The Lancet regional health. Southeast Asia最新文献

{"title":"Trajectories and social determinants of child cognitive development: a prospective cohort study from infancy through middle childhood in Dhaka, Bangladesh","authors":"Viviane Valdes ,&nbsp;Eileen F. Sullivan ,&nbsp;Fahmida Tofail ,&nbsp;Lisa M. Thompson ,&nbsp;Shahria H. Kakon ,&nbsp;Talat Shama ,&nbsp;Rashidul Haque ,&nbsp;Charles A. Nelson","doi":"10.1016/j.lansea.2024.100511","DOIUrl":"10.1016/j.lansea.2024.100511","url":null,"abstract":"<div><h3>Background</h3><div>Over a third of children globally do not meet their developmental potential, and children living in low and middle-income countries (LMICs) are most vulnerable. Understanding the contextual factors that influence cognitive development for children in LMICs is crucial to inform and develop interventions. We sought to characterize developmental trajectories of cognition in Bangladeshi children and identify salient social determinants.</div></div><div><h3>Methods</h3><div>We used a longitudinal design and included 542 children living in Dhaka, Bangladesh. Social determinants (maternal and paternal education, housing risks, household assets, and food security) were assessed at baseline visits using a combination of oral interviews and home assessments. Cognitive development was assessed at 6 months, 2, 3, 4, 5, and 7 years. A total of 1397 cognitive assessments were completed across all participants. Growth curve models and mixed effect models were used.</div></div><div><h3>Findings</h3><div>In children living above the poverty line, there was increasing deviation from expected cognitive scores from 6 months to 2 years (−12.85, <em>p</em> &lt; 0.001) with stable scores from 2 to 7 years. For those below the poverty line, there were widening disparities from expectations in scores from 6 months to 4 years (−24.58, <em>p</em> &lt; 0.001) with stable scores from 4 to 7 years. Higher levels of maternal education (<em>t</em> = 2.22, <em>p</em> = 0.03) and more food security (<em>t</em> = 4.48, <em>p</em> &lt; 0.001) were protective for cognition longitudinally. Interaction effects between poverty level and maternal education and food security respectively were observed.</div></div><div><h3>Interpretation</h3><div>Cognitive development trajectories showed increasing disparities from expectations in the first two years of life, with more pronounced and lasting effects through 4 years for children below the poverty line. Maternal education and food security had promotive/protective effects on longitudinal cognitive development scores for the full sample. Maternal education and food security had stronger effects on cognitive development for children living below the poverty line compared to those living above the poverty line.</div></div><div><h3>Funding</h3><div>Funding for the study was provided by a grant from the <span>Bill and Melinda Gates Foundation</span> (OPP1111625) to CAN.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"32 ","pages":"Article 100511"},"PeriodicalIF":5.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying clustering of cholera cases using geospatial analysis in Kolkata and surrounding districts: data from patients at tertiary care referral hospitals","authors":"Rounik Talukdar ,&nbsp;Suman Kanungo ,&nbsp;Kei Kitahara ,&nbsp;Goutam Chowdhury ,&nbsp;Debmalya Mitra ,&nbsp;Asish Kumar Mukhopadhyay ,&nbsp;Alok Kumar Deb ,&nbsp;Pallavi Indwar ,&nbsp;Biswanath Sharma Sarkar ,&nbsp;Sandip Samanta ,&nbsp;Basilua Andre Muzembo ,&nbsp;Ayumu Ohno ,&nbsp;Shin-ichi Miyoshi ,&nbsp;Shanta Dutta","doi":"10.1016/j.lansea.2024.100510","DOIUrl":"10.1016/j.lansea.2024.100510","url":null,"abstract":"<div><h3>Background</h3><div>Cholera cases have increased globally across the Eastern Mediterranean, Africa, Southeast Asia, and parts of Europe since early 2024. This study aims to identify cholera hotspots and understand the spatial distribution of cholera in Kolkata and surrounding regions, a key cholera reservoir. Additionally, we examine sociodemographic factors and aspects related to water, sanitation, and hygiene (WASH).</div></div><div><h3>Methods</h3><div>Cholera clusters were detected using kernel density estimation and spatial autocorrelation through Global Moran’s-I statistics, with local cluster patterns examined using Local Moran’s-I statistics. Cholera cases from August 2021 to December 2023, treated at two tertiary care facilities in Kolkata: Infectious Diseases and Beleghata General Hospital and Dr. B C Roy Post Graduate Institute of Paediatric Sciences Hospital were included. Additionally, through a case–control study, 196 culture-confirmed cholera cases and 764 age/sex-matched neighborhood controls were enrolled, to investigate cholera risk factors.</div></div><div><h3>Findings</h3><div>Spatial analysis revealed a concentration of 196 cholera cases in Kolkata and its surrounding regions of Howrah, Hooghly, and North and South 24 Parganas. Hotspot analysis showed significant clustering in several Kolkata wards (31, 33, 56, 46, 57, 58, 59, 61, 66, 71, and 107), particularly in the northern, central, and east Kolkata wetlands areas (Global Moran’s I statistic = 0.14, p &lt; 0.001). These clusters had proximity between cases, with a median distance of 187.7 m, and 25.5% of cases as close as 73.9 m apart, suggesting localized transmission. Hotspots were identified with an average distance of 1600 m between them. Local Moran’s I analysis found dense “high–high” clusters in these areas (p &lt; 0.01), with a mean Moran’s I index of 0.3, (range 0.1–4.6). The case–control study revealed that males were more likely to contract cholera, with an adjusted odds ratio of 2.4 (p &lt; 0.01). There was no significant association found between cholera infection and sociodemographic factors or various WASH practices.</div></div><div><h3>Interpretation</h3><div>The findings emphasize the importance of targeted interventions, especially in identified hotspots, to mitigate cholera transmission. Addressing Socio-economic, and environmental factors especially improvement in WASH practices may further enhance prevention effects.</div></div><div><h3>Funding</h3><div>The author KK, received funding from the program of the <span>Japan Initiative</span> for Global Research Network on Infectious Diseases, (grant id: <span><span>JP23wm0125004</span></span>), from the <span>Ministry of Education, Culture, Sports, Science and Technology</span> in Japan, and <span>Japan Agency for Medical Research and Development</span>.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"31 ","pages":"Article 100510"},"PeriodicalIF":5.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: cluster analysis of data from KERALA-AF Registry","authors":"Yang Chen ,&nbsp;Bi Huang ,&nbsp;Peter Calvert ,&nbsp;Yang Liu ,&nbsp;Ying Gue ,&nbsp;Dhiraj Gupta ,&nbsp;Garry McDowell ,&nbsp;Jinbert Lordson Azariah ,&nbsp;Narayanan Namboodiri ,&nbsp;Govindan Unni ,&nbsp;Jayagopal Pathiyil Balagopalan ,&nbsp;Gregory Yoke Hong Lip ,&nbsp;Bahuleyan Charantharayil Gopalan","doi":"10.1016/j.lansea.2024.100507","DOIUrl":"10.1016/j.lansea.2024.100507","url":null,"abstract":"<div><h3>Background</h3><div>Patients with atrial fibrillation (AF) frequently experience multimorbidity. Cluster analysis, a machine learning method for classifying patients with similar phenotypes, has not yet been used in South Asian AF patients.</div></div><div><h3>Methods</h3><div>The Kerala Atrial Fibrillation Registry is a prospective multicentre cohort study in Kerala, India, and the largest prospective AF registry in South Asia. Hierarchical clustering was used to identify different phenotypic clusters. Outcomes were all-cause mortality, major adverse cardiovascular events (MACE), and composite bleeding events within one-year follow-up.</div></div><div><h3>Findings</h3><div>3348 patients were included (median age 65.0 [56.0–74.0] years; 48.8% male; median CHA₂DS₂-VASc 3.0 [2.0–4.0]). Five clusters were identified. Cluster 1: patients aged ≤65 years with rheumatic conditions; Cluster 2: patients aged &gt;65 years with multi-comorbidities, suggestive of cardiovascular-kidney-metabolic syndrome; Cluster 3: patients aged ≤65 years with fewer comorbidities; Cluster 4: heart failure patients with multiple comorbidities; Cluster 5: male patients with lifestyle-related risk factors. Cluster 1, 2 and 4 had significantly higher MACE risk compared to Cluster 3 (Cluster 1: OR 1.36, 95% CI 1.08–1.71; Cluster 2: OR 1.79, 95% CI 1.42–2.25; Cluster 4: OR 1.76, 95% CI 1.31–2.36). The results for other outcomes were similar. Atrial fibrillation Better Care (ABC) pathway in the whole cohort was low (10.1%), especially in Cluster 4 (1.9%). Overall adherence to the ABC pathway was associated with reduced all-cause mortality (OR 0.26, 95% CI 0.15–0.46) and MACE (OR 0.45, 95% CI 0.31–0.46), similar trends were evident in different clusters.</div></div><div><h3>Interpretation</h3><div>Cluster analysis identified distinct phenotypes with implications for outcomes. There was poor ABC pathway adherence overall, but adherence to such integrated care was associated with improved outcomes.</div></div><div><h3>Funding</h3><div>Kerala Chapter of <span>Cardiological Society of India</span>.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"31 ","pages":"Article 100507"},"PeriodicalIF":5.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sex toy use among 18–45-year-old Indian adults: insights from a nationwide online survey","authors":"Pauras Mhatre ,&nbsp;Antara Agrawal ,&nbsp;Pratham Agrawal ,&nbsp;Gaurang Narayan ,&nbsp;Priyanka Kataria ,&nbsp;Pragati Rathod ,&nbsp;Sarita Wadhva","doi":"10.1016/j.lansea.2024.100508","DOIUrl":"10.1016/j.lansea.2024.100508","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"32 ","pages":"Article 100508"},"PeriodicalIF":5.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small-area variation in child under-vaccination in India: a multilevel analysis of cross-sectional data from 36 states and Union Territories, 707 districts, and 22,349 small-area clusters","authors":"Mira Johri ,&nbsp;Sunil Rajpal ,&nbsp;Rockli Kim ,&nbsp;S.V. Subramanian","doi":"10.1016/j.lansea.2024.100504","DOIUrl":"10.1016/j.lansea.2024.100504","url":null,"abstract":"<div><h3>Background</h3><div>India has made exceptional advances in child immunisation, but subnational inequities in vaccination coverage impede attainment of key programmatic goals. Our study provides an up-to-date national portrait of local variations in child vaccination using a comprehensive set of indicators relevant to routine immunisation.</div></div><div><h3>Methods</h3><div>Indicators representing unvaccinated (zero-dose) children, incomplete basic immunisation, and vulnerability to measles and polio, were constructed from India’s 2019–2021 National Family Health Survey. We used four-level random effects logistic regression models to partition the total outcome variation over state, district and cluster levels, and produce precision-weighted estimates of prevalence across clusters. District-level prevalence and within-district variation using standard deviation measures were derived for each outcome. Boxplots graphically summarised the distribution of precision-weighted mean cluster prevalence by state.</div></div><div><h3>Findings</h3><div>The analysis included 87,622 children aged 12–36 months. Clusters accounted for 67.6% (var: 1.36; SE: 0.127) of the variation among zero-dose children, and more than 50% for all indicators. Districts with a higher prevalence of under-vaccination tended to have higher within-district heterogeneity, interpretable as greater within-district child vaccination inequities. For vaccines administered in the first year of life, the northeastern states and Uttar Pradesh had the highest median under-vaccination. Despite India’s high aggregate vaccine coverage, the distribution of small-area (cluster) mean prevalence highlighted pockets of low coverage in most states, suggesting ongoing vulnerability to measles and polio.</div></div><div><h3>Interpretation</h3><div>Achieving India’s vaccination goals requires a strategic shift towards identification and targeting of low-immunity clusters at the sub-district level.</div></div><div><h3>Funding</h3><div><span>Canadian Institutes of Health Research</span>.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"32 ","pages":"Article 100504"},"PeriodicalIF":5.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Road traffic injuries in Southeast Asia: making journeys safer","authors":"The Lancet Regional Health – Southeast Asia","doi":"10.1016/j.lansea.2024.100506","DOIUrl":"10.1016/j.lansea.2024.100506","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"30 ","pages":"Article 100506"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zainab (Lily): a beacon of hope","authors":"Ashfeen Aribea,&nbsp;M. Saiful Huq","doi":"10.1016/j.lansea.2024.100490","DOIUrl":"10.1016/j.lansea.2024.100490","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"30 ","pages":"Article 100490"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One health intervention for the control and elimination of scrub typhus, anthrax, and brucellosis in Southeast Asia: a systematic review","authors":"Shishirendu Ghosal ,&nbsp;Rachita Pradhan ,&nbsp;Sneha Singh ,&nbsp;Anoop Velayudhan ,&nbsp;Sushmita Kerketta ,&nbsp;Debaprasad Parai ,&nbsp;Hari Ram Choudhary ,&nbsp;Matrujyoti Pattnaik ,&nbsp;Debdutta Bhattacharya ,&nbsp;Sanghamitra Pati","doi":"10.1016/j.lansea.2024.100503","DOIUrl":"10.1016/j.lansea.2024.100503","url":null,"abstract":"<div><div>The “One Health” (OH) approach, introduced in 2004, integrates human, animal, and environmental health to address emerging and re-emerging diseases. This study evaluates OH strategies used by southeast Asian countries for brucellosis, anthrax, and scrub typhus. We systematically searched Medline, EMBASE, ProQuest, and EBSCO-CINHL up to May 11, 2023, screened 711 articles, and included ten studies (five on brucellosis, four on anthrax, and two on scrub typhus). Key strategies identified included intersectoral collaboration, vaccination initiatives, and comprehensive surveillance systems for both humans and animals. Additional efforts were noted in improving health infrastructure and implementing preventive measures. The review underscores that although some progress has been made, a more integrated OH approach is crucial for effective prevention and management of zoonotic diseases in southeast Asia, highlighting the need for enhanced collaboration and coordinated efforts across sectors.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"30 ","pages":"Article 100503"},"PeriodicalIF":5.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point of care lactate for differentiating septic shock from hypovolemic shock in non-ICU settings: a prospective observational study","authors":"Lubaba Shahrin ,&nbsp;Monira Sarmin ,&nbsp;Irin Parvin ,&nbsp;Md. Maksud Al Hasan ,&nbsp;Mst. Arifun Nahar ,&nbsp;Abu Sadat Mohammad Sayeem Bin Shahid ,&nbsp;Shamsun Nahar Shaima ,&nbsp;Gazi Md. Salahuddin Mamun ,&nbsp;Shajeda Nasrin ,&nbsp;Tahmeed Ahmed ,&nbsp;Mohammod Jobayer Chisti","doi":"10.1016/j.lansea.2024.100500","DOIUrl":"10.1016/j.lansea.2024.100500","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Septic shock and hypovolemic shock are life-threatening illnesses that necessitate immediate recognition and intervention, as they can result in deadly consequences. While the underlying processes may vary, both entities can exhibit hypotension and organ dysfunction. No studies have been conducted on bedside testing to differentiate between these illnesses. Lactate measurement has been established as a viable option for early detection of septic shock. However, its role in diagnosing hypovolemic shock has yet to be evaluated. The aim of the study was to investigate alterations in lactate levels among diarrheal patients with septic shock and hypovolemic shock following the administration of first fluid resuscitation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We conducted a prospective observational study in critically ill diarrheal adults aged ≥18 years in the emergency ward in Dhaka Hospital of icddr,b from 21st October 2021 to 31st May 2023 (total 19 months). The enrollment process was operational between 8:30 AM and 5:00 PM. Diarrheal adults with a diagnosis of sepsis with shock featured with poor peripheral perfusion (characterized by cold periphery and weak or absent pulse and capillary refill time &gt;3 s) or hypotension (characterized by mean arterial pressure &lt;65 mm-Hg) were enrolled as cases and consecutive diarrheal patients without any obvious features of sepsis with hypovolemic shock (due to severe dehydration) comprised the comparison group. POC lactate test was done at hours 0, 1st and 6th by StatStrip Lactate meters (Nova Biomedical, US) to all enrolled patients. For comparison of POC lactate levels, we used paired t-test for comparing the lactate samples drawn at hour 0, hour 1 and 6 with the septic shock and hypovolemic shock group. Odds ratio (OR) and their 95% confidence intervals (CIs) were used to demonstrate the strength of association. The study was registered at &lt;span&gt;&lt;span&gt;Clinicaltrials.gov&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; (&lt;span&gt;&lt;span&gt;NCT05108467&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;) and received institutional ethical approval (PR-21097).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Of 435 patients, 135 had septic shock and 141 had hypovolemic shock, rest 41 patient responded with fluid bolus. 25% (34/135) of the people in the septic shock group died whereas there is no mortality in the hypovolemic shock group. The number of patients visiting from outside Dhaka city had more septic shock than from inside were higher in comparison with (55% vs. 28%; p &lt; 0.001). Statistically significant difference was observed between septic shock and hypovolemic shock group for a median POC lactate in 0, 1st and 6th hours with an OR of 1.07 (95% CI: 0.99, 1.17; p = 0.039); 1.48, (95% CI: 1.28, 1.70; p &lt; 0.001) and 2.36 (95% CI: 1.85, 3.00; p &lt; 0.001), respectively. The gradient of 1st to 2nd sample between septic shock and hypovolemic shock was found to be significantly different (OR: 0.74, 95% CI: 0.64","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"30 ","pages":"Article 100500"},"PeriodicalIF":5.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of public health laboratory preparedness and response in WHO South-East Asia region during the COVID-19 pandemic: lessons learned and future directions","authors":"Francis Y. Inbanathan ,&nbsp;Pushpa R. Wijesinghe ,&nbsp;Dhamari Naidoo ,&nbsp;Nilesh Buddha ,&nbsp;Edwin Ceniza Salvador ,&nbsp;Khanh Kim Le ,&nbsp;Sandhya Dhawan ,&nbsp;Stuart D. Blacksell","doi":"10.1016/j.lansea.2024.100496","DOIUrl":"10.1016/j.lansea.2024.100496","url":null,"abstract":"<div><div>This Health Policy reviews the preparedness and response of public health laboratories in the WHO South-East Asia Region (SEAR) during the COVID-19 pandemic. Through a scoping review and in-depth interviews with key stakeholders, the study identifies successes, challenges, and lessons learned from available literature and the perspective of senior laboratory leaders. Key themes include human resources, health information systems, diagnostic capacity, public risk communication, biosafety, biosecurity, funding, and laboratory network coordination. The findings provide a comprehensive overview of the adaptive capacities of laboratories, the contextual factors influencing their response, and the implications for future pandemic preparedness. This study demonstrates the resilience and adaptability of diagnostic networks in the face of a pandemic but also emphasises the need for strategic resource allocation, highlighting the importance of flexible and scalable networks in managing public health crises. The success of these deployments highlights the necessity for continual investment and coordination of national, regional, and global resources in diagnostic infrastructure to improve preparedness for future public health crises.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"31 ","pages":"Article 100496"},"PeriodicalIF":5.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}