{"title":"Prostaglandins and implantation in the rat.","authors":"C A Phillips, N L Poyser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"8 ","pages":"1391-3"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18388251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J W Johnson, N H Dubin, S Calhoun, R B Ghodgaonkar, J C Beck
{"title":"Sequential prostaglandin metabolite values in pregnant patients delivering at term and preterm.","authors":"J W Johnson, N H Dubin, S Calhoun, R B Ghodgaonkar, J C Beck","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"8 ","pages":"1407-8"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18388255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A prostaglandin mechanism may contribute to the regulation of blood pressure in spontaneously hypertensive rats during pregnancy.","authors":"B Zamorano, A Terragno, J C McGiff, N A Terragno","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"7 ","pages":"807-10"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18389332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PGE2 at 5 X 10(-8)M is a significant stimulator of GH release and seems to act at a step prior to the first signal for the inhibitory effect of SS. The amount of PGE2 released in the culture medium would appear, from what we have seen in our studies to date, to rule out any possibility that PGE2 is a GRF. However, the powerful role of PGE2 in the GH secretion process is evident. More detailed studies are needed, especially once a defined GRF becomes available. Investigations are currently in progress along these lines.
5 X 10(-8)M的PGE2是生长激素释放的重要刺激物，似乎在SS抑制作用的第一个信号之前的一个步骤起作用。从我们迄今为止的研究中看到，培养基中释放的PGE2的量似乎排除了PGE2是GRF的任何可能性。然而，PGE2在生长激素分泌过程中的强大作用是显而易见的。需要进行更详细的研究，特别是一旦有了明确的粮食产量指标。目前正在沿着这些方向进行调查。
{"title":"Role of prostaglandins on growth hormone secretion: PGE2 a physiological stimulator.","authors":"F Dray, B Kouznetzova, D Harris, P Brazeau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>PGE2 at 5 X 10(-8)M is a significant stimulator of GH release and seems to act at a step prior to the first signal for the inhibitory effect of SS. The amount of PGE2 released in the culture medium would appear, from what we have seen in our studies to date, to rule out any possibility that PGE2 is a GRF. However, the powerful role of PGE2 in the GH secretion process is evident. More detailed studies are needed, especially once a defined GRF becomes available. Investigations are currently in progress along these lines.</p>","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"8 ","pages":"1321-8"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17169600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trimethoquinol selectively antagonizes contractions of rat gastric fundus to TXB2 and epoxymethano analogs of PGH2.","authors":"G J Sanger, A Bennett","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"8 ","pages":"1559-60"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17169601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Determination of dose/response relationships for E and F PGs in guinea pig trachea and human bronchial muscle in vitro indicates that mixed contractant and relaxant activities are present in different proportions in each PG. Further analysis of these effects, using (a) tachyphylaxis to individual PGs and (b) indomethacin as a PG antagonist, argues that two PG receptors exist on tracheobronchial muscle. Activation of one of these (chi receptor) leads to contraction, and of the other (psi receptor) to relaxation. Individual E and F PGs interact with these two receptors in different proportions. A third potent effect of PGs on airways is to elicit cough. That PGF2 alpha elicits cough but has very little relaxant activity, whereas certain PG analogs and PGE1 elicit cough but possess either no bronchomotor or almost entirely relaxant activity, argues that a third receptor (omega) exists, the activation of which elicits cough.
{"title":"Receptors for E and F prostaglandins in airways.","authors":"P J Gardiner, H O Collier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determination of dose/response relationships for E and F PGs in guinea pig trachea and human bronchial muscle in vitro indicates that mixed contractant and relaxant activities are present in different proportions in each PG. Further analysis of these effects, using (a) tachyphylaxis to individual PGs and (b) indomethacin as a PG antagonist, argues that two PG receptors exist on tracheobronchial muscle. Activation of one of these (chi receptor) leads to contraction, and of the other (psi receptor) to relaxation. Individual E and F PGs interact with these two receptors in different proportions. A third potent effect of PGs on airways is to elicit cough. That PGF2 alpha elicits cough but has very little relaxant activity, whereas certain PG analogs and PGE1 elicit cough but possess either no bronchomotor or almost entirely relaxant activity, argues that a third receptor (omega) exists, the activation of which elicits cough.</p>","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"7 ","pages":"1003-8"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17309366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study shows that in vivo, platelet aggregation occurs by both cyclooxygenase- and noncyclooxygenase-dependent mechanisms, so that blockage of partially obstructed coronary arteries still occurs after cyclooxygenase inhibition if the obstruction is severe enough. Prostacyclin prevents blockage of the vessels under all conditions. Furthermore, prostacyclin's ability to block primary aggregation is enhanced after cyclooxygenase inhibition.
{"title":"Blockage of partially obstructed coronary arteries with platelet thrombi: comparison between its prevention with cyclooxygenase inhibitors versus prostacyclin.","authors":"J W Aiken, R J Shebuski, R R Gorman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study shows that in vivo, platelet aggregation occurs by both cyclooxygenase- and noncyclooxygenase-dependent mechanisms, so that blockage of partially obstructed coronary arteries still occurs after cyclooxygenase inhibition if the obstruction is severe enough. Prostacyclin prevents blockage of the vessels under all conditions. Furthermore, prostacyclin's ability to block primary aggregation is enhanced after cyclooxygenase inhibition.</p>","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"7 ","pages":"635-9"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17309371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanism underlying the inhibition of platelet aggregation by eicosapentaenoic acid and its metabolites.","authors":"P Needleman, H Sprecher, M O Whitaker, A Wyche","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"6 ","pages":"61-8"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17312032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Dray, K Gerozissis, B Kouznetzova, S Mamas, P Pradelles, G Trugnan
{"title":"New approach to the RIA of prostaglandins and related compounds using iodinated tracers.","authors":"F Dray, K Gerozissis, B Kouznetzova, S Mamas, P Pradelles, G Trugnan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"6 ","pages":"167-80"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18203957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exaggerated prostaglandin and thromboxane synthesis in the renal vein constricted rabbit.","authors":"S Myers, R Zipser, P Needleman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"7 ","pages":"1171-3"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18378017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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