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Factors influencing hepatitis B vaccine uptake in injecting drug users. 影响注射吸毒者乙肝疫苗接种的因素。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg035
J McGregor, P J Marks, A Hayward, Y Bell, R C B Slack

Background: Hepatitis B infection in injecting drug users is an important public health problem. Active immunization against hepatitis B is immunogenic and safe, but uptake rates in targeted vaccination programmes are low. This study was undertaken to identify factors associated with the uptake of hepatitis B vaccination in injecting drug users attending a needle exchange service.

Methods: A retrospective cross-sectional survey of case-note data of injecting drug users who had no markers of hepatitis B infection or immunity was undertaken within a drop-in needle exchange service for injecting drug users in a large urban area in England. A qualitative study using semi-structured interviews with needle exchange staff was also conducted.

Results: Of 207 injecting drug users, 180 (87 per cent) had been offered vaccine, 123 (59 per cent) accepted at least one dose and 55 (27 per cent) received three or more doses. Vaccine was less likely to be offered to those sharing injecting equipment or known to have hepatitis C. Needle sharing was also associated with failure to accept vaccine, as was increasing age and the length of contact with the service.

Conclusions: Those who are most at risk are least likely to be offered vaccine and accept it. This calls into doubt the effectiveness of hepatitis B vaccination strategies targeted at high-risk groups and adds weight to arguments for universal vaccination.

背景:注射吸毒者乙型肝炎感染是一个重要的公共卫生问题。针对乙型肝炎的主动免疫具有免疫原性和安全性,但在有针对性的疫苗接种规划中的接种率很低。本研究旨在确定与参加针头交换服务的注射吸毒者接种乙型肝炎疫苗相关的因素。方法:回顾性横断面调查的病例记录数据的注射吸毒者谁没有乙型肝炎感染或免疫的标记进行了在注射器针头交换服务在英国一个大城市地区的注射吸毒者。还对针具交换工作人员进行了半结构化访谈,进行了定性研究。结果:在207名注射吸毒者中,180人(87%)接种了疫苗,123人(59%)至少接种了一剂,55人(27%)接种了三剂或三剂以上。向共用注射设备或已知患有丙型肝炎的人提供疫苗的可能性较小。共用针头也与未能接受疫苗有关,年龄增加和接触服务的时间延长也与此有关。结论:那些风险最大的人最不可能获得疫苗并接受疫苗。这使人们对针对高危人群的乙型肝炎疫苗接种策略的有效性产生怀疑,并增加了普遍接种疫苗的论据的份量。
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引用次数: 29
Risk identification, assessment and management in public health practice: a practical approach in one public health department. 公共卫生实践中的风险识别、评估和管理:一个公共卫生部门的实用方法。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg029
R Suckling, M Ferris, C Price

Background: The continuing identification, assessment and management of risks are key themes for clinical governance. These themes are being integrated into both primary and secondary care practice; however, integration into public health practice appears much slower. This paper describes the recent approach that we have taken in Sheffield, and proposes a model for public health departments to identify, assess and manage risks, which complements other risk management processes and is transferable to other settings. It assumes that public health practice is not a risk-free activity and holds that the process of identifying, assessing and managing risks is a key component to raising standards.

Methods: A number of risk 'management' models were reviewed and a primary care approach was applied to public health practice. A list of potential risks was identified using a number of methods including reflective practice, information from complaints and/or critical incidents. Risks were assessed by likelihood and impact, and were captured in a risk framework.

Results: By March 2002, 21 risks had been identified and characterized, and progress had been made to manage 11 of these risks.

Conclusion: This process, and the development of a risk framework, was useful in identifying a prioritized work programme to improve standards of public health practice in this department. This model can also be used not only for planning risk management activities, continual identification and assessment of risks but also to provide inspiration for other clinical governance activities including public health audit.

背景:持续识别、评估和管理风险是临床治理的关键主题。这些主题正在纳入初级和二级保健实践;然而,将其纳入公共卫生实践似乎要慢得多。本文描述了我们最近在谢菲尔德采取的方法,并为公共卫生部门提出了一个识别、评估和管理风险的模型,该模型补充了其他风险管理过程,并可转移到其他环境中。它假定公共卫生做法不是一项无风险的活动,并认为确定、评估和管理风险的过程是提高标准的关键组成部分。方法:回顾了一些风险“管理”模型,并将初级保健方法应用于公共卫生实践。通过反思实践、投诉信息和/或关键事件等多种方法,确定了潜在风险清单。通过可能性和影响评估风险,并在风险框架中捕获风险。结果:到2002年3月,已识别和描述了21个风险,并在管理其中11个风险方面取得了进展。结论:这一进程以及风险框架的制定有助于确定优先工作方案,以提高该部门公共卫生实践的标准。该模型不仅可用于规划风险管理活动、持续识别和评估风险,还可为包括公共卫生审计在内的其他临床治理活动提供启发。
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引用次数: 11
HTA responses and the classic HTA report. HTA的回应和经典的HTA报告。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg023
Ruairidh Milne, Andrew Clegg, Andrew Stevens

Reports produced in response to the need for health technology assessment (HTA) vary greatly in the methods they use, depending on the decision-maker's needs, the technology's characteristics and the resources available. HTA reports vary from the brief, such as 'vignettes' produced when a new technology emerges, to the exhaustive, such as 'Cochrane reviews' synthesising a mature evidence base. They may address a wide range of different questions. 'Classic HTAs', typically those reports prepared to support NICE appraisal decisions, seek to use scientifically rigorous methods to address a focused policy question. These are based on systematic reviews of the effectiveness evidence but this is often fed into economic models, in order to generate estimates of cost-effectiveness. Future developments in HTA responses will reflect both the embedding of systematic methods and a growing responsiveness to customer needs.

根据决策者的需要、技术特点和现有资源的不同,为满足卫生技术评估需求而编写的报告所使用的方法差别很大。HTA的报告各不相同,从简短的,如当一项新技术出现时产生的“小片段”,到详尽的,如“科克伦评论”,综合了一个成熟的证据基础。它们可以解决一系列不同的问题。“经典hta”,通常是那些为支持NICE评估决策而准备的报告,寻求使用科学严谨的方法来解决重点政策问题。这些评估是基于对有效性证据的系统审查,但这通常被输入到经济模型中,以便产生成本效益的估计。HTA应对措施的未来发展将反映系统方法的嵌入和对客户需求的日益响应。
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引用次数: 19
Social class, ethnicity and attendance for antenatal care in the United Kingdom: a systematic review. 社会阶层,种族和出席产前保健在英国:一个系统的回顾。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg025
Rachel E Rowe, Jo Garcia

Background: Evidence from outside the United Kingdom points to several socio-demographic factors associated with late initiation of antenatal care or fewer antenatal visits, but it is not clear how generalizable these studies are to the UK context. This systematic review addresses the question of whether there are social or ethnic inequalities in attendance for antenatal care in the United Kingdom.

Methods: We identified and reviewed UK studies assessing attendance for antenatal care according to any measure of social class, social deprivation or ethnicity. A wide range of electronic databases was searched for published and unpublished studies. Further studies were identified from reference lists, citation searches and key organizations.

Results: From over 1300 identified papers, 20 were potentially relevant. Nine were included in the review. Most studies were of poor quality, with only one study controlling for the effect of potential confounders such as age, parity and clinical risk factors. All but one were based on data collected around 20 years ago. Three of the five studies looking at antenatal attendance and social class found that women from manual classes were more likely to book late for antenatal care and/or make fewer antenatal visits than other women. All four studies reporting on antenatal attendance and ethnicity found that women of Asian origin were more likely to book late for antenatal care than white British women.

Conclusions: There is little good quality evidence on social and ethnic inequalities in attendance for antenatal care in the United Kingdom. Recommendations for further research are suggested.

背景:来自英国以外的证据表明,一些社会人口因素与产前护理开始较晚或产前检查较少有关,但尚不清楚这些研究在英国的普遍性如何。本系统综述解决了在英国产前护理是否存在社会或种族不平等的问题。方法:根据社会阶层、社会剥夺或种族的任何衡量标准,我们确定并回顾了英国评估产前护理出勤率的研究。在广泛的电子数据库中搜索已发表和未发表的研究。从参考文献列表、引文检索和关键组织中确定了进一步的研究。结果:在1300多篇被识别的论文中,有20篇是潜在相关的。其中9人被纳入综述。大多数研究质量较差,只有一项研究控制了潜在混杂因素的影响,如年龄、胎次和临床风险因素。除了一个之外,所有的数据都是基于大约20年前收集的数据。五项关于产前出勤率和社会阶层的研究中有三项发现,来自手工班的妇女比其他妇女更有可能预约较晚的产前护理和/或较少的产前检查。所有四项关于产前护理和种族的研究都发现,亚裔女性比英国白人女性更有可能预约晚到的产前护理。结论:在英国,关于产前护理的社会和种族不平等的高质量证据很少。提出了进一步研究的建议。
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引用次数: 137
The relationship between use of NHS Direct and deprivation in southeast London: an ecological analysis. 伦敦东南部使用NHS直接服务与贫困之间的关系:生态学分析。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg038
Jenni Burt, Richard Hooper, Lynda Jessopp

Background: Little is known about the utilization of NHS Direct by disadvantaged groups, in spite of the service aiming to be 'accessible to all'. This study investigates the relationship between use of NHS Direct and deprivation in one predominantly disadvantaged area.

Methods: Ward-level call rates to NHS Direct South East London over a 6 month period were calculated using postcode data. Jarman and Townsend scores were used as a proxy of deprivation in each ward. We performed negative binomial regression to investigate the relationship between deprivation score and rate of calls to NHS Direct.

Results: There was a significant, non-linear (quadratic) effect of deprivation score on call rates; call rates were lower in both the most affluent and most deprived wards.

Conclusion: Calls to NHS Direct rise with increasing deprivation until, at extreme levels of deprivation, they subsequently decline. This challenges assumptions that NHS Direct is not utilized in deprived areas.

背景:尽管该服务旨在“向所有人开放”,但对弱势群体使用NHS Direct知之甚少。本研究调查了在一个主要处于不利地位的地区使用NHS直接和剥夺之间的关系。方法:使用邮政编码数据计算6个月期间NHS直拨伦敦东南部的病房级通话率。贾曼和汤森评分被用作每个病房的剥夺程度的代表。我们执行负二项回归来调查剥夺评分和NHS直接呼叫率之间的关系。结果:剥夺评分对呼出率有显著的非线性(二次)影响;在最富裕和最贫困的病房,电话率都较低。结论:对国民保健服务的呼吁随着剥夺的增加而直接上升,直到极端剥夺水平,它们随后下降。这挑战了在贫困地区不使用NHS Direct的假设。
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引用次数: 31
Communicable disease and health protection quarterly review: October to December 2002. 传染病和卫生保护季度审查:2002年10月至12月。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg037
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引用次数: 0
Life expectancies in the United Kingdom and Japan. 英国和日本的预期寿命。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg026
Shigeyuki Nakaji, Domhnall MacAuley, Siobhan O'Neill, Oonagh McNally, David Baxter, Kazuo Sugawara

Background: Compared with other developed countries, the United Kingdom has exhibited less of an increase in life expectancy over the past 30 years.

Methods: We compared the chronological changes in the age-adjusted mortality rates (AMRs) from all causes or major causes, and in life expectancy in the United Kingdom and Japan between 1970 and 1997.

Results: In both 1970 and 1997 the AMRs for most major causes were higher in the United Kingdom than in Japan; the difference in the AMR between countries was smaller in 1970 than in 1997. The difference in the AMR from all causes between the United Kingdom and Japan in 1997 was mainly due to differences in the AMR for heart diseases. The trend for an increasing difference over time between the United Kingdom and Japan in the AMR from all causes was due to the decreased rate of AMR from heart diseases from 1970 to 1997 in the United Kingdom being lower than those from cerebrovascular diseases in same period in Japan.

Conclusions: These data suggest that mortality rates could be reduced by a change in focus of the National Health Service toward an emphasis on primary rather than secondary prevention and associated clinical interventions. The greatest priority should be placed on reducing the incidence of heart disease by aggressively improving primary prevention.

背景:与其他发达国家相比,在过去的30年里,英国的预期寿命增长幅度较小。方法:我们比较了1970年至1997年间英国和日本所有原因或主要原因的年龄调整死亡率(AMRs)以及预期寿命的时间变化。结果:1970年和1997年,英国大多数主要原因的amr均高于日本;1970年各国之间的AMR差异比1997年要小。1997年英国和日本所有原因的抗菌素死亡率的差异主要是由于心脏病抗菌素死亡率的差异。随着时间的推移,英国和日本在各种原因造成的抗菌素死亡率差异越来越大的趋势是,1970年至1997年期间,英国心脏病引起的抗菌素死亡率下降,低于同期日本脑血管疾病引起的抗菌素死亡率。结论:这些数据表明,通过改变国家卫生服务的重点,将重点从二级预防和相关的临床干预转向一级预防,可以降低死亡率。最重要的应该是通过积极改善初级预防来减少心脏病的发病率。
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引用次数: 14
Self-exclusion from health care in women at high risk for postpartum depression. 产后抑郁症高危妇女的自我排斥。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg028
Lynne Murray, Matt Woolgar, Joseph Murray, Peter Cooper

Background: A significant proportion of women who are vulnerable to postnatal depression refuse to engage in treatment programmes. Little is known about them, other than some general demographic characteristics. In particular, their access to health care and their own and their infants' health outcomes are uncharted.

Methods: We conducted a nested cohort case-control study, using data from computerized health systems, and general practitioner (GP) and maternity records, to identify the characteristics, health service contacts, and maternal and infant health outcomes for primiparous antenatal clinic attenders at high risk for postnatal depression who either refused (self-exclusion group) or else agreed (take-up group) to receive additional Health Visiting support in pregnancy and the first 2 months postpartum.

Results: Women excluding themselves from Health Visitor support were younger and less highly educated than women willing to take up the support. They were less likely to attend midwifery, GP and routine Health Visitor appointments, but were more likely to book in late and to attend accident and emergency department (A&E). Their infants had poorer outcome in terms of gestation, birthweight and breastfeeding. Differences between the groups still obtained when age and education were taken into account for midwifery contacts, A&E attendance and gestation; the difference in the initiation of breast feeding was attenuated, but not wholly explained, by age and education.

Conclusion: A subgroup of psychologically vulnerable child-bearing women are at particular risk for poor access to health care and adverse infant outcome. Barriers to take-up of services need to be understood in order better to deliver care.

背景:很大一部分易患产后抑郁症的妇女拒绝参加治疗方案。除了一些一般的人口特征外,对它们知之甚少。特别是,她们获得医疗保健的机会以及她们自己及其婴儿的健康状况都不得而知。方法:我们进行了一项嵌套队列病例对照研究,使用计算机化卫生系统、全科医生(GP)和产妇记录的数据,以确定产后抑郁症高风险的初产产前门诊服务人员的特征、卫生服务联系人和母婴健康结果,这些人要么拒绝(自我排除组),要么同意(纳入组)在怀孕期间和产后头2个月接受额外的健康访问支持。结果:将自己排除在保健访视员支持之外的妇女比愿意接受支持的妇女更年轻,受教育程度更低。他们不太可能参加助产、全科医生和常规健康访问者的预约,但更有可能预约到很晚,并去急诊科(A&E)。她们的婴儿在妊娠期、出生体重和母乳喂养方面的结果较差。当考虑到助产接触、急诊就诊和妊娠的年龄和教育程度时,各组之间的差异仍然存在;开始母乳喂养的差异在年龄和教育程度上有所减弱,但不能完全解释。结论:心理脆弱的育龄妇女的一个亚群特别容易难以获得保健和不良的婴儿结局。为了更好地提供护理,需要了解接受服务的障碍。
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引用次数: 96
Systematic review of the effectiveness of community pharmacy-based interventions to reduce risk behaviours and risk factors for coronary heart disease. 对以社区药房为基础的干预措施减少冠心病危险行为和危险因素的有效性进行系统评价。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg030
Alison Blenkinsopp, Claire Anderson, Miriam Armstrong

Background: The aim of the study was to provide a critical and comprehensive overview of the published peer-reviewed evidence relating to community pharmacy-based activity in the reduction of risk behaviours and risk factors for coronary heart disease (CHD).

Method: Electronic databases were searched from 1 January 1990 to 1 February 2001. Hand searches for the same period were undertaken of specific journals and proceedings of peer-reviewed conference abstracts. Data abstracted from publications included: participants/setting; study designs intervention including training); outcome measures; key findings.

Results: Four randomized controlled trials (RCTs) were identified, two in smoking cessation and two in lipid management. All met review criteria and were included. Two (RCTs) involving 976 subjects and three non-randomized experimental studies were identified that evaluated the effectiveness of community pharmacy advice in smoking cessation. Two controlled trials and one before-and-after study investigated the effect of training on pharmacists' smoking cessation advice. One attitudinal survey collected data on reactive and proactive smoking cessation advice-giving by community pharmacists. Two RCTs involving 642 subjects, and two observational studies were identified for community pharmacy-based lipid management. The published studies provided evidence of clinical and cost-effectiveness of community pharmacy services from UK RCTs in smoking cessation, and from US and Canadian RCTs in lipid management in the prevention of heart disease. Although the role of the community pharmacy in disease detection and case finding has been widely discussed, only a small number of studies was found. The findings indicated that further investigation is warranted in these areas.

Conclusion: The peer-reviewed literature demonstrates the contribution of community pharmacy-based services to the reduction of risk behaviours and risk factors for CHD. The evidence supports the wider provision of smoking cessation and lipid management through community pharmacies. Health commissioners and planners can use the findings of this review to incorporate community pharmacy based health development activities into local health services. Further research is needed into the contribution of community pharmacy to disease detection and case finding as part of local public health strategies.

背景:本研究的目的是对已发表的同行评审证据提供一个关键和全面的概述,这些证据与社区药物活动在减少冠心病(CHD)的危险行为和危险因素方面有关。方法:检索1990年1月1日至2001年2月1日的电子数据库。对同一时期的特定期刊和同行评议的会议摘要进行了手工检索。从出版物中摘录的数据包括:参与者/环境;研究设计干预(包括培训);结果措施;关键的发现。结果:确定了四项随机对照试验(rct),两项关于戒烟,两项关于脂质管理。所有人都符合审查标准并被纳入。两项(随机对照试验)涉及976名受试者和三项非随机实验研究,评估了社区药房建议在戒烟中的有效性。两项对照试验和一项前后对照研究调查了培训对药剂师戒烟建议的影响。一项态度调查收集了社区药剂师提供的被动和主动戒烟建议的数据。两项随机对照试验涉及642名受试者,两项观察性研究涉及社区药物脂质管理。已发表的研究为社区药房服务的临床和成本效益提供了证据,这些证据来自英国戒烟的随机对照试验,以及美国和加拿大预防心脏病的脂质管理的随机对照试验。虽然社区药房在疾病检测和病例发现中的作用已经被广泛讨论,但只有少数研究被发现。调查结果表明,有必要在这些领域进行进一步调查。结论:经同行评议的文献表明,社区药房服务有助于减少冠心病的危险行为和危险因素。证据支持通过社区药房更广泛地提供戒烟和脂质管理。卫生专员和规划人员可以利用这次审查的结果,将基于社区药房的卫生发展活动纳入地方卫生服务。需要进一步研究社区药房作为地方公共卫生战略的一部分对疾病检测和病例发现的贡献。
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引用次数: 156
Health technology assessment: history and demand. 卫生技术评估:历史和需求。
Pub Date : 2003-06-01 DOI: 10.1093/pubmed/fdg022
Andrew Stevens, Ruairidh Milne, Amanda Burls

Health technology assessment (HTA)--the provision to decision makers of information on the value of treatments and tests--has come of age in the last two decades. But it has deep roots in health care, with notable landmarks in (1) the mid eighteenth-century development of empiricism, (2) the twentieth century interest in outcomes and variation in health care, and (3) the pioneering work of Archie Cochrane and others in the 1970s. Three main forces have driven the recent developments of HTA: a combination of concerns about the adoption of unproven technologies, rising costs, and an inexorable rise in consumer expectations. The HTA response, essentially initiatives supporting the provision of reliable synthesised research information on the effects and costs of health technologies, have been well supported in the United Kingdom and internationally. We can be sure that HTA is here to stay.

卫生技术评估————向决策者提供有关治疗和检测价值的信息————在过去二十年中已经成熟。但它在医疗保健领域有着深厚的根基,在以下几个方面有着显著的里程碑:(1)18世纪中期经验主义的发展,(2)20世纪对医疗保健结果和变化的兴趣,以及(3)20世纪70年代阿奇·科克伦(Archie Cochrane)等人的开创性工作。推动HTA近期发展的主要力量有三:对采用未经验证的技术的担忧、不断上升的成本以及消费者预期的不可阻挡的上升。卫生管理局的应对措施,主要是支持提供关于卫生技术的影响和成本的可靠综合研究信息的举措,在联合王国和国际上得到了很好的支持。我们可以确定HTA会继续存在下去。
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引用次数: 49
期刊
Journal of public health medicine
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