R M Hoskinson, R D Rigby, P E Mattner, V L Huynh, M D'Occhio, A Neish, T E Trigg, B A Moss, M J Lindsey, G D Coleman
This paper describes the development of a vaccine for the prevention of pregnancy in female cattle. The vaccine is based on the established principle that antibodies to the hypothalamic releasing hormone, gonadotrophin releasing hormone (GnRH) block the action of GnRH on pituitary secretion of luteinizing hormone and follicle stimulating hormone, leading to gonadal atrophy in mammals. The vaccine comprises an immunogenic GnRH:ovalbumin conjugate formulated in a novel double adjuvant system and is administered in a two-dose treatment regimen. Field trials have confirmed efficacy and the product, Vaxstrate, has now been registered and commercialized.
{"title":"Vaxstrate: an anti-reproductive vaccine for cattle.","authors":"R M Hoskinson, R D Rigby, P E Mattner, V L Huynh, M D'Occhio, A Neish, T E Trigg, B A Moss, M J Lindsey, G D Coleman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the development of a vaccine for the prevention of pregnancy in female cattle. The vaccine is based on the established principle that antibodies to the hypothalamic releasing hormone, gonadotrophin releasing hormone (GnRH) block the action of GnRH on pituitary secretion of luteinizing hormone and follicle stimulating hormone, leading to gonadal atrophy in mammals. The vaccine comprises an immunogenic GnRH:ovalbumin conjugate formulated in a novel double adjuvant system and is administered in a two-dose treatment regimen. Field trials have confirmed efficacy and the product, Vaxstrate, has now been registered and commercialized.</p>","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 3","pages":"166-70, 176"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12543520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genesearch is a 10 year old research and development company of Australian scientists, specializing in microbiology and genetics. This research expertise has formed the basis of a number of microbial processes for waste treatment. In addition, a novel type of high yield fermenter for aerobic bacteria allows the economical production of high-potency bacterial preparations for waste treatment processes. A novel approach to the rapid biodegradation of polychlorinated biphenyls has been developed. Photochemical pretreatment partially dechlorinates the molecules, rendering them susceptible to complete and rapid digestion by wild-type soil bacteria. In the area of non-toxic waste, Genesearch has developed products for on-site treatment of, for example, grease-trap wastes and waste oil in ship bilges; and a large scale process for conversion of municipal grease wastes into protein-rich biomass. The prospects for novel biological waste treatment are improving, as public pressure grows, and as increasing government monitoring and penalties make inadequate waste disposal uneconomic.
{"title":"Waste treatment technologies from the Genesearch Group of companies.","authors":"J L Reichelt, B Y Reichelt, R Craig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Genesearch is a 10 year old research and development company of Australian scientists, specializing in microbiology and genetics. This research expertise has formed the basis of a number of microbial processes for waste treatment. In addition, a novel type of high yield fermenter for aerobic bacteria allows the economical production of high-potency bacterial preparations for waste treatment processes. A novel approach to the rapid biodegradation of polychlorinated biphenyls has been developed. Photochemical pretreatment partially dechlorinates the molecules, rendering them susceptible to complete and rapid digestion by wild-type soil bacteria. In the area of non-toxic waste, Genesearch has developed products for on-site treatment of, for example, grease-trap wastes and waste oil in ship bilges; and a large scale process for conversion of municipal grease wastes into protein-rich biomass. The prospects for novel biological waste treatment are improving, as public pressure grows, and as increasing government monitoring and penalties make inadequate waste disposal uneconomic.</p>","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 3","pages":"193-6, 204"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12540382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cost effective environmental control: putting biotechnology to work.","authors":"C K Hertle, T L Bulman, T R Bridle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 3","pages":"189-91"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12540029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biotechnology regulation update.","authors":"S D Meek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Animal cell culture and the AIDS problem.","authors":"P A Kaub, P R Carnegie, M A Lawson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"127-34"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12541282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antarctic biotechnology--what is the potential?","authors":"N J Ashbolt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"103-5, 108"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P P Gray, W L Marsden, J Crowley, C Gebert, K Jirasripongpun, G Lovrecz, C Mitchell, S M Mahler
{"title":"Mammalian cell culture at the University of New South Wales.","authors":"P P Gray, W L Marsden, J Crowley, C Gebert, K Jirasripongpun, G Lovrecz, C Mitchell, S M Mahler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"121-3, 134"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications of cell culture technology at Commonwealth Serum Laboratories.","authors":"N Ackland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"124-6"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our laboratory has over a period of four years conducted extensive research into the metabolism and batch, fed-batch, continuous, perfusion and serum-free culture of hybridomas with a view to increasing the productivity of these animal cell lines. A brief overview of this work and future plans will be presented here. In addition an overview of our more limited work on the Baculovirus expression system using insect cell culture, begun during 1989, will also be given.
{"title":"Studies on hybridoma and insect cells in suspension culture.","authors":"S Reid, P F Greenfield","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our laboratory has over a period of four years conducted extensive research into the metabolism and batch, fed-batch, continuous, perfusion and serum-free culture of hybridomas with a view to increasing the productivity of these animal cell lines. A brief overview of this work and future plans will be presented here. In addition an overview of our more limited work on the Baculovirus expression system using insect cell culture, begun during 1989, will also be given.</p>","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12539531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From LIF to ESGRO.","authors":"A Coker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77022,"journal":{"name":"Australian journal of biotechnology","volume":"4 2","pages":"100-2"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12540376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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