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vol05no2
Pub Date : 2021-12-30 DOI: 10.32441/kjps.05.02
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引用次数: 0
Determination of Fetal sex by Fetal anatomy parameters using a Fuzzy C-Mean Cluster 胎儿解剖参数用模糊c均值聚类法测定胎儿性别
Pub Date : 2021-12-27 DOI: 10.32441/kjps.05.02.p2
Wafaa Kissara, B. Hassan
This paper proposes a new approach to determining the sex of the fetus using the measurement of dimensions of the head. The research attempted to use one of the techniques of fuzzy logic in the field of medicine, and here it was dealt with the visual properties designed to mix the properties of fuzzy logic (FL) and feature images. The results that some traits cannot give good results such as the results obtained from the local binary pattern (LBP) algorithm and the power and superiority of the results of hybrid filters because the ultrasound images have a special color spectrum. The results also showed the ability of the fuzzy logic proposed by using the characteristics derived from the hybrid filter to deal with the study of images and to achieve a better diagnosis of the gender of the fetus through measuring the dimensions of the head.
本文提出了一种新的方法来确定胎儿的性别使用测量尺寸的头部。本研究试图将模糊逻辑的一种技术应用于医学领域,并在此处理混合模糊逻辑和特征图像特性的视觉特性。结果表明,由于超声图像具有特殊的光谱特性,局部二值模式(LBP)算法和混合滤波器的滤波效果不能得到很好的结果。结果还表明,利用混合滤波器的特征所提出的模糊逻辑处理图像研究的能力,以及通过测量胎儿头部尺寸来更好地诊断胎儿性别的能力。
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引用次数: 1
Analysis of Seasonality Precipitation Concentration in Northern of Iraq 伊拉克北部季节性降水浓度分析
Pub Date : 2021-10-10 DOI: 10.32441/kjps.05.01.p5
Surah Hussain, Safa Khalil
This research is about analysis seasonality of precipitation concentration in the north of Iraq, by using multiple methods of precipitation concentration Index .The first is the standard vectors method that determines the date of concentration and the number of the rainy months, the second, precipitation concentration index (PCI) that classify the degree of (PCI) annually, supra-seasonal, seasonal depending on monthly precipitation data from nine metrological stations For 36 years (1979-2014), using Excel, Arc map 10.8 and Oriana software in calculates and representation of precipitation concentration. the result shows that all stations in the study area share the same date (Jan.-Feb.) and the stations differ in the length of the rainy season (7-9) month. and for PCI results, PCI annual shows denote a moderate concentration in the whole study area, PCI supra-seasonal value shows (in the wet season uniform rain distribution, the dry season value shows high concentration, PCI seasonal Shows (autumn) moderate concentration, winter: low concentration in all stations, in the spring: PCI value shows the moderate concentration in Erbil, Kirkuk, Sulaymaniyah, Salaheddin, and the other stations shows uniform rain distribution.Keywords: seasonal rain concentration, mathematical vector, PCI.
本研究利用降水浓度指数的多种方法对伊拉克北部降水浓度的季节性进行分析,首先是确定降水浓度日期和多雨月数的标准向量法,其次是根据36年(1979-2014)9个气象站的逐月降水数据,对降水浓度指数(PCI)的年际、超季节、季节程度进行分类的PCI。使用Excel、Arc map 10.8和Oriana软件进行降水浓度的计算和表示。结果表明:研究区各站点的降雨时间相同(1 ~ 2月),且各站点的雨季长度不同(7 ~ 9月)。对于PCI结果,PCI年度值在整个研究区表现为中等浓度,PCI超季节值在整个研究区表现为(雨季均匀降雨分布,旱季值表现为高浓度,PCI季节性值(秋季)表现为中等浓度,冬季在所有站点表现为低浓度,在春季:PCI值在埃尔比勒、基尔库克、苏莱曼尼亚、萨拉赫丁等站点表现为中等浓度,其他站点表现为均匀降雨分布。关键词:季节性降雨浓度,数学向量,PCI。
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引用次数: 0
Geological, Mineralogical and Geochemical Studies of Kolosh Formation, Dokan Area, Kurdistan Region, Iraq 伊拉克库尔德斯坦地区多坎地区Kolosh组地质、矿物学和地球化学研究
Pub Date : 2021-10-08 DOI: 10.32441/kjps.05.01.p4
A. Mahdi, A. Alshami, A. H. Mohammad, A. M. Al Tarif
The geology, mineralogy and geochemical of The Kolosh Formation in Dokan area, northern Iraq has been studied. The formation sequence includes gray and dark gray marl that alternate from clastic submarine sediments represented by turbid deposits resulted from the last stages of the collision movement between the continental plates. The geochemical study showed that the Kolosh Formation is mainly dominated by detrital sediments (Clay) with a dominance of kaolinite illite, and albite wıth low amounts of quartz. The analysis revealed that the Kolosh Formation is dominated by relatively marginal marine sedimentation where shelf bay facies was deposited with carbonate facies deposited as shallow marine. In contrast, SiO2 is strongly negatively correlated with CaO and MgO, this supports their derivation from terrigenous sources during the deposition of Kolosh sediments. Keywords: Kolosh Formation, sequences, mineralogy, geochemistry.
对伊拉克北部多坎地区Kolosh组进行了地质、矿物学和地球化学研究。形成层序包括灰色和深灰色泥灰岩,由以大陆板块碰撞运动末期形成的浑浊沉积为代表的碎屑海底沉积交替形成。地球化学研究表明,科洛什组以碎屑沉积物(粘土)为主,以高岭石、伊利石为主,钠长石wıth含少量石英。分析表明,科洛什组以相对边缘的海相沉积为主,陆棚湾相沉积,碳酸盐岩相沉积为浅海沉积。SiO2与CaO、MgO呈显著负相关,说明它们是陆源源。关键词:Kolosh组,层序,矿物学,地球化学。
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引用次数: 0
The Effect of Natural Gas Flaring on Air Pollution and its contribution to Climate Change in Basra City 天然气燃烧对巴士拉市空气污染的影响及其对气候变化的贡献
Pub Date : 2021-09-10 DOI: 10.32441/kjps.05.01.p3
Abdul-Haleem Ali Al Muhyi, Faez Aleedani
The effects of climate change differ from one region to another, as its effects are not the same in all regions of the world. The consequences differ from one region to another, according to its geographical location, or according to the ability of the region and its social and environmental systems to adapt to climate change or mitigate its effects. One of the most important factors of climate change is global warming. There are two major sources of global warming: natural and human. The human resource contributes by adding heat and greenhouse gases to the atmosphere because of the global use of fossil fuels, nuclear energy, burning of natural gas, coal, timber, and others. Natural gas flaring is one of the most important challenges facing energy sources and the environment globally and locally. In this study, light was shed on the flaring of natural gas in Basra Governorate and its impact on the environment and climate change. The results showed that burning natural gas in Basra contributes to changing the local climate by adding heat and greenhouse gases to the atmosphere, which led to an increase in the air temperature in the region. In recent years, it has reached (52 degrees Celsius), and it also affects air pollution by increasing concentrations of toxic gases in the atmosphere, and it is one reason for the increase in the number of cancer patients in Basra Governorate. And there was a strong positive correlation between increased gas burning and an increase in cancer cases.
气候变化的影响因区域而异,因为其影响在世界所有区域并不相同。不同地区的后果不同,这取决于其地理位置,也取决于该地区及其社会和环境系统适应气候变化或减轻其影响的能力。气候变化最重要的因素之一是全球变暖。全球变暖有两个主要原因:自然因素和人为因素。由于全球使用化石燃料、核能、燃烧天然气、煤炭、木材等,人类资源的贡献是向大气中增加热量和温室气体。天然气燃除是全球和地方能源和环境面临的最重要挑战之一。在这项研究中,阐明了巴士拉省的天然气燃烧及其对环境和气候变化的影响。结果表明,在巴士拉燃烧天然气会增加大气中的热量和温室气体,从而导致该地区气温升高,从而改变当地气候。近年来,它已达到(52摄氏度),它还通过增加大气中有毒气体的浓度影响空气污染,这是巴士拉省癌症患者人数增加的原因之一。而且,燃气燃烧的增加和癌症病例的增加之间存在很强的正相关。
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引用次数: 1
Impact Of Maternal Factors on Birth weight In Salah- Aldeen general Hospital/Tikrit City 提克里特市Salah- Aldeen综合医院产妇因素对出生体重的影响
Pub Date : 2021-06-01 DOI: 10.32441/kjps.05.01.p1
S. Talab, S. Jasim
Birth weight is a crucial determinant of the developmental potential of the newborn. Birth weight is the body weight of a baby at its birth. The range of normal is between 2.5 and 4.5 kilograms (5.5 and 9.9 lb). On average, babies of south Asian and Chinese heritage weigh about 3.26 kilograms (7.2 lb). Abnormal newborn weights are associated with negative effects on the health and survival of the baby and the mother. World Health Organization has defined low birth weight as birth weight less than 2,500 grams. Giving birth to a low-birth-weight infant is influenced by several factors. This study aimed to identify key determinants that influence the frequency of normal and low birth weight in Salah Al-Deen general Hospital in Tikrit city-Iraq.This study is a Cross- sectional study, was conducted in obstetric department in Salah Al-Deen general hospital during the period from 1st Feb to the 31st of August 2020. The study sample included full term babies (gestational age 37-42 week) chosen by using a convenient sampling method selecting 197 delivered babies with their mothers. Data collection done by face-to-face interview, using the structured questionnaire developed by the researcher include the following information: Information regarding the mother included demographic variables, reproductive health, medical and obstetrical history and antenatal care visits, use of ferrous sulfate and other supplements during pregnancy. Birth weight was measured at birth, to the nearest 50 g, with the nude infant lying on the available scale. Zero adjustment of the scale was frequently done to ensure accuracy of the readings. Birth weight was categorized into two as low birth weight (birth weight < 2500 grams), and normal birth weight (birth weight ≥ 2500 grams).The current study showed that prevalence of low birth weight was (2.4%), macrosomia (15.6%) and normal birth weight was (82%). The study showed that the low birth weight was higher among primigravida (3.4%), than multigravida women (1.7%) and that the low birth weight was higher among 1st and 2nd birth order (3.4%), (6.7%) respectively while it was (0%) among the 3rd baby order. Previous history of Diabetes Mellitus was associated with 0(0%) low birth weight babies and (2.6%) of those women without Diabetes Mellitus had low birth weight babies. Those with history of iron deficiency anemia was more prone to had babies with low birth weight (3.1%), versus those without history of iron deficiency anemia (1.3%). Those with history of hypertension more prone to had babies with low birth weight (4%), versus those without history of iron deficiency anemia (2.2%). The current study showed that those with ferrous sulfate supplements had lower proportion of babies with low birth weight (1.2%), versus those without supplements (7.7%), this relation statistically significant. This study has demonstrated that the younger maternal age, mother with diabetes mellitus, hypertension and irregular antenatal care had babi
出生体重是决定新生儿发育潜力的关键因素。出生体重是指婴儿出生时的体重。正常范围在2.5到4.5公斤(5.5到9.9磅)之间。南亚和中国血统的婴儿平均体重约为3.26公斤(7.2磅)。新生儿体重异常会对母婴的健康和生存产生负面影响。世界卫生组织将低出生体重定义为出生体重低于2500克。低出生体重儿受几个因素的影响。本研究旨在确定影响伊拉克提克里特市萨拉赫·迪恩总医院正常和低出生体重发生率的关键决定因素。本研究是一项横断面研究,于2020年2月1日至8月31日在Salah Al-Deen综合医院产科进行。研究样本包括足月婴儿(胎龄37-42周),采用方便的抽样方法选择了197名与母亲一起分娩的婴儿。通过面对面访谈、使用研究人员编制的结构化问卷收集的数据包括以下信息:关于母亲的信息包括人口统计变量、生殖健康、医疗和产科史、产前护理访问、怀孕期间硫酸亚铁和其他补充剂的使用情况。出生时测量出生体重,精确到50克,婴儿裸体躺在可用的体重秤上。经常对刻度进行调零,以确保读数的准确性。出生体重分为低出生体重(出生体重< 2500克)和正常出生体重(出生体重≥2500克)两类。目前的研究显示,低出生体重的患病率为2.4%,巨大儿的患病率为15.6%,正常出生体重的患病率为82%。研究表明,初产妇女低出生体重率(3.4%)高于多胎妇女(1.7%),第一胎和第二胎低出生体重率(3.4%)和6.7%)高于第三胎低出生体重率(0%)。既往糖尿病史与低出生体重儿相关(0%),无糖尿病妇女中有低出生体重儿(2.6%)。与没有缺铁性贫血史的人(1.3%)相比,有缺铁性贫血史的人更容易生出低出生体重儿(3.1%)。与没有缺铁性贫血史的人(2.2%)相比,有高血压史的人更容易生下低出生体重儿(4%)。目前的研究表明,服用硫酸亚铁补充剂的婴儿低出生体重比例(1.2%)低于未服用补充剂的婴儿(7.7%),这一关系具有统计学意义。本研究表明,母亲年龄较低、患有糖尿病、高血压和产前护理不规律的母亲所生婴儿的出生体重较低。既往低出生体重史也是低出生体重的易感因素。
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引用次数: 0
Activity of Cloves, Cinnamon and Thyme Essential Oils Against Some Oral Bacteria 丁香、肉桂和百里香精油对口腔细菌的活性研究
Pub Date : 2021-06-01 DOI: 10.32441/kjps.05.01.p2
Zainab Al-mahdi, L. Witwit, I. Ubaid
Background:Gastronomic natural flavors and spices have been used as both flavoring agents and preservatives in food preparation for many years. They have also been utilized in medical field for their biological properties shown in previous studies.Objective:The study aimed to evaluate the inhibitory effect of the oil extracts from Cloves, Thyme, and Cinnamon compared with ampicillin on some oral bacteria (Staphylococcus aureus, Streptococcus mutans, Lactobacillus spp., Pseudomonas aeruginosa, and Proteus spp.). Method:Evaluation of the antibacterial effect of herbal and spices essential oil was performed using Agar well diffusion test. Its effect was assessed against oral bacteria, which diagnosed in laboratory by culturing on enriched and selective media and by biochemical test.Results:High inhibitory effect of cinnamon, clove against some Gram positive and Gram negative isolated oral bacteria (Staphylococcus aureus, Streptococcus mutans, Lactobacillus spp., Pseudomonas aeroginosa, and Proteus spp. comparing with ampicillin. While thyme essential oil shows inhibitory effect for the bacterial isolates except for Pseudomonas aeroginosa but less than the inhibitory effects of other essential oils and ampicillin.For Psedomonas aeruginosa result shows the bacteria have resistance to ampicillin and Thyme essential oil while both cloves and cinnamon have antibacterial effect. Conclusions:Cloves, thyme and cinnamon essential oil have a wide antimicrobial activity against some oral bacteria, both cinnamon and cloves essential oils recorded superior antibacterial activity than ampicillin for (Proteus spp and lactobacillus), competence action with ampicillin for Staphylococcus aureus and Streptococcus mutans and novel antibacterial action against Pseudomonas aeroginosa which resist to ampicillin which may be a promising antibacterial management approach and resist development of antibiotic resistance strain if used instead than the antibiotic. Also, suggestion for using these oils orally may provide a degree of protection in oral cavity against some oral pathogens.
背景:烹饪用天然香料和香料在食品制备中作为调味剂和防腐剂已使用多年。由于其生物学特性在以往的研究中已被广泛应用于医学领域。目的:比较丁香、百里香、肉桂精油提取物与氨苄西林对口腔细菌(金黄色葡萄球菌、变形链球菌、乳杆菌、铜绿假单胞菌、变形杆菌)的抑菌效果。方法:采用琼脂孔扩散法评价中药、香料精油的抑菌效果。本品对口腔细菌的抑菌效果进行了评价,并通过强化培养基和选择性培养基培养及生化试验对口腔细菌进行了诊断。结果:与氨苄西林相比,肉桂、丁香对革兰氏阳性和革兰氏阴性口腔分离菌(金黄色葡萄球菌、变形链球菌、乳杆菌、气红假单胞菌和变形杆菌)有较高的抑制作用。百里香精油对除铜绿假单胞菌外的细菌有抑制作用,但对其他精油和氨苄西林的抑制作用较弱。结果表明,铜绿假单胞菌对氨苄西林和百里香精油均有耐药性,丁香和肉桂均有抗菌作用。结论:丁香、百里香和肉桂精油对部分口腔细菌具有广泛的抑菌活性,肉桂和丁香精油对变形杆菌和乳酸菌的抑菌活性均优于氨苄西林;氨苄西林对金黄色葡萄球菌和变形链球菌的拮抗作用以及对耐氨苄西林的空气绿假单胞菌的新型抗菌作用,可能是一种很有前途的抗菌管理方法,可以代替抗生素,防止耐药菌株的产生。此外,建议口服这些油可以在一定程度上保护口腔免受某些口腔病原体的侵害。
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引用次数: 2
Using Of Human Menopausal Gonadotropin Hormone Versus Oral Ovarian Stimulation Agents In Induction Of Ovulation In Women With Polycystic Ovary Syndrome In Salah Al-Deen Hospital/Tikrit City 在Salah Al-Deen医院/提克里特市使用人类绝经期促性腺激素与口服卵巢刺激药物诱导多囊卵巢综合征妇女排卵
Pub Date : 2020-12-31 DOI: 10.32441/KJPS.04.02.P2
H. Ajaj, M. Hassein
Polycystic ovary syndrome is a common cause of an ovulatory infertility. Drugs like Aromatase inhibitors, Human menopausal gonadotropin, used for ovulation induction. The aim of this study was carried out to compare the therapeutic effects of gonadotropin hormone versus oral ovarian stimulating agents. A prospective randomized controlled clinical trial was carried out in the Salahdeen general hospital in Tikrit from 1st Feb-30th August 2020. About 75 PCOs patients enrolled randomly in the study and divided equally into 3 groups as below: Group A treated with (75 IU intramuscular HMG gonadotropin) daily for 5 days starting Day 2 of menstrual cycle. Group B treated with oral clomiphene citrate 100 mg daily for 5 days starting Day 2 of menstrual cycle. Group C treated with oral Letrezole 5 mg daily for 5 days starting Day 2 of menstrual cycle. Multiple mature follicles were obtained commonly by HMG, followed by Letrozole, then Clomiphene, this relation was statistically significant. Endometrial thickness was higher among those treated with HMG (10.5±1.7) than those treated by Clomiphene (9.03±0.9), and then treated by letrozole (8.5±1.2). This is a significant difference in ET value between Clomiphene, letrozole, and HMG. Chemical pregnancy (early pregnancy loss that occurs shortly after implantation may account to 50-75% of all miscarriages) was higher among those treated with HMG (20%), while it was (16%) of those treated with Clomiphene, and (12%) of the Letrozole group, this relation was statistically not significant. In conclusion, HMG had the highest response rate, followed by Letrozole, and Clomiphene. The multiple mature follicles was obtained commonly by HMG, followed by Letrozole, then Clomiphene.
多囊卵巢综合征是排卵性不孕的常见原因。药物如芳香酶抑制剂,人类绝经期促性腺激素,用于促排卵。本研究的目的是比较促性腺激素与口服卵巢刺激药物的治疗效果。2020年2月1日至8月30日在提克里特的萨拉赫丁总医院进行了一项前瞻性随机对照临床试验。随机选取75例PCOs患者,随机分为3组:A组从月经周期第2天开始,每天(75 IU)肌注HMG促性腺激素,连续5天。B组患者从月经周期第2天开始口服枸橼酸克罗米芬100 mg,每日5天。C组患者口服来曲唑5 mg / d,自月经周期第2天起,连用5天。HMG以获得多个成熟卵泡居多,来曲唑次之,克罗米芬次之,差异有统计学意义。HMG组子宫内膜厚度(10.5±1.7)高于克罗米芬组(9.03±0.9),再用来曲唑组(8.5±1.2)。这是克罗米芬、来曲唑和HMG之间ET值的显著差异。化学妊娠(植入后不久发生的早期妊娠丢失可能占所有流产的50-75%)在HMG组中较高(20%),而克罗米芬组为(16%),来曲唑组为(12%),这一关系无统计学意义。结论HMG有效率最高,来曲唑次之,克罗米芬次之。多成熟卵泡以HMG为主,来曲唑次之,克罗米芬次之。
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引用次数: 9
The Role of Diagnostic Laparoscopy in Chronic Pelvic Pain 腹腔镜诊断在慢性盆腔疼痛中的作用
Pub Date : 2020-12-31 DOI: 10.32441/KJPS.04.02.P4
Jwan Abid, Israa Abid Al-Karim, W. Rajab
One of the commonest symptomatology in gynecological outpatient clinics is chronic pelvic pain, it accounts for 10% of gynecologist’s general clinics patients. The study aimed to To evaluate the role of laparoscopy in evaluation of CPP, and its correlation with clinical examination and vaginal ultrasound examination. The present prospective study was done in the Department of Obstetrics and Gynecology Salah Al-Deen general hospital in Tikrit city from 1stApril- 31st August 2020. The study sample consists of 30 patients with chronic pelvic pain, according to the ACOG criteria, with a convenient sampling method. The data collection done through: a designed closed and open-ended questionnaire, physical examination, transvaginal ultrasound & laparoscopic examination for the 30 patients for evaluation of chronic pelvic pain. By laparoscopic examination (90%) of patients had positive findings, pelvic examination identified (89%) of them correctly. Those with negative findings in laparoscopy was (10%) of patient, (33.3%) of them were diagnosed as negative by pelvic examination, there were miss diagnosis in (67%) of the negative patient and (11.1%) of positive diagnosed patient, this was a statically significant relation. Sensitivity of TVS was 85%, versus 89% for the pelvic examination. Specificity for TVS, and pelvic examination was (100%), (33%) respectively. Accuracy of the test for TVS, and pelvic examination was (87%), (83%) respectively. Exploratory laparoscopy provides a definitive diagnosis in 90% of women complaining of unexplained CPP. The surgical treatment of these lesions improves painful symptomatology in 70% of women.
慢性盆腔疼痛是妇科门诊最常见的症状之一,占妇科门诊患者的10%。本研究旨在探讨腹腔镜在评估CPP中的作用及其与临床检查和阴道超声检查的相关性。本前瞻性研究于2020年4月1日至8月31日在提克里特市Salah Al-Deen综合医院妇产科进行。研究样本由30例慢性盆腔疼痛患者组成,根据ACOG标准,采用方便的抽样方法。数据收集通过:设计封闭式开放式问卷、体格检查、经阴道超声及腹腔镜检查对30例慢性盆腔疼痛进行评估。经腹腔镜检查(90%)患者有阳性发现,盆腔检查(89%)正确识别。腹腔镜检查阴性者占10%,盆腔检查阴性者占33.3%,阴性者有67%漏诊,阳性者有11.1%漏诊,两者有统计学意义。TVS的灵敏度为85%,而盆腔检查为89%。TVS和盆腔检查的特异性分别为(100%)、(33%)。TVS和盆腔检查的准确率分别为87%和83%。在90%的抱怨不明原因CPP的妇女中,探查腹腔镜提供了明确的诊断。这些病变的手术治疗改善了70%妇女的疼痛症状。
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引用次数: 0
The Nephroprotective Effect of Zizphus Jujuba Extract Against 5-Flurouracil- Induced Nephropathy 酸枣提取物对5-氟尿嘧啶肾病的肾保护作用
Pub Date : 2020-12-31 DOI: 10.32441/KJPS.04.02.P6
Ayman Shoiab, Ahmed R Gardouh
This study assessed the protective effect of Zizphus jujube (ZJ) extract on 5‑FU‑induced alterations in renal function markers and kidney morphology in Dawley rats. Twenty-four rats were divided randomly into four groups administrated orally with 0.9% normal saline as the control group, 5-FU (40 mg/kg daily for 5 days), ZJ (500 mg/ kg daily for 5 days), and 5-FU‏+ ZJ (for 6 days). further biochemical experiments carried out on blood collected from the heart. Kidney tissues were obtained for analysis of catalase (Cat), glutathione S-transfers (GST), and lipid peroxide levels as well as histology analysis. 5-FU significantly reduced the enzyme activity of Cat and GST and increased levels of lipid peroxidation and plasma creatinine levels (P < 0.005). Histopathological examination showed severe wide ischemia of proximal convoluted tubule (PCT), missing in Bowman's space, and edema in the group treated with 5-FU. In addition, pretreatment with ZJ has significantly improved levels of Cat and GST and reduced lipid peroxidation and plasma creatinine levels (P < 0.05). Moreover, the histopathological analysis showed that ZJ relatively prevented the damage in renal tubular cells compared with 5-FU treated group. Supplementation with ZJ may have clinical benefit in nephrotoxicity caused by 5‑FU.
本研究评价了酸枣提取物对5‑FU诱导的大鼠肾脏功能标志物和肾脏形态改变的保护作用。24只大鼠随机分为4组,分别以0.9%生理盐水为对照组、5- fu (40 mg/kg / d,连用5 d)、ZJ (500 mg/kg / d,连用5 d)、5- fu + ZJ(连用6 d)。对从心脏采集的血液进行了进一步的生化实验。取肾组织进行过氧化氢酶(Cat)、谷胱甘肽s转移(GST)和脂质过氧化水平分析以及组织学分析。5-FU显著降低Cat和GST酶活性,提高脂质过氧化水平和血浆肌酐水平(P < 0.005)。组织病理学检查显示5-FU组近曲小管(PCT)严重大范围缺血,鲍曼间隙缺失,水肿。此外,ZJ预处理显著提高了Cat和GST水平,降低了脂质过氧化和血浆肌酐水平(P < 0.05)。组织病理学分析显示,与5-FU治疗组相比,ZJ对肾小管细胞损伤有较好的预防作用。补充ZJ可能对5‑FU引起的肾毒性有临床益处。
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引用次数: 2
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Al-Kitab Journal for Pure Sciences
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