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Evaluation of the effects of dexmedetomidine on liver damage secondary to renal ischemia-reperfusion 右美托咪定对肾缺血再灌注后肝损伤影响的评价
IF 0.2 Q4 Medicine Pub Date : 2020-06-24 DOI: 10.35975/apic.v24i2.1257
S. Kartal, A. Şen, L. Tumkaya, Abdullah Özdemir, T. Mercantepe, A. Yılmaz
Background: The aim of this study was to evaluate the hepatic protective effects of dexmedetomidine in a rat model of renal ischemia-reperfusion injury  Methodology: Rats were randomly divided into 3 equal groups (n = 6); control (C) group, ischemia / reperfusion (I/R) group, (D + I/R) group which dexmedetomidine was given and I/R was administered.
背景:本研究的目的是评估右美托咪定在大鼠肾缺血再灌注损伤模型中的肝脏保护作用。方法:将大鼠随机分为3组(n=6);对照组(C)、缺血再灌注组(I/R)、(D+I/R)给予右美托咪定并给予I/R。
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引用次数: 0
Reinfection in a healthcare worker with COVID-19 in a hospital in North India 印度北部一家医院中一名医护人员再次感染COVID-19
IF 0.2 Q4 Medicine Pub Date : 2020-06-10 DOI: 10.35975/apic.v24i5.1369
N. Nazir, A. Ahirwar, Shruti Jain
Citation: Nazir N, Ahirwar A, Jain S. Reinfection in a healthcare worker with COVID-19 in a hospital in North India. Anaesth. pain intensive care 2020;24(5):
引文:Nazir N, Ahirwar A, Jain S.印度北部一家医院中一名医护人员再次感染COVID-19。Anaesth。疼痛重症监护2020;24(5):
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引用次数: 3
COVID-19 survivors and neuropsychological issues: A way forward COVID-19幸存者和神经心理问题:前进的道路
IF 0.2 Q4 Medicine Pub Date : 2020-06-10 DOI: 10.35975/apic.v24i5.1368
M. Rafiq, Umaiza Bashir, J. Hasnain
Background: This brief article focuses on highlighting the importance of possible neuropsychological manifestations among the Coronavirus Disease 19 (COVID-19) survivors. Studies have evidenced that like other Coronaviruses, COVID-19 is highly contagious and also responsible for the development of mild to severe respiratory symptoms. As COVID-19 is a recently emerged pandemic that has resulted in more than six hundred thousand deaths around the globe as of July 2020 and most of the researches has focused on the physical manifestations. Purpose: The purpose of this review article was to highlight the importance of COVID-19 infection in perspective to mental health in those patients who are survived. Methodology: For this purpose, an intensive literature review was conducted through different scientific search engines including PubMed, Google Scholars, Science Direct, etc. Results and Conclusion: There is very limited data available on manifestations including psychological and neuropsychological. Studies have shown that viral infections including viruses from Coronaviridae have been implicated in the nervous system including the brain. So, it is important to investigate the post-COVID-19 infection in neuropsychological aspects. Such studies will highlight the importance of post-COVID-19 complications and will also help in redesigning the treatment plan for mental health. Keywords: COVID-19, neuropsychological issues, mental health, Coronavirus Disease 19 Survivors, depression, anxiety, stress Citation: Rafiq M, Bashir U, Hasnain J. COVID-19 survivors and neuropsychological issues: A way forward. Anaesth. pain intensive care 2020;24(5):
背景:这篇简短的文章重点强调了冠状病毒疾病19(新冠肺炎)幸存者可能的神经心理表现的重要性。研究表明,与其他冠状病毒一样,新冠肺炎具有高度传染性,也会导致轻度至重度呼吸道症状。由于新冠肺炎是一种最近出现的流行病,截至2020年7月,已导致全球60多万人死亡,大多数研究都集中在身体表现上。目的:这篇综述文章的目的是强调新冠肺炎感染对幸存患者心理健康的重要性。方法:为此,通过PubMed、Google Scholars、Science Direct等不同的科学搜索引擎进行了深入的文献综述。结果和结论:关于包括心理和神经心理学在内的表现形式的可用数据非常有限。研究表明,包括冠状病毒科病毒在内的病毒感染与包括大脑在内的神经系统有关。因此,对COVID-19后感染的神经心理学研究具有重要意义。这些研究将强调COVID-19后并发症的重要性,也将有助于重新设计心理健康治疗计划。关键词:新冠肺炎,神经心理问题,心理健康,冠状病毒疾病19幸存者,抑郁,焦虑,压力引用:Rafiq M,Bashir U,Hasnain J.新冠肺炎幸存者和神经心理问题:前进的道路。Anaesth。疼痛重症监护2020;24(5):
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引用次数: 0
Henk Haisma Henk Haisma先生
IF 0.2 Q4 Medicine Pub Date : 2020-05-07 DOI: 10.35975/apic.v24i1.1242
Tariq H. Khan
It is with great sadness that we learn of Henk’s untimely death.   Henk Haisma was a Dutch anesthesiologist of the highest order.  During the late 1990s and early 2000s he was pivotal in the early growth and development of Primary Trauma Care (PTC). PTC was, in fact, his second love after anesthesiology.
得知亨克英年早逝,我们深感悲痛。亨克·海斯马是荷兰最高级别的麻醉师。在20世纪90年代末和21世纪初,他在初级创伤护理(PTC)的早期成长和发展中发挥了关键作用。事实上,PTC是他仅次于麻醉学的第二爱好。
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引用次数: 0
The arrival of COVID-19 in the Netherlands 新冠肺炎抵达荷兰
IF 0.2 Q4 Medicine Pub Date : 2020-05-07 DOI: 10.35975/apic.v24i1.1220
X. Falières
The last three months have been the most memorable and the most tense period in the lives of the most of us. After Taking Wuhan (China) by storm, the coronavirus crossed all of the frontiers and reached to 202 countries, including the East Asian countries, Middle East, the Americas and then the European countries. The Netherlands was effected less, with about 1000 deaths and more than 12000 confirmed patients, than its neighbors – Italy and Spain, but had its share. This manuscript presents an outline of the public perceptions, and the guidelines to manage these patients at different stages of the disease, including ventilation and intubation protocols, based upon our experience of over two months. It does not claim to be complete and exhaustive, and the readers are directed to consult their National guidelines (if any). Citation: Falières X. The arrival of COVID-19 in the Netherlands (Perspective). Anaesth pain intensive care 2020;24(1):__ DOI: https://doi.org/10.35975/apic.v24i1. Received – 14 March 2020 Reviewed & Accepted – 18 March 2020
过去的三个月是我们大多数人一生中最难忘、最紧张的时期。在席卷中国武汉之后,冠状病毒跨越了所有的边界,到达了202个国家,包括东亚国家、中东国家、美洲国家,然后是欧洲国家。与邻国意大利和西班牙相比,荷兰受影响较小,约有1000人死亡,确诊患者超过12000人,但也有一部分。根据我们两个多月的经验,本文概述了公众的看法,以及在疾病的不同阶段管理这些患者的指导方针,包括通气和插管方案。它并不声称是完整的和详尽的,读者可以参考他们的国家指导方针(如果有的话)。引用本文:fali res X.新冠肺炎疫情在荷兰的到来(展望)。麻醉性疼痛重症监护2020;24(1):__ DOI: https://doi.org/10.35975/apic.v24i1。收稿日期:2020年3月14日审稿日期:2020年3月18日
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引用次数: 0
Intraocular pressure response to airway management: Comparison between LMA Supreme® and C-MAC® videolaryngoscope in day care surgery 眼压对气道管理的反应:LMA Supreme®和C-MAC®视频喉镜在日托手术中的比较
IF 0.2 Q4 Medicine Pub Date : 2020-04-12 DOI: 10.35975/apic.v24i6.1400
Haramritpal Kaur, Gurpreet Singh, Jaipreet Singh, Munish Dhawan, Amandeep Singh, Kaur
Background: Airway maintenance procedures during anesthesia are usually associated with a rise in intraocular pressure (IOP). This is an important issue especially in vulnerable patients. In the present study we compared the rise in IOP with two different group of airway devices i.e. Laryngeal mask airway Supreme (LMA-S) and endotracheal intubation (ETT) using C-MAC® videolaryngoscope (VLS). Methodology: The present study was conducted on 100 adult patients of ages >18 yrs, of either sex, belonging to American Society of Anesthesiologist (ASA) I and II, scheduled to undergo non-ophthalmic elective surgery under general anesthesia. Patients were divided into two equal groups of 50 each, Group A and Group B. In group A (n = 50), lubricated appropriate sized LMA-S was inserted and in Group B (n=50), lubricated appropriate sized ETT was inserted by an anesthesiologist using VLS. IOP was measured in right eye just before insertion of device and subsequently at 1 min, 3 min, 5 min and 10 min after insertion of device. Hemodynamic parameters were recorded along with IOP measurement. Results: Both the groups were comparable regarding demographic data (p > 0.05), ASA grade (p = 0.069), and Mallampati grade (MPG) (p = 0.646). Airway establishment time (p = 0.011) was significantly less with C-MAC VLS. IOP were comparable at all measurement times, e.g., 1 min (p = 0.216), 3 min (p = 0.093), 5 min (p = 0.859) and 10 min (p = 0.060) after insertion of each device. Hemodynamic parameters measured were also comparable between two groups (p > 0.05). Conclusion: Both LMA Supreme and intubation using C-MAC® videolaryngoscope are safe regarding rise in intraocular pressure. Both methods can be safely used for airway management in suitable patients. Key words: Airway; Anesthesia; Intraocular pressure; LMA; Endotracheal intubation Citation: Kaur H, Singh G, Singh J, Kaur, Dhawan M, Singh A. Intraocular pressure response to airway management: Comparison between LMA Supreme and C-MAC® videolaryngoscope in day care surgery. Anaesth. pain intensive care 2020;24(6):__ Received: 27 January 2020, Revised: 12 May 2020, Reviewed: 25 October 2020, Accepted: 27 October 2020
背景:麻醉期间的气道维持程序通常与眼压升高有关。这是一个重要的问题,尤其是在易受伤害的患者中。在本研究中,我们比较了使用C-MAC®视频喉镜(VLS)的两组不同的气道装置(即喉罩式最高气道罩(LMA-S)和气管插管(ETT))的眼压升高情况。方法:本研究对100名年龄>18岁的成年患者进行,他们属于美国麻醉师协会(ASA)I和II,计划在全麻下接受非眼科选择性手术。患者被分为两组,每组50人,A组和B组。在A组(n=50)中,插入润滑的适当大小的LMA-S,在B组(n=50中)中,麻醉师使用VLS插入润滑的合适大小的ETT。在插入装置之前以及随后在插入装置后1分钟、3分钟、5分钟和10分钟测量右眼的IOP。记录血液动力学参数和眼压测量。结果:两组在人口统计学数据(p>0.05)、ASA分级(p=0.069)和Mallampati分级(MPG)(p=0.646)方面具有可比性。C-MAC VLS的气道建立时间(p=0.011)显著缩短。IOP在所有测量时间都是可比较的,例如,插入每个装置后1分钟(p=0.216)、3分钟(p=0.093)、5分钟(p=0.859)和10分钟(p=0.060)。测量的血液动力学参数在两组之间也具有可比性(p>0.05)。结论:LMA Supreme和使用C-MAC®视频喉镜插管对眼压升高是安全的。这两种方法都可以安全地用于合适患者的气道管理。关键词:Airway;麻醉眼压;LMA;气管插管引文:Kaur H,Singh G,Singh J,Kaur,Dhawan M,Singh A.气道管理的眼压反应:LMA Supreme和C-MAC®视频喉镜在日托手术中的比较。Anaesth。疼痛重症监护2020;24(6):__接收日期:2020年1月27日,修订日期:2020月12日,审核日期:2020年底25日,接受日期:2020年初27日
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引用次数: 0
Double clear plastic screens to minimize droplet spread and aerosolization at extubation in COVID-19 patient 新冠肺炎患者拔管时,双透明塑料滤网可最大限度地减少飞沫扩散和雾化
IF 0.2 Q4 Medicine Pub Date : 2020-04-12 DOI: 10.35975/apic.v24i6.1406
F. Shamim, K. Samad, M. Khan
The droplets of novel coronavirus disease 2019 (COVID-19) can be transmitted during aerosol-generating procedures involving tracheal intubation.1 Anesthesiologists are exposed to a higher risk than other specialty healthcare workers because they manage the airway and ventilation.2 Extubation is as high a risk for aerosolization of respiratory secretions as is intubation. Additional barriers have been described for intubation like using intubation box or clear plastic drapes but limited options have been explored for extubation.3 Some experts suggest placing wet gauze over the patient’s mouth and nose just prior to extubation if the patient starts to cough, and/or covering the patient's face with a clear plastic drape.4
2019年新型冠状病毒病(新冠肺炎)的飞沫可以在涉及气管插管的雾化生成过程中传播。1麻醉医师比其他专业医护人员面临更高的风险,因为他们管理气道和通气。2拔管与插管一样,呼吸道分泌物雾化的风险也很高。已经描述了插管的其他障碍,如使用插管盒或透明塑料窗帘,但对拔管的选择有限。3一些专家建议,如果患者开始咳嗽,在拔管前在患者的口鼻上放置湿纱布,和/或用透明塑料布覆盖患者的脸。4
{"title":"Double clear plastic screens to minimize droplet spread and aerosolization at extubation in COVID-19 patient","authors":"F. Shamim, K. Samad, M. Khan","doi":"10.35975/apic.v24i6.1406","DOIUrl":"https://doi.org/10.35975/apic.v24i6.1406","url":null,"abstract":"The droplets of novel coronavirus disease 2019 (COVID-19) can be transmitted during aerosol-generating procedures involving tracheal intubation.1 Anesthesiologists are exposed to a higher risk than other specialty healthcare workers because they manage the airway and ventilation.2 Extubation is as high a risk for aerosolization of respiratory secretions as is intubation. Additional barriers have been described for intubation like using intubation box or clear plastic drapes but limited options have been explored for extubation.3 Some experts suggest placing wet gauze over the patient’s mouth and nose just prior to extubation if the patient starts to cough, and/or covering the patient's face with a clear plastic drape.4","PeriodicalId":7735,"journal":{"name":"Anaesthesia, Pain & Intensive Care","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46619111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echocardiography-Guided Hemodynamic Management of Severe Sepsis and Septic Shock in Adults: A Randomized Controlled Trial 超声心动图引导下成人严重脓毒症和脓毒性休克的血流动力学管理:一项随机对照试验
IF 0.2 Q4 Medicine Pub Date : 2020-03-17 DOI: 10.21203/rs.3.rs-17392/v1
Walid S. Alhabashy, O. M. Shalaby, A. Elgebaly, M. Ghafar
Background: Echocardiography (ECHO) is used to guide septic shock resuscitation, but without evidence for efficacy. Therefore, we compared the outcome of early goal-directed therapy (EGDT) and ECHO-guided management of hemodynamics in severe sepsis and septic shock. Materials and Methods: This is a single center, randomized controlled trial conducted on 100 adult patients with severe sepsis or septic shock. Patients were assessed and treated with either EGDT protocol (EGDT group) or ECHO-guided resuscitation protocol (ECHO group). Results: Only 87 patients (45 in group I and 42 in group II) were analyzed. There was a significant increase of mean norepinephrine and dobutamine doses and a significant decrease in total fluids in the first 24 hours, time to normalization, time to weaning of vasopressors, total MV days, MV free days and ICU and hospital stays in ECHO group. At 30 days, the mortality rate in EGDT group was 35.6% which was significantly higher compared to 14.3% in ECHO group. At 90 days, the overall mortality was significantly higher in EGDT group compared to Echo group (40.0% vs 16.7% respectively). Hazardous ratio of mortality was 1.630 (95% confidence interval (CI): 1.123 - 2.366) and 1.653 (95% CI: 1.137 - 2.404) at 30 and 90 days respectively in EGDT group compared to ECHO group. Conclusions: In severe sepsis and septic shock, ECHO-guided management of hemodynamics resulted in a decrease in mortality, lower total fluid intake, higher vasopressor and inotrope support, earlier weaning of vasopressors and less MV days, ICU and hospital stay.
背景:超声心动图(ECHO)用于指导感染性休克复苏,但没有疗效证据。因此,我们比较了早期目标导向治疗(EGDT)和ECHO指导的严重败血症和感染性休克血液动力学管理的结果。材料和方法:这是一项针对100名患有严重败血症或感染性休克的成年患者的单中心随机对照试验。采用EGDT方案(EGDT组)或ECHO引导复苏方案(ECHO组)对患者进行评估和治疗。结果:仅对87例患者(Ⅰ组45例,Ⅱ组42例)进行了分析。ECHO组的平均去甲肾上腺素和多巴酚丁胺剂量在前24小时、正常化时间、血管升压药停用时间、总MV天数、无MV天数、ICU和住院时间显著增加,总液体显著减少。30天时,EGDT组的死亡率为35.6%,显著高于ECHO组的14.3%。90天时,EGDT组的总死亡率显著高于Echo组(分别为40.0%和16.7%)。与ECHO组相比,EGDT组在第30天和第90天的死亡率危险比分别为1.630(95%置信区间(CI):1.123-2.366)和1.653(95%可信区间:1.137-2.404)。结论:在严重败血症和感染性休克中,ECHO指导下的血液动力学管理可降低死亡率,降低总液体摄入量,增加血管升压药和止疼药支持,提前停用血管升压药,减少MV天数、ICU和住院时间。
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引用次数: 1
Ultrasound in critical care 重症监护中的超声
IF 0.2 Q4 Medicine Pub Date : 2020-02-25 DOI: 10.35975/apic.v22i1.1206
Saima Rashid, M. Khan, R. Rajendram
Ultrasound (US) was introduced in the 1950s and since then its use has increased exponentially. This has been facilitated by significant improvement in the probe technology, increasing access to portable machines and better understanding of lung, heart, abdominal and vascular US. Use of critical care US (CCUS) is now extremely common. It is important for frontline physicians who must make appropriate and timely decisions within seconds. It is safe, convenient and readily available in many centers. The concept of point of care ultrasound (POCUS) differs from US screening by a radiologist or sonographer. It is, rapid focused and goal-orientated. Despite its major limitation, e.g. operator dependence, bedside CCUS can be used for an ever-increasing range of indications. This narrative review will describe the potential role of CCUS as the replacement for the stethoscope in the 21st century and the limitations which must be overcome to achieve this. Received: 3 Nov 2018Reviewed & Accepted: 10 Nov 2018 Citation: Rashid S, Khan MF, Rajendram R. Ultrasound in critical care. Anaesth Pain & Intensive Care 2018;22 Suppl 1:S160-S163
超声波(美国)于20世纪50年代引入,此后其使用呈指数级增长。这得益于探头技术的显著改进、便携式机器的普及以及对肺部、心脏、腹部和血管超声的更好理解。重症监护超声(CCUS)的使用现在非常普遍。这对一线医生来说很重要,他们必须在几秒钟内做出适当及时的决定。它安全、方便,而且在许多中心都很容易买到。护理点超声(POCUS)的概念不同于放射科医生或声谱学家的超声筛查。它是快速聚焦和目标导向的。尽管其主要局限性,例如操作员依赖性,但床边CCUS可用于不断增加的适应症范围。这篇叙述性综述将描述CCUS在21世纪取代听诊器的潜在作用,以及实现这一目标必须克服的局限性。接收日期:2018年11月3日审核和接受日期:2018月10日引文:Rashid S,Khan MF,Rajendram R.重症监护超声。Anaesth疼痛与重症监护2018;22增刊1:S160-S163
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引用次数: 0
Central venous pressure monitoring 中心静脉压监测
IF 0.2 Q4 Medicine Pub Date : 2020-02-25 DOI: 10.35975/apic.v22i1.1204
Jyoti Gupta
The circulatory dynamics of patients are maintained by a triad of vascular capacitance, effective circulating volume and cardiac pump function. These components interact to provide blood pressure, cardiac output and tissue perfusion. Central venous pressure (CVP) is one of the parameters which is known to be useful in evaluating the interaction of these modalities. It will also help to determine volume status of the patient and need to fill in, as well as the efficacy of the volume therapy. Sometimes central line will be inserted to infuse vasoactive infusions or blood nd blood products. Its an invasive procedure and has its complications. The intensivists need to be fully conversant with the standard guidelines for this procedure for patient safety. Received: 15 Sep 2018Reviewed: 18 Sep 2018Corrected: 28 Sep, 18 Oct 2018Accepted: 5 Nov 2018 Citation: Gupta J. Central venous pressure monitoring. Anaesth Pain & Intensive Care 2018;22 Suppl 1:S137-S141
患者的循环动力学由血管容量、有效循环量和心脏泵功能三者组成。这些成分相互作用以提供血压、心输出量和组织灌注。中心静脉压(CVP)是已知的用于评估这些模式的相互作用的参数之一。它还将有助于确定患者的容量状态和需要填写的内容,以及容量治疗的疗效。有时会插入中心线以注入血管活性输注物或血液和血液制品。这是一种侵入性手术,也有并发症。为了患者安全,重症监护医生需要完全熟悉该程序的标准指南。接收:2018年9月15日审核:2018年10月18日更正:2018年11月5日接受:Gupta J.中心静脉压力监测。Anaesth疼痛与重症监护2018;22增刊1:S137-S141
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引用次数: 0
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Anaesthesia, Pain & Intensive Care
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