Open research Europe最新文献

Arctic regions are among the fastest warming areas of the planet. Increasing average temperatures over the last five decades have deepened the thawing of the upper-most layer of permafrost across the Arctic, which contains significant amounts of organic carbon. The progressive deepening of seasonal thawing releases carbon that is used by active microorganisms which also produce greenhouse gases, potentially onsetting a positive feedback on global warming. Despite their importance in controlling organic matter degradation and greenhouse gas fluxes to the atmosphere, there is a lack of data on activity and dynamics of microbial communities in High Arctic soils in response to seasonal thaw. This report describes three specific expeditions performed on the Svalbard archipelago, carried out within the framework of the PRA (Italian Arctic Research Program) project Melting-ICE, performed between February and October 2022, reporting site characteristics and samples collected. The project aims to investigate the diversity and activity of active layer microbial communities across a full season thaw cycle, correlating microbial diversity with gas fluxes and composition. During these expeditions, a total of eight different sites were selected to investigate the microbiology and geochemistry of soils, as well as to estimate the gas fluxes from the soil to the atmosphere. The data collected in the field, combined with the results obtained in the laboratory, will provide a snapshot of the seasonal activity of the microbial communities present in the permafrost's active layer. The three campaigns will provide data to estimate the impact of permafrost melting on the carbon cycle and the role of microorganisms in the release of greenhouse gases.

Background: Traditional publishing models, open access and major publishers, cannot adequately address the key challenges of academic publishing today: Speed of peer review, recognition of work and incentive mechanisms, transparency and thrust of the system.

Methods: To address these challenges, the authors propose Democratisation of Academic Publishing (DAP) platform, which is based on the novel HashNET DLT platform. The DAP introduces several innovative components: tracking the activities of all participants in the peer review process using blockchain and smart contracts, the introduction of the Scholarly Wallet for holding reputation (non-fungible) and reward (fungible) tokens, the use of the Scholarly Wallet as the main interface to the DAP platform, the Virtual Editor that enables automatic discovery of the research area and invitation of reviewers, and finally the global database of evaluated reviewers, ranked by the quality of their previous work.

Results: The DAP platform is in the development phase, with the design and functionalities of all modules defined. An exception is the central component of DAP, the Scholarly Wallet module, whose first prototype has already been created, tested and published. The implementation of DAP is planned for the next phase of the HorizonEurope TruBlo project and other research initiatives. The DAP platform will be connected to the publishing ecosystem: 1) as a backend system (distributed blockchain database) for existing publishing platforms and 2) as a standalone publishing platform with its own API interface.

Conclusions: The authors believe that DAP has the potential to significantly improve academic peer review and knowledge dissemination. It is expected that the use of blockchain technology, the fast HashNET consensus platform and tokens for reward (fungible) and reputation/ranking (non-fungible) will lead to a more efficient and transparent way of rewarding all participants in the peer review process and ultimately advance scientific research.

Existing steel frames not complying with modern seismic codes are often vulnerable to earthquakes due to inadequate seismic detailing. These types of framed structures typically feature semi-rigid and partial strength column-base connections; the behaviour of such connections may significantly affect their seismic performance. However, current code provisions offer limited guidance for the assessment and retrofit of column-base connections To fill the knowledge gap, the H2020 EU-funded Earthquake Assessment of Base-Column Connections in Existing Steel Frames project experimentally investigated, the response of exposed column-base plate connections. Bi-directional Pseudo-Dynamic tests were carried out at the Structures Laboratory of the University of Patras within the framework of "Engineering Research Infrastructures for European Synergies - ERIES" project. The case-study steel frame featured two types of column-base plate connections, i.e., stiffened and unstiffened, representing respectively the base connections of an external moment-resisting frame and an internal gravity frame. The experimental programme comprised free vibration tests to identify the modal properties of the sample steel frame. A set of quasi-static cyclic tests and pseudo-dynamic tests were then carried out to investigate the performance of the steel frame under bi-directional earthquake sequences. The response of each component constituting the column-base plate connections was monitored during the tests to fully capture the behaviour of the connections. Such experimental results allow model calibration and further parametric investigation on column base plate connections.

Background: Heat-altered stones (HAS) are commonly reported in prehistoric sites across several continents, yet they continue to be generally overlooked and systematic studies on them are scarce.

Methods: We performed a systematic literature review which consisted of searching journal articles, book chapters and books published in English, in Scopus and Web of Science. We collected information on their geographic distribution, chronology, composition, technological aspects and subsistence contexts from 73 records. Our aims were to assess the challenges and opportunities of analysing HAS, while highlighting that this class of artefacts is still largely an untapped source of information on prehistoric human activities.

Results: HAS have been documented since the Pleistocene, attesting that culinary and non-culinary activities using heating stones emerged among foraging groups subsisting on hunting, fishing and gathering. The high frequency of HAS during the middle and late Holocene testifies to the continuation of some practices over long time periods, amid the emergence of new food systems, and the introduction of new resources and technologies, such as domesticated plants and animals, and ceramic containers. A considerable lack of studies on HAS from Africa, Oceania, Asia, and South America was noted, all of which are key geographic areas for assessing the role of heating stones in human evolution, geographic dispersal, early cuisine and diet, and cultural transmission across the globe.

Conclusions: Our results highlight the persistent challenges archaeologists face in establishing fundamental definitions and diagnostic criteria for identifying HAS, while emphasizing the importance of HAS as essential elements for studying ancient foodways and cultural heritage. We call on archaeologists and cultural heritage managers to reconsider the heritage value of HAS and include them in specialised research agendas before significant knowledge of our past is lost.

Background: Problematic Hypersexuality (PH) is defined as a distress caused by hypersexuality, to the extent that seeking treatment is considered. PH was previously measured with instruments stemming from different perspectives on problems related to hypersexuality. These instruments might best be analyzed in unison to discover the most optimal set of characteristics to measure PH.

Methods: A total of 58 items were investigated with Item Response Theory (IRT). We included 1211 participants (592 women, 618 men, 1 other) from a representative Dutch general population sample of 18 years or older. In addition, 371 participants (116 women, 253 men, 2 other) in a web-based survey who sought information on their current level of PH were included. This latter group was divided into those that did or did not consider treatment and group differences in item averages were assessed.

Results: After item selection, 26 out of 58 items were retained and divided in two scales: Emotion Dysregulation-PH - 9 items representing the distressing emotional patterns coinciding with hypersexual preoccupation - and Negative Effects-PH - 17 items representing the negative consequences of patterns of hypersexual thoughts and behavior. Assumptions for IRT analyses were met (unidimensionality, local independence and monotonicity). After an IRT graded response model was fit, the scales showed sufficient reliability for the target population of hypersexual individuals. In the general population the scales showed large floor effects and were less reliable.

Conclusions: With this study a first step is taken in validating two complementary item banks to measure PH. Further development of the item banks should include the investigation of responsiveness. New items should be constructed to assess less-explored areas of PH and improve differentiating power of the scales. This study showed that diagnostic accuracy for PH is currently difficult to attain with a survey, even when using an extended item set representing the most unique characteristics of PH.

Background: Due to the huge amounts of their production in Europe, their environmental impact, and the difficulty in processing them, there is a clear necessity for the valorization of rainbow trout viscera. Considering that the production of fishmeal with viscera can be problematic, and in order to make viscera more profitable, the production of fish protein hydrolysates has been considered. Although silage and enzymatic hydrolysis are the most common methods for obtaining hydrolysates, autolysis has emerged as an alternative method that uses endogenous enzymes of the viscera.

Methods: Considering the stability and characteristics of the enzymes, a factorial design was carried out using three variables: pH, temperature, and water content. The design resulted in 15 experiments, and the results were analyzed using response surface methodology. The optimum parameters were validated by comparing the predicted outcomes with experimental results. Additionally, a kinetics study was conducted to shorten the autolysis time. Results from autolysis were compared with those from silage and enzymatic hydrolysis in a previous study.

Results: The optimal conditions for achieving the highest degree of hydrolysis and yield of free amino acids (FAAs) per 100 g of viscera and per total protein were determined to be a pH of 8, a temperature of 40 °C, and a water content of 6.85%. The pH and content of the added water were found to be significant variables during autolysis ( p < 0.05). The kinetic study showed that 7 h was still required to be effective.

Conclusions: Autolysis achieved a lower degree of hydrolysis than silage; however, as it solubilized more protein, the global yield of free amino acids per 100 g of viscera was slightly higher. It was concluded that endogenous alkaline proteases could be used in an autolytic process to obtain a free amino acid-rich hydrolysate from trout viscera.

Background: Finding appropriate model parameters for multi-compartmental neuron models can be challenging. Parameters such as the leak and axial conductance are not always directly derivable from neuron observations but are crucial for replicating desired observations. The objective of this study is to replicate the attenuation behavior of an excitatory postsynaptic potential (EPSP) traveling along a linear chain of compartments on the analog BrainScaleS-2 neuromorphic hardware platform.

Methods: In the present publication we use genetic algorithms to find suitable model parameters. They promise parameterization without domain knowledge of the neuromorphic substrate or underlying neuron model. To validate the results of the genetic algorithms, a comprehensive grid search was conducted. Furthermore, trial-to-trial variations in the analog system are counteracted utilizing spike-triggered averaging.

Results and conclusions: The algorithm successfully replicated the desired EPSP attenuation behavior in both single and multi-objective searches illustrating the applicability of genetic algorithms to parameterize analog neuromorphic hardware.

Ab initio electronic structure applications are among the most widely used in High-Performance Computing (HPC), and the eigenvalue problem is often their main computational bottleneck. This article presents our initial efforts in porting these codes to a RISC-V prototype platform leveraging a wide Vector Processing Unit (VPU). Our software tester is based on a mini-app extracted from the ELPA eigensolver library. The user-space emulator Vehave and a RISC-V vector architecture implemented on an FPGA were tested. Metrics from both systems and different vectorisation strategies were extracted, ranging from the simplest and most portable one (using autovectorisation and assisting this by fusing loops in the code) to the more complex one (using intrinsics). We observed a progressive reduction in the number of vectorised instructions, executed instructions and computing cycles with the different methodologies, which will lead to a substantial speed-up in the calculations. The obtained outcomes are crucial in advancing the porting of computational materials and molecular science codes to (post)-exascale architectures using RISC-V-based technologies fully developed within the EU. Our evaluation also provides valuable feedback for hardware designers, engineers and compiler developers, making this use case pivotal for co-design efforts.

Gestational Diabetes Mellitus (GDM) is the most frequent pregnancy-related medical issue and presents significant risks to both maternal and foetal health, requiring monitoring and management during pregnancy. The prevalence of GDM has surged globally in recent years, mirroring the rise in diabetes and obesity rates. Estimated to affect from 5% to 25% of pregnancies, GDM impacts approximately 21 million live births annually, according to the International Diabetes Federation (IDF). However, consensus on diagnostic approaches remains elusive, with varying recommendations from international organizations, which makes the comparison between research complicated. Compounding concerns are the short-term and long-term complications stemming from GDM for mothers and offspring. Maternal outcomes include heightened cardiovascular risks and a notable 70% risk of developing Type 2 Diabetes Mellitus (T2DM) within a decade postpartum. Despite this, research into the metabolic profiles associated with a previous GDM predisposing women to T2D remains limited. While genetic biomarkers have been identified, indicating the multifaceted nature of GDM involving hormonal changes, insulin resistance, and impaired insulin secretion, there remains a dearth of exploration into the enduring health implications for both mothers and their children. Furthermore, offspring born to mothers with GDM have been shown to face an increased risk of obesity and metabolic syndrome during childhood and adolescence, with studies indicating a heightened risk ranging from 20% to 50%. This comprehensive review aims to critically assess the current landscape of Gestational Diabetes Mellitus (GDM) research, focusing on its prevalence, diagnostic challenges, and health impacts on mothers and offspring. By examining state-of-the-art knowledge and identifying key knowledge gaps in the scientific literature, this review aims to highlight the multifaceted factors that have hindered a deeper understanding of GDM and its long-term consequences. Ultimately, this scholarly exploration seeks to promote further investigation into this critical area, improving health outcomes for mothers and their children.

We discuss the flip-chip mounting process of photodiodes and fiber sleeves on silicon substrates to meet the increasing demand for fabrication of highly integrated and hybrid quantum circuits for operation at cryogenic temperatures. To further increase the yield and success rate of the flip-chip procedure, the size of the gold stud bumps, and flip-chip parameters were optimized. Moreover, to connect optical fibers to the photodiodes in an optimal position, the fiber sleeves were aligned with specially fabricated alignment circles before applying thermocompression with the flip-chip machine. The mounted photodiodes were tested at both room temperature and cryogenic temperature, and we find that mechanical imperfections of the sleeve-ferrule combination limit the overall alignment accuracy. The experimental results show that our flip-chip process is very reliable and promising for various optical and electrical applications and, thus, paves the way for fabrication of hybrid chips, multi-chip modules and chip-on-chip solutions, which are operated at cryogenic temperatures.