Women's health (London, England)最新文献

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, linked to metabolic, hormonal, and psychological issues. Management typically involves lifestyle changes, including increased physical activity and reduced sedentary behaviour.

Objectives: To compare the health profiles and behaviours of women with and without PCOS.

Design: This study analysed data from the UK Biobank, which is a prospective cohort study.

Methods: Women with PCOS in the UK Biobank were identified, while age- and body mass index (BMI)-matched controls were randomly selected. Data on factors associated with PCOS severity and self-reported lifestyle behaviours were analysed. Group differences were tested for significance, and participants were categorised by health behaviours to assess morbidity risk.

Results: The study included 319 women with PCOS (mean age: 43.9 years) and 638 in each control group. Significant differences (p < 0.05) were observed in anthropometric (e.g. body weight, BMI, waist and hip circumference, and body fat), cardio-metabolic (e.g. blood pressure, triglycerides, and glycated haemoglobin), and androgenic (e.g. sex hormone-binding globulin) indices. Differences were most pronounced between PCOS and age-matched controls but remained when BMI was also considered. Women with PCOS engaged in less vigorous physical activity and had higher screen time and sedentary behaviours. Those with the lowest physical activity and highest sedentary time had the worst health profiles and highest morbidity risk, regardless of group.

Conclusion: Women with PCOS exhibit poorer health despite only slight lifestyle differences. Across all participants, lower physical activity and higher sedentary behaviour were linked to increased health risks. Further research is needed to clarify causal relationships between lifestyle factors and PCOS.

Background: Vulvodynia is a significant genital pain condition, affecting an estimated 10% to 28% of individuals worldwide. Its multifactorial etiology, diagnostic challenges, and limited treatment options contribute to its substantial personal and socioeconomic burden. Despite its prevalence, vulvodynia remains under-recognized and under-researched, necessitating a comprehensive review of existing evidence to inform future research strategies.

Objective: This scoping review examines the extent and nature of clinical and psychosocial research on vulvodynia, with a focus on diagnosis, treatment, healthcare access, and its impact on quality of life, psychological well-being, and intimate relationships.

Eligibility criteria: Eligible studies included primary research using quantitative, qualitative, or mixed methods designs, as well as systematic, scoping, and topical reviews. Studies were included if they examined clinical or psychosocial aspects of vulvodynia. Research on other types of vulvar pain, animal studies, neurobiological research, and studies from non-high-income countries were excluded.Sources of Evidence and Methods:A systematic search of Medline, PubMed, CINAHL, PsycINFO, and Cochrane was conducted in March 2024 using predefined search terms related to vulvodynia, diagnosis, treatment, and patient experiences. Review findings, limitations, and recommendations were extracted to provide an overview of existing research, mapping methodologies, measures, and key findings of primary studies on vulvodynia.

Results: A total of 144 articles were included, comprising 21 reviews and 123 primary studies. Clinical research primarily addressed diagnosis, risk factors, and comorbidities, while treatment studies evaluated pharmacological therapies, psychological therapies, laser therapy, physiotherapy, acupuncture, and multidisciplinary approaches. Psychosocial research focused on patient experiences, psychosocial factors, and barriers to care. However, methodological limitations, inconsistent measurement tools, limited patient involvement, and study heterogeneity challenge the generalizability of findings.

Conclusions: This review highlights critical gaps in vulvodynia research. Despite considerable research efforts, vulvodynia remains poorly understood. Addressing methodological weaknesses and involving patients more robustly in research design are essential to advance knowledge and improve care outcomes in vulvodynia.

Background: Menopause, characterised by significant hormonal changes, can greatly impact mental health. While physical symptoms are well-known, the psychological effects, particularly suicidality, are underexplored. Suicide rates among women aged 45-55, the typical menopausal transition age, are notably higher, potentially linked to hormonal fluctuations that affect mood regulation. Despite this, little qualitative research exists on the relationship between perimenopause and mental health challenges, including suicidality.

Objectives: This study explores the mental health challenges, especially suicidality, experienced by women during perimenopause and menopause. It seeks to understand the factors contributing to these experiences and the role of healthcare in addressing them.

Design: Qualitative semi-structured interviews explored women's experiences of perimenopause and menopause, with a particular focus on mental health challenges including suicidality. The interviews were conducted and spanned from March 2023 to February 2024.

Method: Semi-structured interviews were conducted with 42 women, recruited from a private menopause clinic and the general population. Interviews, lasting 30-45 min, explored participants' mental health experiences during perimenopause and menopause. Data were analysed using reflexive thematic analysis, with NVivo 14 used for data management.

Results: Participants reported varying degrees of suicidality from abstract thoughts to suicide attempts. Feelings of hopelessness and entrapment were common triggers. Delays in receiving appropriate hormone replacement therapy (HRT) and misdiagnoses, such as being prescribed antidepressants instead of HRT, worsened symptoms. Women reported significant improvements in mental well-being after receiving timely HRT. Peer support and lifestyle changes were also identified as beneficial.

Conclusions: Improved training for healthcare providers, timely HRT access and holistic care are crucial for addressing perimenopausal mental health challenges. Women's Health Hubs, as outlined by the Women's Health Strategy for England, offer a potential solution for integrated care.

Background: Choriocarcinoma (CC), a rare and aggressive form of cancer, is composed of cytotrophoblasts and syncytiotrophoblasts. It is present in two subtypes: gestational choriocarcinoma (GCC) and non-gestational choriocarcinoma (NGCC). Recognizing the disparities between GCC and NGCC is essential for the precise staging, prognosis, and determination of the primary treatment strategy.

Objective: This study aimed to differentiate clinical outcomes, treatment responses, and prognostic factors between GCC and NGCC and to introduce innovative tools for personalized treatment strategies.

Design: A retrospective cohort study with Survival Analysis and Nomogram Development.

Methods: We analyzed data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database and identified female patients diagnosed with GCC and NGCC between 2000 and 2020. The clinicopathological features of each group were compared using the chi-square test. Kaplan-Meier curves, log-rank tests, and Cox proportional hazard regression were used to assess overall survival and cancer-specific survival and to determine risk factors. The 5-year survival predicting nomogram was constructed, evaluated, and validated.

Results: The study included 919 patients with 719 CC and 200 patients with NGCC. The NGCC group was characterized by older age, a higher proportion of married individuals, more advanced disease stages, larger tumor sizes, and a higher frequency of surgical interventions than the GCC group. NGCC was associated with worse survival rates than GCC patients.

Conclusions: This study highlights the critical role of chemotherapy in improving the survival of patients with NGCC, in contrast to its limited effect on GCC. The negative prognosis associated with radiotherapy underscores the urgent need for further investigation to optimize its use. In addition, the introduction of the first web-based survival prediction tool and predictive nomogram marked a significant advancement in personalized treatment strategies, enabling improved clinical outcomes by tailoring therapy to individual patients.

Background: The Syrian crisis, severe economic conditions, and the COVID-19 pandemic have significantly impacted the mental health of Syrians, including mothers who have given birth during these difficult times. These conditions have led to an increased prevalence of postpartum depression (PPD), exacerbated by inadequate responses to these crises.

Objectives: The study aims to assess the prevalence of PPD among Syrian mothers during the Syrian crisis, economic crisis, and the COVID-19 pandemic. It also seeks to identify the influence of these factors on the occurrence of PPD.

Design: A prospective longitudinal study was conducted between November 13, 2020 and April 27, 2021, in Damascus, Syria.

Methods: PPD was evaluated among women who visited the Obstetrics and Gynecology University Hospital in Damascus, using the Arabic version of the Edinburgh Postnatal Depression Scale after birth and again 6 weeks later. Pearson's chi-square test and logistic regression were used to investigate the correlation between the variables.

Results: A total of 402 women participated in the study, with only 378 remaining for follow-up at 6 weeks postpartum. The prevalence of PPD was found to be 46% immediately after birth and 25.3% 6 weeks later. Women's house devastation (Sig. 0.033, 95% confidence interval (CI): 1.043-2.801), loss or injury of family members (Sig. 0.018, 95% CI: 1.110-3.008), and a preference for a female child (Sig. 0.034, 95% CI: 0.162-0.931) were significantly associated with PPD. We did not find an impact of COVID-19 pandemic on the prevalence of depression.

Conclusion: Detecting and addressing PPD is crucial, especially during the Syrian crisis, the COVID-19 pandemic, and ongoing economic difficulties, as these factors heighten stress during the postpartum period. Particular attention should be given to displaced mothers and those who have lost family members due to the conflict.

Background: Despite the well-documented benefits of physical activity, particularly strength training, for managing menopause-related physiological changes such as muscle loss and weight gain, few interventions specifically target pre- and perimenopausal women using scalable, remote delivery methods.

Objectives: The purpose of this pilot study was to examine the feasibility and preliminary efficacy of a group-based physical activity and strength intervention delivered via Zoom for pre- and perimenopausal women.

Design: This study was a randomized controlled trial lasting 12 weeks.

Methods: Low active pre- and perimenopausal women between the ages of 40-50 (n = 39) were randomly assigned to a 12-week physical activity strength intervention or a waitlist control. Participants attended the sessions twice per week, which included both a 40-min cardiovascular and strength training component and a 20-min motivational component informed by Self-Determination Theory and Habit Formation Theory. Participants were provided Apple Watch devices to monitor their physical activity.

Results: The physical activity strength intervention appears feasible based on recruitment duration, adherence to the Zoom sessions, retention, and the consumer satisfaction survey. The intervention participants increased their physical activity by 21 min/week, and the control group decreased by 2 min, although the differences were not significant. The intervention participants reported greater positive changes on several of the psychosocial variables, including self-efficacy, habit formation, habit automaticity, self-regulation, goal setting, physical activity enjoyment, physical activity feeling, physical activity revitalization, and physical activity tranquility.

Conclusions: Although there was no evidence that the intervention led to increases in physical activity, this study supports the feasibility of a group-based physical activity strength intervention delivered via Zoom. Additional studies that include larger sample sizes and a longer intervention are needed to better understand the efficacy of the intervention.Registration/clinical trials: https://clinicaltrials.gov/study/NCT05426070.

Background: Ultrasound imaging has become popular among physiotherapists for monitoring diastasis rectus abdominis postpartum, but its reliability requires further exploration.

Objectives: To investigate physiotherapists' intra-tester, inter-tester, and test-retest reliability of inter-recti distance measurement utilizing real-time ultrasound across a mixed women sample.

Design: Reliability study.

Methods: Volunteers comprising nulliparous and parous women of different ages and body mass index participated. Five physiotherapists performed ultrasound measurements, following sonographic training. Four conditions were tested in supine; rest, curl-up, transversus abdominus activation, and transversus abdominus with curl-up. Three locations were randomly measured: umbilicus, 3 cm above the umbilicus, and halfway between the umbilicus and xiphoid process. For intra-tester reliability, each therapist undertook three repeated measurements. For inter-tester reliability, mean inter-recti distance measurements were explored across any two tester combinations within and across sessions. Test-retest reliability explored repeated measurements 5-8 days later. Data were analyzed with intraclass correlation coefficients_2,1.

Results: 54 women (33.2 ± 15.2 years old, body mass index: 24.2 ± 3.7), 19 (35.2%) being parous participated. Intra-tester reliability across each physiotherapist was very good (intraclass correlation coefficients = 0.677-0.989). Intra-session reliability across any two testers yielded very good results (intraclass correlation coefficients = 0.76-0.92), whereas across-session yielded good reliability (intraclass correlation coefficients >0.76) except for one condition (3 cm above umbilicus in combined transversus abdominus and curl-up). Test-retest reliability was also very good (intraclass correlation coefficients = 0.78-0.96). Significant differences in inter-recti distance were found, with parous women showing consistently larger values (p < 0.05).

Conclusion: Physiotherapists, following sonographic training, can reliably measure inter-recti distances in both nulliparous and parous women across active and resting tasks. Thus, ultrasound measurement of inter-recti distance is recommended in physiotherapy practice for monitoring diastasis rectus abdominis and assessing rehabilitation progress. However, sub-umbilical inter-recti distance measurements and the impact of co-contraction on reliability require further research.

Background: Adequate gestational weight gain affects birth outcomes and increases the risk of non-communicable diseases later in life. Weight gain in pregnant Ethiopian women with hyperemesis gravidarum has not been investigated comprehensively.

Objective: To assess the determinants of weight gain in pregnant women with hyperemesis gravida in Dire Dawa Administration, Eastern Ethiopia.

Design: Unmatched case-control studyMethods:Pregnant women who visited health facilities for ante-natal care were recruited into this study using random sampling techniques. The World Health Organization Global Physical Activity Questionnaire, FANTA Version III Women's Dietary Diversity Score Questionnaire, and anthropometric measurements were used for the assessment of physical activities, dietary diversity, and gestational weight gain, respectively. Bivariate and multivariate logistic regression analyses with a 95% confidence interval (CI) and a Hosmer-Lemeshow goodness model were used to identify the determinants of gestational weight gain in the study population. A P value of <0.05 was considered significant.

Results: A total of 657 pregnant women (219 patients and 438 controls) were included in this study. Among them, 44.3% and 47% of those in the patient and control groups, respectively, gained adequate weight during pregnancy (Std. 0.499: 95% CI: 42-49.8). Gravidity (adjusted odds ratio (aOR): 0.43, 95%CI: 0.22-0.81), planned pregnancy (aOR: 0.28, 95%CI: 0.11-0.69), and pre-pregnancy weight (aOR: 0.16, 95%CI: 0.72-0.74) were determinants of weight gain in the patient group, whereas the secondary level of education (aOR: 0.59, 95%CI: 0.36-0.97) and pre-pregnancy weight (aOR: 0.20, 95%CI: 0.08, 0.50) were determinants of gestational weight gain in the control group.

Conclusion: The main determinants of gestational weight gain in women with hyperemesis gravidarum are gravidity, planned pregnancy, and pre-pregnancy weight. However, educational status and pre-pregnancy weight are the main determinants of gestational weight gain in women without hyperemesis gravidarum. Strengthening the nutritional life-cycle approach during pregnancy is important for ensuring that mothers maintain a healthy gestational weight.

Background: In light of ongoing HIV diagnoses among cis women, despite decreases in other populations, such as men who have sex with men, various testing approaches, including HIV self-tests are being targeted at cis women as a means of identifying undiagnosed HIV infections and of linking those with positive test results to care. Little, however, is known about risk characteristics of cis women who access HIV self-tests in Canada.

Objectives: Our objectives were to examine demographic characteristics, risk factors, and test results of cis women who obtained HIV self-tests through the HIV self-testing platform, GetaKit.ca.

Design: GetaKit.ca was an observational cohort study that provided free HIV self-tests to Canadians with reported risk factors for HIV acquisition.

Methods: We completed an analysis of cis women who ordered HIV self-tests from GetaKit.ca between April 1, 2021 and May 31, 2023. Data analysis involved tabulating frequencies and means, plus chi-square calculations to determine significant differences between cis women and cis men who obtained HIV self-tests.

Results: During the study period, 7420 orders for HIV self-tests were made through GetaKit.ca; 22% of these orders were made by cis women. Compared to cis men, cis women had significantly higher reported rates of injection drug use and significantly lower reported rates of prior sexually transmitted infection testing, HIV testing (with more cis women indicating their last HIV test was more than 12 months ago), and reporting HIV self-test results. Despite this, we found no differences in the number of cis women with a positive HIV self-test compared to cis men (positivity rate of 0.2% versus 0.3%, respectively).

Conclusion: Our findings showed less overall uptake of HIV testing in cis women, despite matched risks and positive test results. Future interventions to engage cis women in HIV testing should include increased access points for HIV self-tests and enhanced linkage to care pathways to HIV pre-exposure prophylaxis or HIV treatment.

Background: Antenatal care (ANC) is vital for the health and well-being of mothers and their babies during pregnancy. It provides care, education, counseling, screening, and treatment to manage pregnancy-related complications. However, many pregnant women, especially in low-income regions like sub-Saharan Africa, do not complete recommended visits, leading to high dropout rates. Ethiopia, following WHO 2016 recommendations, has adopted an eight-contact ANC model, but still faces a 30% dropout rate. Effective ANC is crucial for reducing maternal mortality rates and ensuring positive pregnancy outcomes.

Objectives: The aim of the study is to identify the determinants of ANC dropout among mothers who delivered in South Mecha Woreda, North West Ethiopia, 2024.

Design: A community-based unmatched case-control study design was employed.

Methods: Study conducted from May 25 to June 25, 2024, using a structured and pre-tested interviewer-administered questionnaire. The final sample included 111 cases and 215 controls, totaling 326 participants. Participants were selected based on the outcome variable of ANC visit dropout (mothers who did not complete the recommended four visits during pregnancy) and ANC visit completion, identified through simple random sampling. Bivariable and multivariable analyses were performed, with a 95% confidence interval (CI) and p-value used to determine significance.

Results: Women who could not read and write had higher likelihood of ANC drop out (adjusted odds ratio (AOR) = 6.475; 95% CI: 2.662, 13.747; p < 0.001), women from families with a monthly income of less than 3000 (AOR = 2.036; 95% CI: 1.666, 6.221; p = 0.012), women who waited more than 30 min (AOR = 5.132; 95% CI: 3.352, 12.877; p < 0.001), and dissatisfaction with the service received (AOR = 5.397; 95% CI: 1.406, 10.719; p = 0.014).

Conclusion: The research indicates that variables like educational level, family income, service waiting times, and satisfaction with services are significant determinants of ANC dropout rates among women in South Mecha Woreda. Women with lower levels of education and income are at a higher risk of dropping out, highlighting the necessity for focused interventions. The research underscores the need for holistic strategies to enhance maternal health and decrease ANC dropout rates.