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The Quest for the Application of Artificial Intelligence to Whole Slide Imaging: Unique Prospective from New Advanced Tools 人工智能在全切片成像中的应用探索:来自新先进工具的独特视角
IF 2.3 Q2 Mathematics Pub Date : 2024-06-10 DOI: 10.3390/a17060254
Gavino Faa, Massimo Castagnola, Luca Didaci, Fernando Coghe, M. Scartozzi, Luca Saba, Matteo Fraschini
The introduction of machine learning in digital pathology has deeply impacted the field, especially with the advent of whole slide image (WSI) analysis. In this review, we tried to elucidate the role of machine learning algorithms in diagnostic precision, efficiency, and the reproducibility of the results. First, we discuss some of the most used tools, including QuPath, HistoQC, and HistomicsTK, and provide an updated overview of machine learning approaches and their application in pathology. Later, we report how these tools may simplify the automation of WSI analyses, also reducing manual workload and inter-observer variability. A novel aspect of this review is its focus on open-source tools, presented in a way that may help the adoption process for pathologists. Furthermore, we highlight the major benefits of these technologies, with the aim of making this review a practical guide for clinicians seeking to implement machine learning-based solutions in their specific workflows. Moreover, this review also emphasizes some crucial limitations related to data quality and the interpretability of the models, giving insight into future directions for research. Overall, this work tries to bridge the gap between the more recent technological progress in computer science and traditional clinical practice, supporting a broader, yet smooth, adoption of machine learning approaches in digital pathology.
机器学习在数字病理学中的引入对该领域产生了深远影响,尤其是随着全切片图像(WSI)分析的出现。在这篇综述中,我们试图阐明机器学习算法在诊断精确度、效率和结果可重复性方面的作用。首先,我们讨论了一些最常用的工具,包括 QuPath、HistoQC 和 HistomicsTK,并提供了机器学习方法及其在病理学中应用的最新概述。随后,我们将报告这些工具如何简化 WSI 分析的自动化过程,同时减少人工工作量和观察者之间的差异。本综述的一个新颖之处在于它侧重于开源工具,其介绍方式可能有助于病理学家的采用过程。此外,我们还强调了这些技术的主要优点,目的是使本综述成为临床医生在其特定工作流程中寻求实施基于机器学习的解决方案的实用指南。此外,本综述还强调了与数据质量和模型可解释性有关的一些关键局限性,为未来的研究方向提供了启示。总之,这项工作试图在计算机科学的最新技术进步与传统临床实践之间架起一座桥梁,支持在数字病理学中更广泛、更顺利地采用机器学习方法。
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引用次数: 0
Hardware Model Checking Algorithms and Techniques 硬件模型检查算法和技术
IF 2.3 Q2 Mathematics Pub Date : 2024-06-09 DOI: 10.3390/a17060253
G. Cabodi, P. Camurati, M. Palena, P. Pasini
Digital systems are nowadays ubiquitous and often comprise an extremely high level of complexity. Guaranteeing the correct behavior of such systems has become an ever more pressing need for manufacturers. The correctness of digital systems can be addressed resorting to formal verification techniques, such as model checking. Currently, it is usually impossible to determine a priori the best algorithm to use given a verification task and, thus, portfolio approaches have become the de facto standard in model checking verification suites. This paper describes the most relevant algorithms and techniques, at the foundations of bit-level SAT-based model checking itself.
如今,数字系统无处不在,而且往往具有极高的复杂性。对于制造商来说,保证此类系统的正确行为已成为一项日益迫切的需求。数字系统的正确性可以通过形式验证技术(如模型检查)来解决。目前,通常不可能先验地确定给定验证任务应使用的最佳算法,因此,组合方法已成为模型检查验证套件的事实标准。本文从基于 SAT 的位级模型检查本身的基础出发,介绍了最相关的算法和技术。
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引用次数: 0
Research on Distributed Fault Diagnosis Model of Elevator Based on PCA-LSTM 基于 PCA-LSTM 的电梯分布式故障诊断模型研究
IF 2.3 Q2 Mathematics Pub Date : 2024-06-07 DOI: 10.3390/a17060250
Chengming Chen, Xuejun Ren, Guoqing Cheng
A Distributed Elevator Fault Diagnosis System (DEFDS) is developed to tackle frequent malfunctions stemming from the widespread distribution and aging of elevator systems. Due to the complexity of elevator fault data and the subtlety of fault characteristics, traditional methods such as visual inspections and basic operational tests fall short in detecting early signs of mechanical wear and electrical issues. These conventional techniques often fail to recognize subtle fault characteristics, necessitating more advanced diagnostic tools. In response, this paper introduces a Principal Component Analysis–Long Short-Term Memory (PCA-LSTM) method for fault diagnosis. The distributed system decentralizes the fault diagnosis process to individual elevator units, utilizing PCA’s feature selection capabilities in high-dimensional spaces to extract and reduce the dimensionality of fault features. Subsequently, the LSTM model is employed for fault prediction. Elevator models within the system exchange data to refine and optimize a global prediction model. The efficacy of this approach is substantiated through empirical validation with actual data, achieving an accuracy rate of 90% and thereby confirming the method’s effectiveness in facilitating distributed elevator fault diagnosis.
开发分布式电梯故障诊断系统(DEFDS)的目的是解决因电梯系统分布广泛和老化而导致的频繁故障。由于电梯故障数据的复杂性和故障特征的微妙性,目视检查和基本运行测试等传统方法无法检测到机械磨损和电气问题的早期迹象。这些传统技术往往无法识别微妙的故障特征,因此需要更先进的诊断工具。为此,本文介绍了一种用于故障诊断的主成分分析-长短期记忆(PCA-LSTM)方法。分布式系统将故障诊断过程分散到单个电梯单元,利用 PCA 在高维空间的特征选择能力来提取和降低故障特征的维度。随后,采用 LSTM 模型进行故障预测。系统内的电梯模型交换数据,以完善和优化全局预测模型。通过实际数据的经验验证,证实了这种方法的有效性,准确率达到 90%,从而证实了该方法在促进分布式电梯故障诊断方面的有效性。
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引用次数: 0
Prediction of Hippocampal Signals in Mice Using a Deep Learning Approach for Neurohybrid Technology Applications 利用深度学习方法预测小鼠海马信号,促进神经杂交技术应用
IF 2.3 Q2 Mathematics Pub Date : 2024-06-07 DOI: 10.3390/a17060252
Albina V. Lebedeva, Margarita I. Samburova, Vyacheslav V. Razin, Nikolay V. Gromov, S. A. Gerasimova, T. Levanova, L. Smirnov, Alexander N. Pisarchik
The increasing growth in knowledge about the functioning of the nervous system of mammals and humans, as well as the significant neuromorphic technology developments in recent decades, has led to the emergence of a large number of brain–computer interfaces and neuroprosthetics for regenerative medicine tasks. Neurotechnologies have traditionally been developed for therapeutic purposes to help or replace motor, sensory or cognitive abilities damaged by injury or disease. They also have significant potential for memory enhancement. However, there are still no fully developed neurotechnologies and neural interfaces capable of restoring or expanding cognitive functions, in particular memory, in mammals or humans. In this regard, the search for new technologies in the field of the restoration of cognitive functions is an urgent task of modern neurophysiology, neurotechnology and artificial intelligence. The hippocampus is an important brain structure connected to memory and information processing in the brain. The aim of this paper is to propose an approach based on deep neural networks for the prediction of hippocampal signals in the CA1 region based on received biological input in the CA3 region. We compare the results of prediction for two widely used deep architectures: reservoir computing (RC) and long short-term memory (LSTM) networks. The proposed study can be viewed as a first step in the complex task of the development of a neurohybrid chip, which allows one to restore memory functions in the damaged rodent hippocampus.
近几十年来,随着对哺乳动物和人类神经系统功能了解的不断加深,以及神经形态技术的重大发展,出现了大量用于再生医学任务的脑机接口和神经假肢。神经技术传统上是为治疗目的而开发的,用于帮助或替代因受伤或疾病而受损的运动、感官或认知能力。它们在增强记忆方面也有很大的潜力。然而,目前还没有完全成熟的神经技术和神经接口能够恢复或扩展哺乳动物或人类的认知功能,特别是记忆。因此,寻找恢复认知功能的新技术是现代神经生理学、神经技术和人工智能的一项紧迫任务。海马体是与大脑记忆和信息处理有关的重要脑结构。本文旨在提出一种基于深度神经网络的方法,根据 CA3 区接收到的生物输入预测 CA1 区的海马信号。我们比较了两种广泛使用的深度架构:水库计算(RC)和长短期记忆(LSTM)网络的预测结果。我们提出的研究可被视为开发神经杂交芯片这一复杂任务的第一步,该芯片可使人们恢复受损啮齿动物海马的记忆功能。
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引用次数: 0
Distributed Control of Hydrogen-Based Microgrids for the Demand Side: A Multiagent Self-Triggered MPC-Based Strategy 需求方氢基微电网的分布式控制:基于多代理自触发 MPC 的策略
IF 2.3 Q2 Mathematics Pub Date : 2024-06-07 DOI: 10.3390/a17060251
Tingzhe Pan, Jue Hou, Xin Jin, Zhenfan Yu, Wei Zhou, Zhijun Wang
With the global pursuit of renewable energy and carbon neutrality, hydrogen-based microgrids have also become an important area of research, as ensuring proper design and operation is essential to achieve optimal performance from hybrid systems. This paper proposes a distributed control strategy based on multiagent self-triggered model predictive control (ST-MPC), with the aim of achieving demand-side control of hydrogen-based microgrid systems. This architecture considers a hybrid energy storage system with renewable energy as the main power source, supplemented by fuel cells based on electrolytic hydrogen. The primary objective of this architecture is aiming at the supply and demand balance problem under the supply and demand relationship of microgrid, the service life of hydrogen-based microgrid energy storage equipment can be increased on the basis of realizing demand-side control of hydrogen energy microgrid system. To accomplish this, model predictive controllers are implemented within a self-triggered framework that dynamically adjusts the counting period. The simulation results demonstrate that the ST-MPC architecture significantly reduces the frequency of control action changes while maintaining an acceptable level of set-point tracking. These findings highlight the viability of the proposed solution for microgrids equipped with multiple types of electrochemical storage, which contributes to improved sustainability and efficiency in renewable-based microgrid systems.
随着全球对可再生能源和碳中和的追求,氢基微电网也成为一个重要的研究领域,因为确保正确的设计和运行对于实现混合系统的最佳性能至关重要。本文提出了一种基于多代理自触发模型预测控制(ST-MPC)的分布式控制策略,旨在实现氢基微电网系统的需求侧控制。该架构考虑了以可再生能源为主要动力源、以电解氢燃料电池为补充的混合储能系统。该架构的主要目标是针对微电网供需关系下的供需平衡问题,在实现氢能微电网系统需求侧控制的基础上,提高氢基微电网储能设备的使用寿命。为此,在自触发框架内实施了模型预测控制器,动态调整计数周期。仿真结果表明,ST-MPC 架构在保持可接受的设定点跟踪水平的同时,显著降低了控制动作变化的频率。这些研究结果凸显了针对配备多种类型电化学储能的微电网提出的解决方案的可行性,有助于提高基于可再生能源的微电网系统的可持续性和效率。
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引用次数: 0
New Multi-View Feature Learning Method for Accurate Antifungal Peptide Detection 用于准确检测抗真菌肽的新型多视角特征学习方法
IF 2.3 Q2 Mathematics Pub Date : 2024-06-06 DOI: 10.3390/a17060247
S. M. Ferdous, S. Mugdha, Iman Dehzangi
Antimicrobial resistance, particularly the emergence of resistant strains in fungal pathogens, has become a pressing global health concern. Antifungal peptides (AFPs) have shown great potential as a promising alternative therapeutic strategy due to their inherent antimicrobial properties and potential application in combating fungal infections. However, the identification of antifungal peptides using experimental approaches is time-consuming and costly. Hence, there is a demand to propose fast and accurate computational approaches to identifying AFPs. This paper introduces a novel multi-view feature learning (MVFL) model, called AFP-MVFL, for accurate AFP identification, utilizing multi-view feature learning. By integrating the sequential and physicochemical properties of amino acids and employing a multi-view approach, the AFP-MVFL model significantly enhances prediction accuracy. It achieves 97.9%, 98.4%, 0.98, and 0.96 in terms of accuracy, precision, F1 score, and Matthews correlation coefficient (MCC), respectively, outperforming previous studies found in the literature.
抗菌药耐药性,尤其是真菌病原体中耐药菌株的出现,已成为一个紧迫的全球健康问题。抗真菌肽(AFPs)因其固有的抗菌特性和在抗击真菌感染中的潜在应用,已显示出作为一种有前途的替代治疗策略的巨大潜力。然而,利用实验方法鉴定抗真菌肽既费时又费钱。因此,需要提出快速、准确的计算方法来识别 AFPs。本文介绍了一种新颖的多视角特征学习(MVFL)模型,称为 AFP-MVFL,利用多视角特征学习准确识别 AFP。通过整合氨基酸的序列和理化特性并采用多视角方法,AFP-MVFL 模型显著提高了预测准确率。其准确率、精确度、F1得分和马修斯相关系数(MCC)分别达到了97.9%、98.4%、0.98和0.96,优于之前的文献研究。
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引用次数: 0
Automated Recommendation of Aggregate Visualizations for Crowdfunding Data 为众筹数据自动推荐聚合可视化方法
IF 2.3 Q2 Mathematics Pub Date : 2024-06-06 DOI: 10.3390/a17060244
Mohamed A. Sharaf, Heba Helal, Nazar Zaki, Wadha Alketbi, Latifa Alkaabi, Sara Alshamsi, Fatmah Alhefeiti
Analyzing crowdfunding data has been the focus of many research efforts, where analysts typically explore this data to identify the main factors and characteristics of the lending process as well as to discover unique patterns and anomalies in loan distributions. However, the manual exploration and visualization of such data is clearly an ad hoc, time-consuming, and labor-intensive process. Hence, in this work, we propose LoanVis, which is an automated solution for discovering and recommending those valuable and insightful visualizations. LoanVis is a data-driven system that utilizes objective metrics to quantify the “interestingness” of a visualization and employs such metrics in the recommendation process. We demonstrate the effectiveness of LoanVis in analyzing and exploring different aspects of the Kiva crowdfunding dataset.
分析众筹数据一直是许多研究工作的重点,分析人员通常通过探索这些数据来确定借贷过程中的主要因素和特征,并发现贷款分布中的独特模式和异常现象。然而,对这些数据进行手动探索和可视化显然是一个临时、耗时和劳动密集型的过程。因此,在这项工作中,我们提出了 LoanVis,这是一种发现和推荐有价值、有洞察力的可视化数据的自动化解决方案。LoanVis 是一个数据驱动型系统,它利用客观指标来量化可视化的 "趣味性",并在推荐过程中使用这些指标。我们展示了 LoanVis 在分析和探索 Kiva 众筹数据集不同方面的有效性。
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引用次数: 0
A Non-Gradient and Non-Iterative Method for Mapping 3D Mesh Objects Based on a Summation of Dependent Random Values 基于相关随机值总和的非梯度、非迭代三维网格对象映射方法
IF 2.3 Q2 Mathematics Pub Date : 2024-06-06 DOI: 10.3390/a17060248
I. Volkau, Sergei Krasovskii, Abdul Mujeeb, Helen Balinsky
The manuscript presents a novel non-gradient and non-iterative method for mapping two 3D objects by matching extrema. This innovative approach utilizes the amplification of extrema through the summation of dependent random values, accompanied by a comprehensive explanation of the statistical background. The method further incorporates structural patterns based on spherical harmonic functions to calculate the rotation matrix, enabling the juxtaposition of the objects. Without utilizing gradients and iterations to improve the solution step by step, the proposed method generates a limited number of candidates, and the mapping (if it exists) is necessarily among the candidates. For instance, this method holds potential for object analysis and identification in additive manufacturing for 3D printing and protein matching.
手稿介绍了一种通过匹配极值来映射两个三维物体的非梯度、非迭代的新方法。这种创新方法通过对相关随机值的求和,利用极值的放大作用,并附有对统计背景的全面解释。该方法还结合了基于球谐函数的结构模式来计算旋转矩阵,从而实现物体的并置。由于没有利用梯度和迭代来逐步改进解法,所提出的方法只能生成有限数量的候选对象,而映射(如果存在的话)必然是候选对象中的一个。例如,这种方法可用于三维打印增材制造中的对象分析和识别以及蛋白质匹配。
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引用次数: 0
A Modified Analytic Hierarchy Process Suitable for Online Survey Preference Elicitation 适合在线调查偏好激发的改进型层次分析法
IF 2.3 Q2 Mathematics Pub Date : 2024-06-06 DOI: 10.3390/a17060245
Sean Pascoe, A. Farmery, Rachel Nichols, Sarah Lothian, Kamal Azmi
A key component of multi-criteria decision analysis is the estimation of criteria weights, reflecting the preference strength of different stakeholder groups related to different objectives. One common method is the Analytic Hierarchy Process (AHP). A key challenge with the AHP is the potential for inconsistency in responses, resulting in potentially unreliable preference weights. In small groups, interactions between analysts and respondents can compensate for this through reassessment of inconsistent responses. In many cases, however, stakeholders may be geographically dispersed, with online surveys being a more cost-effective means to elicit these preferences, making renegotiating with inconsistent respondents impossible. Further, the potentially large number of bivariate comparisons required using the AHP may adversely affect response rates. In this study, we test a new “modified” AHP (MAHP). The MAHP was designed to retain the key desirable features of the AHP but be more amenable to online surveys, reduce the problem of inconsistencies, and require substantially fewer comparisons. The MAHP is tested using three groups of university students through an online survey platform, along with a “traditional” AHP approach. The results indicate that the MAHP can provide statistically equivalent outcomes to the AHP but without problems arising due to inconsistencies.
多标准决策分析的一个关键组成部分是估算标准权重,以反映不同利益相关群体对不同目标的偏好程度。一种常用的方法是层次分析法(AHP)。AHP 面临的一个主要挑战是答复可能不一致,从而导致偏好权重可能不可靠。在小型小组中,分析人员与受访者之间的互动可以通过重新评估不一致的答复来弥补这一点。然而,在许多情况下,利益相关者可能分散在不同的地理位置,在线调查是一种更具成本效益的获取偏好的方式,因此不可能与不一致的受访者重新协商。此外,使用 AHP 可能需要进行大量的二元比较,这可能会对回复率产生不利影响。在本研究中,我们测试了一种新的 "修正 "AHP(MAHP)。MAHP 在设计上保留了 AHP 的主要理想特性,但更适合在线调查,减少了不一致性问题,并大大减少了所需的比较次数。MAHP 与 "传统 "AHP 方法通过在线调查平台对三组大学生进行了测试。结果表明,MAHP 可以提供与 AHP 相当的统计结果,但不会出现因不一致而产生的问题。
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引用次数: 0
Simulation of Calibrated Complex Synthetic Population Data with XGBoost 利用 XGBoost 模拟校准复杂合成种群数据
IF 2.3 Q2 Mathematics Pub Date : 2024-06-06 DOI: 10.3390/a17060249
J. Gussenbauer, M. Templ, Siro Fritzmann, A. Kowarik
Syntheticdata generation methods are used to transform the original data into privacy-compliant synthetic copies (twin data). With our proposed approach, synthetic data can be simulated in the same size as the input data or in any size, and in the case of finite populations, even the entire population can be simulated. The proposed XGBoost-based method is compared with known model-based approaches to generate synthetic data using a complex survey data set. The XGBoost method shows strong performance, especially with synthetic categorical variables, and outperforms other tested methods. Furthermore, the structure and relationship between variables are well preserved. The tuning of the parameters is performed automatically by a modified k-fold cross-validation. If exact population margins are known, e.g., cross-tabulated population counts on age class, gender and region, the synthetic data must be calibrated to those known population margins. For this purpose, we have implemented a simulated annealing algorithm that is able to use multiple population margins simultaneously to post-calibrate a synthetic population. The algorithm is, thus, able to calibrate simulated population data containing cluster and individual information, e.g., about persons in households, at both person and household level. Furthermore, the algorithm is efficiently implemented so that the adjustment of populations with many millions or more persons is possible.
合成数据生成方法用于将原始数据转化为符合隐私要求的合成副本(孪生数据)。利用我们提出的方法,可以模拟与输入数据相同大小或任意大小的合成数据,在有限群体的情况下,甚至可以模拟整个群体。在使用复杂的调查数据集生成合成数据时,将所提出的基于 XGBoost 的方法与已知的基于模型的方法进行了比较。XGBoost 方法表现出很强的性能,尤其是在合成分类变量方面,优于其他测试方法。此外,变量之间的结构和关系也得到了很好的保留。参数的调整是通过改进的 k 倍交叉验证自动完成的。如果已知确切的人口边际值,例如年龄组、性别和地区的交叉表人口计数,则必须根据这些已知的人口边际值对合成数据进行校准。为此,我们采用了一种模拟退火算法,能够同时使用多个种群边际值对合成种群进行后校准。因此,该算法能够校准包含群组和个体信息的模拟人口数据,例如在个人和家庭层面上校准家庭中的人员信息。此外,该算法的实施效率很高,因此可以对数百万或更多人口进行调整。
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引用次数: 0
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Algorithms
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