Physiologie (Bucarest)最新文献

Spontaneously beating rat heart Langendorff preparations, perfused with Tyrode solution under low flow conditions (1.62 +/- 0.47 ml/min at 55 mmHg), were used to investigate the role of adenosine in the coronary flow control, by means of adenosine-deaminase injections into the perfusion system. Adenosine deaminase did not influence the control coronary flow, but significantly reduced autoregulation, hypoxic vasodilation, reactive hyperemia and functional adrenaline-induced hyperemia. All these effects, excepting the hypoxic vasodilation reduction, dependent upon the moment of enzyme injection during the experiment. Under the mentioned conditions adenosine seems to be responsible for more than half of the autoregulation of the coronary flow. Adenosine deaminase completely abolished reactive hyperemia during control perfusion but only delayed it under adrenaline perfusion.

The authors performed a controlled trial in 18 top athletes (9 weight lifters and 9 rowers, girls) in order to make evident some chronic and acute effects (antioxidant) of selenium. Nonprotein--SH (essential glutathione), lipid peroxides (MDA-malondialdehyde), glucose-6-phosphate dehydrogenases (G-6-PDH) and fructose-1,6-diphosphate aldolase in serum, have been recorded initially on basal conditions, after 3 weeks of treatment (100 micrograms/day selenium or placebo) and again after 3 weeks of treatment, also on basal conditions, when crossing over the groups (between a free interval of 10 days). In another trial we registered these parameters on basal conditions and after two hours of hard training accompanied by a per oral administration of 150 micrograms selenium (respectively placebo). The results show significant changes under selenium treatment of the peroxides, G-6-PDH and light changes, not significant of the nonprotein--SH, changes which could suggest an antioxidant effect of this element.

Concentrations of immunoglobulins and other plasma proteins were determined by radial immunodiffusion in the blood sera and saliva of 16 dysmature (small-for-dates) and of 16 eutrophic healthy infants with an average age of 4.8 and 4.7 months, respectively. The local synthesis of salivary proteins was calculated with a formula used by Deuschl and Johansson for the estimation of local synthesis of bronchial immunoglobulins. The formula was completed by a correction factor established by the authors, based on their previous investigations. Dysmature children had a significantly lower serum IgG, IgA, albumin, transferrin, coeruloplasmin and beta-lipoprotein level. In the dysmature infants the salivary albumin and alpha 1-acid glycoprotein concentration was higher than in the normal controls. A local synthesis of IgA, IgG, transferrin, alpha 1-acid glycoprotein, alpha 1-antitrypsin and haptoglobin was observed in both groups, but the production of these proteins was slightly diminished, while their transudation was more important in the dysmature subjects. The lower level of serum proteins, as well as the lower local synthesis in the salivary glands may be due to the immaturity of the tissues that produce these proteins. The increase of the protein transudation is attributed to a rise of the tissue permeability in the dysmature children which is a late consequence of intrauterine malnutrition.

Our previous studies dealt with the dynamics of the fluid-coagulant equilibrium in rats after confinement hypokinesia (CHK) for 1, 2 and 3 weeks obtained by placing them in small cages permitting only slight movements for spontaneous feeding. We found an acceleration of blood coagulation and fibrinolysis, with a maximal response after 1-2 weeks. In this work attention focussed on the initial more dynamic interval of 1, 3 and 7 days of exposure to CHK. To find certain relations between the central vegetative stimuli and the peripheral responses, experiments were done on normal and adrenalectomized rats and plasma corticosterone, the main glucocorticoid in these species, was measured. CHK accelerated the Quick and the Howell time (QT and HT) and euglobulin lysis time (ELT) progressively, beginning with the first day of exposure. Adrenalectomy as such shortened these parameters, demonstrating an inhibitory action of corticoid hormones in normal conditions. Exposure to CHK of adrenalectomised rats emphasizes these inhibitions. We did not found evident correlations between plasma corticosterone and these processes. The number of thrombocytes had a similar evolution, but in adrenalectomised and CHK rats they increase.

3384 patients over 40 years old referred to our Cardiovascular Laboratory for overt cardiovascular complaints were examined by usual non-invasive investigations. Painless myocardial ischemia (PMI) prevalence was 17.49% and degenerative aortic and mitral valvulopathies incidence was 15.60%. PMI predominate in women especially in the group 50-59 years of age in which painful forms of ischemic heart disease have the highest prevalence in men. Although more affected by painless myocardial ischemia, women show a more favourable outcome than men. Ischemic heart disease was frequently associated with isolated mitral regurgitation. In the elderly patients mitral valvulopathy was associated with calcific aortic stenosis. No significant difference was noted between mitral and aortic valvulopathies prevalence.