American Journal of Men's Health最新文献

Chronic prostatitis (CNP) is a prevalent inflammatory disorder among men. The Xialiqi capsule has been reported to alleviate the clinical symptoms of CNP patients, which may be related to its anti-inflammatory effect; yet, its exact mechanism of action remains unclear. In this study, human normal prostate epithelial cells (RWPE-2 cells) were categorized into a control group, a model group, an inhibitor group, along with high, medium, and low drug-containing serum groups (5%, 10%, and 15%, respectively). With the exception of the control group, cell pyroptosis models were created by stimulating with lipopolysaccharide (100 ng/mL) and adenosine triphosphate (5 mM). Subsequently, drug-containing serum and the NOD-like receptor 3 (NLRP3) inhibitor (MCC950) were utilized to intervene with the model cells according to their respective groups. Post-administration of MCC950 and drug-containing serum, an improvement in cell viability was noted in the inhibitor group and medium-high dosage groups (by 20.5%, 38.2%, and 73.2%). Transmission electron microscopy indicated a reduction in the features characteristic of cell pyroptosis. Levels of nitric oxide, interleukin-18 (IL-18), and tumor necrosis factor-α in the cellular supernatant decreased significantly (60.7%, 21.6%, 33.7%, 41.8%; 49.2%, 54.8%, 53.5%, 69.3%; 31.3%, 44.4%, 38.1%, 51.2%). Immunofluorescence showed reduced fluorescence intensity of NLRP3 and Cysteine aspartate protease-1 (Caspase-1) proteins, and Western Blot analysis revealed a significant decline in the expression of NLRP3, pro-Caspase-1, and gasdermin D (20.5%, 45.9%, 58.1%, 74.8%; 23.2%, 36.7%, 51.6%, 51.9%; 15.4%, 28.6%, 33.1%, 39.2%). In vitro experiments suggest that the Xialiqi capsule may treat CNP by regulating prostate epithelial cell pyroptosis and reducing inflammatory factor release via inhibiting the NLRP3/Caspase-1 signaling pathway. This study offers a novel approach for future CNP treatment with traditional Chinese medicine preparations, deserving further promotion.

Suicide is a leading cause of death in Canada, with men being three times more likely to die from suicide compared with the rest of the population. Among Canadian men, those who are Two-Spirit, gay, bisexual, transgender, and queer (2SGBTQ) are disproportionately impacted by suicidality. Drawing on this growing public health crisis, this current scoping review focuses on Canadian-based 2SGBTQ men to address the research question: What is known about Canadian-based Two-Spirit, gay, bisexual, transgender, and queer (2SGBTQ) men's experiences with suicidality? Keywords related to "2SGBTQ men" and "suicidality" were searched across five bibliographic databases to derive 25 articles for analysis. Three thematic findings were generated: (a) Methodological Approaches, (b) Social Identities and Stigma, and (c) Psychosocial Health Issues. First, we trace how the study designs, data sources, and sampling methods used in research influence how we know about 2SGBTQ men's suicidality. Second, we report on anti-gay, anti-trans, and HIV stigma as characterizing the diverse associations between 2SGBTQ men's multiple social identities and their suicidality risk. Third, we detail how psychosocial health issues, including mental illness, financial precarity, and substance use, exacerbate social stresses and related risks of suicidality for 2SGBTQ men. These findings map understandings about how suicide risk diversely manifests among subgroups of Canadian-based 2SGBTQ men and interconnections between 2SGBTQ men's social identities, stigma, and their psychosocial health issues. We draw on these learnings to recommend future research priorities regarding 2SGBTQ men's suicidality, alongside opportunities to advance knowledge to inform targeted suicide prevention interventions.

Wounds caused by human bites have a high infection rate. A 59-year-old male patient came to our poison control center because of soft tissue injuries in the left arm and left hand, pain, swelling, and necrosis. Before entering the hospital, he had a high fever. Physical examination found that the patient's lips were dry, his tongue was dirty, his skin and mucous membranes were less pink, his pulse was 80 beats/min, and his temperature was 36.5°C. Information on May 9, 2024, the patient was bitten on the left arm by a child. The patient had a negative blood culture, a negative burn fluid culture, high-sensitivity C-reactive protein of blood chemistry is 458.1 mg/L, total blood cell analysis with white blood cell is 19.9 G/L, percent of neutrophil is 92.4, soft magnetic resonance imaging of the arm and hand areas with images is cellulitis under the skin of the left arm.The patient was injected with antitetanus toxin serum, antibiotics (Dalacin C, Linezonide, meropenem), and was infused paracetamol. After 1 day of treatment, the patient's condition did not improve and worsened, so the patient was transferred to the National Burn Hospital for further treatment. This article aims to talk about soft tissue injuries due to soft tissue inflammation or necrosis that can occur in patients who are bitten by human. This is the first patient with soft tissue damage with cellulitis under the skin of the left arm known at our poison center.

Support for abortion is comparable between men and women in the United States; one in five reproductive age men reports abortion involvement. Yet, societal focus on abortion as a uniquely women's issue minimizes men's involvement in abortion. We conducted a secondary analysis of survey (n = 203) and interview data (n = 30) on male partner's experiences accompanying abortion recipients at two family planning clinics in Chicago, Illinois. Respondents identified reasons for abortion from a prepopulated 14-item list. We correlated reasons with respondent's abortion preference and decision satisfaction, characterizing this relationship via thematic analyses of interview transcripts. Nearly all men (97.5%) identified multiple reasons for abortion (median: 6/14), including: mistimed pregnancy (80%), impact on his/his partner's education/career (75%-80%), and finances (71%). Neither individual reasons nor number of reasons was significantly associated with abortion decision preference or decision satisfaction. While 41% would not have chosen abortion, only 10% reported dissatisfaction. Men's perception of decision concordance with their partner was significantly linked to their satisfaction (p < .01). Thematic analysis highlighted complex partner involvement, including shared and deferred decision-making and tension amid demonstrated support. Many abortion-accompanying men preferred to continue the pregnancy, yet very few reported dissatisfaction with the ultimate decision, which may be related to perceived decision concordance with their female partner. Men's decisions for abortion are complex and include varying degrees of male partner involvement and/or decision deferral to female partners.

Anejaculation (AE) has long been a challenging issue in andrology due to its low clinical reporting rate, leading to an insufficient understanding within the academic community. This case report discusses a 52-year-old AE patient with a long-term history of diabetes mellitus. His seminal vesicles ultrasound images revealed a notable absence of anechoic polycyclic areas, a characteristic not previously reported in AE patients. We hypothesize that this finding is attributable to diabetes-induced seminal vesicles secretory dysfunction, leading to AE in this patient. This case underscores the importance of anechoic polycyclic areas in the physiology of ejaculation and highlights the necessity for further research into the correlation between these areas and various types of ejaculatory disorders, aiming to provide valuable insights for the medical community.

Studies indicate that mental health literacy (MHL) is low among college students. Previous studies report that male college students score lower on MHL than female college students. MHL is connected to mental health help-seeking behavior. Black male college students are shown to be at higher risk for mental health problems such as depression, anxiety, and post-traumatic stress disorder, yet are less likely to seek help for these problems compared with other racial groups. Challenges with mental health can lead to significant negative consequences, such as poor academic performance, social isolation, and even suicide attempts. Stigma has been identified as an important factor that can influence the help-seeking behavior of male college students. Previous research has indicated that Black male college students in predominantly White institutions (PWIs) often struggle with seeking mental health compared with those in Historically Black Universities and Colleges (HBCUs). The purpose of the descriptive cross-sectional study was to investigate the relationships among MHL, stigma, and help-seeking behavior among Black males at HBCUs. The results indicate that having better mental health knowledge is linked to seeking help more often, stressing the need to enhance mental health understanding for better support-seeking. Seeking help was positively associated with reduced stigma. The implications for practitioners, policymakers, and administrators were explored, emphasizing the need for targeted, culturally sensitive interventions for young Black men in higher education. This study underscores the importance of addressing their specific challenges to enhance mental health and academic outcomes.

This study aims to evaluate the clinical efficacy of acupuncture and moxibustion in CP treatment and assess the quality of clinical literature. Controlled clinical trials (CCT) and randomized controlled trials (RCTs) from PubMed, Web of Science, NLM, CNKI, and Wanfang (January 2003 to January 2023) were analyzed. Relevant data were extracted and statistically analyzed using RevMan 5.1 software. Twenty high-quality papers (JADAD≥3) involving 1,661 patients were included. Meta-analysis showed a significant difference in the overall response rate between the test and control groups in CP treatment (odds ratio [OR] = 4.08 [95% CI = 3.13, 5.33], p < .001). The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) posttreatment comparison showed significantly better symptom improvement in the acupuncture and moxibustion group (mean difference [MD] = -4.87 [95% CI = -6.145, -3.59]). Acupuncture and moxibustion significantly improve response rates and symptom scores in CP treatment compared with control treatments (drugs, sham acupuncture). This suggests that acupuncture and moxibustion are effective for CP and worth promoting, though further exploration of their mechanisms is needed.

Many observational epidemiological studies have reported an association between matrix metalloproteinases (MMPs) and urologic cancers. However, the causal relationship between these two phenotypes remains uncertain. This study aims to examine the bidirectional causal relationship between serum MMPs and three urologic cancers: kidney, prostate, and bladder cancer. Using data from large-scale genome-wide association studies (GWAS), we employed two-sample Mendelian randomization (MR) methods to assess the causal relationship between serum MMPs and urologic cancers. We performed inverse variance-weighted MR as the primary method for calculating the overall effects of multiple instruments, while implementing additional MR methods and sensitivity analyses. Odds ratios (ORs) were employed to evaluate the causal relationship between serum MMPs and urologic cancers risk. Our findings indicated a causal relationship between serum MMP-3 levels and prostate cancer risk (OR = 1.07, 95% confidence interval [CI] = [1.02, 1.11], p = .003). There was a possible causal relationship between serum MMP-1 and prostate cancer (OR = 0.95, 95% CI = [0.92, 0.99], p = .02). Serum MMP-1 may also increase the risk of bladder cancer (OR = 1.24, 95% CI = [1.04, 1.49], p = .016). We did not find significant associations of the remaining MMPs with prostate, bladder, and kidney cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on MMPs (p > .05). Our study provides evidence of a potential causal relationship between serum MMPs and both prostate cancer and bladder cancer. However, large-scale studies are necessary to confirm and reveal the underlying mechanisms of this association.

Strenuous sports are associated with an enlarged prostate. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between strenuous sports and prostatic hypertrophy. The study utilizes single nucleotide polymorphisms (SNPs) associated with strenuous sports obtained from published genome-wide association studies (GWAS), alongside summarized genetic data related to benign prostatic hyperplasia (BPH) from published GWAS. The primary analytical method used is the Inverse Variance-Weighted (IVW) approach for two-sample MR analysis. Heterogeneity of the results is assessed using Cochran's Q-statistic, while horizontal pleiotropy is evaluated using MR-Egger. Sensitivity analyses include "leave-one-out" tests. The findings indicate a protective causal effect of strenuous sports on BPH (OR = 0.927, 95% CI: [0.870, 0.988]; p = .020). Results from the Weighted Median (WM) method (OR = 0.904, 95% CI: [0.837, 0.978]; p = .011) support this discovery. Using Mendelian randomization, the study provides reliable causal evidence linking high-intensity exercise to a reduced risk of BPH, overcoming biases seen in traditional observational studies. The study demonstrates a causal protective effect of strenuous sports on BPH, suggesting exercise as a preventive strategy for prostate health.

Diabetes-induced erectile dysfunction (DIED) is a type of refractory erectile dysfunction which can be clinically treated using the traditional Chinese medicine leech whose main ingredient is hirudin. Oxidative stress can damage vascular endothelial cells, affect blood circulation, and induce fibrosis of smooth muscle cells. This study assessed the efficacy of hirudin in treating DIED before exploring its potential mechanism of action. DIED was induced in rats using streptozotocin, while experimental apomorphine was used to screen for erectile dysfunction models. The rats were then divided into four groups: a blank control group (NC group), a model group (M group), a hirudin group (H group), and an inhibitor group (YC group). After 2 weeks, the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) were determined. The histological features and HIF-1α/RhoA/ROCK signaling pathway-related proteins of the penile corpus cavernosum were detected. Erectile function improved in the H and YC groups without significantly affecting body weight and blood glucose levels, with histopathological analysis also showing improvement in penile structure in these groups. In addition, the expression of HIF-1α/RhoA/ROCK signaling pathway-related proteins was lower in the penile cavernous tissue of rats in the H and YC groups (p < .05), with the serum levels of NO and SOD also being higher in these groups (p < .05). The serum level of MDA decreased in the YC and H groups (p < .05). In this study, only animal experiments were conducted to investigate the regulation of Rho/ROCK pathway by HIF-1α. Cellular studies of the underlying mechanisms are lacking.