Pub Date : 2023-06-27DOI: 10.21926/obm.geriatr.2302241
Obm Geriatrics Editorial Office
InterviewAn Interview with Dr. Ines TestoniOBM Geriatrics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: geriatrics@lidsen.comOBM Geriatrics 2023, volume 7, issue 2 doi:10.21926/obm.geriatr.2302241Received: June 25, 2023Accepted: June 26, 2023Published: June 27, 2023
美国俄亥俄州比奇伍德市，2000 Auburn Drive, One Chagrin Highlands, Suite 200;E-Mail: geriatrics@lidsen.comOBM老年病学2023，第7卷，第2期doi:10.21926/obm.geriatr。收稿日期:2023年6月25日收稿日期:2023年6月26日发表日期:2023年6月27日
{"title":"An Interview with Dr. Ines Testoni","authors":"Obm Geriatrics Editorial Office","doi":"10.21926/obm.geriatr.2302241","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302241","url":null,"abstract":"Interview<strong>An Interview with Dr. Ines Testoni</strong><em>OBM Geriatrics</em> Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: <a href=\"mailto:geriatrics@lidsen.com\">geriatrics@lidsen.com</a><em>OBM Geriatrics</em> 2023, volume 7, issue 2 doi:10.21926/obm.geriatr.2302241<strong>Received:</strong> June 25, 2023<strong>Accepted:</strong> June 26, 2023<strong>Published:</strong> June 27, 2023","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44652804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.21926/obm.geriatr.2302240
M. Turrin, L. Fornasiero, Antonio Navarro
We describe the clinical case of a 74-year-old male patient who received the second Comirnaty/Pfizer anti-COVID-19 vaccine dose. After 3 weeks he showed the clinical signs of polymyalgia rheumatica. The history included mild chronic normocytic normochromic anemia and hypogammaglobulinemia, osteoarthritis disease, livedo reticularis, hypercholesterolemia, and arterial hypertension. Despite prolonged treatment with NSAIDs and dexamethasone, the disease evolved into remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Neoplastic diseases and associated collagen diseases were excluded. The clinical picture recurred, soon after, the booster dose of the Spikevax/Moderna vaccine. The inflammatory indices were high, the radiographs of the hands were free of erosions, the ultrasound investigations revealed bursitis of the shoulders, knee synovitis, marked subcutaneous edema of the lower limbs, hydrocele, bilateral Baker's cyst in the popliteal cavity, hematoma of a calf. The clinical picture, markedly improved, with oral prednisolone and was stabilized with the association of hydroxychloroquine. The finding of persistent hypomagnesemia was related to chronic intake of esomeprazole. The reports of rheumatological reactions in international databases and the rare cases of RS3PE syndrome following the COVID-19 vaccine described in the literature are considered.
{"title":"Polymyalgia Rheumatica Evolved into RS3PE Syndrome. What is the Culprit: Idiopathic or Secondary, Following mRNA-Based COVID-19 Vaccines? A Case Report and Brief Review of the Literature","authors":"M. Turrin, L. Fornasiero, Antonio Navarro","doi":"10.21926/obm.geriatr.2302240","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302240","url":null,"abstract":"We describe the clinical case of a 74-year-old male patient who received the second Comirnaty/Pfizer anti-COVID-19 vaccine dose. After 3 weeks he showed the clinical signs of polymyalgia rheumatica. The history included mild chronic normocytic normochromic anemia and hypogammaglobulinemia, osteoarthritis disease, livedo reticularis, hypercholesterolemia, and arterial hypertension. Despite prolonged treatment with NSAIDs and dexamethasone, the disease evolved into remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Neoplastic diseases and associated collagen diseases were excluded. The clinical picture recurred, soon after, the booster dose of the Spikevax/Moderna vaccine. The inflammatory indices were high, the radiographs of the hands were free of erosions, the ultrasound investigations revealed bursitis of the shoulders, knee synovitis, marked subcutaneous edema of the lower limbs, hydrocele, bilateral Baker's cyst in the popliteal cavity, hematoma of a calf. The clinical picture, markedly improved, with oral prednisolone and was stabilized with the association of hydroxychloroquine. The finding of persistent hypomagnesemia was related to chronic intake of esomeprazole. The reports of rheumatological reactions in international databases and the rare cases of RS3PE syndrome following the COVID-19 vaccine described in the literature are considered.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.21926/obm.geriatr.2302239
Xiaoli Li, Kendall Brune, Jean Keller, Jennifer Stelter, S. Ingman
Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A survey was conducted to help understand the role of activity professionals in using APIE in long-term care. Questionnaires were completed by 195 activity professionals working as activity directors and activity staff in long-term care settings. The major factors studied were job background, certification, and the performance of activity professionals using the APIE model. Findings showed that 11.8% of the activity professionals had a high school education, 12.3% had no certification, and 9.2% of them had unrelated certifications. When examining the APIE model, we found that activity professionals used person-centered approaches when they assessed residents` needs and wants, planned and implemented the activities, but lacked evaluation when measuring the outcomes; 79.5% of the participants were not tracking the number of minutes residents spent on activities; and 72.8% of the respondents did not measure the impact of resident engagement on clinical outcomes such as falls, depression, cognition, and medication use. Lack of professional training and the application meaningful evaluation related to the impact of activities with residents by activity professionals may challenge administrators’ capacity of estimating the need, value, and role of activity professionals within long-term care facilities. The study advocates for applying the APIE process to the delivery of activities and evaluation of the benefits of residents` activity and engagement.
{"title":"Role of Activity Professionals in Applying APIE Model to Enhance Residents’ Activity and Engagement in Long-Term Care Settings","authors":"Xiaoli Li, Kendall Brune, Jean Keller, Jennifer Stelter, S. Ingman","doi":"10.21926/obm.geriatr.2302239","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302239","url":null,"abstract":"Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A survey was conducted to help understand the role of activity professionals in using APIE in long-term care. Questionnaires were completed by 195 activity professionals working as activity directors and activity staff in long-term care settings. The major factors studied were job background, certification, and the performance of activity professionals using the APIE model. Findings showed that 11.8% of the activity professionals had a high school education, 12.3% had no certification, and 9.2% of them had unrelated certifications. When examining the APIE model, we found that activity professionals used person-centered approaches when they assessed residents` needs and wants, planned and implemented the activities, but lacked evaluation when measuring the outcomes; 79.5% of the participants were not tracking the number of minutes residents spent on activities; and 72.8% of the respondents did not measure the impact of resident engagement on clinical outcomes such as falls, depression, cognition, and medication use. Lack of professional training and the application meaningful evaluation related to the impact of activities with residents by activity professionals may challenge administrators’ capacity of estimating the need, value, and role of activity professionals within long-term care facilities. The study advocates for applying the APIE process to the delivery of activities and evaluation of the benefits of residents` activity and engagement.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44100884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.21926/obm.geriatr.2302238
A. Bellieni, Beatrice Di Capua, E. Villani, L. Tagliaferri, D. Fusco, M. Gambacorta, Francesco Presta, S. Bracci, V. Valentini, F. Landi, G. Colloca
New technologies, aging-related changes, and evolution in patients' needs have led to a new scenario in all oncological fields in front of which we have to move on. Technological progress has made it possible to increase the number of patients treated, including elderly patients and generally those at higher risk of toxicity. However, this scenario has led to new problems requiring new skills to be addressed. For this reason, Gemelli-ART (Advanced Radiation Therapy) of Fondazione Policlinico Universitario A. Gemelli IRCCS – Rome, Italy, started a collaboration with a team of geriatricians trained in geriatric oncology to manage the growing number of elderly patients and to deal with treatment-related toxicity and supportive care to complete planned treatment. This study evaluates the impact of geriatric oncology intervention performed by a geriatrician with particular expertise in managing complex cancer patients admitted to an Oncology Unit. The number of complex patients admitted to the Radiation Oncology Unit raised from 90 in 2016 to 226 in 2018 (+151.1%). 63.4% of complex patients underwent treatment, with a curative goal in 43.7% of cases. Among all admitted patients, the treatment discontinuation rate was 14%. The treatment discontinuation rate was 5.5% in patients over 80 years old with planned admission, versus 27.0% in patients admitted from the emergency room. Our data suggest that geriatric expertise in an Oncology Unit helps personalize patients' treatment and allows for treating an increasing number of complex patients. Identifying frail and complex patients is essential to manage these situations effectively and efficiently, optimize healthcare resources, avoid over and under-treatment, and provide the best care.
{"title":"The Geriatric Impact in the Management of Complex Cancer Patients: A Monocenter Experience","authors":"A. Bellieni, Beatrice Di Capua, E. Villani, L. Tagliaferri, D. Fusco, M. Gambacorta, Francesco Presta, S. Bracci, V. Valentini, F. Landi, G. Colloca","doi":"10.21926/obm.geriatr.2302238","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302238","url":null,"abstract":"New technologies, aging-related changes, and evolution in patients' needs have led to a new scenario in all oncological fields in front of which we have to move on. Technological progress has made it possible to increase the number of patients treated, including elderly patients and generally those at higher risk of toxicity. However, this scenario has led to new problems requiring new skills to be addressed. For this reason, Gemelli-ART (Advanced Radiation Therapy) of Fondazione Policlinico Universitario A. Gemelli IRCCS – Rome, Italy, started a collaboration with a team of geriatricians trained in geriatric oncology to manage the growing number of elderly patients and to deal with treatment-related toxicity and supportive care to complete planned treatment. This study evaluates the impact of geriatric oncology intervention performed by a geriatrician with particular expertise in managing complex cancer patients admitted to an Oncology Unit. The number of complex patients admitted to the Radiation Oncology Unit raised from 90 in 2016 to 226 in 2018 (+151.1%). 63.4% of complex patients underwent treatment, with a curative goal in 43.7% of cases. Among all admitted patients, the treatment discontinuation rate was 14%. The treatment discontinuation rate was 5.5% in patients over 80 years old with planned admission, versus 27.0% in patients admitted from the emergency room. Our data suggest that geriatric expertise in an Oncology Unit helps personalize patients' treatment and allows for treating an increasing number of complex patients. Identifying frail and complex patients is essential to manage these situations effectively and efficiently, optimize healthcare resources, avoid over and under-treatment, and provide the best care.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44771073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-25DOI: 10.21926/obm.geriatr.2302237
P. Brown, Dana Buelsing Sowards, M. Pittman, Gisele Leger, Susan Manns
In August 2022, the Centers for Medicare and Medicaid Services (CMS) adopted its first-ever nutrition electronic clinical quality measure (eCQM), known as the Global Malnutrition Composite Score (GMCS) as part of the Inpatient Hospital Quality Reporting (IQR) Program. Starting in January 2024, hospitals can self-select to include the GMCS as one of three optional eCQMs for reporting. This article focuses on the importance of addressing malnutrition to improve the overall health of the aging population, reduce preventable healthcare expenditures and achieve greater health equity. A detailed explanation of the development of the GMCS, its components, its utility, and the critical role of registered dietitian nutritionists (RDNs) in promoting its adoption are discussed. The successful implementation of malnutrition quality measures and their positive impact on patient care and business operations is exemplified through the experience of the Novant Health New Hanover Regional Medical Center of Southeastern North Carolina. A recommended process for RDNs to pursue to secure the adoption of the GMCS at their respective hospitals and supporting resources are reviewed.
2022年8月，医疗保险和医疗补助服务中心（CMS）通过了其首个营养电子临床质量测量（eCQM），即全球营养不良综合评分（GMCS），作为住院医院质量报告（IQR）计划的一部分。从2024年1月开始，医院可以自行选择将GMCS作为三个可选eCQM之一进行报告。本文重点阐述了解决营养不良问题对改善老龄人口整体健康、减少可预防的医疗支出和实现更大的健康公平的重要性。详细解释了GMCS的发展、成分、用途，以及注册营养师在促进其采用方面的关键作用。营养不良质量措施的成功实施及其对患者护理和商业运营的积极影响体现在北卡罗来纳州东南部Novant Health New Hanover地区医疗中心的经验中。审查了RDN为确保在各自医院采用GMCS而采取的建议流程和支持资源。
{"title":"The Global Malnutrition Composite Score Quality Measure-Seize this Opportunity to Benefit Older Adult Care and Health Equity!","authors":"P. Brown, Dana Buelsing Sowards, M. Pittman, Gisele Leger, Susan Manns","doi":"10.21926/obm.geriatr.2302237","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302237","url":null,"abstract":"In August 2022, the Centers for Medicare and Medicaid Services (CMS) adopted its first-ever nutrition electronic clinical quality measure (eCQM), known as the Global Malnutrition Composite Score (GMCS) as part of the Inpatient Hospital Quality Reporting (IQR) Program. Starting in January 2024, hospitals can self-select to include the GMCS as one of three optional eCQMs for reporting. This article focuses on the importance of addressing malnutrition to improve the overall health of the aging population, reduce preventable healthcare expenditures and achieve greater health equity. A detailed explanation of the development of the GMCS, its components, its utility, and the critical role of registered dietitian nutritionists (RDNs) in promoting its adoption are discussed. The successful implementation of malnutrition quality measures and their positive impact on patient care and business operations is exemplified through the experience of the Novant Health New Hanover Regional Medical Center of Southeastern North Carolina. A recommended process for RDNs to pursue to secure the adoption of the GMCS at their respective hospitals and supporting resources are reviewed.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47838712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.21926/obm.geriatr.2302236
A. Rokach
Social support has been shown to have many positive effects on our lives, health, and ability to grow and flourish. Lack, or diminished social support results in loneliness. This thematic review focuses on the elderly, and the loneliness that is part of the life of many of them. The review highlights the social connections and the expectations that the elderly may have of them, and how being connected to others may alleviate, loneliness. Loneliness is known to negatively affect one’s health, social life, familial relationships, and feelings, and their effect on the elderly is described. We all yearn for social support, and the review examines what are the elderly’s expectations from their social support network. Expectations which will significantly affect their commitment to that network, and feeling fulfilled by it. The review concludes with a focus on successful aging and how they can control and minimize their loneliness and feelings of isolation.
{"title":"The Effects of Loneliness on the Aged: A Review","authors":"A. Rokach","doi":"10.21926/obm.geriatr.2302236","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302236","url":null,"abstract":"Social support has been shown to have many positive effects on our lives, health, and ability to grow and flourish. Lack, or diminished social support results in loneliness. This thematic review focuses on the elderly, and the loneliness that is part of the life of many of them. The review highlights the social connections and the expectations that the elderly may have of them, and how being connected to others may alleviate, loneliness. Loneliness is known to negatively affect one’s health, social life, familial relationships, and feelings, and their effect on the elderly is described. We all yearn for social support, and the review examines what are the elderly’s expectations from their social support network. Expectations which will significantly affect their commitment to that network, and feeling fulfilled by it. The review concludes with a focus on successful aging and how they can control and minimize their loneliness and feelings of isolation.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43736774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.21926/obm.geriatr.2302235
Ondřej Roubal
This research study addresses certain theoretical issues surrounding the relationship between digital technologies, the aging population, and identity. At the same time, it offers a conceptual proposal of indicators of the social inclusion of older people in the digital culture of society as a potential starting point for further empirical research. The progressive trend of a growing proportion of older people is a demographic reality in many economically and technologically advanced societies. This demographic aging of populations raises several economic, sociopolitical, medical, cultural, social, and psychological issues. One of the most important and oft-overlooked sets of issues is the active participation of older people in the digital culture environment and the use of information and communication technologies as an alternative source of social interaction in constructing and affirming their own identity. Aging is often associated with a natural decline in professional activity, poorer health, reduced physical activity, reduced social contacts, and sometimes isolation and loneliness. The active participation of older people in the digital environment of communication and virtual interactions can buffer these negative factors to a certain extent and offer an adequate alternative for fulfilling the need for social relationships, self-actualization, and affirmation of identity. Of course, digital culture does have an ambivalent character. On the one hand, there are obvious positive effects on social life, subjective experience, and consciousness of one's own identity derived from real and virtual social interactions. On the other hand, digitalizing life generates unseen risks in invading an accelerated pace of life, superficiality, and the deepening of social inequalities.
{"title":"Older People and the Construction of Virtual Identities in the Digital Culture","authors":"Ondřej Roubal","doi":"10.21926/obm.geriatr.2302235","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302235","url":null,"abstract":"This research study addresses certain theoretical issues surrounding the relationship between digital technologies, the aging population, and identity. At the same time, it offers a conceptual proposal of indicators of the social inclusion of older people in the digital culture of society as a potential starting point for further empirical research. The progressive trend of a growing proportion of older people is a demographic reality in many economically and technologically advanced societies. This demographic aging of populations raises several economic, sociopolitical, medical, cultural, social, and psychological issues. One of the most important and oft-overlooked sets of issues is the active participation of older people in the digital culture environment and the use of information and communication technologies as an alternative source of social interaction in constructing and affirming their own identity. Aging is often associated with a natural decline in professional activity, poorer health, reduced physical activity, reduced social contacts, and sometimes isolation and loneliness. The active participation of older people in the digital environment of communication and virtual interactions can buffer these negative factors to a certain extent and offer an adequate alternative for fulfilling the need for social relationships, self-actualization, and affirmation of identity. Of course, digital culture does have an ambivalent character. On the one hand, there are obvious positive effects on social life, subjective experience, and consciousness of one's own identity derived from real and virtual social interactions. On the other hand, digitalizing life generates unseen risks in invading an accelerated pace of life, superficiality, and the deepening of social inequalities.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47034612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.21926/obm.geriatr.2302234
V. L. Lo Vasco
Illnesses following the degeneration of the nervous system can occur due to aging or genetic mutations and represent a clinical concern. In neurodegenerative diseases, loss of neuronal structure and functions mainly causes cognitive impairment, representing an increasing social burden. In neurodegenerative diseases, the progressive loss of vulnerable populations of neurons in specific regions of the central nervous system was traced to different pathological events, such as misfolded proteins’ accumulation, abnormalities in proteasomes or phagosomes, as well as anomalies in lysosomes or mitochondria. Many research efforts identified important events involved in neurodegeneration, but the complex pathogenesis of neurodegenerative diseases is far from being fully elucidated. More recently, insights into the signal transduction pathways acting in the nervous system contributed to unveiling some molecular mechanisms triggering neurodegeneration. Abnormalities in the intra- or inter-cellular signaling were described to be involved in the pathogenesis of neurodegenerative disease. Understanding the signal transduction pathways that impact the nervous system homeostasis can offer a wide panel of potential targets for modulating therapeutic approaches. The present review will discuss the main signal transduction pathways involved in neurodegenerative disorders.
{"title":"Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular Targets","authors":"V. L. Lo Vasco","doi":"10.21926/obm.geriatr.2302234","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302234","url":null,"abstract":"Illnesses following the degeneration of the nervous system can occur due to aging or genetic mutations and represent a clinical concern. In neurodegenerative diseases, loss of neuronal structure and functions mainly causes cognitive impairment, representing an increasing social burden. In neurodegenerative diseases, the progressive loss of vulnerable populations of neurons in specific regions of the central nervous system was traced to different pathological events, such as misfolded proteins’ accumulation, abnormalities in proteasomes or phagosomes, as well as anomalies in lysosomes or mitochondria. Many research efforts identified important events involved in neurodegeneration, but the complex pathogenesis of neurodegenerative diseases is far from being fully elucidated. More recently, insights into the signal transduction pathways acting in the nervous system contributed to unveiling some molecular mechanisms triggering neurodegeneration. Abnormalities in the intra- or inter-cellular signaling were described to be involved in the pathogenesis of neurodegenerative disease. Understanding the signal transduction pathways that impact the nervous system homeostasis can offer a wide panel of potential targets for modulating therapeutic approaches. The present review will discuss the main signal transduction pathways involved in neurodegenerative disorders.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49201006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-17DOI: 10.21926/obm.geriatr.2302233
Minh Chung, V. Jiminez, Mohammad Saleem, N. Yusuf
Skin aging is a complex process that involves several extrinsic and intrinsic factors and skin health is an indicator of the well-being of an individual. In recent years, there have been numerous developments using computerized systems to aid in finding solutions and treatments to skin aging processes. Tools like artificial intelligence (AI) can aid in finding solutions and treatments for skin aging. AI can also help in monitoring or identifying early signs of skin aging. Within the field of skin aging, several innovations utilize AI to provide better patient care. There is a gap in knowledge within this field concerning current and future directions concerning skin aging and AI. In this review, we aim to highlight current and prospective applications of AI in skin aging and provide insights into future modalities in this field. Models for AI can serve to increase patient participation in skin-care decisions and eventually enhance the patient-provider experience.
{"title":"Use of Artificial Intelligence in Skin Aging","authors":"Minh Chung, V. Jiminez, Mohammad Saleem, N. Yusuf","doi":"10.21926/obm.geriatr.2302233","DOIUrl":"https://doi.org/10.21926/obm.geriatr.2302233","url":null,"abstract":"Skin aging is a complex process that involves several extrinsic and intrinsic factors and skin health is an indicator of the well-being of an individual. In recent years, there have been numerous developments using computerized systems to aid in finding solutions and treatments to skin aging processes. Tools like artificial intelligence (AI) can aid in finding solutions and treatments for skin aging. AI can also help in monitoring or identifying early signs of skin aging. Within the field of skin aging, several innovations utilize AI to provide better patient care. There is a gap in knowledge within this field concerning current and future directions concerning skin aging and AI. In this review, we aim to highlight current and prospective applications of AI in skin aging and provide insights into future modalities in this field. Models for AI can serve to increase patient participation in skin-care decisions and eventually enhance the patient-provider experience.","PeriodicalId":74332,"journal":{"name":"OBM geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48431648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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