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Advances in prostaglandin and thromboxane research最新文献

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New approach to the RIA of prostaglandins and related compounds using iodinated tracers. 碘化示踪剂对前列腺素及相关化合物RIA的新方法。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
F Dray, K Gerozissis, B Kouznetzova, S Mamas, P Pradelles, G Trugnan
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引用次数: 0
Prostaglandins and human respiratory tract smooth muscle: structure activity relationship. 前列腺素与人呼吸道平滑肌:结构活动关系。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
S M Karim, P G Adaikan, S R Kottegoda
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引用次数: 0
Synthesis and bronchodilation activity of 8,10,12-triazaprostaglandin analogues. 8,10,12-三氮前列腺素类似物的合成及支气管扩张活性。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
D R Adams, A F Barnes, J Bermudez, F Cassidy
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引用次数: 0
PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. PGE2、PGF2 α和TXB2在人类风湿滑膜中的生物合成。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
F Blotman, J Chaintreuil, P Poubelle, O Flandre, A Crastes de Paulet, L Simon

Prostaglandins (PG) are currently suspected to be involved in human rheumatoid arthritis (RA). We have studied the PG [PGE2, PGF2 alpha, and Thromboxane B2 (TXB2)] biosynthesis capacity of normal (from amputations) and pathologic (osteoarthritis (OA) and RA) synovia. The measurement is done on the whole homogenate and microsomal fraction after 40 min incubation, without exogenous arachidonic acid (AA) or with a saturating concentration (25 micrograms/ml) of this compound, using a radioimmunoassay method. There is a considerable increase in PGE2 and PGF2 alpha production by the rheumatoid synovia and more PGE2 and PGF2 alpha are formed. This production is more marked for homogenates than microsomal fraction. The OA group is not homogeneous and does not differ significantly either from normals or from RA. The addition of AA considerably increases the biosynthesis of PG in both normal and pathologic tissue. For TXB2, the first results (four synovia) show no or a small biosynthesis in RA as well as in normals. Nevertheless, the levels before incubation seem higher in RA than in normal tissue.

前列腺素(PG)目前被怀疑与人类类风湿关节炎(RA)有关。我们研究了正常(截肢)和病理(骨关节炎(OA)和RA)滑膜PG [PGE2, PGF2 α和血栓素B2 (TXB2)]的生物合成能力。在不使用外源性花生四烯酸(AA)或该化合物的饱和浓度(25微克/毫升)的情况下，在孵育40分钟后对整个匀浆和微粒体部分进行测量，使用放射免疫分析法。类风湿滑膜产生的PGE2和PGF2 α显著增加，形成更多的PGE2和PGF2 α。匀浆比微粒体分数更明显。OA组不均匀，与正常人或RA没有显著差异。AA的添加大大增加了正常和病理组织中PG的生物合成。对于TXB2，第一个结果(四个滑膜)显示RA和正常人没有或很少生物合成。然而，类风湿关节炎在孵育前的水平似乎高于正常组织。
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引用次数: 0
Formation of prostaglandins in rat brain. Lack of effect of enkephalin. 大鼠脑内前列腺素的形成。缺乏脑啡肽的作用。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
J E Vincent, F J Zijlstra, M R Dzolijic
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引用次数: 0
Plasma levels of prostaglandin metabolites during spontaneous delivery. 自然分娩过程中前列腺素代谢产物的血浆水平。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
B Weppelmann, H O Hoppen, U Gethmann, E Schuster

1. The fetal contribution to PGFM levels is smaller than supposed. 2. The highest levels of PGFM found at placental separation seem to indicate the decidual origin of PGs which enter the maternal organism via the open uterine veins. This assumption is supported by low levels during the postpartum period when contractions are nearly as strong as during labor, but the uterine veins are closed. 3. There is no evidence that obstetrical factors are correlated to PGFM levels.

1. 胎儿对PGFM水平的贡献比预期的要小。2. 在胎盘分离时发现的最高水平的PGFM似乎表明PGs是通过开放的子宫静脉进入母体的个体起源。这种假设得到了产后低水平的支持，因为产后宫缩几乎和分娩时一样强烈，但子宫静脉是闭合的。3.没有证据表明产科因素与PGFM水平相关。
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引用次数: 0
Hemodynamic evaluation of prostaglandin D2 in the conscious baboon. 清醒狒狒前列腺素D2的血流动力学评价。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
J R Fletcher, P W Ramwell
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引用次数: 0
Pharmacologic control of thromboxane A2 generation in lungs. 肺血栓素A2生成的药理控制。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
G C Folco, C Omini, T Viganŏ, G Iantorno, F Berti
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引用次数: 0
Mammary gland prostaglandin synthesis: effect of dietary lipid and propyl gallate. 乳腺前列腺素合成:饲料脂肪和没食子酸丙酯的影响。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
D To, F L Smith, M P Carpenter
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引用次数: 0
Exaggerated prostaglandin and thromboxane synthesis in the renal vein constricted rabbit. 肾静脉收缩家兔前列腺素和血栓素合成增高。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
S Myers, R Zipser, P Needleman
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引用次数: 0
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