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Advances in prostaglandin and thromboxane research最新文献

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Thrombin and bradykinin modulate prostaglandin synthetase independently of phospholipase. 凝血酶和缓激肽独立于磷脂酶调节前列腺素合成酶。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
R W Bonser, K A Chandrabose, P Cuatrecasas

Thrombin and bardykinin stimulate prostaglandin production from exogenous arachidonic acid in 3T3 cells. The increase in PG production cannot be explained simply by the contribution from endogenous AA metabolism. The rates of stimulated PG production from exogenous and endogenous AA both remain linear fro 3 min, then fall rapidly. It is suggested that BK and Th may act by directly stimulating cyclooxygenase independently of phospholipase.

凝血酶和bardykinin刺激3T3细胞外源性花生四烯酸产生前列腺素。PG产量的增加不能简单地用内源性AA代谢的贡献来解释。外源性和内源性AA刺激PG产生的速率从3分钟开始都保持线性，然后迅速下降。提示BK和Th可能独立于磷脂酶直接刺激环加氧酶而起作用。
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引用次数: 0
Role of the arachidonate lipoxygenase pathway in blood platelet aggregation. 花生四烯酸脂氧合酶途径在血小板聚集中的作用。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
C E Dutilh, E Haddeman, F ten Hoor
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引用次数: 0
PGE2 involvement in the regulation of gastric emptying. PGE2参与胃排空的调节。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
D Nompleggi, L Myers, P Ramwell, D Castell, A Dubois
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引用次数: 0
Inhibition of prostaglandins biosynthesis lowers antidiuretic hormone excretion in man. 抑制前列腺素生物合成可降低人体内抗利尿激素的分泌。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
P Glasson, M B Vallotton
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引用次数: 0
Angiotensin II-induced renal prostacyclin release suppresses platelet aggregation in the anesthetized dog. 血管紧张素ii诱导的肾前列环素释放抑制麻醉犬血小板聚集。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
R J Shebuski, J W Aiken
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引用次数: 0
PGF2 alpha stimulates release of PGE2 and PGI2 in the isolated perfused rat heart. PGF2 α刺激离体灌注大鼠心脏中PGE2和PGI2的释放。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
E A de Deckere, F ten Hoor

The effect of prostaglandin F2 alpha on the release of PGI2 and PGE2 was investigated in isolated perfused rat heart. PGF2 alpha at concentrations of 1.7 nmoles liter-1 or higher increased the release of PGI2 and PGE2 alpha. The release of PGI2 was highest after 3 to 4 min of perfusion with PGF2 alpha. This phenomenon may be of physiological significance and might explain the observed variable effects of PGF2 alpha on vascular resistance.

在离体灌注大鼠心脏中研究前列腺素F2 α对PGI2和PGE2释放的影响。PGF2 α浓度为1.7 nmol l -1或更高时，PGI2和PGE2 α的释放增加。PGF2 α灌注3 ~ 4min后，PGI2释放量最高。这一现象可能具有生理意义，并可能解释PGF2 α对血管阻力的可变影响。
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引用次数: 0
Dietary manipulation of prostaglandin and thromboxane synthesis in heart, aorta and blood platelets of the rat. 饮食对大鼠心脏、主动脉和血小板中前列腺素和血栓素合成的影响。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
F ten Hoor, E A de Deckere, E Haddeman, G Hornstra, J F Quadt

We conclude that dietary changes can have a profound influence on prostaglandin and thromboxane synthesis of organ systems. A better insight into underlying mechanisms is necessary before more definite advice with respect to feeding a linolenic acid and very long-chain polyunsaturated fatty acids as found in fish oils can be given.

我们得出结论，饮食的改变可以对器官系统的前列腺素和凝血素合成产生深远的影响。在对食用鱼油中的亚麻酸和长链多不饱和脂肪酸提出更明确的建议之前，有必要更好地了解潜在的机制。
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引用次数: 0
Vasodilator and antiplatelet activities of prostacyclins with modified omega-side chain. 改良ω -侧链前列环素的血管扩张和抗血小板活性。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
B A Schölkens, W Bartmann, G Beck, U Lerch, E Konz, U Weithmann
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引用次数: 0
Treatment of premature labor with indomethacin. 吲哚美辛治疗早产。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
D A Blake, J R Niebyl, R D White, K M Kumor, N H Dubin, J C Robinson, P G Egner
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引用次数: 0
Physiological and biochemical parameters of prostacyclin action on the heart and the coronary vasculature. 前列环素对心脏和冠状血管作用的生理生化参数。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
K Schrör, R Rösen, H B Link, P Rösen
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引用次数: 0
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