们的家庭健康。
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引用次数: 0
The Influence of Contextual Social Deprivation on Poor Health Among Urban Male Residents: A Nationally Respresentative Study in China. 情境性社会剥夺对城市男性居民健康状况不佳的影响:一项具有全国代表性的研究
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-05-28 DOI: 10.1177/15579883251332733
Haibao Zhu, Tingzhong Yang, Tong Pei, Ying Ying, Sihui Peng

This study aimed to examine whether contextual social deprivation is independently associated with health outcomes. A cross-sectional, multistage sampling design was employed to interview participants from six selected cities in China. A standardized questionnaire was used to collect data on individual socioeconomic characteristics and contextual social deprivation. Multilevel logistic regression models were used to assess the association between social deprivation and self-rated health. A total of 5,782 valid questionnaires were collected in this study. The prevalence of poor health was 5.3% (95% CI [4.2%, 6.3%]). Multilevel logistic regression analysis revealed a negative association between social deprivation and self-rated health. The odds ratios for contextual social deprivation scores of 2, 3, and 4 were 1.89 [1.31, 2.72], 4.21 [2.55, 6.94], and 4.63 [2.77, 7.73], respectively. This study offers new insights into the impact of social deprivation on poor health among urban male residents in China. The research emphasizes the urgent need to address poor health as a key measure to protect the well-being of socially and economically vulnerable populations.

本研究旨在检验情境性社会剥夺是否与健康结果独立相关。采用横断面、多阶段抽样设计对中国六个城市的参与者进行访谈。使用标准化问卷收集个人社会经济特征和情境社会剥夺的数据。采用多水平逻辑回归模型评估社会剥夺与自评健康之间的关系。本研究共收集有效问卷5,782份。健康不良的患病率为5.3% (95% CI[4.2%, 6.3%])。多水平logistic回归分析显示社会剥夺与自评健康呈负相关。情境社会剥夺得分2、3和4的比值比分别为1.89[1.31,2.72]、4.21[2.55,6.94]和4.63[2.77,7.73]。本研究对社会剥夺对中国城市男性居民健康状况不佳的影响提供了新的见解。该研究强调,迫切需要解决健康不良问题,将其作为保护社会和经济弱势群体福祉的一项关键措施。
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引用次数: 0
Integrative Approaches to Prostate Disease Management: Nutrition, Exercise, and Lifestyle Modifications. 前列腺疾病管理的综合方法:营养、运动和生活方式的改变。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-06-23 DOI: 10.1177/15579883251344571
Patrick Maduabuchi Aja, Peter Chinedu Agu, Angela Mumbua Musyoka, Wisdom Ngwueche, Joseph Uche Odo, Esther Ugo Alum, Ilemobayo Victor Fasogbon, Mbyemeire Herbert, Ejike Daniel Eze

Prostate-related conditions, including benign prostatic hyperplasia, prostatitis, and prostate cancer, represent significant health concerns, particularly among aging men. This study utilized a comprehensive review of existing literature and case studies to explore the effectiveness of integrative approaches, emphasizing nutrition, exercise, and lifestyle modifications, in managing prostate diseases. Data were collected from peer-reviewed journals, clinical trials, and meta-analyses focusing on dietary patterns, physical activity, and complementary therapies. The findings were synthesized to provide evidence-based recommendations. Results highlight that plant-based diets, rich in fruits, vegetables, whole grains, and healthy fats, demonstrate protective effects against prostate conditions, while diets high in saturated fats and processed foods increase risk. Specific bioactive compounds,such as lycopene, omega-3 fatty acids, and polyphenols, were linked to reduced disease progression. Physical activity emerged as a key component, enhancing hormonal balance, reducing inflammation, and improving survival rates in prostate cancer patients. Aerobic and resistance exercises were particularly effective in mitigating treatment side effects such as fatigue and muscle loss. Stress-reduction techniques, including mindfulness and yoga, alongside moderated alcohol consumption, further improved psychological well-being and overall prostate health. Integrative approaches, combining conventional treatments with holistic care, demonstrated enhanced outcomes by addressing the physical, emotional, and social dimensions of prostate disease. Emerging fields such as nutrigenomics and natural products offer opportunities for personalized interventions, paving the way for innovative management strategies. This study underscores the potential of integrative methods to improve disease outcomes, prevent progression, and enhance the quality of life for men affected by prostate conditions, advocating for their inclusion in prostate disease management protocols.

前列腺相关疾病,包括良性前列腺增生、前列腺炎和前列腺癌,是重要的健康问题,尤其是在老年男性中。本研究利用对现有文献和案例研究的全面回顾来探讨综合方法的有效性,强调营养,运动和生活方式的改变,在管理前列腺疾病。数据收集自同行评审期刊、临床试验和荟萃分析,重点关注饮食模式、身体活动和补充疗法。这些发现被综合起来以提供基于证据的建议。研究结果强调,富含水果、蔬菜、全谷物和健康脂肪的植物性饮食对前列腺疾病有保护作用,而富含饱和脂肪和加工食品的饮食则会增加风险。特定的生物活性化合物,如番茄红素、omega-3脂肪酸和多酚,与减少疾病进展有关。在前列腺癌患者中,体育活动是增强激素平衡、减少炎症和提高生存率的关键因素。有氧运动和阻力运动在减轻治疗副作用如疲劳和肌肉损失方面特别有效。减压技术,包括正念和瑜伽,加上适度饮酒,进一步改善了心理健康和整体前列腺健康。综合方法,将传统治疗与整体护理相结合,通过解决前列腺疾病的身体、情感和社会层面,证明了更好的结果。营养基因组学和天然产品等新兴领域为个性化干预提供了机会,为创新管理战略铺平了道路。本研究强调了综合方法在改善前列腺疾病结局、预防进展和提高受前列腺疾病影响的男性生活质量方面的潜力,提倡将其纳入前列腺疾病管理方案。
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引用次数: 0
Clinical Efficacy Study of Green Light Top-Firing Sharp for the Treatment of Short-Segment Urethral Strictures in Men. 绿光顶射利器治疗男性尿道短段狭窄的临床疗效研究。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-05-01 Epub Date: 2025-05-24 DOI: 10.1177/15579883251336094
Qunfeng Wang, Tong Bao, Zhijie Chen, Zongyao Hao

To analyse and evaluate the safety and efficacy of green light top-firing sharp in the treatment of short-segment urethral stricture in men. A retrospective analysis of the medical records of 65 men with short-segment urethral strictures confirmed at our hospital over the past 5 years was conducted. Patients were divided into two groups based on the surgical procedure: the cold knife urethral stricture endotomy group (direct vision internal urethrotomy [DVIU] group, n = 33) and the green light top-firing sharp urethral stricture endotomy + urethral stricture scar vaporisation group (Photoselective vaporization of the prostate [PVP] group, n = 32). Data before and after surgery were collected. The operation time was shorter and intraoperative bleeding was less in the PVP group than in the DVIU group, and the difference between the two groups was significant. There was no significant difference in the incidence of postoperative complications between the two groups. There were significant differences in the maximum urinary flow rate, residual urine volume, International Prostate Symptom Score and quality of life score before and after surgery between the two groups. Green light top-firing sharp treatment of men's short-segment urethral stricture involves less injury, less bleeding and less complications than cold knife urethral stricture dissection and is a safe and effective method.

目的:分析评价绿光顶射利器治疗男性尿道短段狭窄的安全性和有效性。回顾性分析近5年来本院确诊的男性短段尿道狭窄65例病例。根据手术方式将患者分为两组:冷刀尿道狭窄内切组(直接视觉尿道内切[DVIU]组,n = 33)和绿光顶射尖锐尿道狭窄内切+尿道狭窄瘢痕汽化组(前列腺光选择性汽化[PVP]组,n = 32)。收集手术前后数据。PVP组比DVIU组手术时间短,术中出血少,两组比较差异有统计学意义。两组术后并发症发生率无显著差异。两组患者术前、术后最大尿流率、残尿量、国际前列腺症状评分及生活质量评分差异均有统计学意义。绿光顶射尖锐治疗男性短段尿道狭窄,损伤小,出血少,并发症少,是一种安全有效的方法。
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引用次数: 0
The Earlier Apoptosis in Human Sperm: Its Correlation with Semen Parameters and Assisted Reproduction Outcome. 人类精子早期凋亡:与精液参数和辅助生殖结果的关系。
IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-03-01 Epub Date: 2025-04-16 DOI: 10.1177/15579883251328353
Xuhui Yang, Yonghua Hu, Yuan Fei Wu, Jie Zhang, Zhicheng Huang, Feng He

The combination of Syto16/7-AAD allows the detection of apoptosis at an earlier stage than that of annexin V/7-AAD. The effects of the earlier apoptosis of spermatozoa on fertilization rate and post-embryonic development have not been investigated systematically. The objective of this study is to assess the relationship between the earlier apoptosis of spermatozoa in IVF patients and seminal parameters (concentration and morphology), to assess the effect of the earlier apoptosis of spermatozoa on ART outcomes, especially with regard to clinical pregnancy. The earlier apoptosis of spermatozoa was detected by syto16/7AAD using flow cytometry (FCM) in 98 couples (98 IVF) before and after density gradient centrifugation (DGC), and its relationships with the fertilization rate, the normal fertilization rate, the cleavage rate, the good embryo rate and the cumulative clinical pregnancy rate were assessed. Meanwhile, the correlation with seminal parameters (concentration, motility and morphology) was also analyzed. The rate of the earlier apoptosis was significantly negatively correlated to sperm concentration(r = -.302, p = .003) and membrane integrity rate(r = -.862; p < .01) after DGC. There was also a positive correlation between the rate of the earlier apoptosis and sperm mortality rate (r = .225, p = .027) after DGC. A highly significantly negative correlation was found between the rate of the earlier apoptosis and outcomes in IVF patients: the fertilization rate and the normal fertilization rate decreased as the rate of the earlier apoptosis increased (r = -.271, -.288; p = .008,.004). The cumulative clinical pregnancy rate also significantly differed between patients with the earlier apoptotic rate ≥15% and <15% (57.89% vs. 81.69%, p < .01) after DGC. The earlier apoptosis of spermatozoa seems to affect fertilization, however, it does not affect the early embryo development proficiency in IVF procedures. Because of the decreased fertilization rate, the earlier apoptosis of spermatozoa can compromise the number of available embryos and good embryos, resulting in cumulative clinical pregnancy loss.

与膜联蛋白V/7-AAD相比,Syto16/7-AAD联合使用可以更早地检测细胞凋亡。精子早期凋亡对受精率和胚胎后发育的影响尚未有系统的研究。本研究的目的是评估体外受精患者精子早期凋亡与精液参数(浓度和形态)之间的关系,评估精子早期凋亡对ART治疗结果的影响,特别是对临床妊娠的影响。采用流式细胞仪syto16/7AAD检测98对试管婴儿(IVF)患者密度梯度离心(DGC)前后精子早期凋亡情况,并评价其与受精率、正常受精率、卵裂率、良胚率及临床累计妊娠率的关系。同时,还分析了其与种子参数(浓度、活力和形态)的相关性。早期细胞凋亡率与精子浓度呈显著负相关(r = -)。302, p = .003)和膜完整性率(r = -.862;p r =。225, p = .027)。体外受精患者早期细胞凋亡率与预后呈极显著负相关:随着早期细胞凋亡率的增加,受精率和正常受精率降低(r = -)。271年,-.288;p = 0.008, 0.004)。早期细胞凋亡率≥15%和p
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American Journal of Men's Health
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