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Sensitivity and Specificity of Magnetic Resonance Cholangiopancreatography against Endoscopic Retrograde Cholangiopancreatography in Diagnosing Choledocholithiasis 磁共振胆管造影对内镜逆行胆管造影诊断胆总管结石的敏感性和特异性
Pub Date : 2022-08-23 DOI: 10.47672/ajhmn.1156
Rija Shahid, Sana Fatima, Talia Ahmed, Eiraj Khan, Bakhtawar Mir, Muhammad Arslan Mughal, Tayyab Khan
Background: Various imaging modalities including EUS (Endoscopic ultrasound), CT abdomen (Computed tomography), MRCP (Magnetic resonance cholangiopancreatography), and ERCP (Endoscopic retrograde cholangiopancreatography) are used for diagnosis of choledocholithiasis. ERCP allows direct visualization of bile duct through endoscope, and it also helps in retrieval of stones. On the other hand, MRCP is a noninvasive procedure which uses strong magnetic field to visualize hepatobiliary system. In patients with choledocholithiasis calculi appear as dark filling defects within high signal intensity fluid at MRCP. This study compares the diagnostic accuracy of MRCP in comparison to ERCP in patients with choledocholithiasis. This study aims to compare sensitivity and specificity of MRCP in comparison to ERCP in diagnosing choledocholithiasis. Methodology: This comparative cross-sectional study included 170 patients with clinical diagnosis of choledocholithiasis who presented in Liver Center, Holy Family Hospital, Rawalpindi, during the year 2017. Non-probability consecutive sampling technique and a set of established inclusion and exclusion criteria was used to enroll patients. Data was collected by a self-structured questionnaire. Information about the demographic details and findings of ERCP and MRCP were noted on that questionnaire. Data analysis was done using SPSS 25. Results: Out of 170 patients, 111 (65.29%) were females and 59 (34.71%) were males. The mean of age for study population was 45.68 with standard deviation (SD) of ±12.40. ERCP confirmed stones in 95 patients while in case of MRCP 87 true positives, 55 true negatives, 20 false positives, and 8 false negatives cases were noted. According to these results, the sensitivity and specificity were 91.6% and 73.3% respectively for MRCP against ERCP. Whereas positive predictive value and negative predictive values were 81.3 and 87.3% respectively for MRCP in comparison to ERCP. Conclusion: MRCP has 91.6% sensitivity compared to ERCP. Although MRCP is a comparatively noninvasive procedure, but ERCP remains the diagnostic modality of choice for choledocholithiasis. MRCP could be used in diagnosis of choledocholithiasis instead of ERCP when there are contraindications of ERCP or when no therapeutic role of ERCP is required. Recommendations: MRCP should be used when only diagnostic role of ERCP is needed. MRCP should be used when there are contraindications of ERCP. Level of expertise should be increased for MRCP and ERCP.
背景:超声内镜(EUS)、腹部CT(计算机断层扫描)、磁共振胰胆管造影(MRCP)、逆行胰胆管造影(ERCP)等多种影像学手段用于诊断胆总管结石。ERCP可以通过内窥镜直接看到胆管,也有助于取出结石。另一方面,MRCP是一种利用强磁场可视化肝胆系统的无创手术。胆管结石患者在MRCP上表现为高信号强度液体中的深色充盈缺陷。本研究比较了MRCP与ERCP对胆总管结石患者的诊断准确性。本研究旨在比较MRCP与ERCP诊断胆总管结石的敏感性和特异性。方法:这项比较横断面研究纳入了2017年在拉瓦尔品第神圣家庭医院肝脏中心就诊的170例临床诊断为胆总管结石的患者。采用非概率连续抽样技术和一套既定的纳入和排除标准纳入患者。数据通过自结构化问卷收集。有关ERCP和MRCP的人口统计细节和结果的信息已在该问卷上注明。数据分析采用SPSS 25软件。结果:170例患者中,女性111例(65.29%),男性59例(34.71%)。研究人群的平均年龄为45.68岁,标准差为±12.40。ERCP确诊结石95例,MRCP真阳性87例,真阴性55例,假阳性20例,假阴性8例。结果表明,MRCP对ERCP的敏感性为91.6%,特异性为73.3%。与ERCP相比,MRCP阳性预测值为81.3%,阴性预测值为87.3%。结论:与ERCP相比,MRCP的敏感性为91.6%。虽然MRCP是一种相对无创的手术,但ERCP仍然是胆总管结石的首选诊断方式。当有ERCP禁忌或不需要ERCP治疗作用时,MRCP可替代ERCP诊断胆总管结石。建议:当仅需要ERCP的诊断作用时,应使用MRCP。MRCP应在有ERCP禁忌症时使用。应提高MRCP和ERCP的专业知识水平。
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引用次数: 0
Characteristic of Paracetamol Overdose Before and During COVID-19 Pandemic, Saudi Arabia, 2019-2020 2019-2020年沙特阿拉伯COVID-19大流行前和期间扑热息痛过量的特征
Pub Date : 2022-08-06 DOI: 10.47672/ajhmn.1145
R. Saqah, Jaber Sharaheeli, Lamman Abdulkareem
Purpose: Paracetamol is the most used medication worldwide; due to its analgesic and antipyretic effect; it had been included within the recommended regimen for COVID-19 patients. This study aimed at exploring the changes in the incidence of paracetamol overdose during pandemic compared to pre-pandemic periods. Methodology: Through a record-based study, all cases of paracetamol overdose who had been reported to the ministry of health in Saudi Arabia in the period between January 2019 and December 2020 were included in the study. Data stored in electronic form were retrieved and analyzed using SPSS version 26. Frequency distribution was used to describe categorical variables. Findings: Two hundred and forty four paracetamol overdose cases were reported in 2020 (during the pandemic) compared to 449 in 2019 (pre-pandemic) with dominance of females (62.6%) and Saudis (86.7%). Most cases ingested paracetamol orally mainly in solid forms (76.5%), and they were mostly diagnosed as confirmed cases on admission (84.6%). The great majority recovered and discharged (87.8%). The overall annual incidence of paracetamol in (pre-pandemic) was 1.32/100,000 which dropped markedly during pandemic to 0.71/100,000. Conclusion: There was a general decline in the incidence of paracetamol overdose during COVID-19 pandemic, with relative increase in incidence in home incidents and in children. Recommendation: Health education to the public to increase their awareness about proper and safe use of paracetamol is highly recommended, as well as introducing instructions and guidelines for practitioners about prescribing it.
目的:扑热息痛是世界上使用最多的药物;由于其镇痛解热作用;它已被纳入COVID-19患者的推荐方案。本研究旨在探讨与大流行前相比,大流行期间扑热息痛过量发生率的变化。方法:通过一项基于记录的研究,将2019年1月至2020年12月期间向沙特阿拉伯卫生部报告的所有扑热息痛过量病例纳入研究。以电子形式存储的数据使用SPSS 26进行检索和分析。使用频率分布来描述分类变量。研究结果:2020年(大流行期间)报告了224例扑热息痛过量病例,而2019年(大流行前)报告了449例,其中女性(62.6%)和沙特阿拉伯人(86.7%)占主导地位。大多数病例以口服扑热息痛固体摄入为主(76.5%),入院时确诊病例多(84.6%)。绝大多数恢复出院(87.8%)。对乙酰氨基酚(大流行前)的总年发病率为1.32/100,000,在大流行期间显著下降至0.71/100,000。结论:2019冠状病毒病疫情期间扑热息痛用药过量发生率总体呈下降趋势,家庭和儿童用药过量发生率相对上升。建议:强烈建议向公众进行健康教育,以提高他们对正确和安全使用扑热息痛的认识,并向开业医生介绍有关开处方的说明和指南。
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引用次数: 0
Characteristic of Clorox Poisoning before and during COVID-19 Pandemic, Saudi Arabia, 2019-2020. 2019-2020年沙特阿拉伯COVID-19大流行前后高乐氏中毒特征
Pub Date : 2022-08-06 DOI: 10.47672/ajhmn.1146
Hamoud Marzuq Alrougi, Jaber Sharaheeli
Purpose: Poisoning is one of the leading causes of morbidities and mortalities worldwide. Due to COVID-19 pandemic, there was a dramatic increase in the use of detergents and disinfectants, both in health care and domestic settings. As Clorox is the most used for these purposes; it was expected that there would be changes in the characteristics of Clorox poisoning. Therefore, the current study aimed to investigate characteristics of Clorox poisoning in Saudi Arabia during Covid-19 pandemic compared to the pre-pandemic period. Methodology: Through a record-based study; all Clorox poisoning cases reported to the ministry of health in 2019 (n=267) representing pre-pandemic and 2020 (n=198) representing during the pandemic periods were collected. The data were retrieved from the electronic database, and it was analyzed using SPSS version 26. Categorical variables are represented as frequency distribution. Finding: There was a decrease in the total number of reported Clorox poisoning cases from 267 pre-pandemic to 198 cases during the pandemic. Females were slightly more than males (55.7% vs 44.3%), and most of the cases were in the age groups (1-5 years) and (20-39 years) (27.3%). The overwhelming majority of the cases occurred at home) (96.3%), with a higher percentage during the pandemic than pre-pandemic (98.0% vs 95.1%), and few minorities occurred intentionally (9.3%). Most of the cases arrived the hospital in stable conditions, with few cases (17.0%) needed antidotes. The great majority of the cases recovered before discharge. The overall incidence of Clorox poisoning reached to 0.57/100,000 population during the pandemic, compared to 0.78/100,000 in the pre-pandemic. Conclusion: There was a decline in incidence of Clorox poisoning during the pandemic; with a relative increase in home incidents, with nausea and vomiting as most common symptoms and all cases recovered. Recommendation: It is highly recommended to plan for a health education messages about safe store and using of detergents and disinfectants.
目的:中毒是全世界发病率和死亡率的主要原因之一。由于2019冠状病毒病大流行,在卫生保健和家庭环境中,洗涤剂和消毒剂的使用急剧增加。因为高乐氏是用于这些目的最多的;预计高乐氏中毒的特征会发生变化。因此,本研究旨在调查2019冠状病毒病大流行期间沙特阿拉伯高乐氏中毒与大流行前相比的特征。方法:通过基于记录的研究;收集了2019年(n=267)代表大流行前和2020年(n=198)代表大流行期间向卫生部报告的所有高乐氏中毒病例。数据从电子数据库中检索,并使用SPSS version 26进行分析。分类变量用频率分布表示。发现:报告的高乐氏中毒病例总数从大流行前的267例减少到大流行期间的198例。女性略多于男性(55.7%比44.3%),以1 ~ 5岁和20 ~ 39岁年龄组(27.3%)居多。绝大多数病例发生在家中(96.3%),大流行期间的百分比高于大流行前(98.0%对95.1%),少数人为发生(9.3%)。大多数病例到达医院时病情稳定,需要解毒剂的病例很少(17.0%)。绝大多数病例在出院前就康复了。在大流行期间,高乐氏中毒的总发病率达到0.57/10万人,而大流行前为0.78/10万人。结论:大流行期间高乐氏中毒发生率有所下降;随着家庭事件的相对增加,恶心和呕吐是最常见的症状,所有病例都康复了。建议:强烈建议计划关于安全储存和使用洗涤剂和消毒剂的健康教育信息。
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引用次数: 0
Prevalence of Malnutrition among Patients with Type-2 Diabetes Mellitus in Tertiary Care Hospital in Pakistan 巴基斯坦三级医院2型糖尿病患者营养不良患病率
Pub Date : 2022-07-26 DOI: 10.47672/ajhmn.1132
Ibrar Ahmad, Hoor Maab Kaifi, Fahim Ullah, Adan Javed, H. Tahir, M. Rahman
Purpose: To figure out the prevalence of malnutrition among patients with Type-2 Diabetes Mellitus (T2DM) in tertiary care hospital Methodology: The study adopted a cross-sectional study.  The study took place in Endocrine and Medicine Departments of Lady Reading Hospital, Peshawar, Pakistan from September 2019 to March 2020. A total number of 259 patients of T2DM were screened for screened for nutritional assessment with the help of nurse and supporting staff. The data was recorded with the help of question are and Subjective Global Assessment form (SGA). The nutritional risk parameters and malnutrition status was figured out and the data collected was statistically analyzed with the help of MS Excel and SPSS 22.0. Findings: The results of the current findings revealed that 123 patients out of 259 were at moderate risk of malnutrition, while 136 patients were highly at malnutrition risk. Similarly, 162 patients were sorted out to have the status of moderate malnutrition while 97 patients were severely mal-nourished. Among various categories of BMI the highest frequency has been shown by Obese Class-I with highest risk malnutrition risk and severe malnourished frequency. The Correlation Coefficient R2 value of 0.923. The Chi-Square value of 187.69 and p-value (1.214e-38) nullifies the Null hypothesis. Conclusion: Based on the findings of this study, it may be concluded that a wholesome ratio of T2DM are at nutritional risk or having the status of malnutrition in hospitalized patients. Secondly, it may also be inferred that the largest number of T2DM could be assumed at Obese Class-I of BMI distribution.
目的:了解三级医院2型糖尿病(T2DM)患者营养不良的患病率。该研究于2019年9月至2020年3月在巴基斯坦白沙瓦雷丁夫人医院的内分泌和医学系进行。在护士和辅助人员的帮助下,对259例T2DM患者进行了营养评估筛查。数据采用问卷和主观总体评估表(SGA)进行记录。计算营养风险参数和营养不良状况,并利用MS Excel和SPSS 22.0软件对收集到的数据进行统计分析。研究结果:目前的研究结果显示,259名患者中有123名处于中度营养不良风险,而136名患者处于高度营养不良风险。同样,162例患者为中度营养不良,97例患者为重度营养不良。在BMI的各个类别中,肥胖i类的发病率最高,营养不良风险最高,严重营养不良发生率最高。相关系数R2值为0.923。卡方值为187.69,p值为1.214e-38,证明原假设无效。结论:根据本研究结果,T2DM住院患者中存在营养风险或处于营养不良状态的比例较高。其次,也可以推断,在BMI分布的肥胖i类中,T2DM人数最多。
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引用次数: 0
The Influence of Staffs’ Knowledge on Preparedness of Catholic Mission Hospitals for Health Service Delivery during Emergency Inflow of Patients in Nairobi County, Kenya 肯尼亚奈洛比县天主教会医院医护人员知识对急诊病人入院时卫生服务准备的影响
Pub Date : 2022-07-21 DOI: 10.47672/ajhmn.1131
Petronella Mueni Kiteng’u, Lillian Muiruri, Oluoch Musa
Purpose: To determine the influence of staffs’ knowledge on preparedness of catholic mission hospitals for health service delivery during emergency inflow of patients in Nairobi County, Kenya. Methodology: A cross sectional descriptive study design was used with quantitative approach for data collection and analysis. Four tier-3 Catholic Mission Hospitals were purposively selected and a stratified random sample of 647 members of staff from different cadres was taken. A structured questionnaire was used to collect data. Data was analyzed using STATA software v.16, where descriptive statistics were presented using frequencies and percentages whereas inferential statistics were presented using correlation and regression analysis. Findings: The study found out that staff training and exercises for knowledge and skills influenced preparedness of Catholic Mission Hospitals for health service delivery during emergency influx of patients. A positive and significant relationship was found at (r=0.211; p<0.01). This means that the hospitals are perceived as prepared for health service delivery during emergency influx of patients. However, staff drills (staff exercises) at (r = -0.147; p<0.05) were found insignificantly influencing services delivery. This means that the hospitals would be unprepared even if staff drills were in place. Recommendations: The study recommends that the managers of catholic hospitals should have scheduled staff trainings and drills for efficient and timely response in times of need for emergency service deliver. Policy guidelines on skills acquisition for the staff in the health institutions need to be developed to guide the trainings and frequent drills to sharpen the theory and practice of the healthcare team.
目的:了解工作人员知识对肯尼亚内罗毕县天主教会医院在急诊病人流入期间提供保健服务的准备工作的影响。方法:采用横断面描述性研究设计,采用定量方法进行数据收集和分析。有目的地选择4所三级天主教会医院,分层随机抽样647名不同干部的工作人员。采用结构化问卷收集数据。使用STATA软件v.16分析数据,其中描述性统计使用频率和百分比表示,而推断统计使用相关性和回归分析表示。研究结果:研究发现,工作人员的培训和知识技能练习影响了天主教会医院在病人紧急涌入期间提供保健服务的准备工作。两者之间存在显著正相关(r=0.211;p < 0.01)。这意味着,人们认为医院已做好准备,可以在病人紧急涌入时提供保健服务。然而,员工演练(staff exercises)在(r = -0.147;P <0.05)对服务提供无显著影响。这意味着,即使有人员演练,医院也会毫无准备。建议:该研究建议,天主教医院的管理人员应安排工作人员培训和演习,以便在需要提供紧急服务时作出有效和及时的反应。需要制定卫生机构工作人员获得技能的政策指导方针,以指导培训和频繁的演习,以提高卫生保健团队的理论和实践。
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引用次数: 0
Factors Influencing the Use of Oral Rehydration Solution among Mothers of Under Five Children Attending Holy Rosary Specialist Hospital and Maternity Waterside In Onitsha North Lga, Anambra State. 影响阿南布拉州奥尼沙北Lga圣玫瑰专科医院和产科水边五岁以下儿童母亲使用口服补液的因素。
Pub Date : 2022-06-30 DOI: 10.47672/ajhmn.1095
Esther A Silas, C. Nwankwo, A. Afonne, Ogochukwu T Obionwu, A. M. Ibekwe
Purpose: This study determined factors influencing the use of oral rehydration solution among mothers with children below five years of age attending Holy Rosary Specialist Hospital and Maternity Waterside in Onitsha North LGA, Anambra State. Methodology: A cross-sectional descriptive design was adopted in conducting the study among mothers with children under five years attending Rosary Specialist Hospital and Maternity, Waterside in Onitsha North Local Government Area, Anambra State. A sample size of one hundred and fifty (150) women was selected by convenience sampling techniques. A self-structured questionnaire with a reliability coefficient of 0.98 was used in gathering the necessary data suitable for the study which were analysed with SPSS version 20.0. Findings: It was discovered that majority of the women 141(94.6%) have heard of ORS and they have adequate understanding of the solution, the two different types of oral rehydration solutions (that is solution from oral rehydration salt and salt sugar solution) but do not use SSS hence lack adequate knowledge of its preparation. Also, the mothers 116(95.9%) used ORS when their children had diarrhoea while the remaining 5(4.1%) did not use ORS because their children never had diarrhoea. 65(43.6%) of the women have all the materials needed for the preparation of SSS while 70(47.0%) which were the majority did not know the materials required for the preparation of ORS hence they could not indicate if they had the materials or not. From the hypothesis tested, there is a significant relationship between mothers’ level of education (p=0.030), mother’s occupation (p=0.024), number of under five children (p=0.045) and the use of ORS. From the study, it was ascertained that socio-demographic factors like mother’s level of education, occupation and number of under five children affected the use of ORS in the population used. Mother’s level of knowledge of the solution, availability and accessibility of the ORS sachet (environmental factor) and the occurrence of diarrhoea in a child (Child factor) also affect use of ORS. Recommendations: Health workers in the health care facilities should intensify their effort in the provision of adequate health education to the mothers (may be to be incorporated into antenatal care health talks) on the preparation of Salt Sugar Solution (SSS) type which is cost effective and readily available. Also the hospital management should ensure that Oral Rehydration salt sachets are available in the hospitals and at an affordable price so as to ensure authenticity of the product used by the women.
目的:本研究确定了影响阿南布拉州奥尼沙北LGA圣玫瑰专科医院和产科水边五岁以下儿童的母亲使用口服补液的因素。方法:在阿南布拉州奥尼沙北部地方政府区水边Rosary专科医院和产科医院就诊的五岁以下儿童的母亲中,采用了横断面描述性设计进行研究。通过方便抽样技术选择了150名妇女的样本量。采用信度系数为0.98的自结构化问卷收集适合本研究的必要数据,并使用SPSS 20.0进行分析。结果:141名妇女(94.6%)中大多数听说过口服补液,对两种不同类型的口服补液溶液(即口服补液盐溶液和盐糖溶液)有足够的了解,但未使用SSS,因此对其制备缺乏足够的知识。此外,116名(95.9%)母亲在其子女患有腹泻时使用口服补液,而其余5名(4.1%)母亲因其子女从未患有腹泻而不使用口服补液。65名(43.6%)妇女拥有制备SSS所需的所有材料,而70名(47.0%)妇女不知道制备ORS所需的材料,因此她们无法说明自己是否拥有材料。从检验的假设来看,母亲的受教育程度(p=0.030)、母亲的职业(p=0.024)、五岁以下儿童的数量(p=0.045)与ORS的使用存在显著关系。从研究中,确定了社会人口因素,如母亲的教育水平,职业和五岁以下儿童的数量,影响了使用ORS的人口。母亲对溶液的了解程度、口服补液小袋的可得性和可及性(环境因素)以及儿童腹泻的发生(儿童因素)也会影响口服补液的使用。建议:卫生保健机构的卫生工作者应加紧努力,向母亲提供适当的卫生教育(可纳入产前保健保健讲座),使其了解如何配制具有成本效益且易于获得的盐糖溶液(SSS)。此外,医院管理部门应确保医院以可承受的价格提供口服补液盐袋,以确保妇女使用的产品的真实性。
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引用次数: 0
The Graphical Results of Myopia after Refractive Surgical Treatment by Femto2nd Optical Maser-Assisted and Epiboly’s LASEK (Eye-Surgery) have Remained Comparable. Femto2nd光学激射辅助LASEK(眼外科)屈光手术治疗后近视的图像结果与Epiboly的LASEK(眼外科)保持可比性。
Pub Date : 2022-06-24 DOI: 10.47672/ajhmn.1080
I. Ullah, I. Ahmed, Farrukh Nawab, Khalil Khan Zahir, Irfanullah Khattak
Background: In this prospective cohort study (flap-off epi-eye-surgery), the results of femtosecond optical maser-assisted in situ keratomileusis (femto-eye-surgery) and epipolis eye-surgery refractile surgery for myopia were compared. Purpose: Comparison of the results of eye-surgery myopia or myopic astigmia improvement by a six- multidimensional amaris exciter optical maser and establish that both femto- eye-surgery and flap-off epi-eye-surgery are safe, effective, and predictable in Amanat eye hospital Rawalpindi. The duration of the study was July 2019- July 2021. Sample size was 400 eyes, 200 patients, 81 male and 119 female. The study was conducted after the ethical approval of the hospital ethical committee. Methods: Four hundred (400) eyes from 200 individuals were divided into two groups in this prospective cohort study. For femto-eye-surgery flaps, a femtosecond optical maser was used, while an epikeratome (flap-off) was used for epi-eye-surgery flaps.  The researchers  measured uncorrected distance graphicalacuity (u.d.v.a), corrected distance graphical acuity (c.d.v.a), visible bending (m.r), corneal asphericity (q-value), and corneal higher-order aberrations (hoas) before and after surgery. In both groups, the improvement in logmar udva following refractile surgery was statistically significant (p< 0.001 for all); it was significantly higher for femto-eye-surgery 1 day and 1 week postoperatively (p <0.001 for femto-eye-surgery, respectively). Results: Logarithm of the minimum angle of resolution (logmar) of udva after refractile surgery was statistically significant for both groups (p = 0.002); it was significantly higher for femto-eye-surgery than flap-off epi-eye-surgery (0.03 *0.06 logmar (femto-eye-surgery) and 0.54 * 0.31 logmar (flap-off epi-eye-surgery ) at 1 day postoperatively; 0.02 *0.05 logmar (f the increase in spherical aberration (z4,0) in flap-off epi-eye-surgery was reater than femto-eye- surgery : 0.626 ± 0.232 μm and 0.479 ± 0.139 μm in the front cornea; 0.556 ± 0.227 μm and 0.430 ± 0.137 μm in the total cornea (p = 0.016 and p = 0.017). There was no significant impact of the changes to the corneal hoa in the back of the eye on the corneal hoa in general. Conclusion: Despite the fact that femto-eye-surgery generated better early graphics results than flap-off epi-eye-surgery, there  was no significant difference in the results one week following surgery.
背景:在这项前瞻性队列研究中,比较了飞秒激光激射辅助的原位角膜磨砂术(飞眼手术)和眼珠屈光手术治疗近视的结果。目的:比较在拉瓦尔品第Amanat眼科医院采用六维非晶状体激射光激射器治疗近视或近视散光的效果,确定非晶状体眼手术和非晶状体眼手术均是安全、有效和可预测的。研究时间为2019年7月至2021年7月。样本量400眼,200例,男81例,女119例。该研究是在医院伦理委员会的伦理批准后进行的。方法:在这项前瞻性队列研究中,200人的400只眼睛分为两组。对于飞秒眼手术皮瓣,使用飞秒光学脉泽,而外角膜瓣(皮瓣关闭)用于外眼手术皮瓣。研究人员在手术前后测量了未校正距离视敏度(u.d.v.a.)、校正距离视敏度(c.d.v.a.)、可见弯曲度(m.r)、角膜非球面度(q值)和角膜高阶像差(hoas)。两组屈光手术后logmar udva的改善均有统计学意义(p< 0.001);术后1天和1周飞眼手术明显高于飞眼手术(p <0.001)。结果:两组屈光术后udva最小分辨角(logmar)的对数差异有统计学意义(p = 0.002);术后1 d,飞眼手术明显高于瓣外眼手术(0.03 *0.06 logmar)和瓣外眼手术(0.54 * 0.31 logmar);2 . 0.02 *0.05 logmar (f):前角膜球差(z4,0)增加0.626±0.232 μm,前角膜增大0.479±0.139 μm;总角膜为0.556±0.227 μm和0.430±0.137 μm (p = 0.016和p = 0.017)。一般情况下,眼球后部角膜角膜的变化对角膜角膜的变化没有明显的影响。结论:尽管飞眼手术的早期图像效果优于飞眼手术,但术后一周的结果无显著差异。
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引用次数: 0
The Efficacy and Adverse Effects of Combining Sofosbuvir and Velpatasvir in Viral Hepatitis C Hemodialysis in Pakistani Population. 索非布韦联合维帕他韦治疗巴基斯坦丙型肝炎血液透析的疗效及不良反应。
Pub Date : 2022-06-23 DOI: 10.47672/ajhmn.1079
Shad Muhammad, M. Ikram, A. Khan, I. Ahmed, Ziafat Rehman, Salma Ghulam
Purpose: The study objectives were to evaluate the efficacy and safety of SOF and VLP combination in HCV-infected patients on Hemodialysis (HD) in the local community as usual Pakistani practice. Methodology: In this study, 252 patients were given treatment who participated. Patients who maintain their hemodialysis are often given a combination of SOF and VLP. Before beginning the drug, the patient had testing that included an upper GI endoscopy, genotyping, measurement of the viral load, and a liver brow scan. Patients were administered SOF and VLP at dosages of 400 mg/day and 100 mg/day, respectively, for the duration of the study. Between March 2019 and March 2021, this study was conducted at the Department of Kidney Diseases at LRH Hospital in Peshawar, Pakistan, which was an observational, prospective, single-center study. 27 HCV-HD patients were on a SOF/VLP regimen during the experiment. The ICH-GCP criteria were surveyed in an intended manner. During the data analysis, a p-value of 0.05 or below was considered statistically significant. Results:  Forty percent ofthe patients were male, and sixtypercent were female between the ages of 27 and ninety. According to the findings of 252 participants (n = female 14, 43.5 percent and n = male 18, 45.5 percent), 21 subjects were naïve, and six issues were in the treatment-experienced group (with SOF/RBV), with a mean age of 35.5 years and a standard deviation of 9.6 years. At the post-treatment follow-up visit after 12 weeks of therapy with SOF/VLP, the sustained virological response (SVR) rate was 100 percent (252 of 252), indicating that all of the patients had successfully recovered from their infection. During the study, not a single patient had a virological setback or was lost to follow-up. The most common adverse effects (AEs) recorded were nausea, headache, and tiredness; however, there were no reports of significant AEs. In addition, there were no cases of therapy being stopped prematurely owing to adverse effects. Conclusion: Patients in regular care in Pakistan who have HCV and are receiving HD are offered an extraordinarily efficient, risk-free, and well-tolerated treatment consisting of the total dosage of SOF-VLP given for 12 weeks.
目的:按照巴基斯坦的常规做法,评价SOF和VLP联合治疗当地社区hcv感染血液透析(HD)患者的疗效和安全性。方法:本研究共纳入252例接受治疗的患者。维持血液透析的患者通常给予SOF和VLP的联合治疗。在开始用药之前,患者进行了检查,包括上消化道内窥镜检查、基因分型、病毒载量测量和肝额扫描。在研究期间,患者分别以400 mg/天和100 mg/天的剂量给予SOF和VLP。2019年3月至2021年3月期间,本研究在巴基斯坦白沙瓦LRH医院肾病科进行,这是一项观察性、前瞻性、单中心研究。27例HCV-HD患者在实验期间采用SOF/VLP方案。ICH-GCP标准按预期方式进行了调查。在数据分析中,p值小于等于0.05被认为具有统计学意义。结果:27 ~ 90岁,男性占40%,女性占60%。根据252名参与者(n =女性14名,43.5%,n =男性18名,45.5%)的研究结果,21名受试者为naïve, 6名受试者为治疗经验组(SOF/RBV),平均年龄为35.5岁,标准差为9.6岁。在使用SOF/VLP治疗12周后的治疗后随访中,持续病毒学应答(SVR)率为100%(252 / 252),表明所有患者都成功地从感染中恢复。在研究期间,没有一个病人出现病毒学上的挫折或失去随访。最常见的不良反应(ae)记录为恶心、头痛和疲劳;然而,没有明显不良反应的报道。此外,没有因副作用而过早停止治疗的病例。结论:在巴基斯坦接受常规治疗的HCV和HD患者可以获得非常有效、无风险和耐受性良好的治疗,包括给予总剂量的sofv - vlp 12周。
{"title":"The Efficacy and Adverse Effects of Combining Sofosbuvir and Velpatasvir in Viral Hepatitis C Hemodialysis in Pakistani Population.","authors":"Shad Muhammad, M. Ikram, A. Khan, I. Ahmed, Ziafat Rehman, Salma Ghulam","doi":"10.47672/ajhmn.1079","DOIUrl":"https://doi.org/10.47672/ajhmn.1079","url":null,"abstract":"Purpose: The study objectives were to evaluate the efficacy and safety of SOF and VLP combination in HCV-infected patients on Hemodialysis (HD) in the local community as usual Pakistani practice. \u0000Methodology: In this study, 252 patients were given treatment who participated. Patients who maintain their hemodialysis are often given a combination of SOF and VLP. Before beginning the drug, the patient had testing that included an upper GI endoscopy, genotyping, measurement of the viral load, and a liver brow scan. Patients were administered SOF and VLP at dosages of 400 mg/day and 100 mg/day, respectively, for the duration of the study. Between March 2019 and March 2021, this study was conducted at the Department of Kidney Diseases at LRH Hospital in Peshawar, Pakistan, which was an observational, prospective, single-center study. 27 HCV-HD patients were on a SOF/VLP regimen during the experiment. The ICH-GCP criteria were surveyed in an intended manner. During the data analysis, a p-value of 0.05 or below was considered statistically significant. \u0000Results:  Forty percent ofthe patients were male, and sixtypercent were female between the ages of 27 and ninety. According to the findings of 252 participants (n = female 14, 43.5 percent and n = male 18, 45.5 percent), 21 subjects were naïve, and six issues were in the treatment-experienced group (with SOF/RBV), with a mean age of 35.5 years and a standard deviation of 9.6 years. At the post-treatment follow-up visit after 12 weeks of therapy with SOF/VLP, the sustained virological response (SVR) rate was 100 percent (252 of 252), indicating that all of the patients had successfully recovered from their infection. During the study, not a single patient had a virological setback or was lost to follow-up. The most common adverse effects (AEs) recorded were nausea, headache, and tiredness; however, there were no reports of significant AEs. In addition, there were no cases of therapy being stopped prematurely owing to adverse effects. \u0000Conclusion: Patients in regular care in Pakistan who have HCV and are receiving HD are offered an extraordinarily efficient, risk-free, and well-tolerated treatment consisting of the total dosage of SOF-VLP given for 12 weeks.","PeriodicalId":7672,"journal":{"name":"American Journal of Health, Medicine and Nursing Practice","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89870939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal and New-Born Outcomes When Using Upright and Supine Birth Positions During Labour and Delivery: A Quasi-Experimental Study 在分娩和分娩过程中使用直立和仰卧分娩姿势的产妇和新生儿结局:一项准实验研究
Pub Date : 2022-06-20 DOI: 10.47672/ajhmn.1076
Advera V Mtatina, Lilian Teddy Mselle, D. Mwakawanga, D. Sando, D. Mkoka
Purpose: The purpose of the study is to assess the effects of upright and supine birth positions on maternal and new-born outcomes including maternal blood losses, duration of labor, perineum tear or intact, and APGAR score of the new-born in the first and fifth minutes in two District hospitals in Tanzania. Methodology: A quasi-experimental study design using a quantitative approach was conducted to assess the maternal and new-born outcomes in the in intervention study group (upright) and non-intervention group (supine). A convenient sample of 150 parturient were included, among them 73 formed an intervention group and 77 were in the non-intervention group. Data analysis was done using SPSS version 23 whereby STATA software was used to assess the effect of the independent variables (birth positions) to the dependent variables (maternal and new-born outcomes). Results were compared using chi-square test at P-value <0. 05 Findings: Among of women who assumed upright birth position were experienced good maternal and new-born outcomes more than those in supine position. 93% and 96% of women in upright had short labour in 1st and 2nd stage respectively compered 24.68% and 44% in supine respectively (P-value <0.001). Maternal blood loss and perineum status had no significant differences in both positions while the APGAR score of the new-born in upright (p=0.018) were more advanced than those in supine group. The study revealed that, Upright birth positions provides positive effects to maternal and new-born more than supine positions.  The findings of this study will help pregnant women to have choice on birthing position they feel comfortable to use during labour and delivery. Recommendation: The Ministry of Health should build capacity of midwives to be able to conduct labour using alternative birthing positions including upright position.
目的:本研究的目的是评估坦桑尼亚两家区县医院直立和仰卧分娩体位对产妇和新生儿结局的影响,包括产妇失血、分娩时间、会阴撕裂或完整以及新生儿第1分钟和第5分钟APGAR评分。方法:采用准实验研究设计,采用定量方法评估干预组(直立)和非干预组(仰卧)的产妇和新生儿结局。方便抽样150例产妇,其中干预组73例,不干预组77例。数据分析使用SPSS 23版,其中使用STATA软件评估自变量(出生位置)对因变量(产妇和新生儿结局)的影响。比较结果采用卡方检验,p值<0。05研究结果:与仰卧位相比,采用直立体位分娩的妇女产妇和新生儿的结局更好。仰卧位产妇第一、二期短产率分别为24.68%和44% (p值<0.001),直立位产妇短产率分别为93%和96%。产妇失血量和会阴状态两种体位差异无统计学意义,而新生儿仰卧位APGAR评分高于仰卧位(p=0.018)。研究表明,直立分娩比仰卧分娩对产妇和新生儿有更积极的影响。这项研究的结果将有助于孕妇在分娩和分娩过程中选择她们觉得舒适的分娩姿势。建议:卫生部应建设助产士的能力,使其能够使用包括直立体位在内的其他分娩体位进行分娩。
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引用次数: 0
Patterns and Short Term Outcome of Children with Major Congenital Anterior Abdominal Wall Defects Admitted At Mbarara Regional Referral Hospital, South Western Uganda, from September 2019 to June 2020. 2019年9月至2020年6月乌干达西南部姆巴拉拉地区转诊医院收治的严重先天性腹壁缺陷儿童的模式和短期预后
Pub Date : 2022-06-19 DOI: 10.47672/ajhmn.1074
Jamal A. Mohamed, R. Migisha, Felix Oyania, A. Wesonga, A. Mohamed, Martin Situma
Background: Omphalocele and gastroschisis are the most common major congenital abdominal wall defects (CAWDs) globally. Mortality among neonates major CAWDs is higher in low-income countries than in high-income countries. This study described the patterns and short-term clinical outcomes of infants with gastroschisis and omphalocele at a regional referral hospital in southwestern Uganda. Methods: A case series was conducted at Mbarara Regional Referral Hospital ten months. Children born with CAWD during the study period 54 samples size were consecutively recruited into the study. Data were entered, cleaned, and analyzed using Stata version 15. Descriptive statistics were performed where continuous variables were summarized using median and interquartile ranges, while categorical variables were summarized using frequencies and proportions.  Time to mortality was assessed using Kaplan–Meier survival analysis. Results:  A total of 54 newborns were recruited into the study, of which 40 (70.04%) had Gastroschisis and 14(25.93%) had omphalocele. The median age of the infants was 9 days with an interquartile range of 4 to 21days. Of the 54 newborns, 30(69.2%) were male within the age group of 1-10 days. Mortality was higher in babies with complex gastroschisis (22) than simple gastroschisis (10).  Not administering antibiotics and low birth weight were the factors associated with mortality among infants diagnosed with gastroschisis and omphalocele in the neonatal period. Conclusion: The most common observed defect was gastroschisis, Mortality was generally high among children presenting with gastroschisis.  Complex gastroschisis has a poorer prognosis than simple gastroschisis over 30 days follow up period.  Non-use of antibiotics before referral to a health facility and low birth weight were the factors associated with mortality among infants diagnosed with gastroschisis and omphalocele in the neonatal period. Recommendation: The most common pattern observed was Gastroschisis. The majority of children presenting with Omphalocele were more likely to survive for 30 days. There is a need for timely referral for babies born with congenital anterior abdominal wall defects.
背景:脐膨出和胃裂是全球最常见的先天性腹壁缺陷(CAWDs)。低收入国家重症新生儿死亡率高于高收入国家。本研究描述了在乌干达西南部一家地区转诊医院胃裂和脐膨出婴儿的模式和短期临床结果。方法:在姆巴拉拉地区转诊医院进行了为期10个月的病例系列研究。在研究期间出生的CAWD儿童连续招募了54个样本量。使用Stata version 15输入、清理和分析数据。进行描述性统计,其中连续变量使用中位数和四分位数范围进行汇总,而分类变量使用频率和比例进行汇总。采用Kaplan-Meier生存分析评估死亡时间。结果:共纳入54例新生儿,其中腹裂40例(70.04%),脐膨出14例(25.93%)。婴儿的中位年龄为9天,四分位数范围为4至21天。54例新生儿中,30例(69.2%)为1 ~ 10日龄男性。复杂性腹裂婴儿的死亡率(22)高于单纯性腹裂婴儿(10)。未使用抗生素和低出生体重是与新生儿期诊断为胃裂和脐膨出的婴儿死亡率相关的因素。结论:胃裂是最常见的缺陷,儿童胃裂死亡率普遍较高。在30天随访期内,复杂性胃裂的预后比单纯性胃裂差。在转诊到卫生机构之前未使用抗生素和低出生体重是与新生儿期诊断为胃裂和脐膨出的婴儿死亡率相关的因素。建议:观察到的最常见的类型是胃裂。大多数出现脐膨出的儿童更有可能存活30天。先天性前腹壁缺损婴儿需要及时转诊。
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引用次数: 0
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American Journal of Health, Medicine and Nursing Practice
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