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Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health. 分子大数据、机器智能和个性化健康时代的药食交互作用。
Pub Date : 2022-11-14 DOI: 10.2174/2212798412666220620104809
Romy Roy, Shamsudheen Marakkar, Munawar Peringadi Vayalil, Alisha Shahanaz, Athira Panicker Anil, Shameer Kunnathpeedikayil, Ishaan Rawal, Kavya Shetty, Zahrah Shameer, Saraswathi Sathees, Adarsh Pooradan Prasannakumar, Oommen Kaleeckal Mathew, Lakshminarayanan Subramanian, Khader Shameer, Kamlesh K Yadav

The drug-food interaction brings forth changes in the clinical effects of drugs. While favourable interactions bring positive clinical outcomes, unfavourable interactions may lead to toxicity. This article reviews the impact of food intake on drug-food interactions, the clinical effects of drugs, and the effect of drug-food in correlation with diet and precision medicine. Emerging areas in drug-food interactions are the food-genome interface (nutrigenomics) and nutrigenetics. Understanding the molecular basis of food ingredients, including genomic sequencing and pharmacological implications of food molecules, helps to reduce the impact of drug-food interactions. Various strategies are being leveraged to alleviate drug-food interactions; measures including patient engagement, digital health, approaches involving machine intelligence, and big data are a few of them. Furthermore, delineating the molecular communications across dietmicrobiome- drug-food-drug interactions in a pharmacomicrobiome framework may also play a vital role in personalized nutrition. Determining nutrient-gene interactions aids in making nutrition deeply personalized and helps mitigate unwanted drug-food interactions, chronic diseases, and adverse events from their onset. Translational bioinformatics approaches could play an essential role in the next generation of drug-food interaction research. In this landscape review, we discuss important tools, databases, and approaches along with key challenges and opportunities in drug-food interaction and its immediate impact on precision medicine.

药物与食物的相互作用会改变药物的临床效果。有利的相互作用会带来积极的临床结果,而不利的相互作用则可能导致药物毒性。本文回顾了食物摄入对药物-食物相互作用的影响、药物的临床效应以及药物-食物与饮食和精准医疗的相关效应。药物与食物相互作用的新兴领域是食物基因组界面(营养基因组学)和营养遗传学。了解食品成分的分子基础,包括基因组测序和食品分子的药理作用,有助于减少药食相互作用的影响。目前正在利用各种策略来减轻药物与食品之间的相互作用,其中包括患者参与、数字健康、涉及机器智能的方法和大数据等措施。此外,在药物微生物组框架内描述膳食微生物组-药物-食物-药物相互作用的分子沟通也可能在个性化营养方面发挥重要作用。确定营养素与基因之间的相互作用有助于实现深度个性化营养,并有助于从一开始就减轻不必要的药物-食物相互作用、慢性疾病和不良事件。转化生物信息学方法可在下一代药物-食物相互作用研究中发挥重要作用。在这篇综述中,我们将讨论重要的工具、数据库和方法,以及药物-食物相互作用的关键挑战和机遇及其对精准医学的直接影响。
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引用次数: 0
A Patent Data Analysis of the Innovation Trends in Biological Control Agent Formulations. 生物防治制剂创新趋势的专利数据分析。
Pub Date : 2022-11-14 DOI: 10.2174/2772574X13666220831122154
Ahmed Fatimi

Background: Biological control (i.e., biocontrol) can be defined as the use of microbial inoculants with a direct and purposeful manipulation of natural enemies, potentially replacing harmful pesticides, to control pests, plant pathogens, and weeds. This study concerns patent analysis of biocontrol agent-based formulations. This form of patent analysis encapsulates information that could be used as a reference by researchers in the fields of agriculture and plants, as well as those interested, especially in biocontrol agents for agriculture.

Methods: The state has been reviewed by introducing what has been patented concerning Biocontrol Agents (BCAs). Four patent databases have been used, and different keywords and related terms to BCAs were used, and patents were searched according to title, abstract, and claims. The search was then filtered regarding publication year, patent families, patent classifications, inventors, applicants, owners, and jurisdictions.

Results: During a search, 2371 patent documents were found between 1982 and 2021. The United States was ranked first with 694 patent documents. 2015 was the year with the maximum number of patent documents (278). The patent classification codes reveal that most inventions are intended for biocides, pest repellants or attractants, or plant growth regulators containing or obtained from microorganisms, viruses, microbial fungi, etc. Moreover, they are also intended for biocidal, pest repellant, pest attractant, or plant growth regulatory activities of chemical compounds or preparations, such as fungicides, athropodicides, and nematocides, which are concentrated in most patents.

Conclusion: The knowledge clusters and expert driving factors of this patent analysis indicate that the research and development based on the formulation of biocontrol agents are concentrated in most patents.

背景:生物防治(即生物防治)可以定义为使用微生物接种剂直接和有目的地操纵天敌,可能取代有害农药,以控制害虫,植物病原体和杂草。本研究涉及生物防治制剂的专利分析。这种形式的专利分析包含了可以作为农业和植物领域的研究人员以及对农业生物防治剂感兴趣的研究人员参考的信息。方法:通过对生物防治剂(bca)专利申请情况的介绍,对我国生物防治剂专利申请情况进行综述。使用了4个专利数据库,使用了不同的关键字和与bca相关的术语,并根据标题、摘要和权利要求进行了专利检索。然后根据出版年份、专利族、专利分类、发明人、申请人、所有者和司法管辖区对搜索进行过滤。结果:在检索过程中,在1982年至2021年间发现了2371份专利文件。美国以694件专利文件排名第一。2015年是专利文献数量最多的一年(278份)。专利分类代码显示,大多数发明用于含有或从微生物、病毒、微生物真菌等中获得的杀菌剂、害虫驱避剂或引诱剂或植物生长调节剂。此外,它们也用于杀菌剂、害虫驱避剂、害虫引诱剂或具有植物生长调节活性的化合物或制剂,如杀菌剂、杀肌剂和杀线虫剂,这些都集中在大多数专利中。结论:本专利分析的知识集群和专家驱动因素表明,以生物防治剂配方为基础的研发集中在大部分专利中。
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引用次数: 7
Locust Bean Gum: Processing, Properties and Food Applications. 槐豆胶:加工、特性和食品应用。
Pub Date : 2022-01-01 DOI: 10.2174/2772574X14666221107104357
Arun Kumar Singh, Rishabha Malviya, Gudhanti Siva Naga Koteswara Rao

Locust bean gum is derived from the seed endosperm of the Ceratonia siliqua carob tree and is known as locust bean or carob gum. Food, medicines, paper, textile, oil drilling, and cosmetic sectors all use it as an ingredient. Hydrogen bonding with water molecules makes locust bean gum useful in industrial settings. In addition, its dietary fibre activity helps regulate numerous health issues, including diabetes, bowel motions, heart disease and colon cancer. Locust bean gum production, processing, composition, characteristics, culinary applications, and health advantages are the subject of this article.

槐豆胶提取自 Ceratonia siliqua 角豆树的种子胚乳,被称为槐豆胶或角豆胶。食品、医药、造纸、纺织、石油钻探和化妆品行业都使用它作为原料。与水分子的氢键作用使刺槐豆胶在工业环境中大显身手。此外,它的膳食纤维活性有助于调节许多健康问题,包括糖尿病、肠蠕动、心脏病和结肠癌。槐豆胶的生产、加工、成分、特性、烹饪应用和健康优势是本文的主题。
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引用次数: 0
Sustainable Approaches to Boost Yield and Chemical Constituents of Aromatic and Medicinal Plants by Application of Biostimulants. 应用生物刺激剂提高芳香植物和药用植物产量和化学成分的可持续方法。
Pub Date : 2022-01-01 DOI: 10.2174/2772574X13666221004151822
Mohamad Hesam Shahrajabian, Wenli Sun

Introduction: Biostimulants consist of natural ingredients, metabolites of fermentation, micro-organisms, algae or plant extracts, bacteria, mushrooms, humus substances, amino acids, biomolecules, etc. Methods: In this study, all relevant English-language articles were collected. The literature was reviewed using the keywords of biostimulant, medicinal plant, aromatic plant, natural products, and pharmaceutical benefits from Google Scholar, Scopus, and PubMed databases.

Results: The significant and promoting impact of biostimulants has been reported for different medicinal and aromatic plants, such as salicylic acid for ajuga, artichoke, ajwain, basil, common rue, common sage, common thyme, coneflower, coriander, dendrobium, desert Indian wheat, dragonhead, fennel, fenugreek, feverfew, ginger, groundnut, guava, henna, Iranian soda, lavender, lemon balm, lemongrass, Malabar spinach; seaweed extract on almond, bird,s eye chili; amino acids on artemisia, broccoli, chamomile, beneficial bacteria on ashwagandha; humic acid on black cumin, cannabis, chicory, garlic, gerbera, Hungarian vetch, Moldavian dragonhead, niger plant; chitosan on dragon fruit, marigold, milk thistle, etc. The suggested mechanisms include the stimulatory impacts on the activity of enzymes involved in different biosynthetic processes, the hormone-like activity of biostimulant compounds and the improvement of nutrient uptake of plants.

Conclusion: The current manuscript gives many examples of the potential of biostimulants for medicinal and aromatic plant production. However, further studies are needed to better understand the effectiveness of different biostimulants and foliar applications in sustainable agriculture.

简介生物刺激剂由天然成分、发酵代谢物、微生物、藻类或植物提取物、细菌、蘑菇、腐殖质、氨基酸、生物大分子等组成。研究方法本研究收集了所有相关的英文文章。使用谷歌学术、Scopus 和 PubMed 数据库中的生物刺激剂、药用植物、芳香植物、天然产品和制药效益等关键词对文献进行了综述:结果:生物刺激剂对不同的药用植物和芳香植物具有重要的促进作用,如水杨酸对矢车菊、朝鲜蓟、天竺葵、罗勒、普通芸香、普通鼠尾草、普通百里香、锥栗、芫荽、石斛、印度沙漠小麦、龙头、茴香、葫芦巴、发热草、生姜、落花生、番石榴、指甲花、伊朗苏打、薰衣草、柠檬香脂、柠檬草、马拉巴尔菠菜、海藻萃取物对杏仁、鸽子草、鸢尾、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物、鸢尾属植物和鸢尾属植物的影响;杏仁、鸟眼辣椒中的海藻提取物;青蒿、西兰花、甘菊中的氨基酸;灰树花中的有益菌;黑小茴香、大麻、菊苣、大蒜、非洲菊、匈牙利薇菜、摩尔达维亚龙头菜、尼格植物中的腐殖酸;火龙果、万寿菊、奶蓟草中的甲壳素等。所提出的机制包括对参与不同生物合成过程的酶的活性产生刺激影响、生物刺激素化合物具有类似激素的活性以及改善植物对养分的吸收:本手稿举例说明了生物刺激剂在药用植物和芳香植物生产中的潜力。然而,要更好地了解不同生物刺激剂和叶面喷施在可持续农业中的效果,还需要进一步的研究。
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引用次数: 0
Punica granatum Peel Waste - An Underutilized Substrate of Therapeutic Potential: An Overview. 石榴皮废料--一种未充分利用的具有治疗潜力的底物:概述。
Pub Date : 2022-01-01 DOI: 10.2174/2772574X14666221124163344
Uroosa Noor, Shashi Soni, Ena Gupta

India is the second largest consumer and producer of fruits globally. It leads to ample solid waste per year from fruit processing industries that have been proven hazardous to the surroundings. Punica granatum (Pomegranate) belongs to the Lythraceae subfamily Punicoideae, which exhibits immense nutritional properties and delicious flavoring components. The weight of this fruit mainly consists of peel, i.e., 50%, followed by 40% of arils and 10% of seeds. Thus, the major byproduct is peel that holds many valuable bioactive compounds in higher concentrations viz saponins, carotenoids, steroids, polyphenols, quercetin derivatives, caffeic acid, phenolic acids, flavonoids, ellagitannins, p-coumaric acid, chlorogenic acid, quinic acid, anthocyanidins, triterpenoids, glycosides, tannins, and many more. Consequently, it results in wideranging therapeutic applications, including antioxidative, anti-microbial, antihypertensive, anticarcinogenic, anti-genotoxic, anti-inflammatory, glucoregulation, cardio-protective, hepatoprotective and nephroprotective effects along with prebiotic potential. Considering their nutritional and therapeutic aspects, these peels can be used for many purposes rather than being disposed off. With a value-added approach, it is utilized in many food and non-food sectors. So, this review aims to explore the therapeutic potential of P. granatum peel and enlighten its diverse applications in the food industry.

印度是全球第二大水果消费国和生产国。事实证明,水果加工业每年产生大量固体废物,对周围环境造成危害。石榴(Punica granatum)属于荔枝科石榴亚科,具有丰富的营养成分和美味的风味成分。这种水果的重量主要由果皮组成,占 50%,其次是 40%的果仁和 10%的种子。因此,主要副产品是果皮,果皮中含有许多高浓度的珍贵生物活性化合物,如皂苷、类胡萝卜素、类固醇、多酚、槲皮素衍生物、咖啡酸、酚酸、类黄酮、鞣花丹宁、对香豆酸、绿原酸、奎宁酸、花青素、三萜类、苷、单宁等。因此,它具有广泛的治疗用途,包括抗氧化、抗微生物、抗高血压、抗致癌、抗基因毒性、抗炎、葡萄糖调节、心血管保护、肝脏保护和肾脏保护作用以及益生元潜力。考虑到它们的营养和治疗作用,这些果皮可用于多种用途,而不是被丢弃。通过增值方法,它被用于许多食品和非食品领域。因此,本综述旨在探究 P. granatum 果皮的治疗潜力,并介绍其在食品工业中的多种应用。
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Recent advances in food, nutrition & agriculture
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