The journal of allergy and clinical immunology. Global最新文献

{"title":"Tezepelumab treatment in severe asthma with recurrent chronic rhinosinusitis with nasal polyps: Case series","authors":"Yoshiro Kai MD, PhD","doi":"10.1016/j.jacig.2024.100396","DOIUrl":"10.1016/j.jacig.2024.100396","url":null,"abstract":"<div><h3>Background</h3><div>Tezepelumab is a human IgG2 mAb that inhibits thymic stromal lymphopoietin (TSLP) and is approved for treatment of severe asthma. Bronchial asthma, usually a type 2 inflammatory disease, often co-occurs with chronic rhinosinusitis with nasal polyps (CRSwNP). However, tezepelumab has unknown effects on severe asthma with CRSwNP. Patients with CRSwNP are frequently candidates for endoscopic sinus surgery (ESS). CRSwNP is a crucial factor influencing asthma symptoms. However, some patients experience recurrent CRSwNP.</div></div><div><h3>Objective</h3><div>Tezepelumab was approved for use with CRSwNP, and TSLP is involved in the pathogenesis of CRSwNP. This study presents the cases of 2 patients with severe asthma complicated with recurrent CRSwNP after ESS in whom tezepelumab rapidly improved asthma and sinusitis symptoms.</div></div><div><h3>Methods</h3><div>We evaluated tezepelumab treatment in patients with severe asthma with recurrent CRSwNP based on symptoms, asthma exacerbation, level of type 2 cytokines, and lung function.</div></div><div><h3>Results</h3><div>After they had received a high-dose inhaled corticosteroid and long-acting β₂-agonist, the patients’ asthma remained uncontrolled, as defined by a low Asthma Control Test score. However, tezepelumab reduced severe asthma exacerbation, improved lung function, and controlled asthma symptoms. It improved CRSwNP, asthma-related symptoms, and exercise tolerance, and it inhibited type 2 cytokines extensively, indicating its effectiveness in treating CRSwNP. Tezepelumab was efficacious in these patients and improved their symptoms in terms of comorbidities of the upper and lower airways.</div></div><div><h3>Conclusion</h3><div>Tezepelumab was effective in treating asthma complicated with CRSwNP recurrence after ESS. However, further studies are required to identify the general and specific roles of tezepelumab in treating severe asthma and recurrent CRSwNP.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100396"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil ETosis and Charcot-Leyden crystals in Kimura disease","authors":"Yuzaburo Inoue MD, PhD ,&nbsp;Hitoshi Ogata MD ,&nbsp;Yoshitake Sato MD ,&nbsp;Daigo Kato MD, PhD ,&nbsp;Kanako Mitsunaga MD ,&nbsp;Mamiko Saito MD, PhD ,&nbsp;Tatsuya Ishigaki MD, PhD ,&nbsp;Minako Tomiita MD, PhD ,&nbsp;Hiroshi Kuraishi MD, PhD ,&nbsp;Keisuke Ito DDS ,&nbsp;Shigeharu Ueki MD, PhD","doi":"10.1016/j.jacig.2024.100397","DOIUrl":"10.1016/j.jacig.2024.100397","url":null,"abstract":"<div><div>Two cases of refractory Kimura disease that required treatment with biologic agents are reported. Their pathology suggests the involvement of eosinophil ETosis, which is active cell death producing Charcot-Leyden crystals.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100397"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence re: Randhawa et al, TIP’s success in the treatment of cow’s milk anaphylaxis leaves many questions unanswered","authors":"Brian D. Modena MD, MSc ,&nbsp;Allison Ramsey MD ,&nbsp;Shahzad Mustafa MD ,&nbsp;Doug Jones MD ,&nbsp;Caroline Caperton MD, MSPH","doi":"10.1016/j.jacig.2024.100394","DOIUrl":"10.1016/j.jacig.2024.100394","url":null,"abstract":"","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100394"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional bronchial tree visualization in exercise-induced severe asthma following tezepelumab treatment","authors":"Yoshiro Kai MD, PhD ,&nbsp;Yuichi Hishida RT","doi":"10.1016/j.jacig.2024.100398","DOIUrl":"10.1016/j.jacig.2024.100398","url":null,"abstract":"<div><div>Airway hyperresponsiveness, a key feature of asthma, is associated with exercise-induced asthma. Tezepelumab was reported to reduce airway hyperresponsiveness. Tezepelumab was confirmed through 3-dimensional bronchial tree visualization to be effective for exercise-induced asthma, reducing the need for a short-acting β2 agonist.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100398"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence re: Long-term efficacy and safety of cow's milk anaphylaxis specific immunotherapy: Allergen unresponsiveness via the Tolerance Induction Program","authors":"Richard L. Wasserman MD, PhD","doi":"10.1016/j.jacig.2024.100393","DOIUrl":"10.1016/j.jacig.2024.100393","url":null,"abstract":"","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100393"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema","authors":"Torsten Zuberbier MD ,&nbsp;Ana M. Giménez-Arnau MD ,&nbsp;Marcus Maurer MD","doi":"10.1016/j.jacig.2024.100389","DOIUrl":"10.1016/j.jacig.2024.100389","url":null,"abstract":"","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 2","pages":"Article 100389"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conflicting predictions of whole egg versus egg component testing: A case report","authors":"Seth T. Knight MD ,&nbsp;Brett K. Muramoto ,&nbsp;Erin C. Lindgren ,&nbsp;John C. Carlson MD, PhD","doi":"10.1016/j.jacig.2024.100370","DOIUrl":"10.1016/j.jacig.2024.100370","url":null,"abstract":"<div><div>The results of component testing for patients with egg allergy may conflict with the results of whole allergen testing, with the potential of influencing patients’ decision to undergo high-risk ingestion challenge.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 1","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtype prevalence and treatment implication in adolescents and adults with mild-to-moderate asthma: Systematic review and meta-analysis","authors":"Chamard Wongsa MD ,&nbsp;Pakpoom Wongyikul MD ,&nbsp;Piyaporn Chokevittaya MD ,&nbsp;Anapat Nititammaluk MD ,&nbsp;Kay Khine Soe MD, PhD ,&nbsp;Phichayut Phinyo MD, PhD ,&nbsp;Jonathan A. Bernstein MD ,&nbsp;Torpong Thongngarm MD","doi":"10.1016/j.jacig.2024.100366","DOIUrl":"10.1016/j.jacig.2024.100366","url":null,"abstract":"<div><h3>Background</h3><div>Inhaled corticosteroid (ICS)-containing regimens are the mainstay for treating asthma despite usually being ineffective in noneosinophilic asthma (NEA). Data on the prevalence of NEA versus eosinophilic asthma (EA) in mild-to-moderate asthma are limited.</div></div><div><h3>Objective</h3><div>We performed a systematic review of the prevalence of mild-to-moderate asthma in adolescents and adults using sputum inflammatory cell analysis and their responses to ICS.</div></div><div><h3>Methods</h3><div>We searched electronic databases (PubMed, Scopus, EMBASE, Cochrane) for studies in adolescents and adults with mild-to-moderate asthma. The primary outcome was the prevalence of asthma subtypes based on sputum inflammatory cell analysis, categorized into EA and NEA. The secondary outcome involved comparing asthma outcomes between different subtypes after ICS therapy. Certainty of evidence was reported for each pooled analysis.</div></div><div><h3>Results</h3><div>Eighteen studies involving 3,533 adolescents and adults with mild-to-moderate asthma were reviewed. The pooled prevalence (95% confidence interval) of NEA was estimated at 40.39% (27.54, 53.93) in patients with ICS naive with very low certainty of evidence. On reevaluating sputum cytology, the disease of approximately 20% to 30% of patients initially diagnosed as NEA transitioned to the EA subtype. EA patients showed significant improvements in asthma symptoms after ICS therapy: forced expiratory volume in 1 second (standardized mean difference, 0.79; 95% confidence interval, 0.30, 1.27), and airway hyperresponsiveness (standardized mean difference, 1.34; 95% confidence interval, 0.29, 2.40). NEA patients exhibited limited response.</div></div><div><h3>Conclusion</h3><div>A high proportion of adolescents and adults with mild-to-moderate asthma were identified with NEA subtype disease, which exhibited a poor response to ICS. A thorough diagnostic evaluation before initiating treatment should be integrated into clinical practice.</div><div>Registered in PROSPERO (CRD42023484334)</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 1","pages":"Article 100366"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims and scope","authors":"","doi":"10.1016/S2772-8293(24)00155-3","DOIUrl":"10.1016/S2772-8293(24)00155-3","url":null,"abstract":"","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"3 4","pages":"Article 100359"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory phenotype of Aspergillus-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis","authors":"Natsuko Nomura MD, PhD ,&nbsp;Hisako Matsumoto MD, PhD ,&nbsp;Koichiro Asano MD, PhD ,&nbsp;Yusuke Hayashi MD ,&nbsp;Akihito Yokoyama MD, PhD ,&nbsp;Yoshihiro Nishimura MD, PhD ,&nbsp;Naozumi Hashimoto MD, PhD ,&nbsp;Takuro Sakagami MD, PhD ,&nbsp;Koichi Fukunaga MD, PhD ,&nbsp;Nobuyuki Hizawa MD, PhD ,&nbsp;Akira Yamasaki MD, PhD ,&nbsp;Hiroyuki Nagase MD, PhD ,&nbsp;Noboru Hattori MD, PhD ,&nbsp;Mitsuko Kondo MD, PhD ,&nbsp;Norihiro Harada MD, PhD ,&nbsp;Hisatoshi Sugiura MD, PhD ,&nbsp;Mari Miki MD, PhD ,&nbsp;Tomoki Kimura MD, PhD ,&nbsp;Mikio Toyoshima MD, PhD ,&nbsp;Osamu Matsuno MD, PhD ,&nbsp;Yoko Sato","doi":"10.1016/j.jacig.2024.100364","DOIUrl":"10.1016/j.jacig.2024.100364","url":null,"abstract":"<div><h3>Background</h3><div>Sensitization to <em>Aspergillus,</em> mucus plugs, and bacterial colonization may coexist and relate to a refractory phenotype during follow-up in asthma with bronchiectasis and allergic bronchopulmonary aspergillosis (ABPA).</div></div><div><h3>Objective</h3><div>This study aimed to clarify the features of <em>Aspergillus</em>-sensitized refractory asthma with bronchiectasis and determine the refractory phenotype in this population and ABPA.</div></div><div><h3>Methods</h3><div>This study included cases of the oldest available <em>Aspergillus fumigatus</em>–specific IgE data and chest computed tomography images from a nationwide survey of refractory asthma with bronchiectasis. The characteristics of the <em>A fumigatus</em>–IgE positive (<em>Af</em> sIgE⁺) group were investigated and compared with its nonsensitized counterpart (<em>Af</em> sIgE⁻) and ABPA group. Cluster analysis was conducted to determine the refractory phenotype.</div></div><div><h3>Results</h3><div>The <em>Af</em> sIgE⁺ group (n = 35) demonstrated type 2 inflammation levels intermediate between the ABPA (n = 42) and <em>Af</em> sIgE⁻ (n = 38) groups while exhibiting higher blood monocyte counts than the <em>Af</em> sIgE⁻ group. Cluster analysis conducted in patients with ABPA and <em>Af</em> sIgE⁺ newly determined 2 clusters: one was characterized by a younger age of asthma onset with fungal detection in sputum, and the other was characterized by mucus plugs and inflammation with eosinophils and monocytes, which was significantly related to mucus plugs, airflow limitation, and trend to show exacerbation. In the latter cluster, mucus plugs persisted, and 30% yielded <em>Pseudomonas aeruginosa</em> in the sputum &lt;5 years later.</div></div><div><h3>Conclusion</h3><div>The refractory phenotype with persistent mucus plugs was identified in <em>Aspergillus</em>-sensitized refractory asthma with bronchiectasis and ABPA. Mucus plug prevention is warranted.</div></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. Global","volume":"4 1","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}