The Lancet regional health. Southeast Asia最新文献

{"title":"Strengthening WHO's South-East Asia Regional Office: from crisis to opportunity?","authors":"Swarup Sarkar , Diah Saminarsih , J.V.R. Prasada Rao , Kent Buse","doi":"10.1016/j.lansea.2025.100684","DOIUrl":"10.1016/j.lansea.2025.100684","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100684"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The domino effect: projecting the effects of US funding cuts to health aid in the global south","authors":"Rechel Shrisunder, Dwight Figueiredo","doi":"10.1016/j.lansea.2025.100700","DOIUrl":"10.1016/j.lansea.2025.100700","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100700"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive primary health care for cost-effective scale-up of depression screening in India: an economic modelling study","authors":"Neha Purohit ,&nbsp;Shubh Mohan Singh ,&nbsp;Girish N. Rao ,&nbsp;Kathirvel Soundappan ,&nbsp;Atul Kotwal ,&nbsp;Shankar Prinja","doi":"10.1016/j.lansea.2025.100701","DOIUrl":"10.1016/j.lansea.2025.100701","url":null,"abstract":"<div><h3>Background</h3><div>The Government of India envisions integrating population-based depression screening within the framework of comprehensive primary health care. This study assesses the economic impact and cost-utility of implementing universal depression screening for different age groups (≥30 years and ≥20 years) compared to the current practice of opportunistic diagnosis and management of symptomatic patients.</div></div><div><h3>Methods</h3><div>A hybrid model comprising of a decision tree and Markov model was developed for economic evaluation. The input parameters were acquired through comprehensive literature search, stakeholder consultations, analysis of the data from National Mental Health Survey, and the National Sample Survey, besides primary data collected from 259 patients for quality of life. The analysis was performed from both abridged societal (consideration of direct costs) and societal perspective (consideration of direct as well as indirect costs). In line with Indian economic evaluation standards, a screening strategy was deemed cost-effective if its incremental cost-utility ratio (ICUR) was below the per capita gross domestic product (GDP) threshold of ₹1,71,498 ($2182).</div></div><div><h3>Findings</h3><div>The gain in QALYs per person from universal screening ranged from 0·0273 (0·0265–0·0281) to 0·0295 (0·0287–0·0303), depending on the target age group. The program is expected to generate net savings of ₹291 billion ($3·7 billion) to ₹482 billion ($6·1 billion), equivalent to 0·19% to 0·32% of GDP. Furthermore, the ICURs were below the threshold, with ≥20 years aged cohort screening (₹43,995, $620) being more cost-effective than the screening in ≥30 years aged population (₹48,746, $560) from the abridged societal perspective. However, the program ceases to yield positive net health benefits if the sensitivity of the PHQ-2 decreases to 26%, or if the combined sensitivity of the sequential PHQ-2 and PHQ-9 approach falls below 35%. The intervention is likely to result in cost savings if at least 60% of patients seeking treatment after screening use public health facilities.</div></div><div><h3>Interpretation</h3><div>Integrating depression screening and management into the government primary healthcare system provides substantial public health and economic benefits, supporting the case for a PHC-oriented health system. Expanding coverage to individuals aged 20 years and above, along with ensuring high diagnostic accuracy through quality training and supportive supervision, will be key to sustaining and maximizing the programme's impact.</div></div><div><h3>Funding</h3><div>The study was supported by funding from the <span>Department of Health Research</span>, <span>Ministry of Health and Family Welfare</span>, <span>Government of India</span></div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100701"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-specific thresholds of treatment initiation delay and assessment of their confounding variables: authors' reply","authors":"Jyoti Dixit ,&nbsp;Nidhi Gupta ,&nbsp;Pritam Halder ,&nbsp;Shankar Prinja","doi":"10.1016/j.lansea.2025.100675","DOIUrl":"10.1016/j.lansea.2025.100675","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100675"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns on construct validity and contamination in the Lay-CARE study — authors’ reply","authors":"Tawanchai Jirapramukpitak ,&nbsp;Suttha Supanya","doi":"10.1016/j.lansea.2025.100655","DOIUrl":"10.1016/j.lansea.2025.100655","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100655"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality among hospitalized children with melioidosis in Thailand: a retrospective national database analysis (2015–2023)","authors":"Phanthila Sitthikarnkha ,&nbsp;Sirapoom Niamsanit ,&nbsp;Leelawadee Techasatian ,&nbsp;Suchaorn Saengnipanthkul ,&nbsp;Kaewjai Thepsuthammarat ,&nbsp;Pope Kosararaksa ,&nbsp;Nattakarn Tantawarak ,&nbsp;Punnathorn Auaboonkanok ,&nbsp;Phenphitcha Pornprasitsakul ,&nbsp;Rattapon Uppala","doi":"10.1016/j.lansea.2025.100707","DOIUrl":"10.1016/j.lansea.2025.100707","url":null,"abstract":"<div><h3>Background</h3><div>Pediatric melioidosis remains under-characterized nationally in Thailand, hindering triage and critical-care planning. We quantified epidemiology, complications, and mortality correlates among hospitalized children.</div></div><div><h3>Methods</h3><div>Retrospective analysis of Thailand's National Health Security Office database from January 2015 to Dec 2023, including patients &lt;18 years with principal melioidosis. Incidence and case-fatality rate were calculated. Mortality-related clinical characteristics were compared using descriptive statistics.</div></div><div><h3>Findings</h3><div>Among 5044 admissions, 58.3% were male and 80.5% from the Northeast; annual incidence ranged 3.7–5.8 per 100,000, peaking in 2023. Median length of hospital stay was 11 days. Lower respiratory tract infection was the commonest localized focus (17.6%), followed by septic shock (2.9%). Organ dysfunction consisted of acute respiratory failure 3.2%, acute renal failure 2.3%, and disseminated intravascular coagulation (DIC) 1.7%. There were 2.3% required intubation with mechanical ventilation &gt;96 h, and 2.2% needed renal replacement therapy. Overall, 84 children died (1.7%); deaths clustered in tertiary hospitals (71.4%). Mortality was markedly higher among children with septic shock, lower respiratory tract infection, and acute respiratory failure compared with children without these complications.</div></div><div><h3>Interpretation</h3><div>National data identify a Northeast-weighted pediatric burden and a high-risk trajectory from pneumonia to acute respiratory failure, shock, and DIC. Embedding pediatric sepsis bundles with early melioidosis-active therapy and seasonal pediatric intensive care unit (PICU) surge/transfer protocols, may shorten time-to-treatment and reduce deaths substantially and equitably.</div></div><div><h3>Funding</h3><div>This study was supported by the <span>Fundamental Fund</span>, <span>Khon Kaen University</span>, Thailand.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100707"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological issue in a dental neuromelioidosis outbreak investigation","authors":"Bijayini Behera ,&nbsp;Prasanta Raghab Mohapatra","doi":"10.1016/j.lansea.2025.100658","DOIUrl":"10.1016/j.lansea.2025.100658","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100658"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lancet Regional Health—Southeast Asia: 2025 year in review","authors":"Shalini Garg,&nbsp;Bhavani Nivetha,&nbsp;Apoorva Dharmendra","doi":"10.1016/j.lansea.2025.100704","DOIUrl":"10.1016/j.lansea.2025.100704","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100704"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indonesia leaves SEARO: what it means for regional health and WHO","authors":"Habib Benzian ,&nbsp;Manu Raj Mathur","doi":"10.1016/j.lansea.2025.100660","DOIUrl":"10.1016/j.lansea.2025.100660","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100660"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiny lives, big failures: India's drug regulation crisis","authors":"The Lancet Regional Health – Southeast Asia","doi":"10.1016/j.lansea.2025.100705","DOIUrl":"10.1016/j.lansea.2025.100705","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100705"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}