Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.37700
Irmanida Batubara, Faradina Aulia Putri, D. Tohir, Shadila Fira Asoka
The appearance of brown spots and wrinkles can be a sign of aging which can increase the risk of cancer. Compounds in broadleaf mahogany seeds (Swietenia macrophylla) contains many compounds and is known to have anticancer activity. The purpose of this study was to determine the compounds in the seeds of these plants have the potential to antiaging by analyzing their molecular docking interaction on the MMP-1 enzyme (matrix metalloproteinase), NEP (neprilysin), PPO3 (polyphenol oxidase), and as a support for the search for anticancer compounds. Two compounds that have the potential as strong inhibitors towards MMP-1 and PPO3 enzymes, namely β-cytostenone and 3β-hydroxystigmast-5-en-7-on which is a steroid group, as well as germacrena A and germacrena D which are terpenoids. Only compound 3β-hydroxystigmast-5-en-7-on which has the potential as a strong inhibitor of the NEP enzyme. All compounds have the potential to be strong inhibitors according to the Lipinski rule. Only compounds which binds to the PPO3 enzyme which has better activity than natural ligand based on ΔG and Binding Site Similarity (BSS) values.
{"title":"Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds as Antiaging Agent Based on Molecular Docking Study","authors":"Irmanida Batubara, Faradina Aulia Putri, D. Tohir, Shadila Fira Asoka","doi":"10.24252/al-kimia.v11i1.37700","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.37700","url":null,"abstract":"The appearance of brown spots and wrinkles can be a sign of aging which can increase the risk of cancer. Compounds in broadleaf mahogany seeds (Swietenia macrophylla) contains many compounds and is known to have anticancer activity. The purpose of this study was to determine the compounds in the seeds of these plants have the potential to antiaging by analyzing their molecular docking interaction on the MMP-1 enzyme (matrix metalloproteinase), NEP (neprilysin), PPO3 (polyphenol oxidase), and as a support for the search for anticancer compounds. Two compounds that have the potential as strong inhibitors towards MMP-1 and PPO3 enzymes, namely β-cytostenone and 3β-hydroxystigmast-5-en-7-on which is a steroid group, as well as germacrena A and germacrena D which are terpenoids. Only compound 3β-hydroxystigmast-5-en-7-on which has the potential as a strong inhibitor of the NEP enzyme. All compounds have the potential to be strong inhibitors according to the Lipinski rule. Only compounds which binds to the PPO3 enzyme which has better activity than natural ligand based on ΔG and Binding Site Similarity (BSS) values.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45021212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.35688
H. Pardi, D. Fitriyah
The study was carried out to determination the metal Ni(II) in river water samples using cathodic stripping voltammetry (CSV) method. In order to achieve optimum conditions for the determination of metal Ni(II), the accumulation potential and accumulation time conditions of the CSV method have been achieved. The results of this research obtained under the optimum conditions for Ni(II) measurement using an electrolyte solution of ammonium chloride with a potential accumulation (accv) of -0.7 V and a time accumulation (acct) of 60 s. The relative standard deviation of the 10 µg/L Ni(II) standard solution (n=8) is 0.53%, the recovery value is 98.82%. The CSV method for the determination of Ni(II) metal has been successfully applied to river water samples.
{"title":"Optimisation of The Cathodic Stripping Voltammetry For The Determination of Metal Ni(II) in The River Water","authors":"H. Pardi, D. Fitriyah","doi":"10.24252/al-kimia.v11i1.35688","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.35688","url":null,"abstract":"The study was carried out to determination the metal Ni(II) in river water samples using cathodic stripping voltammetry (CSV) method. In order to achieve optimum conditions for the determination of metal Ni(II), the accumulation potential and accumulation time conditions of the CSV method have been achieved. The results of this research obtained under the optimum conditions for Ni(II) measurement using an electrolyte solution of ammonium chloride with a potential accumulation (accv) of -0.7 V and a time accumulation (acct) of 60 s. The relative standard deviation of the 10 µg/L Ni(II) standard solution (n=8) is 0.53%, the recovery value is 98.82%. The CSV method for the determination of Ni(II) metal has been successfully applied to river water samples.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45201900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.36326
Iin Novianty, A. Suratman, Mudasir
Biosorption of Cu (II) using bacteria Pseudomonas aeruginosa FNCC-0063 was immobilized on calcium alginate (PAI). This research examined the effect of various parameters such as pH, contact time, and initial Cu (II) concentration. The biosorption mechanism of Cu (II) was studied by sequential desorption with H2O, KNO3 1 M, HNO3 0.5 M and Na2EDTA 0.1 M. Cu (II) concentration was analyzed using atomic absorption spectrophotometer (AAS). The results showed that optimum Cu (II) ion biosorption occurred at a pH biosorption rate constant of 0.03724 g mg-1.min-1. The kinetics studies showed that Cu (II) biosorption follows pseudo-second-order. The biosorption capacities of 36.60 mg/g. Cu (II) Biosorption followed the Freundlich equation, as shown by a high correlation coefficient (R2) of about 0.99. Ionic bonds dominated the biosorption mechanism of Cu (II) ion on immobilized PAI.
{"title":"Immobilization of Pseudomonas aeruginosa FNCC-0063 on Calcium Alginate and Its Application as Bioabsorbent","authors":"Iin Novianty, A. Suratman, Mudasir","doi":"10.24252/al-kimia.v11i1.36326","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.36326","url":null,"abstract":"Biosorption of Cu (II) using bacteria Pseudomonas aeruginosa FNCC-0063 was immobilized on calcium alginate (PAI). This research examined the effect of various parameters such as pH, contact time, and initial Cu (II) concentration. The biosorption mechanism of Cu (II) was studied by sequential desorption with H2O, KNO3 1 M, HNO3 0.5 M and Na2EDTA 0.1 M. Cu (II) concentration was analyzed using atomic absorption spectrophotometer (AAS). The results showed that optimum Cu (II) ion biosorption occurred at a pH biosorption rate constant of 0.03724 g mg-1.min-1. The kinetics studies showed that Cu (II) biosorption follows pseudo-second-order. The biosorption capacities of 36.60 mg/g. Cu (II) Biosorption followed the Freundlich equation, as shown by a high correlation coefficient (R2) of about 0.99. Ionic bonds dominated the biosorption mechanism of Cu (II) ion on immobilized PAI.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48978390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.38217
M. Ariefin, M. H. Pasaribu
Corrosion of iron is a persistent problem that affects its structural integrity and durability in various industrial applications. The design of effective corrosion inhibitors is crucial for mitigating aluminum corrosion. In recent years, coumarin derivatives have shown promising potential as corrosion inhibitors for iron due to their unique chemical properties. In this research, we employ density functional theory (DFT) calculations to investigate electrochemical parameters of coumarin derivatives on iron corrosion. Coumarin (a) and its derivative: hymechromone (b), esculetin (c), and scopoletin (d) are analyzed using DFT calculation. Some descriptor is used to identify such as ionisation energy (I), electron affinity (A), EHOMO, ELUMO, Egap, electronegativity ( ), hardness ( ), number of fraction electron transferred ( N). Based on the EHOMO, ELUMO, Egap, electronegativity ( ), hardness ( ), the order of inhibitor potential of coumarin and it derivative is c > d > b > a. However, based on the number of fractional electrons transferred ( N), the potential inhibitor of coumarin and it derivative are c > b > d > a.
{"title":"Theoritical Studies of Corossion Inhibition of Coumarin and Coumarin Derivative on Iron by Density Functional Theory Approaches","authors":"M. Ariefin, M. H. Pasaribu","doi":"10.24252/al-kimia.v11i1.38217","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.38217","url":null,"abstract":"Corrosion of iron is a persistent problem that affects its structural integrity and durability in various industrial applications. The design of effective corrosion inhibitors is crucial for mitigating aluminum corrosion. In recent years, coumarin derivatives have shown promising potential as corrosion inhibitors for iron due to their unique chemical properties. In this research, we employ density functional theory (DFT) calculations to investigate electrochemical parameters of coumarin derivatives on iron corrosion. Coumarin (a) and its derivative: hymechromone (b), esculetin (c), and scopoletin (d) are analyzed using DFT calculation. Some descriptor is used to identify such as ionisation energy (I), electron affinity (A), EHOMO, ELUMO, Egap, electronegativity ( ), hardness ( ), number of fraction electron transferred ( N). Based on the EHOMO, ELUMO, Egap, electronegativity ( ), hardness ( ), the order of inhibitor potential of coumarin and it derivative is c > d > b > a. However, based on the number of fractional electrons transferred ( N), the potential inhibitor of coumarin and it derivative are c > b > d > a.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46201683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.35337
Hazimah, Haiyul Fadhli, D. Fitriyah
Solanum ferox L merupakan salah satu jenis sayuran yang sering dijadikan perisa dalam masakan yang termasuk ke dalam famili Solanaceae. Solanum ferox L mengandung senyawa terpenoid, steroid, flavonoid, alkaloid, dan fenolik. Solanum ferox memiliki berbagai senyawa bioaktif digunakan sebagai antirematik, antiasma, antivirus, antikanker dan antibakteri. Tujuan dari penelitian ini yaitu isolasi dan karakterisasi senyawa stigmasterol dari tanaman Solanum ferox. Senyawa dielusidasi dengan spektroskopi UV, IR, NMR dan diberi nama HSF. Senyawa HSF memiliki rumus kimia C29H48O dengan nama Stigmasterol
{"title":"Stigmasterol (Steroid) From Leaves of Solanum ferox L (Sour Eggplant) Plant","authors":"Hazimah, Haiyul Fadhli, D. Fitriyah","doi":"10.24252/al-kimia.v11i1.35337","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.35337","url":null,"abstract":"Solanum ferox L merupakan salah satu jenis sayuran yang sering dijadikan perisa dalam masakan yang termasuk ke dalam famili Solanaceae. Solanum ferox L mengandung senyawa terpenoid, steroid, flavonoid, alkaloid, dan fenolik. Solanum ferox memiliki berbagai senyawa bioaktif digunakan sebagai antirematik, antiasma, antivirus, antikanker dan antibakteri. Tujuan dari penelitian ini yaitu isolasi dan karakterisasi senyawa stigmasterol dari tanaman Solanum ferox. Senyawa dielusidasi dengan spektroskopi UV, IR, NMR dan diberi nama HSF. Senyawa HSF memiliki rumus kimia C29H48O dengan nama Stigmasterol","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41965925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.37136
Febri Intan Listiani, Mutista Hafshah, R. N. Latifah
Dental caries is caused by the Streptococcus mutans bacteria, which causes a food deposit to harden and adhere to the tooth surface. Cavities will develop if food residue is not removed. Herbal plants, specifically sappan wood, can be used as an antibiotic. The purpose of this study was to look at the secondary metabolite content of sappan wood extract, antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of sappan wood extract against Streptococcus mutans bacteria. This research method includes the maceration of sappan wood extract with 96% ethanol solvent, phytochemical screening of sappan wood extract, inhibition zone test with paper disc method, and MIC and MBC tests. Qualitative testing revealed that the sappan wood extract contained alkaloids, flavonoids, tannins, and saponins. Flavonoids, tannins, and saponins are all constituents of plants. Secang wood extract has antibacterial activity against Streptococcus mutans, as evidenced by the formation of inhibition zones at concentrations of 20%, 40%, 60%, 80%, and 100%, namely 8.75±0.354; 11±1.41;, 12.75±0.354; 16.25±0.354; and 17.5±0.000 mm. Sappan wood ethanol extract had a MIC of 12.5% against Streptococcus mutans and an MBC of 25%.
{"title":"Antibacterial Activity Test of Secang Wood (Caesalpinia sappan L.) Ethanol Extract Against Streptococcus mutans","authors":"Febri Intan Listiani, Mutista Hafshah, R. N. Latifah","doi":"10.24252/al-kimia.v11i1.37136","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.37136","url":null,"abstract":"Dental caries is caused by the Streptococcus mutans bacteria, which causes a food deposit to harden and adhere to the tooth surface. Cavities will develop if food residue is not removed. Herbal plants, specifically sappan wood, can be used as an antibiotic. The purpose of this study was to look at the secondary metabolite content of sappan wood extract, antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of sappan wood extract against Streptococcus mutans bacteria. This research method includes the maceration of sappan wood extract with 96% ethanol solvent, phytochemical screening of sappan wood extract, inhibition zone test with paper disc method, and MIC and MBC tests. Qualitative testing revealed that the sappan wood extract contained alkaloids, flavonoids, tannins, and saponins. Flavonoids, tannins, and saponins are all constituents of plants. Secang wood extract has antibacterial activity against Streptococcus mutans, as evidenced by the formation of inhibition zones at concentrations of 20%, 40%, 60%, 80%, and 100%, namely 8.75±0.354; 11±1.41;, 12.75±0.354; 16.25±0.354; and 17.5±0.000 mm. Sappan wood ethanol extract had a MIC of 12.5% against Streptococcus mutans and an MBC of 25%.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42101192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.34386
Elfira Jumrah, Rosmaniar
Lahuna and betel are plants that have been used traditionally as medicine. The content of secondary metabolites in lahuna and betel leaves can be used as active compounds in the manufacture of liquid soap. This study aims to evaluate liquid soap formulations of lahuna leaf extract and betel leaf extract and to test its activity against Escherichia coli. The research method used was pH test, organoleptic test, homogeneity test, foam height test, water content test according to SNI 1996 and antibacterial activity test with agar diffusion method. The results showed that the liquid soap formulation was in accordance with SNI 1996 which was based on pH test, organoleptic test, homogeneity test, foam height test and water content test. Also, the liquid soap formulation has very strong activity against Escherichia coli characterized by a clear zone that is formed more than 19 mm
{"title":"Evaluation of Liquid Soap Formulation of Lahuna Leaf Extract (Eupatorium odoratum) and Betel Leaf Extract (Piper betle L.) and Activity Tests Against Escherichia coli","authors":"Elfira Jumrah, Rosmaniar","doi":"10.24252/al-kimia.v11i1.34386","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.34386","url":null,"abstract":"Lahuna and betel are plants that have been used traditionally as medicine. The content of secondary metabolites in lahuna and betel leaves can be used as active compounds in the manufacture of liquid soap. This study aims to evaluate liquid soap formulations of lahuna leaf extract and betel leaf extract and to test its activity against Escherichia coli. The research method used was pH test, organoleptic test, homogeneity test, foam height test, water content test according to SNI 1996 and antibacterial activity test with agar diffusion method. The results showed that the liquid soap formulation was in accordance with SNI 1996 which was based on pH test, organoleptic test, homogeneity test, foam height test and water content test. Also, the liquid soap formulation has very strong activity against Escherichia coli characterized by a clear zone that is formed more than 19 mm","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49587058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.32781
R. Mahmudah, Muslimah, E. Yulianti
Vegetable oil extract moringa leaf (Moringa Oleifera Lamk.) is an herbal oil that has the potential as a medicine. The study aimed to determine the content of secondary metabolites through photochemical tests and the total phenol content of Moringa leaf extract in extra virgin olive oil and virgin coconut oil. The extraction method used is hot maceration with various doses of Moringa leaves. The best amount is used by extraction with variations in temperature and heating time. The functional groups of herbal oils were identified using an FTIR spectrophotometer. Phytochemical test results showed that the vegetable oil extract of Moringa leaf contains secondary metabolites in the form of flavonoids, phenolics, terpenoids, alkaloids, steroids, and tannins. The highest total phenol content in Moringa leaf extract in virgin olive oil at a concentration of 40%, extraction temperature 50°C with a heating time of 2 hours with a total phenol content value of 15.78% GAE (Gallic Acid Equivalent). The results of the FTIR interpretation show that herbal oils have O-H, C-H, C=O, C=C aromatic, C-O, and aliphatic C-H functional groups.
{"title":"Analysis of Total Phenol Levels in Moringa Extract (Moringa Oliefera Lamk.) in Vegetable Oil","authors":"R. Mahmudah, Muslimah, E. Yulianti","doi":"10.24252/al-kimia.v11i1.32781","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.32781","url":null,"abstract":"Vegetable oil extract moringa leaf (Moringa Oleifera Lamk.) is an herbal oil that has the potential as a medicine. The study aimed to determine the content of secondary metabolites through photochemical tests and the total phenol content of Moringa leaf extract in extra virgin olive oil and virgin coconut oil. The extraction method used is hot maceration with various doses of Moringa leaves. The best amount is used by extraction with variations in temperature and heating time. The functional groups of herbal oils were identified using an FTIR spectrophotometer. Phytochemical test results showed that the vegetable oil extract of Moringa leaf contains secondary metabolites in the form of flavonoids, phenolics, terpenoids, alkaloids, steroids, and tannins. The highest total phenol content in Moringa leaf extract in virgin olive oil at a concentration of 40%, extraction temperature 50°C with a heating time of 2 hours with a total phenol content value of 15.78% GAE (Gallic Acid Equivalent). The results of the FTIR interpretation show that herbal oils have O-H, C-H, C=O, C=C aromatic, C-O, and aliphatic C-H functional groups.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41307399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.24252/al-kimia.v11i1.37280
Agus Suprijono, Vicky Selta Agatha Z, Anang Budi Utomo
Hyperuricemia is a condition of high concentration of uric acid in the blood that occurs because of a buildup of uric acid in the body. Uric acid is formed as a residue of the protein metabolism of foods containing purine. Some of the active compounds in the sambiloto leave (Andrographis Paniculata (Burm.F.) Nees) and sambung nyawa leave of allegedly being able to decrease the concentration of uric acid. The aims of this research is to know the influence of the difference between the ability of ethanol extract of sambiloto leaves and ethanol extract of sambung nyawa leaves (Gynura Procumbens (Lour.)Merr.) against the concentration of uric acid in vitro as well as know the effective concentration of ethanol extract of sambiloto leaves and extract ethanol of sambung nyawa leaves against a decrease in the concentration of uric acid in vitro. The extraction method used in this research is the method of extraction re-maceration by solvent ethanol 70% in 5 days, the sampling technique used was purposive sampling. The determination of concentration of uric acid is determined out by the Spectrophotometry method ABX Pentra. Series of concentrations used was 250, 500, 750, 1000, 1250, 1500, and 1750 ppm. The results of the research, the ability is effective in decreaced the concentration of uric acid in vitro on the extract of sambiloto leaves and extract of sambung nyawa leaves is 250 ppm. Statistical results showed that there is an influence of the ethanol extracts of sambiloto leaves and ethanol extracts of sambung nyawa leaves against decreasing the concentration of uric acid in vitro. And there is no difference between ethanol extracts of sambiloto leaves with ethanol extracts of sambung nyawa leaves against a decreased in the concentration of uric acid in vitro.
{"title":"Uric acid The Influence of Ethanol Extract of Sambiloto Leaves and Sambung Nyawa Leaves To Decrease Concentration of Uric Acid","authors":"Agus Suprijono, Vicky Selta Agatha Z, Anang Budi Utomo","doi":"10.24252/al-kimia.v11i1.37280","DOIUrl":"https://doi.org/10.24252/al-kimia.v11i1.37280","url":null,"abstract":"Hyperuricemia is a condition of high concentration of uric acid in the blood that occurs because of a buildup of uric acid in the body. Uric acid is formed as a residue of the protein metabolism of foods containing purine. Some of the active compounds in the sambiloto leave (Andrographis Paniculata (Burm.F.) Nees) and sambung nyawa leave of allegedly being able to decrease the concentration of uric acid. The aims of this research is to know the influence of the difference between the ability of ethanol extract of sambiloto leaves and ethanol extract of sambung nyawa leaves (Gynura Procumbens (Lour.)Merr.) against the concentration of uric acid in vitro as well as know the effective concentration of ethanol extract of sambiloto leaves and extract ethanol of sambung nyawa leaves against a decrease in the concentration of uric acid in vitro. The extraction method used in this research is the method of extraction re-maceration by solvent ethanol 70% in 5 days, the sampling technique used was purposive sampling. The determination of concentration of uric acid is determined out by the Spectrophotometry method ABX Pentra. Series of concentrations used was 250, 500, 750, 1000, 1250, 1500, and 1750 ppm. The results of the research, the ability is effective in decreaced the concentration of uric acid in vitro on the extract of sambiloto leaves and extract of sambung nyawa leaves is 250 ppm. Statistical results showed that there is an influence of the ethanol extracts of sambiloto leaves and ethanol extracts of sambung nyawa leaves against decreasing the concentration of uric acid in vitro. And there is no difference between ethanol extracts of sambiloto leaves with ethanol extracts of sambung nyawa leaves against a decreased in the concentration of uric acid in vitro.","PeriodicalId":7535,"journal":{"name":"Al-Kimia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41653371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-26DOI: 10.24252/al-kimia.v10i2.29257
R. Irfandi, Riny Febriani Danur
Fitoremediasi merupakan salah satu metode penanganan lahan tercemar akibat pertambangan. Penelitian ini bertujuan untuk mengkaji pengaruh penanaman tanaman vetiver (Vetiveria zizanioides) terhadap fitoremediasi limbah pertambangan yang tercemar merkuri (Hg) di Kabupaten Mandailing Natal untuk mengurangi dampak pencemaran lingkungan akibat aktivitas pertambangan. Penelitian ini dilaksanakan selama tiga bulan di Rumah Kaca FMIPA Universitas Negeri Medan dan Laboratorium Balai Riset dan Standardisasi Kota Medan. Jenis penelitian ini adalah penelitian eksperimental dengan Rancangan Acak Lengkap. Jumlah kombinasi perlakuan terdiri atas 4 variasi paparan limbah dengan 2 kali pengulangan pengujian kandungan merkuri pada tanaman. Dari hasil penelitian diperoleh tanaman vetiver mampu menyerap logam merkuri pada media tanam yang dikontaminasi dengan limbah asli pertambangan paling tinggi sebesar 7,1045 mg/Kg dan sebesar 15,68 mg/Kg pada kontaminasi limbah sintetik selama 12 hari pemaparan. Dengan bertambahnya waktu fitoremediasi, tanaman akar wangi (Vetiveria zizanioides) mampu mengakumulasi lebih banyak logam berat merkuri (Hg) yang terdapat di dalam tanah.
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