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Systematic review of the use and value of computer simulation modelling in population health and health care delivery. 系统回顾计算机模拟建模在人口健康和卫生保健服务中的应用和价值。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg075
David Fone, Sandra Hollinghurst, Mark Temple, Alison Round, Nathan Lester, Alison Weightman, Katherine Roberts, Edward Coyle, Gwyn Bevan, Stephen Palmer

Background: The objective of the review was to evaluate the extent, quality and value of computer simulation modelling in population health and health care delivery.

Methods: A narrative systematic review was carried out of world literature from 1980 to 1999, searching Medline, INSPEC, Embase, HealthSTAR, Science Citation Index, CINAHL, MathSci, INFORMS Online and SIGLE databases, and researchers in the field were contacted. Papers were included if they contained a computer simulation model of individuals in a stochastic system and the topic or setting related to population health or health service delivery.

Results: A total of 182 papers met the inclusion criteria. Simulation modelling has been undertaken in a wide range of health care topic areas, including hospital scheduling and organization, communicable disease, screening, costs of illness and economic evaluation. However, the quality of published papers was variable and few reported on the outcomes of implementation of models, so that the value of modelling could not be assessed.

Conclusion: Simulation modelling is a powerful method for modelling both small and large populations to inform policy makers in the provision of health care. It has been applied to a wide variety of health care problems. Although the number of modelling papers has grown substantially over recent years, further research is required to assess the value of modelling.

背景:本综述的目的是评价计算机模拟建模在人口健康和卫生保健服务中的范围、质量和价值。方法:检索Medline、INSPEC、Embase、HealthSTAR、Science Citation Index、CINAHL、MathSci、INFORMS Online和SIGLE数据库,对1980 ~ 1999年的世界文献进行叙述性系统综述。如果论文包含随机系统中个人的计算机模拟模型以及与人口健康或卫生服务提供相关的主题或设置,则纳入。结果:182篇论文符合纳入标准。仿真建模已在广泛的卫生保健主题领域进行,包括医院调度和组织、传染病、筛查、疾病成本和经济评估。然而,已发表论文的质量参差不齐,而且很少报道模型实施的结果,因此无法评估模型的价值。结论:模拟建模是一种强大的方法,可以为小型和大型人群建模,从而为决策者提供卫生保健服务。它已被广泛应用于各种卫生保健问题。虽然近年来建模论文的数量大幅增加,但需要进一步的研究来评估建模的价值。
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引用次数: 565
Caring-related inequalities in psychological distress in Britain during the 1990s. 20世纪90年代英国心理困扰中与关怀相关的不平等。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg082
Michael Hirst

Background: This paper examines recent trends in inequalities in psychological distress associated with the provision of unpaid care by those who look after frail older people and younger disabled adults and children. Caring activities intensified during the 1990s, associated with increasing amounts of time devoted to the more demanding types of care and to those relationships that typically make heavy demands on the carer. Heavy involvement in caregiving is often associated with symptoms of anxiety and distress, and the intensification of care may increase rates of distress in carers relative to that in non-carers.

Methods: A secondary analysis was carried out of data drawn from the first 10 waves of the British Household Panel Survey covering 1991-2000, based on around 9000 adults interviewed personally in successive waves. Symptoms of psychological distress, including anxiety and depression, were assessed using the 12-item General Health Questionnaire.

Results: Carers present higher rates of distress than noncarers and the health gap widens as the definition of caregiving focuses on those living with the person they care for, and those devoting 20 h or more per week to their caring activities. Differences in distress rates between carers and non-carers are greater for women than for men. There is no support for the hypothesis that inequalities in distress associated with caregiving have increased over time.

Conclusion: There was no change during the 1990s in the extent of inequalities in psychological distress associated with caregiving in Britain. The need to maintain carers' emotional and mental health is as compelling as ever it was.

背景:本文研究了与那些照顾体弱老年人和年轻残疾成人和儿童的人提供无偿护理相关的心理困扰不平等的最新趋势。在20世纪90年代,照顾活动加强了,与越来越多的时间投入到要求更高的照顾类型和那些通常对照顾者要求很高的关系中。大量参与照顾往往与焦虑和痛苦的症状有关,而加强照顾可能会增加照顾者相对于非照顾者的痛苦率。方法:对1991-2000年英国家庭小组调查的前10波数据进行了二次分析,这些数据是基于连续几波对约9000名成年人的亲自采访。心理困扰的症状,包括焦虑和抑郁,使用12项一般健康问卷进行评估。结果:照顾者比非照顾者表现出更高的痛苦率,并且随着照顾者的定义集中在那些与他们所照顾的人生活在一起的人,以及那些每周花20小时或更多时间照顾他们的人,健康差距扩大了。照顾者和非照顾者之间的痛苦程度差异,女性比男性更大。没有证据支持与照顾相关的痛苦不平等随着时间的推移而增加的假设。结论:在20世纪90年代,英国与护理相关的心理困扰的不平等程度没有变化。保持护理人员的情感和心理健康的需求与以往一样迫切。
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引用次数: 47
Socio-economic position and health: what you observe depends on how you measure it. 社会经济地位和健康:你观察到什么取决于你如何衡量它。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg089
Sally Macintyre, Laura McKay, Geoff Der, Rosemary Hiscock

Background: A number of different socio-economic classifications have been used in relation to health in the United Kingdom. The aim of this study was to compare the predictive power of different socio-economic classifications in relation to a range of health measures.

Methods: A postal questionnaire was sent to a random sample of adults in the West of Scotland (sampling from 1997 electoral roll, response rate 50 percent achieved sample 2,867).

Results: Associations between social position and health vary by socio-economic classification, health measure and gender. Limiting long-standing illness is more socially patterned than recent illness; income, Registrar General Social Class, housing tenure and car access are more predictive of health than the new National Statistics Socio Economic Classification; and men show steeper socio-economic gradients than women.

Conclusion: Although there is a consistent picture of poorer health among more disadvantaged groups, however measured, in seeking to explain and reduce social inequalities in health we need to take a more differentiated approach that does not assume equivalence among social classifications and health measures.

背景:联合王国在保健方面采用了若干不同的社会经济分类。本研究的目的是比较不同社会经济分类对一系列健康措施的预测能力。方法:对苏格兰西部地区的成年人随机进行邮寄问卷调查(抽样自1997年的选民名册,回复率50%,达到样本2,867)。结果:社会地位与健康之间的关系因社会经济分类、健康措施和性别而异。限制长期疾病比最近的疾病更具有社会模式;收入、社会阶层、住房使用权和汽车使用权比新的国家统计社会经济分类更能预测健康状况;男性表现出比女性更大的社会经济梯度。结论:尽管处境较不利的群体的健康状况较差,无论如何衡量,在寻求解释和减少健康方面的社会不平等时,我们需要采取一种更有区别的方法,不假设社会分类和健康措施之间是对等的。
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引用次数: 140
A survey of hepatitis C prevalence amongst the homeless community of Oxford. 牛津无家可归者社区丙型肝炎流行率调查。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg088
Luke C H Sherriff, R T Mayon-White

Hepatitis C (HCV) is an emerging health concern across the world, with 170 million people chronically infected and at risk of liver cancer, cirrhosis or liver failure. There is no vaccination and so it is important to learn as much as possible about how to prevent future infection. Modes of transmission include intravenous drug use (IDU), blood products, tattooing and, to a lesser extent, sexual intercourse. Homelessness is a risk factor of HCV because of the environments and behaviours associated with homeless communities such as poor hygiene, poor nutrition and high levels of IDU. The aim of this project was to determine the prevalence of HCV and its risk factors amongst the homeless community of Oxford, which is the second largest in the country. Ninety-eight individuals of the Oxford homeless community were interviewed and tested for HCV. The results gave an estimated HCV prevalence of 26.5 percent. The major risk factors in this population were IDU (past and present), age (over 20 years old) and sharing the paraphernalia used by i.v. drug users (e.g. spoons, foil and filters). With the exception of age, these risk factors could all be targeted in an attempt to reduce this prevalence and combat the major public health concern that HCV poses to the homeless community of Oxford.

丙型肝炎(HCV)是全球新兴的健康问题,有1.7亿人慢性感染,并有肝癌、肝硬化或肝功能衰竭的风险。目前还没有疫苗,因此尽可能多地了解如何预防未来的感染是很重要的。传播方式包括静脉注射药物、血液制品、纹身以及在较小程度上的性交。由于与无家可归社区相关的环境和行为,如卫生条件差、营养不良和高水平的IDU,无家可归是HCV的一个风险因素。该项目的目的是确定牛津无家可归者社区中丙型肝炎病毒的患病率及其风险因素,这是该国第二大无家可归者社区。牛津无家可归者社区的98个人接受了采访并进行了丙型肝炎病毒检测。结果估计HCV患病率为26.5%。这一人群的主要危险因素是静脉注射吸毒者(过去和现在)、年龄(20岁以上)和共用静脉注射吸毒者使用的用具(例如勺子、锡箔纸和过滤器)。除了年龄之外,这些风险因素都可以作为目标,试图降低这种流行率,并对抗HCV对牛津无家可归者社区构成的主要公共卫生问题。
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引用次数: 33
Health effects of a sulphur dioxide air pollution episode. 二氧化硫空气污染事件对健康的影响。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg083
Terry P Brown, Lesley Rushton, Moira A Mugglestone, David F Meechan

Background: A sulphur dioxide (SO(2)) episode occurred in the United Kingdom in 1998. The worst affected area was the city of Nottingham.

Methods: Emergency hospital admissions in Nottingham in the episode week were compared with those in the previous week.

Results: A statistically significant increase in admissions for all respiratory diseases occurred in the episode week (odds ratio (OR) = 1.40, 95 per cent confidence interval (CI) = 1.00-1.94). Ten of the 25 excess admissions were for asthma, although the excess for asthma alone was not statistically significant (OR = 1.90, 95 per cent CI = 0.87-4.15).

Conclusions: The excess admissions for respiratory diseases could have been caused by exposure to SO(2), to other pollutants present in increased concentrations during the pollution episode, or by seasonal variations in the frequency of asthma symptoms, or prevailing weather conditions. This study shows how simple analyses of routinely collected health data can be used to assess public health impacts of pollution episodes.

背景:1998年在英国发生了一次二氧化硫(SO(2))事件。受影响最严重的地区是诺丁汉市。方法:对发作周与前一周的急诊住院人数进行比较。结果:发作周发生的所有呼吸系统疾病入院率均有统计学意义上的显著增加(优势比(OR) = 1.40, 95%可信区间(CI) = 1.00-1.94)。25例额外入院中有10例是哮喘,尽管哮喘单独的额外入院没有统计学意义(OR = 1.90, 95% CI = 0.87-4.15)。结论:呼吸道疾病的过量入院可能是由于暴露于SO(2),污染发作期间浓度增加的其他污染物,或哮喘症状频率的季节性变化或当时的天气条件造成的。这项研究表明,对常规收集的健康数据进行简单分析可以用来评估污染事件对公众健康的影响。
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引用次数: 28
Urban-rural differences in self-reported limiting long-term illness in Scotland. 苏格兰自我报告限制长期疾病的城乡差异。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg084
Kate A Levin

Background: Previous research suggests that there are significant differences in health between urban and rural areas. The aim of this study is to describe the pattern and magnitude of urban-rural variation in health in Scotland and to examine the factors associated with health inequalities in urban and rural areas.

Methods: The data used in this study were limiting long-term illness (LLTI) and socio-economic data collected by the 1991 Census. A rurality indicator was created using Scottish Household Survey rurality classifications. Multilevel Poisson regression modelling was carried out with LLTI as a health indicator for each type of rurality within Scotland. A variety of socio-economic factors were investigated for each rurality.

Results: Areas with the highest Standardized Illness Ratios (SIRs) (>125) are predominantly urban whereas the lowest SIRs (<75) are found in both urban and rural areas. Rural communities are more heterogeneous than urban areas in terms of their social make-up with relation to health; however, when these areas are split according to minor road length and different socio-economic factors are added, the model fit for each new model is improved and the reduction in total variation is comparable with that of the urban models.

Conclusion: These findings suggest that rural areas should not be treated as a homogeneous group but should be subdivided into rural types.

背景:以往的研究表明,城市和农村地区的健康状况存在显著差异。这项研究的目的是描述苏格兰城乡健康差异的模式和程度,并研究与城乡健康不平等有关的因素。方法:本研究使用的数据是1991年人口普查收集的限制长期疾病(LLTI)和社会经济数据。利用苏格兰家庭调查的农村分类,创建了一个农村指标。采用多水平泊松回归模型,将LLTI作为苏格兰各类型乡村的健康指标。对每个农村的各种社会经济因素进行了调查。结果:标准化疾病比(SIRs)最高的地区(>125)主要是城市,而SIRs最低的地区(结论:这些发现表明,农村地区不应被视为一个同质群体,而应细分为农村类型。
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引用次数: 23
A model to predict the results of changes in smoking behaviour on smoking prevalence. 预测吸烟行为变化对吸烟率影响的模型。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg077
John Kemm

Background: Data are available on the prevalence of smoking states (never, current and ex). However, data on behaviour change rates (starting - never to current, quitting - current to ex and lapsing - ex to current) are not readily available and cannot be simply derived from or related to prevalence data.

Method: A model was constructed to relate prevalence of smoking states to behaviour change rates. It was populated with prevalence of smoking status taken from the General Household Survey together with population structure, age- and sex-specific death rates, and birth rates for England and Wales. This model could be used to calculate past behaviour change given observed prevalence of smoking states or future prevalence of smoking given predicted rates of behaviour change.

Results: To fit data it was necessary to assume that as they age some ex smokers reclassify themselves as never smokers. In the age band 16-19 years about 9 percent of never smokers start smoking, and about 5 percent of current smokers quit. In the age band 20-24 years the corresponding figures for starting are about 4 percent in males and 2 percent in females, and for quitting about 2 percent in both. In older age bands the percentages starting are zero or less than zero (indicating reclassifying), and the percentage quitting rises with age. Net lapsing (shift from ex to current) occurred very infrequently and is quantitatively unimportant. If the current starting, quitting and lapsing rates are maintained the Smoking kills target will not be met. Future prevalence of smoking under different scenarios is examined.

Conclusion: The model is useful in calculating the proportions changing smoking state from serial cross-sectional data on prevalence and for predicting future prevalence.

背景:有关于吸烟状态(从不吸烟、现在吸烟和曾经吸烟)患病率的数据。然而,关于行为改变率的数据(开始-从不到目前,戒烟-从现在到现在以及从过去到现在)并不容易获得,不能简单地从流行数据中得出或与之相关。方法:建立吸烟状态患病率与行为改变率之间的关系模型。研究人员从家庭综合调查中获取了吸烟的流行状况,以及英格兰和威尔士的人口结构、特定年龄和性别的死亡率和出生率。这个模型可以用来计算过去吸烟状态下的行为变化,或者根据预测的行为改变率来计算未来吸烟的流行程度。结果:为了拟合数据,有必要假设随着年龄的增长,一些前吸烟者将自己重新归类为从不吸烟者。在16-19岁年龄段中,从不吸烟的人中约有9%开始吸烟,目前吸烟者中约有5%戒烟。在20-24岁年龄段中,男性开始吸烟的比例约为4%,女性为2%,两者的戒烟比例均为2%。在年龄较大的年龄组中,开始吸烟的百分比为零或小于零(表明重新分类),戒烟的百分比随着年龄的增长而上升。净损耗(从电流转移到电流)很少发生,在数量上也不重要。如果保持目前的开始、戒烟和戒烟率,吸烟致死目标将无法实现。研究了未来不同情景下的吸烟流行率。结论:该模型可用于从流行率的连续横断面数据中计算吸烟状态变化的比例和预测未来流行率。
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引用次数: 11
Patterns of adult and old-age mortality in rural Burkina Faso. 布基纳法索农村地区成人和老年人死亡率模式。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg080
Osman A Sankoh, Gisela Kynast-Wolf, Bocar Kouyaté, Heiko Becher

Based on a demographic surveillance population from 39 villages in rural Burkina Faso, we describe mortality patterns in adults (15-59 years) and older people (> or = 60 years), and discuss seasonal trends in mortality. During the study period 1993-1998, 589 deaths in adults and 593 deaths in older people were recorded from an average adult and older people population of 13 550. The crude all-cause mortality rate per 1000 for adults was 7.3 (95 per cent confidence interval (CI) 6.7-7.8) and for older people 55.8 (95 percent CI 51.3-60.3). The probability of dying before age 60 after reaching age 15 was 34 percent for males and 32 percent for females. Malaria and diarrhoea, recorded through verbal autopsy, accounted for 21 percent of total deaths in adults and 22 per cent in older people. A seasonal trend in mortality for older people with a peak in February was identified. The study shows that malaria is an important cause of death in adulthood.

基于布基纳法索农村39个村庄的人口监测人口,我们描述了成人(15-59岁)和老年人(>或= 60岁)的死亡率模式,并讨论了死亡率的季节性趋势。在1993-1998年的研究期间,在平均13 550名成年人和老年人中记录了589名成年人死亡和593名老年人死亡。成人的粗全因死亡率为每1000人7.3%(95%可信区间(CI) 6.7-7.8),老年人为55.8%(95%可信区间(CI) 51.3-60.3)。在15岁之后,男性在60岁之前死亡的概率为34%,女性为32%。通过尸检记录的疟疾和腹泻占成年人死亡总数的21%,占老年人死亡总数的22%。确定了老年人死亡率的季节性趋势,并在2月份达到高峰。研究表明,疟疾是成年人死亡的一个重要原因。
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引用次数: 22
Change in adult health following medical priority rehousing. 医疗优先安置后成人健康的变化。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg070
Peter Elton
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引用次数: 1
Inhalation sedation with nitrous oxide as an alternative to dental general anaesthesia for children. 一氧化二氮吸入镇静作为儿童牙科全身麻醉的替代方法。
Pub Date : 2003-12-01 DOI: 10.1093/pubmed/fdg068
G Lyratzopoulos, K M Blain

This review paper examines (using systematic methodology) the evidence for the use of inhalation sedation (IHS) instead of dental general anaesthesia (DGA) for dental treatment. It finds that this is an area of healthcare lacking high-quality clinical evidence (i.e. derived from randomized controlled trials). However, evidence from seven case series studies (level of evidence 3) of variable quality and design is examined. Those studies suggest that IHS is effective for a large proportion (83-97 percent) of selected subgroups of children who would have otherwise required DGA. This may represent 45-64 percent of all children who are referred for DGA. There is a remarkable degree of consistency between all studies in the reported treatment effectiveness of IHS, despite differences in design and populations treated. IHS is particularly suitable for orthodontic treatment, for older children, and for children requiring no more than four extractions. Morbidity associated with IHS is minor and infrequent, and user satisfaction is high, or higher compared with DGA. Comparing with DGA, IHS requires significantly longer time per episode and more treatment sessions per patient. In teaching dental hospitals, staffing costs for IHS are estimated to be cheaper by about a third compared with outpatient DGA. Indications for further areas of research are made.

这篇综述研究了(使用系统的方法)使用吸入镇静(IHS)代替牙科全身麻醉(DGA)用于牙科治疗的证据。它发现这是一个缺乏高质量临床证据(即来自随机对照试验)的医疗保健领域。然而,来自七个不同质量和设计的案例系列研究(证据水平3)的证据被检查。这些研究表明,IHS对大部分(83- 97%)本来需要DGA的选定儿童亚组是有效的。这可能占所有转介到DGA的儿童的45- 64%。尽管设计和治疗人群存在差异,但所有研究报告的IHS治疗效果之间存在显著的一致性。IHS特别适用于正畸治疗,适用于年龄较大的儿童,以及不需要超过四次拔牙的儿童。与IHS相关的发病率较小且不常见,用户满意度高,或高于DGA。与DGA相比,his每次发作需要更长的时间,每位患者需要更多的治疗时间。在教学牙科医院,IHS的人员成本估计比门诊DGA便宜约三分之一。提出了进一步研究领域的指示。
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引用次数: 50
期刊
Journal of public health medicine
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