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HIV Psychiatry: The Missing Link to HIV Prevention and Comprehensive Care. 艾滋病毒精神病学——艾滋病毒预防和综合护理的缺失环节。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-11-03 DOI: 10.1089/AID.2022.0184
Mary Ann Adler Cohen, James A Bourgeois

HIV psychiatry may be the missing link to HIV prevention and care. Although HIV has been transformed from a fatal illness to a chronic and manageable illness, morbidity and mortality from HIV and AIDS continue to persist despite advances in prevention and care. In the 42 years since the HIV pandemic began in 1981, >84 million people were infected with HIV and 40 million people with HIV have died. In 2021, 1.5 million were newly infected and as of 2022, >38 million people were living with HIV.

艾滋病毒精神病学可能是艾滋病毒预防和护理中缺失的环节。尽管艾滋病毒已从一种致命疾病转变为一种可控制的慢性疾病,但尽管在预防和护理方面取得了进展,艾滋病毒和艾滋病的发病率和死亡率仍在持续。自1981年艾滋病毒流行以来的41年里,超过8400万人感染了艾滋病毒,4000万艾滋病毒感染者死亡。2021年,150万人新感染,截至2022年,超过3800万人感染艾滋病毒。
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引用次数: 0
Using the Molecular Transmission Networks to Analyze the Epidemic Characteristics of HIV-1 CRF08_BC in Kunming, Yunnan. 利用分子传播网络分析云南昆明地区HIV-1 CRF08_BC的流行特征。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-10-12 DOI: 10.1089/AID.2023.0060
Peng Cheng, Bao-Cui He, Jia-Fa Liu, Jia-Li Wang, Cui-Xian Yang, Sha Ma, Mi Zhang, Xing-Qi Dong, Jian-Jian Li

HIV-1CRF08_BC is the most prevalent epidemic subtype among heterosexual (HET) and intravenous drug users (IDUs) in Kunming, Yunnan. Using the pol region of gene sequences derived from molecular epidemiological surveys, we developed a molecular transmission network for the purpose of analyzing its epidemiological characteristics, assessing its epidemiological trends, identifying its potential transmission relationships, and developing targeted interventions. HyPhy 2.2.4 was used to calculate pairwise genetic distances between sequences; GraphPad-Prism 8.0 was employed to determine the standard genetic distance; and Cytoscope 3.7.2 was applied to visualize the network. We used the network analysis tools to investigate network characteristics and the Molecular Complex Detection (MCODE) tool to observe the growth of the network. We utilized a logistic regression model to examine the factors influencing clustering and a zero-inflated Poisson model to investigate the factors influencing potential transmission links. At the standard genetic distance threshold of 0.008, 406 out of 858 study participants were clustered in 132 dissemination networks with a total network linkage of 868, and the number of links per sequence ranged from 1 to 19. The MCODE analysis identified three significant modular clusters in the networks, with network scores ranging from 4.9 to 7. In models of logistic regression, HET, middle-aged and elderly individuals, and residents of northern and southeastern Kunming were more likely to enter the transmission network. According to the zero-inflated Poisson model, age, transmission category, sampling year, marital status, and CD4+ T level had a significant effect on the size of links. The molecular clusters in Kunming's molecular transmission network are specific and aggregate to a certain extent. HIV-1 molecular network analysis provided information on local transmission characteristics, and these findings helped to determine the priority of transmission-reduction interventions.

HIV-1CRF08_BC是云南昆明市异性恋(HET)和静脉注射吸毒者(IDU)中最常见的流行亚型。利用分子流行病学调查得出的基因序列的pol区域,我们开发了一个分子传播网络,目的是分析其流行病学特征,评估其流行病学趋势,确定其潜在的传播关系,并制定有针对性的干预措施。HyPhy 2.2.4用于计算序列之间的成对遗传距离;GraphPad Prism 8.0用于确定标准遗传距离;并应用细胞镜3.7.2对网络进行可视化。我们使用网络分析工具来研究网络特性,并使用分子复合物检测(MCODE)工具来观察网络的增长。我们使用逻辑回归模型来检验影响聚类的因素,并使用零膨胀泊松模型来研究影响潜在传输链路的因素。在0.008的标准遗传距离阈值下,858名研究参与者中有406人聚集在132个传播网络中,网络链接总数为868,每个序列的链接数量从1到19不等。MCODE分析确定了网络中的三个重要模块集群,网络得分在4.9到7之间。在逻辑回归模型中,HET、中老年人以及昆明北部和东南部的居民更有可能进入传播网络。根据零膨胀泊松模型,年龄、传播类别、采样年份、婚姻状况和CD4+T水平对链路大小有显著影响。昆明分子传递网络中的分子簇具有一定的特异性和聚集性。HIV-1分子网络分析提供了有关本地传播特征的信息,这些发现有助于确定减少传播干预的优先顺序。
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引用次数: 0
Perspectives on Design Approaches for HIV Prevention Efficacy Trials. 艾滋病预防效果试验设计方法透视。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-09-04 DOI: 10.1089/AID.2022.0150
Holly J Prudden, Roger Tatoud, Holly Janes, Stephaun Wallace, Veronica Miller, Linda-Gail Bekker, Deborah Donnell

The challenge of designing future HIV prevention efficacy trials in a rapidly evolving HIV prevention landscape was explored through a series of virtual stakeholder's engagement meetings convened online between October 2020 and April 2021. A broad array of stakeholders from the HIV prevention research community reviewed current trial designs and lessons learned, explored issues specific to unique product classes, and concluded with specialist-focused examinations of statistical design concepts and the importance of community engagement in research. The aim was to reflect on current approaches and evaluate new trial design approaches for evaluating efficacy of a candidate prevention strategy in the context of an active-controlled trial, which does not include a placebo arm. In this report, we provide a summary of the discussion points that included gaps in understanding and logical next steps in the prevention research pathway. The technical challenges involved in the statistical design approaches are described in a companion article.

2020 年 10 月至 2021 年 4 月期间,通过在线召开一系列虚拟利益相关者参与会议,探讨了在快速发展的艾滋病预防环境中设计未来艾滋病预防疗效试验所面临的挑战。来自艾滋病预防研究界的众多利益相关者回顾了当前的试验设计和经验教训,探讨了独特产品类别的具体问题,最后对统计设计概念和社区参与研究的重要性进行了专业性的探讨。目的是反思当前的方法并评估新的试验设计方法,以便在不包括安慰剂组的主动对照试验中评估候选预防策略的疗效。在本报告中,我们对讨论要点进行了总结,其中包括预防研究途径中的认识差距和合理的下一步措施。统计设计方法所涉及的技术挑战将在另一篇文章中介绍。
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引用次数: 0
Perceived Risks and Benefits and Frequency of Cannabis Use Among People with HIV in Different Legal Environments. 艾滋病毒感染者在不同法律环境中感知的风险和益处以及大麻使用频率。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-11-06 DOI: 10.1089/AID.2022.0144
Sarah Laper, Corrilynn O Hileman, Graham Block, Kristine M Erlandson, Martin Krsak

We sought to describe the prevalence of and motivation for cannabis use and whether legalization of cannabis impacts the frequency and perceived risks and benefits of use in people living with HIV (PWH). The study was based on two HIV clinics located in Cleveland, Ohio, and Aurora, Colorado. Participants responded to a 45-question survey, and responses were summarized in aggregate and stratified by the frequency of cannabis use and site. Three hundred ninety-seven participants completed the survey. The frequency of use was not different between the sites. Daily cannabis users compared with yearly or never users identified the benefits of cannabis as relief from stress, anxiety, or depression, improved sleep, improved creativity, improved focus or concentration, and increased energy. The benefits of pain management, improved appetite, and helping to decrease or stop other medications were selected at similar rates, regardless of the frequency of use. Daily users were less likely to identify treatment of disease as a benefit and legal problems, addiction to cannabis, impaired memory, increased use of other drugs, personal or relationship problems, decrease in intelligence, new or worsening health problems, and getting high as risks of use compared with yearly or never users. Compared with participants in Ohio, Coloradoans were more likely to identify cannabis benefits as decreasing/stopping other medications and getting high, and less likely to identify legal problems and addiction as risks. Legalization of cannabis did not affect the frequency of cannabis use in PWH. Daily cannabis users are more likely to identify benefits and less likely to identify risks of use compared with yearly or never users. A better understanding of the potential benefits and risks of cannabis use can help guide safer use of cannabis in PWH and allow physicians to provide better counseling on risk reduction.

目的:我们试图描述大麻使用的流行率和动机,以及大麻合法化是否会影响艾滋病毒感染者(PWH)使用大麻的频率、感知风险和益处。方法:该研究基于俄亥俄州克利夫兰和科罗拉多州奥罗拉的两个艾滋病毒诊所。参与者对一项45个问题的调查做出了答复,并对答复进行了汇总,并按大麻使用频率和地点进行了分层。结果:397名参与者完成了调查。不同地点的使用频率没有差异。与每年或从未吸食过大麻的人相比,每天吸食大麻的人认为大麻的好处是缓解压力、焦虑或抑郁、改善睡眠、提高创造力、集中注意力和增加能量。无论使用频率如何,疼痛管理、改善食欲以及帮助减少或停止其他药物的益处都以相似的比率选择。与每年或从未使用过大麻的人相比,每天使用大麻的人不太可能将疾病治疗视为一种福利和法律问题、大麻成瘾、记忆力受损、其他药物使用增加、个人或关系问题、智力下降、新的或恶化的健康问题,以及使用大麻的风险越来越高。与俄亥俄州的参与者相比,科罗拉多人更有可能将大麻的益处确定为减少/停止其他药物并变得兴奋,而不太可能将法律问题和成瘾确定为风险。结论:大麻合法化不会影响PWH中大麻使用的频率。与每年或从未吸食过大麻的人相比,每天吸食大麻的人更有可能识别其益处,而不太可能识别其使用风险。更好地了解大麻使用的潜在益处和风险,有助于指导PWH更安全地使用大麻,并使医生能够就降低风险提供更好的咨询。
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引用次数: 0
The Role of Extracellular Traps in HIV Infection. 细胞外陷阱在HIV感染中的作用。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-10-23 DOI: 10.1089/AID.2022.0178
Natanias Macson da Silva, Nicolas Patrícius de Medeiros Leite, Amanda Estevam Carvalho, Valéria Duarte de Almeida, Ísis Kelly Dos Santos, José Rodolfo Lopes de Paiva Cavalcanti, Thales Allyrio Araújo de Medeiros Fernandes, Ellany Gurgel Cosme do Nascimento, Micássio Fernandes de Andrade

Human immunodeficiency virus (HIV) infection is still an important public health problem, which justifies the research of new therapies to combat it. Recent studies show that Extracellular Traps (ETs) are cellular mechanisms useful in the capture and destruction of some viruses, such as the HIV. Here, we show that neutrophils from peripheral blood, genital tissues, and placenta are activated when exposed to human immunodeficiency virus type 1 (HIV-1) and release Neutrophil Extracellular Traps (NETs). The NETs can capture, neutralize, and inactivate the virus and, also, protect other target cells from HIV infection, as long as the DNA and other constituents of the NETs remain intact. Further, the review indicates that the immunoprotective role of NETs in the context of HIV-1 infection is a promising finding for the development of new antiviral therapies. It is necessary, however, the development of studies that evaluate the tissue injury that NETs can cause and the biological relationships with other cells to improve them as therapeutic targets.

HIV感染仍然是一个重要的公共卫生问题,这证明了研究新的治疗方法来对抗它的合理性。最近的研究表明,细胞外陷阱(ET)是一种可用于捕获和摧毁某些病毒的细胞机制,如人类免疫缺陷病毒(HIV)。在这里,我们发现,当暴露于HIV-1时,来自外周血、生殖器组织和胎盘的中性粒细胞被激活,并释放中性粒细胞外陷阱(NETs)。只要NETs的DNA和其他成分保持完整,NETs可以捕获、中和和灭活病毒,还可以保护其他靶细胞免受HIV感染。此外,该综述表明,NETs在HIV-1感染中的免疫保护作用是开发新的抗病毒疗法的一个有希望的发现。然而,有必要开展研究,评估NETs可能引起的组织损伤以及与其他细胞的生物学关系,以便将其作为治疗靶点加以改进。
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引用次数: 0
Acceptability of Switching to Long-Acting Cabotegravir and Rilpivirine Among People Living with HIV on Dolutegravir/Rilpivirine Combination: A Single-Center Experience. 使用多卢替拉韦/利匹韦林联合用药的HIV感染者改用长效卡博替拉韦和利匹韦灵的可接受性:单中心体验。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-10-23 DOI: 10.1089/AID.2023.0070
Alessandro Castelli, Massimiliano Lanzafame, Matteo Morra, Marco Bertoldi, Andrea Delama, Daniela Fait, Sandro Vento

The availability of long-acting cabotegravir and rilpivirine injection combination requires some changes in service delivery of outpatient HIV clinics; it is therefore important for clinicians to know the potential number of people living with HIV (PLWH) who are interested in a long-acting antiretroviral treatment. We aimed to determine in an outpatient clinic the number of PLWH, on dolutegravir/rilpivirine, accepting a switch to an injectable long-acting antiretroviral treatment, and the reasons underlying this choice. In our single-center study, in this subset of HIV-infected patients, the main cause for refusal of a long-acting injectable regimen was the need for the administration to be done in hospital, as required in Italy, suggesting that current regulations about this aspect must be changed.

长效卡博替拉韦和利匹韦林联合注射的可用性需要对门诊HIV诊所的服务提供进行一些改变;因此,临床医生了解对长效抗逆转录病毒治疗感兴趣的HIV感染者(PLWH)的潜在人数是很重要的。我们的目的是在门诊确定接受注射长效抗逆转录病毒治疗的艾滋病毒感染者(PLWH)的人数,以及这种选择的原因。在我们的单中心研究中,在这部分HIV感染患者中,拒绝长效注射方案的主要原因是需要按照意大利的要求在医院进行给药,这表明必须改变有关这方面的现行规定。
{"title":"Acceptability of Switching to Long-Acting Cabotegravir and Rilpivirine Among People Living with HIV on Dolutegravir/Rilpivirine Combination: A Single-Center Experience.","authors":"Alessandro Castelli, Massimiliano Lanzafame, Matteo Morra, Marco Bertoldi, Andrea Delama, Daniela Fait, Sandro Vento","doi":"10.1089/AID.2023.0070","DOIUrl":"10.1089/AID.2023.0070","url":null,"abstract":"<p><p>The availability of long-acting cabotegravir and rilpivirine injection combination requires some changes in service delivery of outpatient HIV clinics; it is therefore important for clinicians to know the potential number of people living with HIV (PLWH) who are interested in a long-acting antiretroviral treatment. We aimed to determine in an outpatient clinic the number of PLWH, on dolutegravir/rilpivirine, accepting a switch to an injectable long-acting antiretroviral treatment, and the reasons underlying this choice. In our single-center study, in this subset of HIV-infected patients, the main cause for refusal of a long-acting injectable regimen was the need for the administration to be done in hospital, as required in Italy, suggesting that current regulations about this aspect must be changed.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"283-285"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNA Expression Levels in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus Type 1 Positive Individuals and Relationship with Different Levels of Viral Suppression. 人类免疫缺陷病毒 1 型阳性个体外周血单核细胞中的微 RNA 表达水平及其与不同病毒抑制水平的关系。
IF 1.5 4区 医学 Q4 IMMUNOLOGY Pub Date : 2024-05-01 Epub Date: 2023-07-31 DOI: 10.1089/aid.2022.0165
Daniele Di Carlo, Francesca Falasca, Laura Mazzuti, Giuliana Guerrizio, Giuseppe Migliara, Marta Santori, Alessandro Lazzaro, Ivano Mezzaroma, Gabriella D'Ettorre, Caterina Fimiani, Giancarlo Iaiani, Guido Antonelli, Ombretta Turriziani

The persistence of low human immunodeficiency virus type 1 (HIV-1) replication in individuals undergoing antiretroviral therapy (ART) still threatens their health. Previous findings have shown that microRNAs (miRNAs) could interfere with several steps of the viral life cycle. Herein, we set out to investigate the expression of miR-150, miR-223, miR-382, miR-324-5p, miR-33a-5p, miR-34a, and miR-132 in the whole peripheral blood mononuclear cell (PBMC) population from people living with HIV-1 showing different levels of viral suppression. Levels of PBMC-associated miRNAs were analyzed in 30 individuals with undetectable viremia (target not detected) and 30 individuals with detectable low-level viremia (1-200 copies/mL). In addition, 30 samples from treatment-naive (NAIVE) individuals were investigated. Results were compared to a control group of 28 HIV-negative donors. All miRNAs analyzed were strongly downregulated in the NAIVE population, either compared to the treated group or to controls. Stratification of ART-treated donors according to the therapeutic regimen showed the downregulation of miR-33a-5p in subjects treated with non-nucleoside reverse transcriptase inhibitors compared with those treated with protease inhibitors. Collectively, the present study shows that uncontrolled viral replication leads to profound miRNA deregulation while treated individuals, irrespective of the degree of viral suppression, and even the types of antiviral drugs seem to be specifically associated with miRNA expression profiles. These evidences suggest that virological suppression could be favored by miRNA modulation.

正在接受抗逆转录病毒疗法(ART)的人体内持续存在的低水平人类免疫缺陷病毒 1 型(HIV-1)复制仍然威胁着他们的健康。以前的研究结果表明,微RNA(miRNA)可以干扰病毒生命周期的几个步骤。在此,我们着手研究了不同病毒抑制水平的 HIV-1 感染者的整个外周血单核细胞(PBMC)中 miR-150、miR-223、miR-382、miR-324-5p、miR-33a-5p、miR-34a 和 miR-132 的表达情况。我们分析了 30 名检测不到病毒血症(未检测到目标)的患者和 30 名检测到低水平病毒血症(1-200 拷贝/毫升)的患者的 PBMC 相关 miRNA 水平。此外,还调查了 30 份未接受治疗者(NAIVE)的样本。研究结果与由 28 名 HIV 阴性捐献者组成的对照组进行了比较。与治疗组或对照组相比,所有被分析的 miRNA 在 NAIVE 群体中均强烈下调。根据治疗方案对接受抗逆转录病毒疗法治疗的供体进行分层,结果显示,与接受蛋白酶抑制剂治疗的受试者相比,接受非核苷类逆转录酶抑制剂治疗的受试者体内的 miR-33a-5p 出现了下调。总之,本研究表明,无论病毒抑制程度如何,病毒复制失控都会导致接受治疗者体内的 miRNA 出现严重的失调,甚至抗病毒药物的类型似乎也与 miRNA 的表达谱有特殊关系。这些证据表明,miRNA 的调节可能有利于病毒抑制。
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引用次数: 0
Identification of New Circulating Recombinant Form of HIV-1 CRF127_07109 in Northern Vietnam. 在越南北部发现新的 HIV-1 CRF127_07109 循环重组形式。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2024-04-26 DOI: 10.1089/AID.2024.0022
Tsunefusa Hayashida, Linh Khanh Tran, An Luong-Dieu Dang, Moeko Nagai, Shoko Matsumoto, Hoa Nguyen-Minh Le, T. D. Van, Giang Van Tran, J. Tanuma, Thach Ngoc Pham, Shinichi Oka
Some candidates of a new circulating recombinant form (CRF) of HIV-1 were found in northern Vietnam in our previous study. We succeeded in near full-length sequencing using MinION with plasma samples from 12 people living with HIV. Three of the samples were CRF109_0107, which was recently reported in China. Three others were the newly identified CRF127_07109, while six of them were considered to be CRF127_07109-related unique recombinant forms (URFs). The time to the most recent common ancestor of CRF127_07109 was estimated to be between 2015 and 2019. Our findings showed that CRF127_07109 and related URFs were generated recently in northern Vietnam, rather than migrated independently to northern Vietnam.
在我们之前的研究中,在越南北部发现了一些新的循环重组型(CRF)HIV-1 候选者。我们利用 MinION 成功地对 12 名 HIV 感染者的血浆样本进行了近全长测序。其中三个样本是最近在中国报道的 CRF109_0107。另外三个是新发现的CRF127_07109,而其中六个被认为是与CRF127_07109相关的独特重组形式(URF)。据估计,CRF127_07109的最近共同祖先的时间在2015年至2019年之间。我们的研究结果表明,CRF127_07109和相关的URF是最近在越南北部产生的,而不是独立迁移到越南北部的。
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引用次数: 0
Comparison of four predictive scores for cardiovascular risk in Mexican people living with HIV. 比较四种预测墨西哥艾滋病病毒感染者心血管风险的评分方法。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2024-04-26 DOI: 10.1089/AID.2023.0085
Pablo Franco Oliva-Sánchez, Salvador Landeros-López, Maria Margarita Rosas-Dossetti, Samuel Grobeisen-Levin, Jorge Alberto Islas-Martínez, Daniel Aznar-Guerra, Aneth Paola Valdez-Celiz, Luis Soto-Ramirez
Persons with HIV (PWH) face an increased risk of cardiovascular events due to immune activation, comorbidities, and certain antiretrovirals. However, the current cardiovascular risk (CVR) scores are not specifically directed toward PWH. This study aimed to assess the agreement between different predictive CVR scores and explore their relationship with clinical and demographic data in Mexican PWH. A descriptive cross-sectional analysis was conducted in 200 PWH with a mean age of 42 years who were treated at a Mexican urban center from 2017 to 2018. The majority (83%) were on antiretroviral treatment and 79.5% had undetectable viral loads. Moderate-to-high risk scores were infrequent, with Framingham Risk Score for Hard Coronary Heart Disease (FRS-HCHD) scores showing higher values, with very low concordance among all scores. Logistic regression analysis revealed significant associations between the CVR scores and the initial recorded viral load, CD4 cell count, and elevated triglyceride levels. However, no associations were found with measures such as body mass index or abdominal circumference. Treatment with integrase inhibitors (INSTIs), particularly first-generation inhibitors, showed strong associations with all predictive scores, notably ASCVD (OR=7.03, 95% CI 1.67-29.64). The poor concordance among the CVR scores in PWH highlights the need for a specific score that considers comorbidities and ARV drugs. Despite the relatively young age of the participants, significant correlations were observed between INSTI use, initial viral load, CD4 cell count, and triglyceride levels, which are factors not considered in the existing risk scores. Regardless of the actual value of the scores, screening for CVR in PWH is recommended.
由于免疫激活、合并症和某些抗逆转录病毒药物,艾滋病病毒感染者(PWH)发生心血管事件的风险增加。然而,目前的心血管风险(CVR)评分并非专门针对艾滋病感染者。本研究旨在评估不同预测性 CVR 评分之间的一致性,并探讨它们与墨西哥 PWH 的临床和人口统计学数据之间的关系。研究对 2017 年至 2018 年期间在墨西哥城市中心接受治疗的 200 名 PWH 进行了描述性横断面分析,他们的平均年龄为 42 岁。大多数人(83%)正在接受抗逆转录病毒治疗,79.5%的人病毒载量检测不到。中度至高度风险评分并不常见,而弗雷明汉硬性冠心病风险评分(FRS-HCHD)的评分值较高,所有评分之间的一致性很低。逻辑回归分析显示,CVR 评分与最初记录的病毒载量、CD4 细胞计数和甘油三酯水平升高之间存在明显关联。但是,与体重指数或腹围等指标没有关联。整合酶抑制剂(INSTIs)的治疗,尤其是第一代抑制剂的治疗,与所有预测评分都有很强的相关性,尤其是ASCVD(OR=7.03,95% CI 1.67-29.64)。PWH人群CVR评分的一致性较差,这突出表明需要一个考虑到合并症和抗逆转录病毒药物的特定评分。尽管参与者的年龄相对较小,但仍观察到 INSTI 的使用、初始病毒载量、CD4 细胞计数和甘油三酯水平之间存在显著的相关性,而现有的风险评分并未考虑这些因素。无论评分的实际价值如何,都建议对 PWH 进行 CVR 筛查。
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引用次数: 0
Characterization of two HIV-1 strains with novel unique recombinant genome in Hebei, China. 中国河北两株具有新型独特重组基因组的 HIV-1 株系的特征。
IF 1.5 4区 医学 Q3 Medicine Pub Date : 2024-04-26 DOI: 10.1089/AID.2024.0006
Weizhen Li, Yuxin Feng, Jingwan Han, Xiao-lin Wang, Yong-jian Liu, Lei Jia, Erhei Dai, Yuling Wang, Hanping Li, Lin Li
In China, the proportion of HIV-1 infections due to men who have sex with men (MSM) has increased rapidly. More and more new subtypes are found among MSM populations besides known CRF01_AE, CRF07_BC, and B. The co-circulation of several HIV subtypes in the same population provides the opportunity to develop a new CRF and URF. Here we reported two new URFs from two HIV-1 positive subjects infected through homosexual contact in Hebei, China. Phylogenetic and recombinant analyses based on the near full-length genome (NFLG) of the two URFs are the second-generation recombinant strains originated from B, CRF01_AE, and CRF07_BC. The CRF01_AE segments in the genome of two URFs originated from cluster 4 of CRF01_AE strains, while The CRF07_BC segments were clustered with 07BC_N in the phylogenetic tree. The emergence of the novel CRF01_AE/CRF07_BC and CRF01_AE/B recombinant forms indicated the importance of the continuous monitoring of the HIV-1 epidemic and new URFs among the MSM populations.
在中国,男男性行为者(MSM)感染 HIV-1 的比例迅速上升。除了已知的 CRF01_AE、CRF07_BC 和 B 之外,在 MSM 群体中还发现了越来越多的新亚型。在此,我们报告了中国河北两名通过同性恋接触感染的 HIV-1 阳性受试者的两个新的 URF。基于这两个URF的近全长基因组(NFLG)的系统发育和重组分析表明,这两个URF是源于B型、CRF01_AE和CRF07_BC的第二代重组株。两个URF基因组中的CRF01_AE片段来源于CRF01_AE菌株的第4群,而CRF07_BC片段在系统发生树中与07BC_N聚类。新型 CRF01_AE/CRF07_BC 和 CRF01_AE/B 重组形式的出现表明,在 MSM 群体中持续监测 HIV-1 流行和新型 URF 的重要性。
{"title":"Characterization of two HIV-1 strains with novel unique recombinant genome in Hebei, China.","authors":"Weizhen Li, Yuxin Feng, Jingwan Han, Xiao-lin Wang, Yong-jian Liu, Lei Jia, Erhei Dai, Yuling Wang, Hanping Li, Lin Li","doi":"10.1089/AID.2024.0006","DOIUrl":"https://doi.org/10.1089/AID.2024.0006","url":null,"abstract":"In China, the proportion of HIV-1 infections due to men who have sex with men (MSM) has increased rapidly. More and more new subtypes are found among MSM populations besides known CRF01_AE, CRF07_BC, and B. The co-circulation of several HIV subtypes in the same population provides the opportunity to develop a new CRF and URF. Here we reported two new URFs from two HIV-1 positive subjects infected through homosexual contact in Hebei, China. Phylogenetic and recombinant analyses based on the near full-length genome (NFLG) of the two URFs are the second-generation recombinant strains originated from B, CRF01_AE, and CRF07_BC. The CRF01_AE segments in the genome of two URFs originated from cluster 4 of CRF01_AE strains, while The CRF07_BC segments were clustered with 07BC_N in the phylogenetic tree. The emergence of the novel CRF01_AE/CRF07_BC and CRF01_AE/B recombinant forms indicated the importance of the continuous monitoring of the HIV-1 epidemic and new URFs among the MSM populations.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":"11 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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AIDS research and human retroviruses
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