The drug-food interaction brings forth changes in the clinical effects of drugs. While favourable interactions bring positive clinical outcomes, unfavourable interactions may lead to toxicity. This article reviews the impact of food intake on drug-food interactions, the clinical effects of drugs, and the effect of drug-food in correlation with diet and precision medicine. Emerging areas in drug-food interactions are the food-genome interface (nutrigenomics) and nutrigenetics. Understanding the molecular basis of food ingredients, including genomic sequencing and pharmacological implications of food molecules, helps to reduce the impact of drug-food interactions. Various strategies are being leveraged to alleviate drug-food interactions; measures including patient engagement, digital health, approaches involving machine intelligence, and big data are a few of them. Furthermore, delineating the molecular communications across dietmicrobiome- drug-food-drug interactions in a pharmacomicrobiome framework may also play a vital role in personalized nutrition. Determining nutrient-gene interactions aids in making nutrition deeply personalized and helps mitigate unwanted drug-food interactions, chronic diseases, and adverse events from their onset. Translational bioinformatics approaches could play an essential role in the next generation of drug-food interaction research. In this landscape review, we discuss important tools, databases, and approaches along with key challenges and opportunities in drug-food interaction and its immediate impact on precision medicine.
{"title":"Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health.","authors":"Romy Roy, Shamsudheen Marakkar, Munawar Peringadi Vayalil, Alisha Shahanaz, Athira Panicker Anil, Shameer Kunnathpeedikayil, Ishaan Rawal, Kavya Shetty, Zahrah Shameer, Saraswathi Sathees, Adarsh Pooradan Prasannakumar, Oommen Kaleeckal Mathew, Lakshminarayanan Subramanian, Khader Shameer, Kamlesh K Yadav","doi":"10.2174/2212798412666220620104809","DOIUrl":"10.2174/2212798412666220620104809","url":null,"abstract":"<p><p>The drug-food interaction brings forth changes in the clinical effects of drugs. While favourable interactions bring positive clinical outcomes, unfavourable interactions may lead to toxicity. This article reviews the impact of food intake on drug-food interactions, the clinical effects of drugs, and the effect of drug-food in correlation with diet and precision medicine. Emerging areas in drug-food interactions are the food-genome interface (nutrigenomics) and nutrigenetics. Understanding the molecular basis of food ingredients, including genomic sequencing and pharmacological implications of food molecules, helps to reduce the impact of drug-food interactions. Various strategies are being leveraged to alleviate drug-food interactions; measures including patient engagement, digital health, approaches involving machine intelligence, and big data are a few of them. Furthermore, delineating the molecular communications across dietmicrobiome- drug-food-drug interactions in a pharmacomicrobiome framework may also play a vital role in personalized nutrition. Determining nutrient-gene interactions aids in making nutrition deeply personalized and helps mitigate unwanted drug-food interactions, chronic diseases, and adverse events from their onset. Translational bioinformatics approaches could play an essential role in the next generation of drug-food interaction research. In this landscape review, we discuss important tools, databases, and approaches along with key challenges and opportunities in drug-food interaction and its immediate impact on precision medicine.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":"13 1","pages":"27-50"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9978523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.2174/2772574X13666220831122154
Ahmed Fatimi
Background: Biological control (i.e., biocontrol) can be defined as the use of microbial inoculants with a direct and purposeful manipulation of natural enemies, potentially replacing harmful pesticides, to control pests, plant pathogens, and weeds. This study concerns patent analysis of biocontrol agent-based formulations. This form of patent analysis encapsulates information that could be used as a reference by researchers in the fields of agriculture and plants, as well as those interested, especially in biocontrol agents for agriculture.
Methods: The state has been reviewed by introducing what has been patented concerning Biocontrol Agents (BCAs). Four patent databases have been used, and different keywords and related terms to BCAs were used, and patents were searched according to title, abstract, and claims. The search was then filtered regarding publication year, patent families, patent classifications, inventors, applicants, owners, and jurisdictions.
Results: During a search, 2371 patent documents were found between 1982 and 2021. The United States was ranked first with 694 patent documents. 2015 was the year with the maximum number of patent documents (278). The patent classification codes reveal that most inventions are intended for biocides, pest repellants or attractants, or plant growth regulators containing or obtained from microorganisms, viruses, microbial fungi, etc. Moreover, they are also intended for biocidal, pest repellant, pest attractant, or plant growth regulatory activities of chemical compounds or preparations, such as fungicides, athropodicides, and nematocides, which are concentrated in most patents.
Conclusion: The knowledge clusters and expert driving factors of this patent analysis indicate that the research and development based on the formulation of biocontrol agents are concentrated in most patents.
{"title":"A Patent Data Analysis of the Innovation Trends in Biological Control Agent Formulations.","authors":"Ahmed Fatimi","doi":"10.2174/2772574X13666220831122154","DOIUrl":"https://doi.org/10.2174/2772574X13666220831122154","url":null,"abstract":"<p><strong>Background: </strong>Biological control (i.e., biocontrol) can be defined as the use of microbial inoculants with a direct and purposeful manipulation of natural enemies, potentially replacing harmful pesticides, to control pests, plant pathogens, and weeds. This study concerns patent analysis of biocontrol agent-based formulations. This form of patent analysis encapsulates information that could be used as a reference by researchers in the fields of agriculture and plants, as well as those interested, especially in biocontrol agents for agriculture.</p><p><strong>Methods: </strong>The state has been reviewed by introducing what has been patented concerning Biocontrol Agents (BCAs). Four patent databases have been used, and different keywords and related terms to BCAs were used, and patents were searched according to title, abstract, and claims. The search was then filtered regarding publication year, patent families, patent classifications, inventors, applicants, owners, and jurisdictions.</p><p><strong>Results: </strong>During a search, 2371 patent documents were found between 1982 and 2021. The United States was ranked first with 694 patent documents. 2015 was the year with the maximum number of patent documents (278). The patent classification codes reveal that most inventions are intended for biocides, pest repellants or attractants, or plant growth regulators containing or obtained from microorganisms, viruses, microbial fungi, etc. Moreover, they are also intended for biocidal, pest repellant, pest attractant, or plant growth regulatory activities of chemical compounds or preparations, such as fungicides, athropodicides, and nematocides, which are concentrated in most patents.</p><p><strong>Conclusion: </strong>The knowledge clusters and expert driving factors of this patent analysis indicate that the research and development based on the formulation of biocontrol agents are concentrated in most patents.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":"13 1","pages":"59-69"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Locust bean gum is derived from the seed endosperm of the Ceratonia siliqua carob tree and is known as locust bean or carob gum. Food, medicines, paper, textile, oil drilling, and cosmetic sectors all use it as an ingredient. Hydrogen bonding with water molecules makes locust bean gum useful in industrial settings. In addition, its dietary fibre activity helps regulate numerous health issues, including diabetes, bowel motions, heart disease and colon cancer. Locust bean gum production, processing, composition, characteristics, culinary applications, and health advantages are the subject of this article.
{"title":"Locust Bean Gum: Processing, Properties and Food Applications.","authors":"Arun Kumar Singh, Rishabha Malviya, Gudhanti Siva Naga Koteswara Rao","doi":"10.2174/2772574X14666221107104357","DOIUrl":"10.2174/2772574X14666221107104357","url":null,"abstract":"<p><p>Locust bean gum is derived from the seed endosperm of the Ceratonia siliqua carob tree and is known as locust bean or carob gum. Food, medicines, paper, textile, oil drilling, and cosmetic sectors all use it as an ingredient. Hydrogen bonding with water molecules makes locust bean gum useful in industrial settings. In addition, its dietary fibre activity helps regulate numerous health issues, including diabetes, bowel motions, heart disease and colon cancer. Locust bean gum production, processing, composition, characteristics, culinary applications, and health advantages are the subject of this article.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.2174/2772574X13666221004151822
Mohamad Hesam Shahrajabian, Wenli Sun
Introduction: Biostimulants consist of natural ingredients, metabolites of fermentation, micro-organisms, algae or plant extracts, bacteria, mushrooms, humus substances, amino acids, biomolecules, etc. Methods: In this study, all relevant English-language articles were collected. The literature was reviewed using the keywords of biostimulant, medicinal plant, aromatic plant, natural products, and pharmaceutical benefits from Google Scholar, Scopus, and PubMed databases.
Results: The significant and promoting impact of biostimulants has been reported for different medicinal and aromatic plants, such as salicylic acid for ajuga, artichoke, ajwain, basil, common rue, common sage, common thyme, coneflower, coriander, dendrobium, desert Indian wheat, dragonhead, fennel, fenugreek, feverfew, ginger, groundnut, guava, henna, Iranian soda, lavender, lemon balm, lemongrass, Malabar spinach; seaweed extract on almond, bird,s eye chili; amino acids on artemisia, broccoli, chamomile, beneficial bacteria on ashwagandha; humic acid on black cumin, cannabis, chicory, garlic, gerbera, Hungarian vetch, Moldavian dragonhead, niger plant; chitosan on dragon fruit, marigold, milk thistle, etc. The suggested mechanisms include the stimulatory impacts on the activity of enzymes involved in different biosynthetic processes, the hormone-like activity of biostimulant compounds and the improvement of nutrient uptake of plants.
Conclusion: The current manuscript gives many examples of the potential of biostimulants for medicinal and aromatic plant production. However, further studies are needed to better understand the effectiveness of different biostimulants and foliar applications in sustainable agriculture.
{"title":"Sustainable Approaches to Boost Yield and Chemical Constituents of Aromatic and Medicinal Plants by Application of Biostimulants.","authors":"Mohamad Hesam Shahrajabian, Wenli Sun","doi":"10.2174/2772574X13666221004151822","DOIUrl":"10.2174/2772574X13666221004151822","url":null,"abstract":"<p><strong>Introduction: </strong>Biostimulants consist of natural ingredients, metabolites of fermentation, micro-organisms, algae or plant extracts, bacteria, mushrooms, humus substances, amino acids, biomolecules, etc. Methods: In this study, all relevant English-language articles were collected. The literature was reviewed using the keywords of biostimulant, medicinal plant, aromatic plant, natural products, and pharmaceutical benefits from Google Scholar, Scopus, and PubMed databases.</p><p><strong>Results: </strong>The significant and promoting impact of biostimulants has been reported for different medicinal and aromatic plants, such as salicylic acid for ajuga, artichoke, ajwain, basil, common rue, common sage, common thyme, coneflower, coriander, dendrobium, desert Indian wheat, dragonhead, fennel, fenugreek, feverfew, ginger, groundnut, guava, henna, Iranian soda, lavender, lemon balm, lemongrass, Malabar spinach; seaweed extract on almond, bird,s eye chili; amino acids on artemisia, broccoli, chamomile, beneficial bacteria on ashwagandha; humic acid on black cumin, cannabis, chicory, garlic, gerbera, Hungarian vetch, Moldavian dragonhead, niger plant; chitosan on dragon fruit, marigold, milk thistle, etc. The suggested mechanisms include the stimulatory impacts on the activity of enzymes involved in different biosynthetic processes, the hormone-like activity of biostimulant compounds and the improvement of nutrient uptake of plants.</p><p><strong>Conclusion: </strong>The current manuscript gives many examples of the potential of biostimulants for medicinal and aromatic plant production. However, further studies are needed to better understand the effectiveness of different biostimulants and foliar applications in sustainable agriculture.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"72-92"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33490336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.2174/2772574X14666221124163344
Uroosa Noor, Shashi Soni, Ena Gupta
India is the second largest consumer and producer of fruits globally. It leads to ample solid waste per year from fruit processing industries that have been proven hazardous to the surroundings. Punica granatum (Pomegranate) belongs to the Lythraceae subfamily Punicoideae, which exhibits immense nutritional properties and delicious flavoring components. The weight of this fruit mainly consists of peel, i.e., 50%, followed by 40% of arils and 10% of seeds. Thus, the major byproduct is peel that holds many valuable bioactive compounds in higher concentrations viz saponins, carotenoids, steroids, polyphenols, quercetin derivatives, caffeic acid, phenolic acids, flavonoids, ellagitannins, p-coumaric acid, chlorogenic acid, quinic acid, anthocyanidins, triterpenoids, glycosides, tannins, and many more. Consequently, it results in wideranging therapeutic applications, including antioxidative, anti-microbial, antihypertensive, anticarcinogenic, anti-genotoxic, anti-inflammatory, glucoregulation, cardio-protective, hepatoprotective and nephroprotective effects along with prebiotic potential. Considering their nutritional and therapeutic aspects, these peels can be used for many purposes rather than being disposed off. With a value-added approach, it is utilized in many food and non-food sectors. So, this review aims to explore the therapeutic potential of P. granatum peel and enlighten its diverse applications in the food industry.
印度是全球第二大水果消费国和生产国。事实证明,水果加工业每年产生大量固体废物,对周围环境造成危害。石榴(Punica granatum)属于荔枝科石榴亚科,具有丰富的营养成分和美味的风味成分。这种水果的重量主要由果皮组成,占 50%,其次是 40%的果仁和 10%的种子。因此,主要副产品是果皮,果皮中含有许多高浓度的珍贵生物活性化合物,如皂苷、类胡萝卜素、类固醇、多酚、槲皮素衍生物、咖啡酸、酚酸、类黄酮、鞣花丹宁、对香豆酸、绿原酸、奎宁酸、花青素、三萜类、苷、单宁等。因此,它具有广泛的治疗用途,包括抗氧化、抗微生物、抗高血压、抗致癌、抗基因毒性、抗炎、葡萄糖调节、心血管保护、肝脏保护和肾脏保护作用以及益生元潜力。考虑到它们的营养和治疗作用,这些果皮可用于多种用途,而不是被丢弃。通过增值方法,它被用于许多食品和非食品领域。因此,本综述旨在探究 P. granatum 果皮的治疗潜力,并介绍其在食品工业中的多种应用。
{"title":"<i>Punica granatum</i> Peel Waste - An Underutilized Substrate of Therapeutic Potential: An Overview.","authors":"Uroosa Noor, Shashi Soni, Ena Gupta","doi":"10.2174/2772574X14666221124163344","DOIUrl":"10.2174/2772574X14666221124163344","url":null,"abstract":"<p><p>India is the second largest consumer and producer of fruits globally. It leads to ample solid waste per year from fruit processing industries that have been proven hazardous to the surroundings. Punica granatum (Pomegranate) belongs to the Lythraceae subfamily Punicoideae, which exhibits immense nutritional properties and delicious flavoring components. The weight of this fruit mainly consists of peel, i.e., 50%, followed by 40% of arils and 10% of seeds. Thus, the major byproduct is peel that holds many valuable bioactive compounds in higher concentrations viz saponins, carotenoids, steroids, polyphenols, quercetin derivatives, caffeic acid, phenolic acids, flavonoids, ellagitannins, p-coumaric acid, chlorogenic acid, quinic acid, anthocyanidins, triterpenoids, glycosides, tannins, and many more. Consequently, it results in wideranging therapeutic applications, including antioxidative, anti-microbial, antihypertensive, anticarcinogenic, anti-genotoxic, anti-inflammatory, glucoregulation, cardio-protective, hepatoprotective and nephroprotective effects along with prebiotic potential. Considering their nutritional and therapeutic aspects, these peels can be used for many purposes rather than being disposed off. With a value-added approach, it is utilized in many food and non-food sectors. So, this review aims to explore the therapeutic potential of P. granatum peel and enlighten its diverse applications in the food industry.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"103-119"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40483800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}