{"title":"Bioactive gangliosides: differentiation inducers for hematopoietic cells and their mechanism(s) of actions.","authors":"M Saito","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19354772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fumonisins and other inhibitors of de novo sphingolipid biosynthesis.","authors":"A H Merrill, E Wang, D G Gilchrist, R T Riley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19364576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extracellular sialidases.","authors":"C C Sweeley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19365194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glycosphingolipids of the invertebrata as exemplified by a cestode platyhelminth, Taenia crassiceps, and a dipteran insect, Calliphora vicina.","authors":"R D Dennis, H Wiegandt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19365199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction: sphingolipids and their metabolites in cell regulation.","authors":"A H Merrill, Y A Hannun, R M Bell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19354765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of sphingosine in cell growth regulation and transmembrane signaling.","authors":"S Spiegel, A Olivera, R O Carlson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19354766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor-associated glycosphingolipids are a common finding in human tumors, and monoclonal antibodies directed to defined carbohydrate epitopes of these structures have been developed. A majority of the glycosphingolipid antigens are of the lacto series, types 1 and 2, and these epitopes are often also found on glycoproteins. The tumor-associated gangliosides of the ganglio series, preferentially found in tumors of neuroectodermal origin, have binding epitopes that have not been detected in glycoproteins. A large number of monoclonal antibodies, mainly murine but some human, have been produced, and their epitope specificity defined. These antibodies have been used for investigation of the role of tumor-associated glycosphingolipids in tumor cells. Some antibodies have been shown to inhibit the growth of tumor cell lines in vitro and in vivo and to influence the adhesion properties of tumor cells, and some antibodies have been shown to give a clinical response. Tumor cell lines are commonly used in tumor biology studies, but the expression of tumor-associated glycosphingolipids in tumor cell lines does not always reflect their expression in the tumor tissue from which the cell line originates. The expression of tumor-associated glycosphingolipids has also been shown to be different in cells grown in vitro or as solid tumors in nude mice or rats. In conclusion, monoclonal antibodies specific for tumor-associated glycosphingolipids may be valuable tools in diagnosis and, in addition, in therapy, glycosphingolipids may also be used in active immunotherapy. The availability of these antibodies also opens the possibility of studying the biological function of glycosphingolipids and may then lead to new approaches for the improved diagnosis and therapy of human tumors.
{"title":"Glycosphingolipid tumor antigens.","authors":"P Fredman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumor-associated glycosphingolipids are a common finding in human tumors, and monoclonal antibodies directed to defined carbohydrate epitopes of these structures have been developed. A majority of the glycosphingolipid antigens are of the lacto series, types 1 and 2, and these epitopes are often also found on glycoproteins. The tumor-associated gangliosides of the ganglio series, preferentially found in tumors of neuroectodermal origin, have binding epitopes that have not been detected in glycoproteins. A large number of monoclonal antibodies, mainly murine but some human, have been produced, and their epitope specificity defined. These antibodies have been used for investigation of the role of tumor-associated glycosphingolipids in tumor cells. Some antibodies have been shown to inhibit the growth of tumor cell lines in vitro and in vivo and to influence the adhesion properties of tumor cells, and some antibodies have been shown to give a clinical response. Tumor cell lines are commonly used in tumor biology studies, but the expression of tumor-associated glycosphingolipids in tumor cell lines does not always reflect their expression in the tumor tissue from which the cell line originates. The expression of tumor-associated glycosphingolipids has also been shown to be different in cells grown in vitro or as solid tumors in nude mice or rats. In conclusion, monoclonal antibodies specific for tumor-associated glycosphingolipids may be valuable tools in diagnosis and, in addition, in therapy, glycosphingolipids may also be used in active immunotherapy. The availability of these antibodies also opens the possibility of studying the biological function of glycosphingolipids and may then lead to new approaches for the improved diagnosis and therapy of human tumors.</p>","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19354768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ganglioside metabolism--topology and regulation.","authors":"K Sandhoff, G van Echten","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19364572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developmental changes of glycosphingolipid composition of epithelia of rat digestive tract.","authors":"J F Bouhours, D Bouhours, G C Hansson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19365200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sphingomyelinase D: a pathogenic agent produced by bacteria and arthropods.","authors":"A P Truett, L E King","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19382506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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