Open research Europe最新文献

We discuss the flip-chip mounting process of photodiodes and fiber sleeves on silicon substrates to meet the increasing demand for fabrication of highly integrated and hybrid quantum circuits for operation at cryogenic temperatures. To further increase the yield and success rate of the flip-chip procedure, the size of the gold stud bumps, and flip-chip parameters were optimized. Moreover, to connect optical fibers to the photodiodes in an optimal position, the fiber sleeves were aligned with specially fabricated alignment circles before applying thermocompression with the flip-chip machine. The mounted photodiodes were tested at both room temperature and cryogenic temperature, and we find that mechanical imperfections of the sleeve-ferrule combination limit the overall alignment accuracy. The experimental results show that our flip-chip process is very reliable and promising for various optical and electrical applications and, thus, paves the way for fabrication of hybrid chips, multi-chip modules and chip-on-chip solutions, which are operated at cryogenic temperatures.

Honey is a food of great nutritional importance and has always been used for human consumption. The production of honey and other beekeeping products depends on the proper functioning of this extremely important sector, as it has a direct impact on other sectors such as agriculture. The decline in bee colony numbers has been linked, among other factors, to bacterial diseases affecting bees, including American and European foulbrood, and Nosema spp. disease. In this matter, prophylactic or therapeutic use of veterinary drugs in apiculture is common but can lead to their accumulation in bees and in honey. Consumption of contaminated honey can have adverse effects such as allergic or hypersensitivity reactions, carcinogenicity, reproductive effects, and teratogenicity. Commission Regulation (EU) N ^⍛ 37/2010 sets MRLs for antibiotics in various foods, but these limits are not set for api-products. The lack of harmonized rules has led some countries to set recommended concentrations and minimum performance limits. Nonetheless, to achieve this goal, development of accurate and precise analytical methodologies is crucial. In recent years, the analysis of antibiotics in honey has led to the development of methods in an extensive range of families, including aminoglycosides, amphenicols, lincosamides, macrolides, nitroimidazoles, quinolones, sulfonamides, tetracyclines and nitrofurans. This review work entails an in-depth exploration of occurrence studies, extraction methodologies, and analytical techniques for the determination of antibiotics in apiculture products. It was found that the most used extraction methods include solid-phase extraction, dispersed solid or liquid phase extraction and QuEChERS. Due to the complexity of the honey matrix, samples are often diluted or acidified using McIlvaine buffer, H ₂O, MeOH, acidified ACN and TCA solution. This is usually followed by a purification step using SPE cartridges or PSA. Golden analytical methodologies include high-performance liquid chromatography coupled to a triple quadrupole mass spectrometer (MS/MS) with Orbitrap or Q-ToF detectors.

European research funding organizations (RFOs) are increasingly experimenting with public engagement in their funding activities. This case study draws attention to the challenges they face in preparing, implementing, and evaluating ethical public engagement in the context of setting funding priorities, formulating calls for proposals, and evaluating project proposals. We discuss challenges related to seven themes: (1) recruiting participants; (2) commitments and expectations; (3) meaningful dialogue and equal engagement; (4) accommodating vulnerability; (5) funding call formulations; (6) lack of expertise in engagement ethics; and (7) uncertainty, resource constraints, and external factors. To address these challenges, we propose the following seven interventions: (1) developing comprehensive recruitment strategies with experienced recruiters and community organizations; (2) establishing clear communication of roles, expectations, and outcomes through codes of conduct; (3) training mediators to address power imbalances; (4) designing flexible engagement methods and providing tailored support; (5) implementing collaborative feedback loops for inclusive funding call formulation; (6) enhancing ethical standards through internal expertise and external advisory inputs; and (7) developing adaptive strategies for flexible and ethical public engagement. These recommendations emphasize the need for context-adaptive insights to support funding organizations to implement ethical public engagement activities, even when faced with organizational constraints and a lack of ethical expertise.

Background: The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need for evidence-based information to support guidelines and protocols for sustainable One Health PVBD drug development and use, while promoting greener research practices. Here, we reflect on the potential environmental impacts of PVBD drugs in current use, and the environmental impact of our research practices for developing new antiparasitics.

Methods: We conducted a survey of the membership of the "One Health drugs against parasitic vector borne diseases in Europe and beyond" Cooperation in Science and Technology (COST) Action 21111 (OneHealth drugs) to assess the current appreciation of sustainable drug design concepts and the extent to which One Health and sustainability principles are integrated into PVBD drug discovery and development. The survey also explored which human, technical, and funding resources are currently used in Europe and neighbouring countries in PVBD drugs research.

Results: The survey was conducted and analysed by OneHealth drugs and garnered 89 respondents, representing a response rate of 66% from 32 countries, predominantly European. 87% of participating collaborators worked in Academia; research groups were small (60% with 1-4 researchers) and mostly consist of few researchers, mostly at early career stages (63% <35 years old). Collaborations were mostly between academics, and 60% collaborated with non-European researchers, while funding was mostly from national governments. Motivation for greener research practices was high but there was as yet low implementation of green strategies or the incorporation of ecotoxicological test in drug development workflows, due to cost and unfamiliarity.

Conclusions: We highlight the need for early-ecotoxicological testing of new drug candidates and suggest best practices as we move towards standardized protocols in developing safe and efficacious PVBD drugs.

Text and data mining (TDM) is a process, typically automated, that looks for patterns in data that may otherwise remain unnoticed. In a world where data driven solutions play a progressively more important role, TDM has become a vital tool in sectors ranging from medicine, to commerce, gaining widespread attraction. Nevertheless, a variety of regulatory frameworks not always specifically attuned towards regulating TDM continue to apply concurrently. The literature within the context of regulatory frameworks governing TDM is a fragmented piecemeal of valuable insights into what "lawful" TDM resembles. This literature review adopts a grounded theory approach analysing 88 pieces of literature, collating views regarding "lawful" TDM, ultimately providing a holistic assessment of academics' and practitioners' views and opinions regarding the regulatory framework which governs TDM. A total of 7 categories were identified and each of these are analysed. Tables are provided in the Appendix (accessible here: https://doi.org/10.5281/zenodo.12654691)highlighting which scholarly works were used for each section of the literature review, but also how those works were used. It is ultimately concluded that the regulatory frameworks that apply to users conducting TDM are multifaceted, and ever-changing on a case-by-case basis. There is an ever-growing need for a holistic interpretation of the regulatory frameworks which apply, creating a map which would allow for users conducting TDM to navigate this complex web of legal rules.

Background: Agent-based modelling provides an appealing methodological choice for simulating human behaviour and decisions. The currently dominant approaches based on static transition rates or unverified assumptions are restrictive, and could be enhanced with insights from cognitive experiments on actual decision making. Here, one common concern is that standard surveys or experiments may lack ecological validity, limiting the extent to which research findings can be generalised to real-life settings. For complex, highly emotive decision-making scenarios, such as those related to irregular migration, the typically used short, methodical survey questions may not appropriately map onto complex real-world decisions of interest. Immersive contexts may offer more accurate representations of reality, potentially enhancing the usefulness of experimental information in multi-disciplinary modelling endeavours.

Methods: This preregistered study, aimed directly at examining the effect of immersion on risk-taking in the context of migration decisions, and indirectly at informing a multi-disciplinary construction of an agent-based model of migration, presents a choice-based interactive fiction game in which players make migration decisions to advance through a story.

Participants: (N = 1000 Prolific users) took part in one of four experimental conditions, three involving different renditions of the game attempting to create immersion, with the last condition presenting the decisions in standard survey format.

Results: Although addressing the lack of ecological validity in survey data is important for improving agent-based modelling methodology, the experimental design used to tackle this issue, while responding directly to modelling needs, proved too complex. The created experimental conditions ended up too distinct from each other, involving stimuli that differed in quantity and content. This introduced several unintended and uncontrolled confounds, making it impossible to meaningfully interpret the results of this experiment on its own. Our results act as a cautionary tale for agent-based modellers, highlighting that the modelling needs should not override the principles of experimental design, and provide motivation for more rigorous research on this topic.

This brief report focuses on top-down and bottom-up processes within the field of energy transition. It aims at gaining a better understanding of the needs of the local energy initiatives. On this basis, policy recommendations are formulated to help the municipality of Groningen to facilitate local energy initiatives, ultimately leading to a more balanced approach of the local energy transition. Thus, this study explored the (mutual) interests, barriers and expectations of the municipality and local citizen initiatives. The theoretical framework is the implementation analysis framework, distinguishing top-down and bottom-up approaches. Specifically, this qualitative (thematic analysis) research study investigates the mismatch in expectations between a number of local energy initiatives and the municipality of Groningen regarding their roles within the local energy transition context. To this end, semi-structured interviews have been conducted with members of the municipality of Groningen, Grunneger Power (a local energy intermediary), and four local energy initiatives. Need and expectation gaps have been identified and potential solutions have been explored. The main findings of the study illustrate the need of professional support for citizen initiatives, at both technical and organizational level, especially in the first phases of their development. Additionally, clear mutual communication on short and long-term planning and ambitions of the involved parties is of key importance for the alignment of the interests and the course of actions. Consequently, a clear context is needed, within which an exchange of feedback on the envisioned strategies, and the subsequent energy saving or generation interventions, can take place in an efficient and effective way. Additionally, such a context increases confidence and provides a clear understanding to the citizen initiatives regarding their role and the level and nature of support they can expect in their intended projects and activities. Based on these findings, policy implications have been drawn.

Our current global Food System is facing extraordinary challenges in both size and severity, including a rise in unsustainable consumption behaviours, continued environmental degradation, growing food insecurity, and widening social inequalities. A Food System transformation is now both critically important and overwhelmingly complex, requiring nothing less than a complete overhaul of the entire value chain. Everyone is needed: Small Medium Enterprises (SMEs) with technological solutions, Non-Governmental Organisations (NGOs) with social innovations, researchers with novel methodologies, governments with food policy advancements, professionals with varying expertise, and last but not least, empowered and informed citizens with the ability and resources for better decision-making. Living Labs offer a holistic, place-based approach needed to facilitate multi-actor inputs on various levels, specifically Food System Living Labs (FSLLs) like the ones established as part of the FoodSHIFT 2030 Project. Nine front-runner Food System Living Labs were operationalised alongside a novel framework merging high-level interdisciplinary initiatives with a diverse set of innovative approaches towards more Sustainable Food Systems (SFS). The FoodSHIFT Approach concept was praised by external evaluators for its ground-breaking framework, and the nearly completed project has been listed as a best practice. However, positive applications alone will not ensure a cross-sector European-wide Food System transformation, and the following text offers a critical reflection coupled with experience-based solutions to further improve the FoodSHIFT Approach.

This article presents an analysis of the impact of Open Educational Resources (OER) during the COVID-19 pandemic, as well as their potential use in the post-pandemic, in Library and Information Science (LIS) higher education institutions. The research explored how OER were used and created, what were the main barriers and drivers in practice and some main lessons learned that can help to improve the quality and increase the use of OER beyond times of crisis. The research was based on fieldwork carried out in the LIS departments of the universities of Barcelona (Spain), Hildesheim (Germany), Osijek and Zagreb (Croatia) and the University of Library Studies and Information Technologies in Sofia (Bulgaria). The methodology approach was qualitative and was based on interviews with faculty and focus groups with students. Results show that faculty members were still hesitant to adopt OER since they generally did not consider them. Moreover, those who did use them did so on their own initiative and as additional resources. We discuss the different speeds of OER implementation that have been observed depending on the faculty's prior level of knowledge, and on whether their institutions and countries are prepared to support the use of OER. The promotion of post-pandemic OER involves greater capacity building, as well as collaboration and institutional support. Students' attitudes about the usefulness of OER focus on their availability. The large number of teachers and students who participated in the study, as well as the international scope of the study, constitute a strength in the treatment of a topic such as the use of OER where the user perspectives and LIS context have been little addressed in the literature.

Background: Every few years, juvenile Kemp's ridley turtles ( Lepidochelys kempii) are stranded on the Dutch coasts. The main population distribution of this critically endangered species primarily inhabits the Gulf of Mexico and the east coast of the United States. This study focuses on five reports from the Netherlands between 2007 and 2022, where juvenile turtles were reported to strand alive during the winter, albeit in a hypothermic state. At ambient ocean temperatures between 10°C and 13°C, Kemp's ridley turtles begin to show an inability to actively swim and remain afloat on the ocean's surface, a condition termed 'cold stunning'. Understanding their transport in cold-stunned state can help improve the rehabilitation process of stranded turtles.

Methods: Cold-stunned turtles are back-tracked as passive, virtual particles from their stranding location using Lagrangian flow modelling. This study investigates when and where these juvenile turtles cross the threshold temperatures between 10° C and 14° C before stranding by tracking the temperature along the trajectories.

Results: As expected, the simulations show the transport of the cold-stunned turtles via the English Channel. More surprisingly, the analysis suggests they likely experience cold-stunning in the southern North Sea region and encounter temperatures below 10°C for only a few days to up to three weeks, and below 12°C for up to a month before stranding.

Conclusions: The estimate of cold-stunned drift duration of the turtles provides additional knowledge about their health status at the time of stranding. Adherence to rehabilitation protocols for Kemp's ridley and post-release monitoring are recommended to improve their long-term survival.