In the last decade, development in nanotechnology has been used intensively. By studying nanotechnology and nanomaterials, we can generate excellent responses in healthcare related to neurological disorders. It also includes easy diagnosis of diseases in their early stages, delivery of genes, and many more. Neurological disorders are one of the most sensitive topics. Therefore, nanomaterials promise to treat neurological disorders as they are highly efficient. Nanomaterials will significantly expand our knowledge of how the disease originates in the nervous system so that we can diagnose the disease in its early stages. This review will describe nanomaterials as an overview of neurological disorders. This paper will present the utilization of nanomaterials in neurological disorders with the help of recent data and current research. This paper will also focus on the significant importance of nanomaterials and their toxicology in neurology. This review paper will deal with many of the different applications of nanomaterials in neurological studies and their impact on developing new types of treatment for neurological disorders. Lastly, this paper will discuss all the challenges nanomaterials face and all the promises that will help their future development in this vast field.
{"title":"Scope of Nanomaterials in Treating Neurological Disorders","authors":"Aaryan Gupta, Arpita Roy, Kirtanjot Kaur, Sarvesh Rustagi, Sumira Malik, Soumya Pandit","doi":"10.21926/obm.neurobiol.2401208","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401208","url":null,"abstract":"In the last decade, development in nanotechnology has been used intensively. By studying nanotechnology and nanomaterials, we can generate excellent responses in healthcare related to neurological disorders. It also includes easy diagnosis of diseases in their early stages, delivery of genes, and many more. Neurological disorders are one of the most sensitive topics. Therefore, nanomaterials promise to treat neurological disorders as they are highly efficient. Nanomaterials will significantly expand our knowledge of how the disease originates in the nervous system so that we can diagnose the disease in its early stages. This review will describe nanomaterials as an overview of neurological disorders. This paper will present the utilization of nanomaterials in neurological disorders with the help of recent data and current research. This paper will also focus on the significant importance of nanomaterials and their toxicology in neurology. This review paper will deal with many of the different applications of nanomaterials in neurological studies and their impact on developing new types of treatment for neurological disorders. Lastly, this paper will discuss all the challenges nanomaterials face and all the promises that will help their future development in this vast field.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.21926/obm.neurobiol.2401206
T. Nazir, Muhammad Umair, Muhammad Mushhood Ur Rehman, Reeda Saeed, Osama O Zaidat, J. Kalia
According to 2019 WHO data, neurological conditions contribute to 1503.39 disability-adjusted life years (DALYs) per 100,000 population. Approximately 57% of office-based physicians use EHR systems and the natural place to incorporate standardized ePRO is into EHR. However, implementing patient-reported outcomes (PROs) for neurological conditions is challenging because many patients are elderly, have comorbidities, and experience cognitive impairment. As healthcare digitization increases, we propose a framework for easily customizable electronic PROs (ePROMs) in neurology. The framework requires implementation of technological standards, including governance plans, integration, and reporting workflows. It consists of four steps: developing an ePRO questionnaire, making ePRO mobile-compatible and user-friendly, building consensus around ePRO, and validating ePRO. It is important to involve all stakeholders in the ePRO development process and continuously monitor and evaluate progress in real-time to sustain ePRO tools over time.
{"title":"Patient-Reported Outcome Measures (PROMs) in Neurology for Web 3.0 and mHealth: A Conceptual Framework","authors":"T. Nazir, Muhammad Umair, Muhammad Mushhood Ur Rehman, Reeda Saeed, Osama O Zaidat, J. Kalia","doi":"10.21926/obm.neurobiol.2401206","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401206","url":null,"abstract":"According to 2019 WHO data, neurological conditions contribute to 1503.39 disability-adjusted life years (DALYs) per 100,000 population. Approximately 57% of office-based physicians use EHR systems and the natural place to incorporate standardized ePRO is into EHR. However, implementing patient-reported outcomes (PROs) for neurological conditions is challenging because many patients are elderly, have comorbidities, and experience cognitive impairment. As healthcare digitization increases, we propose a framework for easily customizable electronic PROs (ePROMs) in neurology. The framework requires implementation of technological standards, including governance plans, integration, and reporting workflows. It consists of four steps: developing an ePRO questionnaire, making ePRO mobile-compatible and user-friendly, building consensus around ePRO, and validating ePRO. It is important to involve all stakeholders in the ePRO development process and continuously monitor and evaluate progress in real-time to sustain ePRO tools over time.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Here, we report the results of an investigation of the neuroprotective effects of securinine with tryptamine conjugate-allomargaritarine (2b), previously selected as the leading compound among a wide range of natural derivatives. 2b was synthesized from securinine using various Lewis acids as catalysts. In addition to the antioxidant and cytoprotective properties previously shown for 2b, in this work, in vitro analysis of the biological activity of the compound demonstrated that this conjugate is also able to influence the primary pathogenetic mechanism of Alzheimer's disease - proteinopathy, modulating the homeostasis of β-amyloid peptide. In particular, it was found that 2b is an effective inhibitor of β-secretase 1 - an enzyme responsible for initiating the generation of pathological forms of β-amyloid peptide, as well as directly preventing the pathological aggregation of Aβ1-42. As a compound with a promising biological activity profile found in vitro, 2b has also demonstrated excellent neuroprotective effects on the in vivo 5xFAD Alzheimer's disease transgenic mice model. Thus, 2b effectively restored cognitive dysfunction: short-term and long-term episodic and spatial memory, which in the post-mortem studies was also accompanied by a decrease in the number of amyloid deposits and the intensity of oxidative stress in brain samples. These results provide an opportunity to draw a line under years of research on the neuroprotective potential of 2b as a viable therapy for Alzheimer's disease.
{"title":"Neuroprotective Effects and Cognitive Enhancement of Allomargaritarine in 5xFAD Alzheimer's Disease Mice Model","authors":"Yulia Aleksandrova, Alexey Semakov, Dmitry Tsypyshev, Kirill Chaprov, Sergey Klochkov, M. Neganova","doi":"10.21926/obm.neurobiol.2401207","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401207","url":null,"abstract":"Here, we report the results of an investigation of the neuroprotective effects of securinine with tryptamine conjugate-allomargaritarine (2b), previously selected as the leading compound among a wide range of natural derivatives. 2b was synthesized from securinine using various Lewis acids as catalysts. In addition to the antioxidant and cytoprotective properties previously shown for 2b, in this work, in vitro analysis of the biological activity of the compound demonstrated that this conjugate is also able to influence the primary pathogenetic mechanism of Alzheimer's disease - proteinopathy, modulating the homeostasis of β-amyloid peptide. In particular, it was found that 2b is an effective inhibitor of β-secretase 1 - an enzyme responsible for initiating the generation of pathological forms of β-amyloid peptide, as well as directly preventing the pathological aggregation of Aβ1-42. As a compound with a promising biological activity profile found in vitro, 2b has also demonstrated excellent neuroprotective effects on the in vivo 5xFAD Alzheimer's disease transgenic mice model. Thus, 2b effectively restored cognitive dysfunction: short-term and long-term episodic and spatial memory, which in the post-mortem studies was also accompanied by a decrease in the number of amyloid deposits and the intensity of oxidative stress in brain samples. These results provide an opportunity to draw a line under years of research on the neuroprotective potential of 2b as a viable therapy for Alzheimer's disease.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.21926/obm.neurobiol.2401205
Nadia A. Abdelmegeed Abdelwahed
Entrepreneurial intention plays a pivotal role within entrepreneurship ecosystems, acting as a catalyst for economic growth and innovation by inspiring individuals to embrace entrepreneurship as a viable career pursuit. The present research delves into the intricate dynamics between stress, entrepreneurial intention, personal income, and physical health within Egypt's entrepreneurial landscape. Grounded in a quantitative analysis of 286 valid samples and utilizing SmartPLS 4, this study unveils compelling insights. It reveals a stark negative correlation between stress and entrepreneurial intention, personal income, and physical health while highlighting the affirmative association between individual income, physical health, and entrepreneurial intention among Egyptian entrepreneurs. These findings underscore the imperative of integrating stress management and mental health support mechanisms into entrepreneurship support programs, offering entrepreneurs invaluable resources to fortify their resolve and adaptability in navigating the entrepreneurial journey.
{"title":"The Impact of Psychological Stress on Personal Income, Physical Health and Entrepreneurial Intentions among Entrepreneurs","authors":"Nadia A. Abdelmegeed Abdelwahed","doi":"10.21926/obm.neurobiol.2401205","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401205","url":null,"abstract":"Entrepreneurial intention plays a pivotal role within entrepreneurship ecosystems, acting as a catalyst for economic growth and innovation by inspiring individuals to embrace entrepreneurship as a viable career pursuit. The present research delves into the intricate dynamics between stress, entrepreneurial intention, personal income, and physical health within Egypt's entrepreneurial landscape. Grounded in a quantitative analysis of 286 valid samples and utilizing SmartPLS 4, this study unveils compelling insights. It reveals a stark negative correlation between stress and entrepreneurial intention, personal income, and physical health while highlighting the affirmative association between individual income, physical health, and entrepreneurial intention among Egyptian entrepreneurs. These findings underscore the imperative of integrating stress management and mental health support mechanisms into entrepreneurship support programs, offering entrepreneurs invaluable resources to fortify their resolve and adaptability in navigating the entrepreneurial journey.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.21926/obm.neurobiol.2401204
Obm Neurobiology Editorial Office
The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
{"title":"Acknowledgement to Reviewers of OBM Neurobiology in 2023","authors":"Obm Neurobiology Editorial Office","doi":"10.21926/obm.neurobiol.2401204","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401204","url":null,"abstract":"The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.21926/obm.neurobiol.2401203
G. Lancioni, Gloria Alberti, Chiara Filippini, Alessandra Fiore, Clarissa Simonetti, Nirbhay Singh, M. O'Reilly, J. Sigafoos
This study adapted a new interactive technology system to help six participants with intellectual disability and visual and motor impairments to exercise relevant physical responses as part of an occupational task. The task was to place objects into different containers from a sitting position. The responses, which changed across sessions, consisted of the participants (a) stretching the left arm and shoulder to place objects in a container located to their left, (b) stretching the right arm and shoulder to place objects in a container located to their right, or (c) stretching one or both arms and shoulders forward and upward to place objects in a container located high up in front of them. The technology, which entailed a portable computer, a webcam, and a mini speaker, monitored the participants’ responses, gave brief periods of preferred stimulation contingent on the responses, provided verbal encouragements/prompts in case of no response, and assisted in data recording. The study was carried out according to a non-concurrent multiple baseline across participants design and included baseline and intervention sessions of 10 min. During the baseline (when the technology system only served to monitor and record the responses), the participants’ mean frequency of responses varied between near zero and about 10 per session. During the intervention (when the technology system was fully operational), the participant’s mean response frequency increased to between about 29 and 46 per session. In light of the results, one might consider the technology system a useful support tool to help people with multiple disabilities engage in relevant physical responses.
{"title":"Interactive Technology to Help People with Multiple Disabilities Practice Relevant Physical Responses within an Occupational Task","authors":"G. Lancioni, Gloria Alberti, Chiara Filippini, Alessandra Fiore, Clarissa Simonetti, Nirbhay Singh, M. O'Reilly, J. Sigafoos","doi":"10.21926/obm.neurobiol.2401203","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2401203","url":null,"abstract":"This study adapted a new interactive technology system to help six participants with intellectual disability and visual and motor impairments to exercise relevant physical responses as part of an occupational task. The task was to place objects into different containers from a sitting position. The responses, which changed across sessions, consisted of the participants (a) stretching the left arm and shoulder to place objects in a container located to their left, (b) stretching the right arm and shoulder to place objects in a container located to their right, or (c) stretching one or both arms and shoulders forward and upward to place objects in a container located high up in front of them. The technology, which entailed a portable computer, a webcam, and a mini speaker, monitored the participants’ responses, gave brief periods of preferred stimulation contingent on the responses, provided verbal encouragements/prompts in case of no response, and assisted in data recording. The study was carried out according to a non-concurrent multiple baseline across participants design and included baseline and intervention sessions of 10 min. During the baseline (when the technology system only served to monitor and record the responses), the participants’ mean frequency of responses varied between near zero and about 10 per session. During the intervention (when the technology system was fully operational), the participant’s mean response frequency increased to between about 29 and 46 per session. In light of the results, one might consider the technology system a useful support tool to help people with multiple disabilities engage in relevant physical responses.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.21926/obm.neurobiol.2304202
G. Lancioni, Nirbhay Singh, M. O'Reilly, J. Sigafoos, Gloria Alberti, Marta Olivetti Belardinelli
The paper presents an overview of recent studies assessing technology-aided strategies aimed at helping people with intellectual and multiple disabilities reach relevant rehabilitation goals. The 16 studies included in the paper addressed four specific rehabilitation goals, that is, (a) performance of functional activities, (b) access to leisure and communication and performance of functional activities, (c) increase of adaptive responses and decrease of problem behavior or inadequate posture, and (d) increase of ambulation responses. For each study, the paper reports the participants involved, the technology and the assessment process used, and the results obtained. Following the presentation of the studies, the paper focuses on three practically relevant issues: the role of technology-aided strategies over time, the relative potential of various technology-aided strategies, and the accessibility and applicability of the strategies.
{"title":"An Overview of Recent Technology-Aided Intervention Strategies to Help People with Intellectual and Multiple Disabilities Meet Relevant Rehabilitation Goals","authors":"G. Lancioni, Nirbhay Singh, M. O'Reilly, J. Sigafoos, Gloria Alberti, Marta Olivetti Belardinelli","doi":"10.21926/obm.neurobiol.2304202","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304202","url":null,"abstract":"The paper presents an overview of recent studies assessing technology-aided strategies aimed at helping people with intellectual and multiple disabilities reach relevant rehabilitation goals. The 16 studies included in the paper addressed four specific rehabilitation goals, that is, (a) performance of functional activities, (b) access to leisure and communication and performance of functional activities, (c) increase of adaptive responses and decrease of problem behavior or inadequate posture, and (d) increase of ambulation responses. For each study, the paper reports the participants involved, the technology and the assessment process used, and the results obtained. Following the presentation of the studies, the paper focuses on three practically relevant issues: the role of technology-aided strategies over time, the relative potential of various technology-aided strategies, and the accessibility and applicability of the strategies.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.21926/obm.neurobiol.2304201
Gil Newburn, Joshua McGeown, Eryn Kwon, M. Tayebi, Paul Condron, Taylor Emsden, Samantha Holdsworth, Daniel Cornfeld, Graeme Bydder
In modelling studies targeted MRI (tMRI) of small increases in the T1 of tissues using divided Subtracted Inversion Recovery (dSIR) sequences show ten or more times the contrast seen with conventional IR sequences. This may be particularly useful in imaging normal appearing white matter where there may be small changes in T1 and/or T2 in disease but these changes may be insufficient to produce useful contrast with conventional T2-weighted spin echo (T2-wSE) and T2-FLuid Attenuated Inversion Recovery (T2-FLAIR) sequences. In a case of recurrent mild Traumatic Brain Injury (mTBI), very extensive high contrast abnormalities were seen in white matter using a dSIR sequence that targeted small increases in T1 in areas where no abnormality was apparent with T2-wSE or T2-FLAIR sequences. The increases in T1 may be due to neuroinflammation and/or degeneration which produces the abnormalities seen on the dSIR images. tMRI of normal appearing white matter may have widespread application in clinical MRI of the brain.
{"title":"Targeted MRI (tMRI) of Small Increases in the T1 of Normal Appearing White Matter in Mild Traumatic Brain Injury (mTBI) Using a Divided Subtracted Inversion Recovery (dSIR) Sequence","authors":"Gil Newburn, Joshua McGeown, Eryn Kwon, M. Tayebi, Paul Condron, Taylor Emsden, Samantha Holdsworth, Daniel Cornfeld, Graeme Bydder","doi":"10.21926/obm.neurobiol.2304201","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304201","url":null,"abstract":"In modelling studies targeted MRI (tMRI) of small increases in the T<sub>1</sub> of tissues using divided Subtracted Inversion Recovery (dSIR) sequences show ten or more times the contrast seen with conventional IR sequences. This may be particularly useful in imaging normal appearing white matter where there may be small changes in T<sub>1</sub> and/or T<sub>2</sub> in disease but these changes may be insufficient to produce useful contrast with conventional T<sub>2</sub>-weighted spin echo (T<sub>2</sub>-wSE) and T<sub>2</sub>-FLuid Attenuated Inversion Recovery (T<sub>2</sub>-FLAIR) sequences. In a case of recurrent mild Traumatic Brain Injury (mTBI), very extensive high contrast abnormalities were seen in white matter using a dSIR sequence that targeted small increases in T<sub>1</sub> in areas where no abnormality was apparent with T<sub>2</sub>-wSE or T<sub>2</sub>-FLAIR sequences. The increases in T<sub>1</sub> may be due to neuroinflammation and/or degeneration which produces the abnormalities seen on the dSIR images. tMRI of normal appearing white matter may have widespread application in clinical MRI of the brain.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05DOI: 10.21926/obm.neurobiol.2304200
Axel Becker, Martin Helmuth, B. Chindo
A stroke is a cerebrovascular disease that results from a blockage in the blood supply to part of the brain or a burst blood vessel in the brain. It is the second leading cause of death worldwide, with an annual mortality rate of about 5.5 million. Antithrombotic therapies have failed to provide a cure for this debilitating cerebrovascular disorder, and hypothermia is gaining interest as a novel strategy for the management of stroke. In this study, we evaluated the effects of Ficus platyphylla-induced hypothermia on long-term functional recovery after ischaemic stroke. Histomorphological analysis of the brain demonstrated pathological alterations in the ipsilateral hemisphere of all animals. Animals treated before or immediately after permanent occlusion of the middle cerebral artery (MCAO) had significantly smaller infarct sizes than those given saline. Surgery and treatment did not affect locomotor activity. There were no significant differences between the groups of mice in terms of parameters associated with situational anxiety, including the number of arm changes and percentile time spent on open arms. There were no significant differences between groups regarding the number of buried marbles and sociability. Surgery and treatment did not affect social recognition, but a significant interaction between surgery and treatment was observed. The time mice remained on the rota rod was relatively similar for all groups tested, with no significant differences related to surgery and treatment, nor was there any surgery/treatment interaction. A learning effect represented by a decrease in exploratory activity was observed irrespective of surgery and treatment, and there was no surgery/treatment interaction. The results suggest that Ficus platyphylla-induced hypothermia could be beneficial to long-term functional recovery after ischaemic stroke.
{"title":"Effects of Ficus Platyphylla-Induced Hypothermia on Long-term Functional Recovery after Ischaemic Stroke","authors":"Axel Becker, Martin Helmuth, B. Chindo","doi":"10.21926/obm.neurobiol.2304200","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2304200","url":null,"abstract":"A stroke is a cerebrovascular disease that results from a blockage in the blood supply to part of the brain or a burst blood vessel in the brain. It is the second leading cause of death worldwide, with an annual mortality rate of about 5.5 million. Antithrombotic therapies have failed to provide a cure for this debilitating cerebrovascular disorder, and hypothermia is gaining interest as a novel strategy for the management of stroke. In this study, we evaluated the effects of Ficus platyphylla-induced hypothermia on long-term functional recovery after ischaemic stroke. Histomorphological analysis of the brain demonstrated pathological alterations in the ipsilateral hemisphere of all animals. Animals treated before or immediately after permanent occlusion of the middle cerebral artery (MCAO) had significantly smaller infarct sizes than those given saline. Surgery and treatment did not affect locomotor activity. There were no significant differences between the groups of mice in terms of parameters associated with situational anxiety, including the number of arm changes and percentile time spent on open arms. There were no significant differences between groups regarding the number of buried marbles and sociability. Surgery and treatment did not affect social recognition, but a significant interaction between surgery and treatment was observed. The time mice remained on the rota rod was relatively similar for all groups tested, with no significant differences related to surgery and treatment, nor was there any surgery/treatment interaction. A learning effect represented by a decrease in exploratory activity was observed irrespective of surgery and treatment, and there was no surgery/treatment interaction. The results suggest that Ficus platyphylla-induced hypothermia could be beneficial to long-term functional recovery after ischaemic stroke.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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