Pub Date : 2019-04-14DOI: 10.21518/1995-1477-2019-1-2-19-25
V. Bogachev, B. Boldin, O. Dzhenina
1 Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации: 117997, Россия, г. Москва, ул. Островитянова, д. 1 2 Общество с ограниченной ответственностью «Первый флебологический центр»: 117447, Россия, г. Москва, ул. Дмитрия Ульянова, д. 31
{"title":"Aescusan: pharmacology, pharmacokinetics and therapeutic characteristics","authors":"V. Bogachev, B. Boldin, O. Dzhenina","doi":"10.21518/1995-1477-2019-1-2-19-25","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-19-25","url":null,"abstract":"1 Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации: 117997, Россия, г. Москва, ул. Островитянова, д. 1 2 Общество с ограниченной ответственностью «Первый флебологический центр»: 117447, Россия, г. Москва, ул. Дмитрия Ульянова, д. 31","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74924567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.21518/1995-1477-2019-1-2-132-138
I. Makarov, N. Makarova
This clinical review describes the patient’s history of a third degree lymphedema of the right lower extremity, who underwent 33 surgical interventions in the form of lipodermatofasciectomy, complicated by frequent recurrent episodes of erysipelas. The article describes the tactics of treatment and the specifics of the selection of knitwear for such a patient.
{"title":"Analysis of a clinical case of a patient with a lymphedema of the right lower limb","authors":"I. Makarov, N. Makarova","doi":"10.21518/1995-1477-2019-1-2-132-138","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-132-138","url":null,"abstract":"This clinical review describes the patient’s history of a third degree lymphedema of the right lower extremity, who underwent 33 surgical interventions in the form of lipodermatofasciectomy, complicated by frequent recurrent episodes of erysipelas. The article describes the tactics of treatment and the specifics of the selection of knitwear for such a patient.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83689101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.21518/1995-1477-2019-1-2-140-145
П М Лаврешин, O. V. Vladimirova, P. M. Lavreshin, Sergey V. Minayev, Vladimir I. Vladimirov
The article describes the experience of application of the combined antiscar agent containing boswellic acid, cepalin, hyaluronic acid and allantoin with the subsequent application of the prolonged action pressing patch with the matrix of active release of cepalin and allantoin at the early stages of formation and maturation of scars in the patients with postoperative, post-burn scars and traces after cosmetic manipulations in the form of persistent skin redness. A comparison of the efficacy of two therapy schemes for 43 patients aged 18 to 45 in two groups was shown. When evaluating the effectiveness of the therapy by analyzing the data of evaluation scales, ultrasound, dermatoscopy, a greater effectiveness of the combined antiscar agent and pressure patch in comparison with the use of hydrating agents and silicone patches was noted.
{"title":"The experience of application of antiscar combined agent with boswellic and hyaluronic acids and cepalin in patients with scars at early stages of their development","authors":"П М Лаврешин, O. V. Vladimirova, P. M. Lavreshin, Sergey V. Minayev, Vladimir I. Vladimirov","doi":"10.21518/1995-1477-2019-1-2-140-145","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-140-145","url":null,"abstract":"The article describes the experience of application of the combined antiscar agent containing boswellic acid, cepalin, hyaluronic acid and allantoin with the subsequent application of the prolonged action pressing patch with the matrix of active release of cepalin and allantoin at the early stages of formation and maturation of scars in the patients with postoperative, post-burn scars and traces after cosmetic manipulations in the form of persistent skin redness. A comparison of the efficacy of two therapy schemes for 43 patients aged 18 to 45 in two groups was shown. When evaluating the effectiveness of the therapy by analyzing the data of evaluation scales, ultrasound, dermatoscopy, a greater effectiveness of the combined antiscar agent and pressure patch in comparison with the use of hydrating agents and silicone patches was noted.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90845230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-14DOI: 10.21518/1995-1477-2019-1-2-59-63
M. Parikov
One of the variants of CLaCS therapy is presented the method of treatment of reticular varicosity based on the combined application of injectable sclerotherapy and transdermal neodymium laser in combination with skin cooling. This CLaCS variant is the most understandable, logical and easy to use.
{"title":"CLaCS – Cryo-Laser and Cryo-Sclerotherapy: the use of a transdermal laser in combination with sclerotherapy for the treatment of reticular varicosity","authors":"M. Parikov","doi":"10.21518/1995-1477-2019-1-2-59-63","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-59-63","url":null,"abstract":"One of the variants of CLaCS therapy is presented the method of treatment of reticular varicosity based on the combined application of injectable sclerotherapy and transdermal neodymium laser in combination with skin cooling. This CLaCS variant is the most understandable, logical and easy to use.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85676098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-13DOI: 10.21518/1995-1477-2019-1-2-106-111
Н. Деговцов, D. Trukhan, E. N. Degovtsov, L. Belkina
Hemorrhoidal disease has been known since ancient times and remains one of the most common human diseases. This review presents the results of tribenoside and lidocaine combinations used in the conservative therapy of hemorrhoids, which give grounds to recommend combination therapy with tribenoside and lidocaine in the form of rectal cream and rectal suppositories as an effective and safe method of local treatment of hemorrhoids and moderate severity in different categories of patients, allowing to achieve rapid clinical improvement.
{"title":"Conservative treatment of hemorrhoids: focus on combination tribenoside and lidocaine","authors":"Н. Деговцов, D. Trukhan, E. N. Degovtsov, L. Belkina","doi":"10.21518/1995-1477-2019-1-2-106-111","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-106-111","url":null,"abstract":"Hemorrhoidal disease has been known since ancient times and remains one of the most common human diseases. This review presents the results of tribenoside and lidocaine combinations used in the conservative therapy of hemorrhoids, which give grounds to recommend combination therapy with tribenoside and lidocaine in the form of rectal cream and rectal suppositories as an effective and safe method of local treatment of hemorrhoids and moderate severity in different categories of patients, allowing to achieve rapid clinical improvement.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88481168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-13DOI: 10.21518/1995-1477-2019-1-2-118-123
M. V. Abritsova
The article presents the results of conservative therapy of patients with acute hemorrhoids, with a 10-day follow-up period, the purpose of which is to improve the results of treatment of this category of patients. The patients of Group I received conservative therapy with heparin ointment and Relief Pro® suppositories; Group II received local therapy with heparin ointment without rectal suppositories. Design: a single-center randomized controlled follow-up study. The study showed the efficacy of Relief Pro® suppositories in patients with acute haemorrhoids. The use of suppositories allowed to statistically reliably reduce the level of pain (2.59 ± 0.6 points in Group I versus 3.87 ± 0.7 points in Group II (p < 0.05)) on Day 3 of the therapy, reduce the frequency of blood excretion on Day 2 of the therapy (83% and 32% of patients, respectively (p <0.05)) and eliminate the discomfort in the anus (100% observations in Group I by Day 5 of the therapy and 67% in Group 2 by Day 10 of the therapy (p <0.05)).
{"title":"The optimal choice of therapy for acute hemorrhoids","authors":"M. V. Abritsova","doi":"10.21518/1995-1477-2019-1-2-118-123","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-118-123","url":null,"abstract":"The article presents the results of conservative therapy of patients with acute hemorrhoids, with a 10-day follow-up period, the purpose of which is to improve the results of treatment of this category of patients. The patients of Group I received conservative therapy with heparin ointment and Relief Pro® suppositories; Group II received local therapy with heparin ointment without rectal suppositories. Design: a single-center randomized controlled follow-up study. The study showed the efficacy of Relief Pro® suppositories in patients with acute haemorrhoids. The use of suppositories allowed to statistically reliably reduce the level of pain (2.59 ± 0.6 points in Group I versus 3.87 ± 0.7 points in Group II (p < 0.05)) on Day 3 of the therapy, reduce the frequency of blood excretion on Day 2 of the therapy (83% and 32% of patients, respectively (p <0.05)) and eliminate the discomfort in the anus (100% observations in Group I by Day 5 of the therapy and 67% in Group 2 by Day 10 of the therapy (p <0.05)).","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80664058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-13DOI: 10.21518/1995-1477-2019-1-2-99-105
B. K. Vandanov, N. N. Lebedev, A. N. Shikhmetov
The paper presents the basic principles of accelerated reabiletacii patient in the practice of ambulatory surgery. Pathophysiological mechanisms revealed organism response to surgical trauma. Pain, as a powerful trigger of surgical stress response due to neurohumoral, endocrine, immune, Hemostatic and metabolic mechanisms largely determines the results of surgical treatment. The most commonly used ketorolac (Ketanov) having the form parenteralnuju. The summary of the application of both drug ketorolac argued with pronounced analgesic effect. Intra-operative use of ketorolac is justified, as the drug reduces the total dose of anesthetics and Narcotic analgesics. Improving the quality of postoperative analgesia has predetermined creation protocol analgesia, as basic drugs used non-steroidal anti-inflammatory drugs.
{"title":"The role of ketorolac in the accelerated rehabilitation program for patients in outpatient surgery","authors":"B. K. Vandanov, N. N. Lebedev, A. N. Shikhmetov","doi":"10.21518/1995-1477-2019-1-2-99-105","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-99-105","url":null,"abstract":"The paper presents the basic principles of accelerated reabiletacii patient in the practice of ambulatory surgery. Pathophysiological mechanisms revealed organism response to surgical trauma. Pain, as a powerful trigger of surgical stress response due to neurohumoral, endocrine, immune, Hemostatic and metabolic mechanisms largely determines the results of surgical treatment. The most commonly used ketorolac (Ketanov) having the form parenteralnuju. The summary of the application of both drug ketorolac argued with pronounced analgesic effect. Intra-operative use of ketorolac is justified, as the drug reduces the total dose of anesthetics and Narcotic analgesics. Improving the quality of postoperative analgesia has predetermined creation protocol analgesia, as basic drugs used non-steroidal anti-inflammatory drugs.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72698403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-12DOI: 10.21518/1995-1477-2019-1-2-27-33
A. Voronkov, O. Gamzeleva
This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is shown. The need for early pharmacotherapy of phleboprotectors with endothelioprotective activity is discussed in order to slow the progression of CVD. Effects of flavonoids as perspective endothelioprotectors on various links in the pathogenesis of endothelial dysfunction are considered. On the example of the micronized purified flavonoid fraction (MPFF), the effect of flavonoid compounds on endothelial dysfunction in CVD is demonstrated, and the mechanisms of action have been examined in detail. In addition, the pharmacological effects of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed. Features of the micronized form that affect bioavailability and, ultimately, determine the pharmacological effectiveness of the drug are considered.
{"title":"Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins","authors":"A. Voronkov, O. Gamzeleva","doi":"10.21518/1995-1477-2019-1-2-27-33","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-27-33","url":null,"abstract":"This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is shown. The need for early pharmacotherapy of phleboprotectors with endothelioprotective activity is discussed in order to slow the progression of CVD. Effects of flavonoids as perspective endothelioprotectors on various links in the pathogenesis of endothelial dysfunction are considered. On the example of the micronized purified flavonoid fraction (MPFF), the effect of flavonoid compounds on endothelial dysfunction in CVD is demonstrated, and the mechanisms of action have been examined in detail. In addition, the pharmacological effects of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed. Features of the micronized form that affect bioavailability and, ultimately, determine the pharmacological effectiveness of the drug are considered.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76668832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.21518/1995-1477-2019-1-2-34-37
M. N. Kudykin
The review presents literature on the epidemiology of chronic venous diseases (CVD) and chronic venous insufficiency (CVI). The main approaches to the choice of conservative therapy for CVD and CVI are presented. The rationality of symptomatic treatment of this category of patients is justified. Data on clinical effects and mechanisms of their realization in the preparation of calcium dobesilate are given. The results of preclinical and clinical studies to assess the efficacy and safety of calcium dobesilate in relation to the symptomatic treatment of CVD and CVI are presented. On the basis of the analysis of literary sources the conclusion on expediency of wide application of calcium dobesilate in phlebological practice is presented.
{"title":"Possibilities of treatment of symptoms of chronic diseases of lower limbs veins","authors":"M. N. Kudykin","doi":"10.21518/1995-1477-2019-1-2-34-37","DOIUrl":"https://doi.org/10.21518/1995-1477-2019-1-2-34-37","url":null,"abstract":"The review presents literature on the epidemiology of chronic venous diseases (CVD) and chronic venous insufficiency (CVI). The main approaches to the choice of conservative therapy for CVD and CVI are presented. The rationality of symptomatic treatment of this category of patients is justified. Data on clinical effects and mechanisms of their realization in the preparation of calcium dobesilate are given. The results of preclinical and clinical studies to assess the efficacy and safety of calcium dobesilate in relation to the symptomatic treatment of CVD and CVI are presented. On the basis of the analysis of literary sources the conclusion on expediency of wide application of calcium dobesilate in phlebological practice is presented.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74527850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-04DOI: 10.21518/1995-1477-2018-3-4-36-41
M. N. Kudykin
The article presents up-to-date information about epidemiology, pathogenesis and clinical manifestations of chronic venous diseases and chronic venous insufficiency of the lower extremities. It discusses the mechanism of action of various phlebotrophic drugs intended for the treatment of symptoms of chronic venous diseases and chronic venous insufficiency and describes the advantages of micronized purified flavonoid fraction for the treatment of all clinical classes of chronic venous diseases.
{"title":"Management of chronic venous insufficiency of the lower extremities","authors":"M. N. Kudykin","doi":"10.21518/1995-1477-2018-3-4-36-41","DOIUrl":"https://doi.org/10.21518/1995-1477-2018-3-4-36-41","url":null,"abstract":"The article presents up-to-date information about epidemiology, pathogenesis and clinical manifestations of chronic venous diseases and chronic venous insufficiency of the lower extremities. It discusses the mechanism of action of various phlebotrophic drugs intended for the treatment of symptoms of chronic venous diseases and chronic venous insufficiency and describes the advantages of micronized purified flavonoid fraction for the treatment of all clinical classes of chronic venous diseases.","PeriodicalId":7496,"journal":{"name":"Ambulatory surgery: hospital-replacing technologies","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84062842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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