Pub Date : 2026-01-23DOI: 10.1016/j.ajog.2026.01.020
Natalie Braun, Alvaro C. Laga Canales, Susan Burgin
{"title":"Adult-Onset Cutaneous Mastocytosis Presenting as Vulvar Papules","authors":"Natalie Braun, Alvaro C. Laga Canales, Susan Burgin","doi":"10.1016/j.ajog.2026.01.020","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.020","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"71 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.ajog.2026.01.018
Jose “Tony” Carugno
{"title":"Requiring general oral examinations for subspecialists (Letter-to-the-Editor)","authors":"Jose “Tony” Carugno","doi":"10.1016/j.ajog.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.018","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"2 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.ajog.2026.01.016
Savitree Pranpanus, Christoph C. Lees
{"title":"3-Dimensional ultrasound imaging to delineate focal lesions of placenta accreta spectrum","authors":"Savitree Pranpanus, Christoph C. Lees","doi":"10.1016/j.ajog.2026.01.016","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.016","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"5 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.ajog.2026.01.015
Howard Minkoff, Richard Berkowitz
{"title":"Board to Death (Reply to Letter-to-the- Editor)","authors":"Howard Minkoff, Richard Berkowitz","doi":"10.1016/j.ajog.2026.01.015","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.015","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"60 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-19DOI: 10.1016/j.ajog.2026.01.017
Christoph C. Lees, Savitree Pranpanus, Andrea Dall’Asta, Rozi Aryananda, Jin-Chung Shih
{"title":"Diagnosis of placenta accreta spectrum by the ‘Rail’ and ‘Tramline’ signs: similar names but different techniques and topography","authors":"Christoph C. Lees, Savitree Pranpanus, Andrea Dall’Asta, Rozi Aryananda, Jin-Chung Shih","doi":"10.1016/j.ajog.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.017","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"5 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.ajog.2026.01.012
Oluwatosin Goje,Paul Nyirjesy,Jack D Sobel
{"title":"Methodologic and analytic considerations in the CANDLE trial of ibrexafungerp for recurrent vulvovaginal candidiasis (Reply to Letter-to-the-Editor).","authors":"Oluwatosin Goje,Paul Nyirjesy,Jack D Sobel","doi":"10.1016/j.ajog.2026.01.012","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.012","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"22 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.ajog.2026.01.013
Federico Ferrari,Filippo Alberto Ferrari
{"title":"Challenges in interpreting prognostic markers in Endometrial Cancer with No Specific Molecular Profile (Reply to Letter-to-the-Editor).","authors":"Federico Ferrari,Filippo Alberto Ferrari","doi":"10.1016/j.ajog.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.013","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"269 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.ajog.2026.01.014
Mohammad Azizi,Zeinab Sinaeifar
{"title":"Methodologic and analytic considerations in the CANDLE trial of ibrexafungerp for recurrent vulvovaginal candidiasis (Letter-to-the-Editor).","authors":"Mohammad Azizi,Zeinab Sinaeifar","doi":"10.1016/j.ajog.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.014","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"39 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDChromosomal aberrations in tumors are key indicators of genomic instability and important drivers of neoplasia. While chromosomal changes in uterine leiomyomas have been studied for decades, comprehensive evaluation of chromosomal aberrations in uterine leiomyomas on the scale of modern tumor research has been lacking.OBJECTIVETo comprehensively characterize somatic chromosomal aberrations in uterine leiomyoma, providing a missing layer of stratified data for research towards detailed understanding of the genesis of this important tumor type.STUDY DESIGNIn this retrospective study, we analyzed 1,963 uterine leiomyomas from 629 patients using SNP array data. Our goal was to identify subtype-specific chromosomal rearrangement patterns across nine known uterine leiomyoma subtypes named after the respective driver gene: MED12, HMGA2, HMGA1, FH, YEATS4, oSRCAP, COL4A5/6, PLAG1 and NEDDYLATION, as well as tumors lacking known driver mutations. We identified recurrently deleted and gained chromosomal regions from SNP array data and integrated these findings with gene expression and long-read sequencing data. Complex chromosomal rearrangements resembling chromothripsis were assessed through breakpoint analysis. Our findings were also scrutinized with respect to clinical background information and inherited uterine leiomyoma risk.RESULTSApproximately 39% (or 50% among tumors selected as one per patient) of uterine leiomyomas harbored chromosomal aberrations. Uterine leiomyoma subtypes displayed unique chromosomal features: FH- and MED12-driven tumors were largely chromosomally stable, FH tumors harboring almost exclusively only focal 1q deletions and MED12 tumors being enriched for 7q22 deletions. Meanwhile, HMGA2, HMGA1, PLAG1 and COL4A5/6 subtypes frequently displayed extensive chromosomal aberrations. Complex chromosomal rearrangements were particularly frequent in HMGA1 and PLAG1 tumors and were typically encountered on chromosomes with known uterine leiomyoma driver genes. YEATS4 tumors harbored deletions of chromosome 16. UNKNOWN tumors were heterogeneous as expected, some exhibiting multiple large deletions in 1p, 14q and 15q or 1p, 14q and 22q. Chromosomal gains were rare and enriched to chromosome 1. Differential expression analysis revealed known recurrent alterations in uterine leiomyomas as well as new loci for future scrutiny, such as CDKN2C in HMGA2 tumors. Clinical characteristics were examined, notably linking chromosomal aberrations and complex chromosomal rearrangements to larger tumors and younger age at hysterectomy in select subtypes. Examined overall, somatic aberrations at germline predisposition loci preferred a loss of the protective allele.CONCLUSIONSThis study revealed uterine leiomyoma subtypes to have distinct chromosomal aberration landscapes. Our large sample collection, detailed subclassification and extensive expression data integration enabled the identification of rare aberrations and subtype-specificity not pr
{"title":"Large-scale analysis of chromosomal aberrations in uterine leiomyoma.","authors":"Sini Ilves,Vilja Jokinen,Riku Katainen,Emma Siili,Ralf Bützow,Oskari Heikinheimo,Annukka Pasanen,Auli Karhu,Niko Välimäki,Lauri A Aaltonen","doi":"10.1016/j.ajog.2026.01.010","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.01.010","url":null,"abstract":"BACKGROUNDChromosomal aberrations in tumors are key indicators of genomic instability and important drivers of neoplasia. While chromosomal changes in uterine leiomyomas have been studied for decades, comprehensive evaluation of chromosomal aberrations in uterine leiomyomas on the scale of modern tumor research has been lacking.OBJECTIVETo comprehensively characterize somatic chromosomal aberrations in uterine leiomyoma, providing a missing layer of stratified data for research towards detailed understanding of the genesis of this important tumor type.STUDY DESIGNIn this retrospective study, we analyzed 1,963 uterine leiomyomas from 629 patients using SNP array data. Our goal was to identify subtype-specific chromosomal rearrangement patterns across nine known uterine leiomyoma subtypes named after the respective driver gene: MED12, HMGA2, HMGA1, FH, YEATS4, oSRCAP, COL4A5/6, PLAG1 and NEDDYLATION, as well as tumors lacking known driver mutations. We identified recurrently deleted and gained chromosomal regions from SNP array data and integrated these findings with gene expression and long-read sequencing data. Complex chromosomal rearrangements resembling chromothripsis were assessed through breakpoint analysis. Our findings were also scrutinized with respect to clinical background information and inherited uterine leiomyoma risk.RESULTSApproximately 39% (or 50% among tumors selected as one per patient) of uterine leiomyomas harbored chromosomal aberrations. Uterine leiomyoma subtypes displayed unique chromosomal features: FH- and MED12-driven tumors were largely chromosomally stable, FH tumors harboring almost exclusively only focal 1q deletions and MED12 tumors being enriched for 7q22 deletions. Meanwhile, HMGA2, HMGA1, PLAG1 and COL4A5/6 subtypes frequently displayed extensive chromosomal aberrations. Complex chromosomal rearrangements were particularly frequent in HMGA1 and PLAG1 tumors and were typically encountered on chromosomes with known uterine leiomyoma driver genes. YEATS4 tumors harbored deletions of chromosome 16. UNKNOWN tumors were heterogeneous as expected, some exhibiting multiple large deletions in 1p, 14q and 15q or 1p, 14q and 22q. Chromosomal gains were rare and enriched to chromosome 1. Differential expression analysis revealed known recurrent alterations in uterine leiomyomas as well as new loci for future scrutiny, such as CDKN2C in HMGA2 tumors. Clinical characteristics were examined, notably linking chromosomal aberrations and complex chromosomal rearrangements to larger tumors and younger age at hysterectomy in select subtypes. Examined overall, somatic aberrations at germline predisposition loci preferred a loss of the protective allele.CONCLUSIONSThis study revealed uterine leiomyoma subtypes to have distinct chromosomal aberration landscapes. Our large sample collection, detailed subclassification and extensive expression data integration enabled the identification of rare aberrations and subtype-specificity not pr","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"35 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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