Pub Date : 2026-02-01Epub Date: 2025-11-07DOI: 10.1213/ANE.0000000000007836
Jaideep J Pandit
{"title":"Units of Measurement of Vascular and Gas Pressures: Journal Response.","authors":"Jaideep J Pandit","doi":"10.1213/ANE.0000000000007836","DOIUrl":"10.1213/ANE.0000000000007836","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"e20-e21"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-08-29DOI: 10.1213/ANE.0000000000007702
Martin Dupuis, Alexia Bacci, Anaïs Adolle, Dimitri Sourd, Antoine Vilotitch, Pierre Bouzat
{"title":"Regional Analgesia Through Posterior Quadratus Lumborum Block in Laparoscopic and Robot-Assisted Nephrectomies: A Retrospective Observational Study.","authors":"Martin Dupuis, Alexia Bacci, Anaïs Adolle, Dimitri Sourd, Antoine Vilotitch, Pierre Bouzat","doi":"10.1213/ANE.0000000000007702","DOIUrl":"10.1213/ANE.0000000000007702","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"425-428"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-24DOI: 10.1213/ANE.0000000000007849
Frank R Major, Trevor A Pickering, Jeffry T Nahmias, Catherine M Kuza
{"title":"In Response.","authors":"Frank R Major, Trevor A Pickering, Jeffry T Nahmias, Catherine M Kuza","doi":"10.1213/ANE.0000000000007849","DOIUrl":"10.1213/ANE.0000000000007849","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":"e27-e28"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-09DOI: 10.1213/ANE.0000000000007913
{"title":"Multi-modal Analgesia and Cardiac Surgery.","authors":"","doi":"10.1213/ANE.0000000000007913","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007913","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"142 2","pages":"219"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-09DOI: 10.1213/ANE.0000000000007798
Neerja Bharti, Parag Kumar, Indu Bala, Vikas Gupta
{"title":"Erratum: The Efficacy of a Novel Approach to Transversus Abdominis Plane Block for Postoperative Analgesia After Colorectal Surgery.","authors":"Neerja Bharti, Parag Kumar, Indu Bala, Vikas Gupta","doi":"10.1213/ANE.0000000000007798","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007798","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"142 2","pages":"e37"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-19DOI: 10.1213/ANE.0000000000007840
Aditi Suri, Gaurav Sindwani
{"title":"Development and Validation of a Virtual Interactive Avatar for Regional Anesthesia.","authors":"Aditi Suri, Gaurav Sindwani","doi":"10.1213/ANE.0000000000007840","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007840","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"142 2","pages":"e21-e23"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-11-24DOI: 10.1213/ANE.0000000000007872
Benjamin Fisher, Huafeng Wei
{"title":"A Review of Existing Case Reports on Sugammadex-Associated Bradycardia and Cardiac Arrest.","authors":"Benjamin Fisher, Huafeng Wei","doi":"10.1213/ANE.0000000000007872","DOIUrl":"10.1213/ANE.0000000000007872","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":"142 2","pages":"e33-e36"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1213/ANE.0000000000007868
Ashley N Budd, Miklos D Kertai, Moritz C Wyler von Ballmoos, Jacob Raphael, Kamrouz Ghadimi, Jerrold H Levy, Linda J Shore-Lesserson, Michael A Mazzeffi, Roman M Sniecinski, Kenichi A Tanaka, Daniel Bolliger, Mohamed Abdalla, Kelly G Ural, Patrick A Upchurch, Olga Rozental, Caroline B Hunter, Adam R Seibert, John C Klick, David Carroll, Katie Lobner, Nadia B Hensley
The Society of Cardiovascular Anesthesiologists (SCA) along with the Society of Thoracic Surgeons (STS) sought to improve the care of adult patients undergoing cardiac surgery who are taking direct oral anticoagulants (DOACs), such as factor Xa and direct thrombin inhibitors. To fulfill this, a systematic review of the literature on cessation of DOACs before cardiac surgery, options for monitoring DOACs, the need for bridging, reversal agents, and resuming the medications after surgery was performed. Additionally, an expert consensus around the management of these patients was completed. Summary statements were created using evidence and expert consensus to guide care of patients in each of these domains, with the ultimate goal to enhance patient safety and outcomes.
{"title":"Management of Direct Oral Anticoagulants in Adult Patients Undergoing Cardiac Surgery: A Joint Consensus Statement by the Society of Cardiovascular Anesthesiologists and the Society of Thoracic Surgeons.","authors":"Ashley N Budd, Miklos D Kertai, Moritz C Wyler von Ballmoos, Jacob Raphael, Kamrouz Ghadimi, Jerrold H Levy, Linda J Shore-Lesserson, Michael A Mazzeffi, Roman M Sniecinski, Kenichi A Tanaka, Daniel Bolliger, Mohamed Abdalla, Kelly G Ural, Patrick A Upchurch, Olga Rozental, Caroline B Hunter, Adam R Seibert, John C Klick, David Carroll, Katie Lobner, Nadia B Hensley","doi":"10.1213/ANE.0000000000007868","DOIUrl":"10.1213/ANE.0000000000007868","url":null,"abstract":"<p><p>The Society of Cardiovascular Anesthesiologists (SCA) along with the Society of Thoracic Surgeons (STS) sought to improve the care of adult patients undergoing cardiac surgery who are taking direct oral anticoagulants (DOACs), such as factor Xa and direct thrombin inhibitors. To fulfill this, a systematic review of the literature on cessation of DOACs before cardiac surgery, options for monitoring DOACs, the need for bridging, reversal agents, and resuming the medications after surgery was performed. Additionally, an expert consensus around the management of these patients was completed. Summary statements were created using evidence and expert consensus to guide care of patients in each of these domains, with the ultimate goal to enhance patient safety and outcomes.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1213/ANE.0000000000007888
Kush M Kale, Peter A Goldstein, Jaideep J Pandit
In the literature, anesthetic agents are commonly described as if their hypnotic action is mediated by a predominant molecular target, using terminology such as "GABAergic" or "NMDAergic." The justification for this is unclear. The authors might thereby imply a single target hypothesis (ie, the named target is the sole or predominant molecular mechanism for that agent); or that in an in vitro dose-response plot, the potency or efficacy of this agent is distinctly (ie, several orders of magnitude) highest for interaction with the named target as compared with others. We explored if this last was the case, through review of data reported across 310 in vitro studies. We found that all but a few agents were highly "promiscuous," influencing several different molecular targets with similar potency, making it difficult to justify that any one was predominant. Notably, propofol, often cited as a "typical GABAergic agent" in fact shows higher potency at nicotinic receptors and HCN ion channels than for GABAA receptors (GABAARs). Exceptions to promiscuity were, to an extent, etomidate and dexmedetomidine, which were relatively "monogomous" for GABAAR and α2-adrenoreceptors, respectively, and ketamine for NMDA receptors. Moreover, molecular targets were also promiscuous for which agents they were influenced by. This was in a manner that did not always correspond to the "preference" of an agent for a receptor. We discuss how this mutual promiscuity is consistent with a multi-site mechanism of anesthetic action.
{"title":"Are \"GABAergic\" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro.","authors":"Kush M Kale, Peter A Goldstein, Jaideep J Pandit","doi":"10.1213/ANE.0000000000007888","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007888","url":null,"abstract":"<p><p>In the literature, anesthetic agents are commonly described as if their hypnotic action is mediated by a predominant molecular target, using terminology such as \"GABAergic\" or \"NMDAergic.\" The justification for this is unclear. The authors might thereby imply a single target hypothesis (ie, the named target is the sole or predominant molecular mechanism for that agent); or that in an in vitro dose-response plot, the potency or efficacy of this agent is distinctly (ie, several orders of magnitude) highest for interaction with the named target as compared with others. We explored if this last was the case, through review of data reported across 310 in vitro studies. We found that all but a few agents were highly \"promiscuous,\" influencing several different molecular targets with similar potency, making it difficult to justify that any one was predominant. Notably, propofol, often cited as a \"typical GABAergic agent\" in fact shows higher potency at nicotinic receptors and HCN ion channels than for GABAA receptors (GABAARs). Exceptions to promiscuity were, to an extent, etomidate and dexmedetomidine, which were relatively \"monogomous\" for GABAAR and α2-adrenoreceptors, respectively, and ketamine for NMDA receptors. Moreover, molecular targets were also promiscuous for which agents they were influenced by. This was in a manner that did not always correspond to the \"preference\" of an agent for a receptor. We discuss how this mutual promiscuity is consistent with a multi-site mechanism of anesthetic action.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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