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Advances in prostaglandin and thromboxane research最新文献

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Prevention of aspirin-induced fecal blood loss in men with prostaglandin E2. 预防前列腺素E2患者阿斯匹林引起的粪便失血。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
M M Cohen, G Cheung, D M Lyster
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引用次数: 0
Dexamethasone inhibits the release of prostaglandins and the formation of autophagic vacuoles from stimulated macrophages. 地塞米松抑制前列腺素的释放和刺激的巨噬细胞自噬空泡的形成。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
K Brune, H Kälin, K D Rainsford, K Wagner
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引用次数: 0
Receptors for E and F prostaglandins in airways. 气道中前列腺素E和F受体。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
P J Gardiner, H O Collier

Determination of dose/response relationships for E and F PGs in guinea pig trachea and human bronchial muscle in vitro indicates that mixed contractant and relaxant activities are present in different proportions in each PG. Further analysis of these effects, using (a) tachyphylaxis to individual PGs and (b) indomethacin as a PG antagonist, argues that two PG receptors exist on tracheobronchial muscle. Activation of one of these (chi receptor) leads to contraction, and of the other (psi receptor) to relaxation. Individual E and F PGs interact with these two receptors in different proportions. A third potent effect of PGs on airways is to elicit cough. That PGF2 alpha elicits cough but has very little relaxant activity, whereas certain PG analogs and PGE1 elicit cough but possess either no bronchomotor or almost entirely relaxant activity, argues that a third receptor (omega) exists, the activation of which elicits cough.

体外测定豚鼠气管和人支气管肌肉中E和F类PG的剂量/反应关系表明，每种PG中存在不同比例的混合收缩和松弛活性。进一步分析这些作用，使用(a)对单个PG的快速反应和(b)吲哚美辛作为PG拮抗剂，认为气管支气管肌肉中存在两种PG受体。其中一个(chi受体)的激活导致收缩，另一个(psi受体)的激活导致放松。个体E和F pg以不同的比例与这两种受体相互作用。pg对气道的第三个有效作用是引起咳嗽。PGF2 α引起咳嗽，但几乎没有松弛活性，而某些PG类似物和PGE1引起咳嗽，但没有支气管运动活性或几乎完全松弛活性，这表明存在第三种受体(ω)，其激活引起咳嗽。
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引用次数: 0
Blockage of partially obstructed coronary arteries with platelet thrombi: comparison between its prevention with cyclooxygenase inhibitors versus prostacyclin. 部分阻塞的冠状动脉合并血小板血栓:环氧化酶抑制剂与前列环素预防的比较。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
J W Aiken, R J Shebuski, R R Gorman

This study shows that in vivo, platelet aggregation occurs by both cyclooxygenase- and noncyclooxygenase-dependent mechanisms, so that blockage of partially obstructed coronary arteries still occurs after cyclooxygenase inhibition if the obstruction is severe enough. Prostacyclin prevents blockage of the vessels under all conditions. Furthermore, prostacyclin's ability to block primary aggregation is enhanced after cyclooxygenase inhibition.

本研究表明，在体内，血小板聚集通过环加氧酶依赖机制和非环加氧酶依赖机制发生，因此在环加氧酶抑制后，如果阻塞足够严重，仍会发生部分阻塞的冠状动脉阻塞。前列环素在任何情况下都能防止血管堵塞。此外，环加氧酶抑制后，前列环素阻断初级聚集的能力增强。
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引用次数: 0
Prostacyclin stimulates short circuit current in the isolated toad (Bufo marinus) urinary bladder. 前列环素刺激分离蟾蜍(Bufo marinus)膀胱的短路电流。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
P V Halushka, A Levanho, M Auber
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引用次数: 0
Effects of prostacyclin on the hemodynamics of the rat. 前列环素对大鼠血流动力学的影响。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
V G Pinelis, C M Markov
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引用次数: 0
Cardiovascular research on PGI2, 6-keto-PGF1 alpha, PGF2 alpha, and 15(S)-15-methyl-PGF2 alpha. PGI2、6-酮- pgf1 α、PGF2 α和15(S)-15-甲基-PGF2 α的心血管研究。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
E Marmo, F Rossi, E Lampa, L Giordano, A P Caputi, C Vacca, B Ariello, F Rosatti
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引用次数: 0
Release of prostacyclin into the bloodstream in humans after local blood flow changes. 局部血流改变后，人体内释放前列环素进入血液。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
G C Serneri, G Masotti, L Poggesi, G Galanti
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引用次数: 0
Effects of Prostaglandin E1, prostacyclin, and tolazoline on elevated pulmonary vascular resistance in neonatal swine. 前列腺素E1、前列环素和托唑啉对新生猪肺血管阻力升高的影响。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
M B Starling, J M Neutze, R L Elliott
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引用次数: 0
Flurbiprofen and human intraocular inflammation. 氟比洛芬与人眼内炎症。
Advances in prostaglandin and thromboxane research
Pub Date : 1980-01-01
J S Hillman, G J Frank, M B Kheskani
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引用次数: 0
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