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Why wait for DTP-E-IPV? 为什么要等待DTP-E-IPV?
Pub Date : 1989-09-01 DOI: 10.1001/ARCHPEDI.1989.02150210031012
E. Marcuse
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引用次数: 4
Clear heads and bayesian tales: predictive value and the coin toss? 清醒的头脑和贝叶斯故事:预测价值和抛硬币?
Pub Date : 1989-09-01 DOI: 10.1001/archpedi.1989.02150210017009
R. D. Mauro
In Reply .—Dr Mauro's remarks would be very pertinent if we had suggested in our reply that platelet antibodies should be detected as part of a screening program of ITP in the general population . This is not so, however. Such a screening test would be unjustifiable, not only because of its immense costs, but mainly because it would offer no therapeutic or preventive advantage to the patients detected in this manner, as compared with those whose thrombocytopenia has been discovered, as is usually the case, on clinical grounds. Thus, the controversy regarding the utility of platelet antibody testing is limited to the population of patients with thrombocytopenia and cannot be extrapolated to the general population. In this setting, our statement on "coin flipping" remains correct. Platelet antibody testing has a positive predictive value for ITP of 50%. In other words, the probability for a patient with thrombocytopenia of having ITP if the
如果我们在答复中建议将血小板抗体检测作为一般人群ITP筛查计划的一部分,Mauro博士的评论将非常相关。然而,事实并非如此。这样的筛查试验是不合理的,不仅因为其巨大的成本,而且主要是因为与那些在临床基础上发现血小板减少症的患者相比,它不会为以这种方式检测到的患者提供治疗或预防方面的优势。因此,关于血小板抗体检测效用的争议仅限于血小板减少症患者群体,而不能外推到一般人群。在这种情况下,我们关于“抛硬币”的说法仍然是正确的。血小板抗体检测对ITP的阳性预测值为50%。换句话说,血小板减少症患者发生ITP的概率
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引用次数: 0
Computers in medicine. Augmenting medical care in pediatric patients with chronic illnesses. 医学中的计算机。加强对患有慢性疾病的儿科患者的医疗护理。
Pub Date : 1989-09-01 DOI: 10.1001/ARCHPEDI.1989.02150210047016
E. Handler
The use of computers to aid care for chronically ill pediatric patients is a relatively new concept. We are currently using Filemaker II software and a Macintosh Plus computer to augment overall patient care in children with chronic diseases, such as spina bifida, cerebral palsy, neuromuscular diseases, head injury, and spinal cord injury. This is a computerized medical record with a clinical database for dissemination of information to multidisciplinary team members, generating letters to private health care providers, displaying telephone messages, and assisting inpatient care. Advances in computer technology will provide future applications to aid health care providers in caring for patients with chronic illnesses.
使用电脑来辅助慢性儿科病人的护理是一个相对较新的概念。我们目前正在使用Filemaker II软件和Macintosh Plus计算机来增强对患有慢性疾病(如脊柱裂、脑瘫、神经肌肉疾病、头部损伤和脊髓损伤)的儿童的整体患者护理。这是一个带有临床数据库的计算机化医疗记录,用于向多学科团队成员传播信息,生成给私人医疗保健提供者的信件,显示电话信息,并协助住院治疗。计算机技术的进步将提供未来的应用,以帮助卫生保健提供者照顾慢性病患者。
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引用次数: 4
Gastroesophageal reflux-induced hypoxemia in infants with apparent life-threatening event(s). 有明显危及生命事件的婴儿胃食管反流引起的低氧血症
Pub Date : 1989-08-01 DOI: 10.1001/ARCHPEDI.1989.02150200111028
Cynthia C. See, L. Newman, S. Berezin, M. Glassman, M. Medow, A. Dozor, S. Schwarz
To evaluate relationships between gastroesophageal reflux (GER) and the development and onset of apparent life-threatening event(s) (ALTE), 16 infants presenting with ALTE and 6 control subjects manifesting clinical GER alone were studied using prolonged, esophageal pH monitoring in conjunction with simultaneous pulse oximetry and transthoracic impedance pneumocardiography. Despite the absence of a clinical vomiting history in 14 of 16 patients with ALTE, the incidence of GER was similar in both groups (patients with ALTE vs control subjects, 95% vs 100%). Significant arterial oxygen desaturation (less than 90% for greater than 3 minutes) was monitored during 60 episodes in 14 of 16 infants with ALTE, compared with no episodes of reduced arterial oxygen saturation in control subjects. Fifty-four of 60 of these desaturation events commenced within 3.9 +/- 0.4 minutes (mean +/- SD) of onset of a drop in esophageal pH to less than 4.0. Linear regression analysis indicates a significant correlation between duration of esophageal acidification and length of individual hypoxemic episodes (r = .39). Pneumocardiograms were normal in all patients. These data suggest that unsuspected GER is common in infants presenting with ALTE and, in these patients, GER may be directly associated with reflex hypoxemic episodes. Prolonged intraesophageal pH monitoring, performed simultaneously with evaluation for apnea, should be considered in all infants presenting with ALTE.
为了评估胃食管反流(GER)与明显危及生命事件(ALTE)的发生和发展之间的关系,我们对16名表现为ALTE的婴儿和6名单纯表现为临床GER的对照组进行了研究,采用长时间食管pH监测,同时进行脉搏血氧测定和经胸阻抗肺心动图。尽管16例ALTE患者中有14例没有临床呕吐史,但两组患者的GER发生率相似(ALTE患者与对照组,95% vs 100%)。16例ALTE患儿中有14例在60次发作中监测到明显的动脉血氧饱和度降低(低于90%,持续时间大于3分钟),而对照组没有出现动脉血氧饱和度降低。60例去饱和事件中有54例发生在食道pH降至4.0以下的3.9 +/- 0.4分钟内(平均+/- SD)。线性回归分析显示,食管酸化持续时间与个体低氧血症发作时间之间存在显著相关性(r = 0.39)。所有患者的肺心动图均正常。这些数据表明,未预料到的GER在ALTE患儿中很常见,在这些患者中,GER可能与反射性低氧血症发作直接相关。所有ALTE患儿均应考虑延长食管内pH监测时间,并与呼吸暂停评估同时进行。
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引用次数: 40
Chronic sinusitis. The disease of all ages. 慢性鼻窦炎。老少皆宜的疾病。
Pub Date : 1989-08-01 DOI: 10.1001/ARCHPEDI.1989.02150200030013
G. Rachelefsky
Sinusitis is one of the most frequently overlooked and poorly understood diseases of childhood. There is a lack of information regarding criteria for diagnosis and the most effective method of management of sinusiSee also p 938. tis in children. Controversy exists regarding whether a sinus cavity is infected, how to diagnose sinusitis, and what the best treatment choice and duration is. The article by Tinkelman and Silk 1 in this issue of AJDC has prompted this editorial to bring the pediatrician up to date regarding these issues. I will limit my remarks to chronic sinusitis, that is, compatible symptoms that have been present for at least 3 weeks. (Some experts in the field would shorten this time to 10 days. 2,3 ) The nasal sinuses are four paired structures: the maxillary, ethmoidal, sphenoidal, and frontal sinuses that develop as evaginations of the mucous membranes of the nasal meatuses. The origin of
鼻窦炎是儿童最常被忽视和理解不足的疾病之一。关于鼻窦炎的诊断标准和最有效的治疗方法缺乏相关信息(参见938页)。这发生在儿童身上。关于鼻窦腔是否感染,如何诊断鼻窦炎,以及最佳治疗选择和持续时间存在争议。Tinkelman和Silk在本期AJDC上的文章促使这篇社论向儿科医生介绍这些问题的最新情况。我将限制我的言论慢性鼻窦炎,即相容的症状已经存在至少3周。(该领域的一些专家会把这个时间缩短到10天。2,3)鼻窦是四个成对的结构:上颌窦、筛窦、蝶窦和额窦,它们是鼻腔粘膜外翻形成的。的起源
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引用次数: 11
Adolescents and condoms. Associations of beliefs with intentions to use. 青少年和避孕套。信念与使用意图的联系。
Pub Date : 1989-08-01 DOI: 10.1001/ARCHPEDI.1989.02150200063019
Susan M. Kegeles, Nancy E. Adler, Charles E. Irwin
Sexually active adolescents should use condoms to prevent the transmission of sexually transmitted diseases, including human immunodeficiency virus. This study examined, among male and female adolescents, which beliefs about condoms are associated with intentions to use them if they have coitus in the next year. Teenagers attending adolescent health clinics completed self-administered surveys. Although most adolescents knew that condoms prevent sexually transmitted diseases, an increasing belief in the preventive effects of condoms was not associated with an increased motivation to use them. Instead, other immediate, short-term consequences, such as the ease with which they can be used and discomfort associated with their use, were most strongly associated with adolescents' intentions to use condoms. To encourage condom use, messages from physicians and other health care professionals must focus on adolescents' beliefs that are most likely to encourage or inhibit use of condoms. Health considerations should not be the sole emphasis of such communications if the goal is to increase the use of condoms among sexually active adolescents.
性活跃的青少年应使用避孕套,以防止性传播疾病的传播,包括人体免疫缺陷病毒。这项研究调查了男性和女性青少年,他们对避孕套的看法与明年性交时使用避孕套的意图有关。参加青少年健康诊所的青少年完成了自我管理的调查。虽然大多数青少年知道避孕套可以预防性传播疾病,但对避孕套预防作用的日益信任与使用避孕套的动机的增加并没有联系。相反,其他直接的、短期的后果,比如使用避孕套的方便性和使用过程中的不适,与青少年使用避孕套的意图有着最强烈的联系。为了鼓励使用避孕套,来自医生和其他卫生保健专业人员的信息必须集中在青少年最有可能鼓励或禁止使用避孕套的信念上。如果目的是在性活跃的青少年中增加避孕套的使用,就不应该把健康考虑作为这种宣传的唯一重点。
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引用次数: 97
Campylobacter pylori gastritis and peptic ulcer in children. 儿童幽门螺杆菌性胃炎和消化性溃疡。
Pub Date : 1989-08-01 DOI: 10.1001/ARCHPEDI.1989.02150200014004
B. Dahms, S. Czinn, P. Kilbridge
In Reply. —Chiesa et al and Oderda et al agree with us regarding the high prevalence of CP infection and its relationship to antral gastritis and duodenal ulcer. The highly effective results of antimicrobial therapy reported by Chiesa et al are interesting. To date, we have en unsuccessful in eradicating CP with amoxicillin monotherapy. Our results are in agreement with recently reported adult studies by Rauws et al, 1 as well as pediatric studies by De Giacomo et al. 2 The latter group had no success in eradicating CP or improving the underlying gastritis in their pediatric patients. The experience cited above by Oderda et al also indicates failure to achieve permanent eradication of the organism with ampicillin. We look forward to the publication of the study done by Chiesa et al. Perhaps we may be able to determine why we and others have not been successful in our efforts to eradicate
在回答。-Chiesa et al和Oderda et al同意我们关于CP感染高发及其与胃窦性胃炎和十二指肠溃疡的关系的观点。Chiesa等人报道的抗菌治疗的高效结果是有趣的。到目前为止,我们用阿莫西林单药治疗已经成功根除了CP。我们的研究结果与最近报道的Rauws等人的成人研究1以及De Giacomo等人的儿科研究一致。后一组在根除CP或改善其儿科患者的潜在胃炎方面没有成功。Oderda等人引用的上述经验也表明氨苄西林无法永久根除该菌。我们期待Chiesa等人的研究成果发表。也许我们可以确定为什么我们和其他人在根除疟疾的努力中没有成功
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引用次数: 0
Neurofibromatosis type 1 (Recklinghausen's disease). Neurologic and cognitive assessment with sibling controls. 1型神经纤维瘤病(雷克林豪森病)。兄弟姐妹对照的神经和认知评估。
Pub Date : 1989-07-01 DOI: 10.1001/ARCHPEDI.1989.02150190083027
R. Eldridge, Martha Bridge Denckla, Ellen Bien, Susan E. Myers, Muriel I. Kaiser-Kupfer, A. Pikus, Sandra Schlesinger, D. M. Parry, James M. Dambrosia, Michael Zasloff, John J. Mulvihill
Neurologic and cognitive function in neurofibromatosis type 1 (NF1) were assessed in a controlled pilot study of 13 pairs of siblings aged 6 to 27 years. One subject in each pair was affected with NF1, and the other, the control subject, was unaffected. Subjects with evidence of focal central nervous system disease were excluded. The 13 subjects with NF1 had no excess of mental retardation, attention-deficit disorder, or specific learning disorders (using Wilcoxon's Signed Rank Test and McNemar's Test for Symmetry). These subjects, however, had significantly higher scores for subtle neurologic abnormalities (21 vs 6) and significantly lower full-scale IQ scores (94 vs 105) than their unaffected siblings. The IQ scores of the affected subjects were not clustered at the lower end of the scale but showed a slight downward shift in distribution compared with those of their siblings. In addition, a visual-spatial orientation deficit was present in eight of nine affected subjects so evaluated. The findings suggest that subjects with NF1 have a widespread alteration of the brain during development that manifests as one or more specific types of neuropsychologic deficits.
1型神经纤维瘤病(NF1)的神经和认知功能在一项对照试验中进行了评估,研究对象是13对6至27岁的兄弟姐妹。每对中有一名受试者受到NF1的影响,而另一名对照受试者则未受影响。排除有局灶性中枢神经系统疾病证据的受试者。13名患有NF1的受试者没有过度的智力迟钝、注意力缺陷障碍或特殊学习障碍(使用Wilcoxon's Signed Rank检验和McNemar's Test for Symmetry)。然而,与未受影响的兄弟姐妹相比,这些受试者在细微神经异常方面的得分明显较高(21比6),而全面智商得分明显较低(94比105)。受影响的受试者的智商分数并没有集中在量表的低端,但与他们的兄弟姐妹相比,在分布上有轻微的下降。此外,在接受评估的9名受影响的受试者中,有8人存在视觉空间定向缺陷。研究结果表明,患有NF1的受试者在发育过程中大脑有广泛的改变,表现为一种或多种特定类型的神经心理缺陷。
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引用次数: 93
Does a residents' continuity clinic provide primary care? 居民连续性诊所提供初级保健吗?
Pub Date : 1989-07-01 DOI: 10.1001/ARCHPEDI.1989.02150190059021
M. E. Wilson, J. Weiner, J. Bender, S. Bergstrom, B. Starfield
Pediatric residents are required to care for a group of children over a period of time. For many, this "continuity" experience is in a hospital outpatient department that may or may not provide primary care. We applied a measure of primary care to the Primary Care Clinic, the continuity clinic at The Johns Hopkins Hospital, Baltimore, Md, and found that it compared favorably with private pediatric practices in the Baltimore area, providing significantly more "principal care" (93% vs. 84.5% of encounters), and to the Harris Lane Home walk-in clinic, where only 51% of encounters were "principal care". The Primary Care Clinic scored higher on a primary care index, a measure of the extent to which the facility serves as a primary care source for patients, suggesting that hospital-based training can provide residents with an opportunity to provide primary care.
儿科住院医师需要在一段时间内照顾一组儿童。对许多人来说,这种“连续性”的经历是在医院门诊部,可能提供也可能不提供初级保健。我们对初级保健诊所,马里兰州巴尔的摩市约翰霍普金斯医院的连续性诊所进行了初级保健测量,发现与巴尔的摩地区的私人儿科诊所相比,它提供了更多的“主要护理”(93%对84.5%),而哈里斯巷家庭免预约诊所只有51%的就诊是“主要护理”。初级保健诊所在初级保健指数上得分较高,初级保健指数是衡量该机构作为患者初级保健来源的程度的指标,这表明以医院为基础的培训可以为住院医生提供提供初级保健的机会。
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引用次数: 10
Adolescence. What is normal? 青春期。什么是正常的?
Pub Date : 1989-06-01 DOI: 10.1001/ARCHPEDI.1989.02150180113031
D. Offer, E. Ostrov, K. I. Howard
We present in some detail what constitutes normal behavior, or mental health, among teenagers. Our data are based on the results of a specially devised psychological questionnaire by one of us (D.O.). This questionnaire has been shown to reliably distinguish mentally healthy from psychiatrically disturbed populations. Results are presented across three decades (1960s, 1970s, and 1980s), across genders, and across the high school years. A conceptual framework is presented to help the clinician working with adolescents to understand the fluctuation in psychopathology among youth. Adolescent density in the total population is shown to be a significant factor in determining the rate of disturbance among teenagers. Our research findings demonstrate that the rate of behavioral disturbance among adolescents is the same as in other parts of the life cycle. The clinician working with adolescents tends to underestimate the severity of adolescent problems because of the near-universal belief that all adolescents undergo "adolescent turmoil." We have found that adolescents who are experiencing turmoil need professional help.
我们详细介绍了青少年的正常行为或心理健康的构成。我们的数据是基于我们其中一人(D.O.)特别设计的心理问卷的结果。该问卷已被证明能够可靠地区分精神健康人群和精神紊乱人群。研究结果跨越三十年(1960年代、1970年代和1980年代),跨越性别,跨越高中阶段。提出了一个概念框架,以帮助临床医生与青少年工作,以了解在青少年的精神病理波动。青少年在总人口中的密度被证明是决定青少年骚扰率的一个重要因素。我们的研究结果表明,青少年的行为障碍率与生命周期的其他部分相同。与青少年打交道的临床医生往往低估了青少年问题的严重性,因为人们普遍认为所有的青少年都会经历“青春期动荡”。我们发现正在经历混乱的青少年需要专业帮助。
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引用次数: 46
期刊
American journal of diseases of children
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