Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_13
C Desjardins, A J Zeleznik, A R Midgley, L E Reichert
{"title":"In vitro binding and autoradiographic localization of human chorionic gonadotropin and follicle stimulating hormone in rat testes during development.","authors":"C Desjardins, A J Zeleznik, A R Midgley, L E Reichert","doi":"10.1007/978-1-4684-2595-6_13","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_13","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"221-35"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_4
D Rodbard, W Moyle, J Ramanchandran
In vitro accumulation of cyclic AMP by rat Leydig cell preparation and mouse tumor Leydig cells in response to exogenous LH appears to display an apparent Hill coefficient of 2.5. This is suggestive of positive cooperativity at a level intermediate between binding and cyclic AMP production, although several alternative hypothesis cannot be excluded on the basis of these data alone. The Hill coefficient for testosterone is higher than unity, although it has not been established with adequate precision in these experiments.
{"title":"Apparent positive cooperativity in the mechanism of action of luteinizng hormone.","authors":"D Rodbard, W Moyle, J Ramanchandran","doi":"10.1007/978-1-4684-2595-6_4","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_4","url":null,"abstract":"<p><p>In vitro accumulation of cyclic AMP by rat Leydig cell preparation and mouse tumor Leydig cells in response to exogenous LH appears to display an apparent Hill coefficient of 2.5. This is suggestive of positive cooperativity at a level intermediate between binding and cyclic AMP production, although several alternative hypothesis cannot be excluded on the basis of these data alone. The Hill coefficient for testosterone is higher than unity, although it has not been established with adequate precision in these experiments.</p>","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"79-87"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15483936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_9
D J Tindall, W T Schrader, A R Means
{"title":"The production of androgen binding protein by Sertoli Cells.","authors":"D J Tindall, W T Schrader, A R Means","doi":"10.1007/978-1-4684-2595-6_9","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_9","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"167-75"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15575350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_12
V K Bhalla, L E Reichert
{"title":"FSH receptors in rat testis: chemical properties and solubilization studies.","authors":"V K Bhalla, L E Reichert","doi":"10.1007/978-1-4684-2595-6_12","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_12","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"201-20"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_14
J H Dorrington, N F Roller, I B Fritz
{"title":"The effects of FSH on cell preparations from the rat testis.","authors":"J H Dorrington, N F Roller, I B Fritz","doi":"10.1007/978-1-4684-2595-6_14","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_14","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"237-41"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_15
T Braun
{"title":"Evidence for multiple, cell specific, distinctive adenylate cyclase systems in rat testis.","authors":"T Braun","doi":"10.1007/978-1-4684-2595-6_15","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_15","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"243-64"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_1
K J Catt, T Tsuruhara, C Mendelson, J M Ketelslegers, M L Dufau
{"title":"Gonadotroping binding and activation of the interstitial cells of the testis.","authors":"K J Catt, T Tsuruhara, C Mendelson, J M Ketelslegers, M L Dufau","doi":"10.1007/978-1-4684-2595-6_1","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_1","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_20
J A Blaquier, M S Cameo, R Calandra
Rat epididymal tubules maintained in organ culture for 3 or 7 days in media containing androgen showed a marked increase in the incorporation of radioactive amino acids and uridine into acid insoluble material. When the tubules were exposed to these hormones for brief periods, the incorporation of precursors was inhibited initially. In studying the time course of binding of 3H testosterone to the cytoplasmic receptor, a significant amount of radioactivity bound to the receptor was detected only after 12 hr of exposure to the hormone which increased three-fold after 24 hr. The time lag in the binding corresponded closely to the shortest times of observed hormone action wherein a significant increase in the incoporation of uridine (16 hr) and amino acids (24 hr) was produced. Evidence is presented demonstrating that testosterone is bound with high affinity by components of the fetal calf serum present in the culture medium.
{"title":"Studies on the correlation between androgen binding and activation of rat epididymal tubules in culture.","authors":"J A Blaquier, M S Cameo, R Calandra","doi":"10.1007/978-1-4684-2595-6_20","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_20","url":null,"abstract":"<p><p>Rat epididymal tubules maintained in organ culture for 3 or 7 days in media containing androgen showed a marked increase in the incorporation of radioactive amino acids and uridine into acid insoluble material. When the tubules were exposed to these hormones for brief periods, the incorporation of precursors was inhibited initially. In studying the time course of binding of 3H testosterone to the cytoplasmic receptor, a significant amount of radioactivity bound to the receptor was detected only after 12 hr of exposure to the hormone which increased three-fold after 24 hr. The time lag in the binding corresponded closely to the shortest times of observed hormone action wherein a significant increase in the incoporation of uridine (16 hr) and amino acids (24 hr) was produced. Evidence is presented demonstrating that testosterone is bound with high affinity by components of the fetal calf serum present in the culture medium.</p>","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"329-41"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15579615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_5
W K Liu, K P Yang, B D Burleigh, D N Ward
{"title":"Functional groups in ovine luteinizing hormone and their receptor site interactions-a chemical study.","authors":"W K Liu, K P Yang, B D Burleigh, D N Ward","doi":"10.1007/978-1-4684-2595-6_5","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_5","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"89-108"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15483937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1974-01-01DOI: 10.1007/978-1-4684-2595-6_2
J M Ketelslegers, G D Knott, K J Catt
{"title":"Computer analysis of the binding reaction between hCG and gonadotropin receptors of the rat testis.","authors":"J M Ketelslegers, G D Knott, K J Catt","doi":"10.1007/978-1-4684-2595-6_2","DOIUrl":"https://doi.org/10.1007/978-1-4684-2595-6_2","url":null,"abstract":"","PeriodicalId":75766,"journal":{"name":"Current topics in molecular endocrinology","volume":"1 ","pages":"31-45"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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