Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007953
Gaston Nyirigira, Emile Twagirumukiza, Jean de Dieu Singirankabo, Kara L Neil
{"title":"Chronic Pain Self-Management for Health Equity in Limited Resource Settings: The Rwandan Experience.","authors":"Gaston Nyirigira, Emile Twagirumukiza, Jean de Dieu Singirankabo, Kara L Neil","doi":"10.1213/ANE.0000000000007953","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007953","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007955
Robert J Brosnan, Shane Austin, Joseph F Antognini
{"title":"A New General Anesthetic BTTE: Physical Properties, Hypnotic and Hemodynamic Effects in Rats, and Effects on GABA and NMDA Receptors Expressed in Frog Oocytes.","authors":"Robert J Brosnan, Shane Austin, Joseph F Antognini","doi":"10.1213/ANE.0000000000007955","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007955","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007963
Mark L van Zuylen
{"title":"Dexmedetomidine's Effect on Delirium, Cognitive Dysfunction, and Sleep: More Questions Than Answers.","authors":"Mark L van Zuylen","doi":"10.1213/ANE.0000000000007963","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007963","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007959
Yasmine Tameze, Kenneth T Shelton
{"title":"The Critical Role of Hospital Identifiers in Evaluating Failure-to-Rescue Disparities.","authors":"Yasmine Tameze, Kenneth T Shelton","doi":"10.1213/ANE.0000000000007959","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007959","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007919
Oluwakemi Tomobi, Catherine Gouge, Alyssa Brashear, Daniel Totzkay, Fei Chen, Julie Huffmyer, David Scalzo, Edward C Nemergut, Rebekah Guillow
Background: Empathy is a crucial part of the therapeutic relationship. Inadequate patient-physician communication can result in misunderstanding, reduced patient satisfaction, poor compliance with recommended interventions, and increased malpractice risk. Despite its importance, empathy among anesthesiology trainees remains under explored. This observational study used validated tools to evaluate trainee empathy in the pre-anesthesia setting from different perspectives.
Methods: Participating anesthesiology trainees were observed as they conducted pre-anesthesia patient encounters. First, they completed self-evaluations using the Jefferson Scale of Empathy (JSE) and the Resident Wellness Scale. Additionally, patients who were 18 years or older completed the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE) after their pre-anesthesia interview with the anesthesia trainee. A non-anesthesiologist physician evaluated the interactions between patients and anesthesia trainees with the Jefferson Empathy Scale for Observers (JSEO). Quantitative analyses of closed questions (including empathy scales) included descriptive statistics, correlations, and multivariable linear regression analysis. Open-ended questions were analyzed using thematic analysis.
Results: Twenty-four trainees completed 151 observed patient pre-anesthesia encounters with at least 5 observations per trainee. There was a modest, negative correlation between average time (seconds) in patient interaction and trainee wellness (r = -0.421, P = .041), and a moderate negative correlation between the trainee empathy subdomain "walking in the patient's shoes" and year in training (r = -0.451, P = .021). Male trainees spent more time during the consultation (mean time ± SD = 396 ± 80 seconds vs. 323 ± 50 seconds, P = .035) and had higher mean ratings from patients (JSPPPE rating 33.1 ± 3.00 vs 32.2 ± 3.00, P = .020) than female trainees. On multivariable analysis, predictors of highest empathy ratings were male gender (JSPPPE: P = .022) and the year of training (JSE: P = .013; JSEO: p =0.023). Thematic analysis of patient and observer comments suggests a discrepancy in perceived empathy, with patients less likely to perceive positive behaviors as empathetic, but an emphasis on importance of information delivered in the pre-anesthesia encounter.
Conclusion: Patients found male trainees and trainees earlier in training to display higher levels of empathy which differed from observer ratings. Qualitative evaluation may offer insights into our understanding of patient-perceived empathy in anesthesiology trainees. The discrepancy between patient, trainee, and observer ratings suggests that perceived empathy in anesthesiology pre-anesthesia interviews may be driven by different factors than in other specialties, particularly information exchange and efficiency of communication.
背景:共情是治疗关系的重要组成部分。医患沟通不足会导致误解,降低患者满意度,对推荐干预措施的依从性差,并增加医疗事故风险。尽管移情很重要,但麻醉学受训者之间的移情仍有待探索。本观察性研究使用经过验证的工具,从不同角度评估麻醉前情境下受训者的同理心。方法:对参与麻醉培训的学员进行麻醉前患者接触时的观察。首先,他们使用杰弗逊共情量表(JSE)和居民健康量表完成自我评估。此外,18岁或以上的患者在麻醉前与麻醉培训生面谈后完成了杰弗逊患者对医生共情感知量表(JSPPPE)。一名非麻醉科医师用杰弗逊观察者共情量表(JSEO)评估患者与麻醉学员之间的互动。封闭问题(包括共情量表)的定量分析包括描述性统计、相关性和多变量线性回归分析。开放式问题采用主题分析法进行分析。结果:24名受训者完成了151次麻醉前观察,每位受训者至少有5次观察。与患者互动的平均时间(秒)与受训人员健康之间存在适度的负相关(r = -0.421, P = 0.041),受训人员共情子域“换位思考”与培训时间之间存在适度的负相关(r = -0.451, P = 0.021)。男性学员会诊时间更长(平均时间±SD = 396±80秒比323±50秒,P = 0.035),患者平均评分(JSPPPE评分33.1±3.00比32.2±3.00,P = 0.020)高于女性学员。在多变量分析中,共情评分最高的预测因子是男性性别(JSPPPE: P = 0.022)和培训年份(JSE: P = 0.013; JSEO: P =0.023)。对患者和观察者评论的专题分析表明,在感知共情方面存在差异,患者不太可能将积极行为视为共情,但强调在麻醉前遇到的信息传递的重要性。结论:患者发现男性受训者和较早接受训练的受训者表现出较高的共情水平,与观察者的评分不同。定性评估可以为我们理解麻醉受训者的患者感知共情提供见解。患者、受训者和观察员评分之间的差异表明,麻醉前访谈中感知到的共情可能受到与其他专业不同的因素驱动,尤其是信息交换和沟通效率。
{"title":"Evaluating Perspectives on Empathy in Anesthesiology Trainees: A Mixed-Methods Study of Pre-Anesthesia Encounters.","authors":"Oluwakemi Tomobi, Catherine Gouge, Alyssa Brashear, Daniel Totzkay, Fei Chen, Julie Huffmyer, David Scalzo, Edward C Nemergut, Rebekah Guillow","doi":"10.1213/ANE.0000000000007919","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007919","url":null,"abstract":"<p><strong>Background: </strong>Empathy is a crucial part of the therapeutic relationship. Inadequate patient-physician communication can result in misunderstanding, reduced patient satisfaction, poor compliance with recommended interventions, and increased malpractice risk. Despite its importance, empathy among anesthesiology trainees remains under explored. This observational study used validated tools to evaluate trainee empathy in the pre-anesthesia setting from different perspectives.</p><p><strong>Methods: </strong>Participating anesthesiology trainees were observed as they conducted pre-anesthesia patient encounters. First, they completed self-evaluations using the Jefferson Scale of Empathy (JSE) and the Resident Wellness Scale. Additionally, patients who were 18 years or older completed the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE) after their pre-anesthesia interview with the anesthesia trainee. A non-anesthesiologist physician evaluated the interactions between patients and anesthesia trainees with the Jefferson Empathy Scale for Observers (JSEO). Quantitative analyses of closed questions (including empathy scales) included descriptive statistics, correlations, and multivariable linear regression analysis. Open-ended questions were analyzed using thematic analysis.</p><p><strong>Results: </strong>Twenty-four trainees completed 151 observed patient pre-anesthesia encounters with at least 5 observations per trainee. There was a modest, negative correlation between average time (seconds) in patient interaction and trainee wellness (r = -0.421, P = .041), and a moderate negative correlation between the trainee empathy subdomain \"walking in the patient's shoes\" and year in training (r = -0.451, P = .021). Male trainees spent more time during the consultation (mean time ± SD = 396 ± 80 seconds vs. 323 ± 50 seconds, P = .035) and had higher mean ratings from patients (JSPPPE rating 33.1 ± 3.00 vs 32.2 ± 3.00, P = .020) than female trainees. On multivariable analysis, predictors of highest empathy ratings were male gender (JSPPPE: P = .022) and the year of training (JSE: P = .013; JSEO: p =0.023). Thematic analysis of patient and observer comments suggests a discrepancy in perceived empathy, with patients less likely to perceive positive behaviors as empathetic, but an emphasis on importance of information delivered in the pre-anesthesia encounter.</p><p><strong>Conclusion: </strong>Patients found male trainees and trainees earlier in training to display higher levels of empathy which differed from observer ratings. Qualitative evaluation may offer insights into our understanding of patient-perceived empathy in anesthesiology trainees. The discrepancy between patient, trainee, and observer ratings suggests that perceived empathy in anesthesiology pre-anesthesia interviews may be driven by different factors than in other specialties, particularly information exchange and efficiency of communication.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007927
Ting Sun, Yoon Soo Park, Fei Chen, Nikki Wilkinson, Pedro Tanaka
Background: Competency-based medical education (CBME) relies on criterion-referenced assessments to track residents' progression toward independent practice. The Accreditation Council for Graduate Medical Education (ACGME) Milestones serve as a structured framework to evaluate trainee performance, yet concerns have been raised about potential demographic differences in Milestone ratings. This study examined gender and race differences in Milestone ratings among anesthesiology residents.
Methods: We conducted a retrospective cohort study of 4997 residents from 141 anesthesiology programs graduating between 2017 and 2019. Milestone data from ACGME were linked with the Association of American Medical Colleges demographic data. Three-level mixed-effects models were conducted to estimate the differences in baseline Milestone ratings and growth trajectories, and predict marginal means of ratings at graduation by gender and race across 25 subcompetencies.
Results: At baseline, no significant differences in Milestone ratings were observed by gender or race. However, underrepresented minorities in medicine (URiM) residents demonstrated slower growth in ratings over time, resulting in significantly lower scores across all subcompetencies at graduation. Gender-based growth trajectories over time did not differ significantly between male and female residents, but by graduation, women received significantly lower ratings in 7 of 25 subcompetencies, primarily in patient care (PC) and medical knowledge (MK) competencies. The largest differences were observed in MK-1. Effect sizes for other subcompetencies were smaller, suggesting limited practical differences overall.
Conclusions: These findings highlight that comparable Milestones ratings at baseline, yet modest but cumulative differences over time may lead to meaningful differences at graduation, particularly in MK-1 for URiM residents.
{"title":"National Study of Milestone Evaluation Differences by Gender and Race in Anesthesiology Residency Training.","authors":"Ting Sun, Yoon Soo Park, Fei Chen, Nikki Wilkinson, Pedro Tanaka","doi":"10.1213/ANE.0000000000007927","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007927","url":null,"abstract":"<p><strong>Background: </strong>Competency-based medical education (CBME) relies on criterion-referenced assessments to track residents' progression toward independent practice. The Accreditation Council for Graduate Medical Education (ACGME) Milestones serve as a structured framework to evaluate trainee performance, yet concerns have been raised about potential demographic differences in Milestone ratings. This study examined gender and race differences in Milestone ratings among anesthesiology residents.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 4997 residents from 141 anesthesiology programs graduating between 2017 and 2019. Milestone data from ACGME were linked with the Association of American Medical Colleges demographic data. Three-level mixed-effects models were conducted to estimate the differences in baseline Milestone ratings and growth trajectories, and predict marginal means of ratings at graduation by gender and race across 25 subcompetencies.</p><p><strong>Results: </strong>At baseline, no significant differences in Milestone ratings were observed by gender or race. However, underrepresented minorities in medicine (URiM) residents demonstrated slower growth in ratings over time, resulting in significantly lower scores across all subcompetencies at graduation. Gender-based growth trajectories over time did not differ significantly between male and female residents, but by graduation, women received significantly lower ratings in 7 of 25 subcompetencies, primarily in patient care (PC) and medical knowledge (MK) competencies. The largest differences were observed in MK-1. Effect sizes for other subcompetencies were smaller, suggesting limited practical differences overall.</p><p><strong>Conclusions: </strong>These findings highlight that comparable Milestones ratings at baseline, yet modest but cumulative differences over time may lead to meaningful differences at graduation, particularly in MK-1 for URiM residents.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1213/ANE.0000000000007928
Ruth Shaylor, Vladimir Verenkin, Michael Peer, Orie Sella, Carolyn Weiniger, Barak Cohen
{"title":"Use of Three-Dimensional Spine Reconstruction to Guide Paramedian Thoracic Epidural Insertion: A Proof-of-Concept Study.","authors":"Ruth Shaylor, Vladimir Verenkin, Michael Peer, Orie Sella, Carolyn Weiniger, Barak Cohen","doi":"10.1213/ANE.0000000000007928","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007928","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1213/ANE.0000000000007934
Paul S García, Peter A Goldstein
{"title":"The Myth of Depth of Anesthesia Monitors: When a \"Normal\" Bispectral Index Does not Mean What You Think It Means.","authors":"Paul S García, Peter A Goldstein","doi":"10.1213/ANE.0000000000007934","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007934","url":null,"abstract":"","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1213/ANE.0000000000007929
Leonard J Soloniuk, Jasmine Sran, Christopher Baker, Andrew Kim, Blake Han, Sallie Canumay, Daniel Novak, Ashish C Sinha, Gary Stier
Background: Postoperative nausea and vomiting (PONV) remain a significant consideration in perioperative care; however, the incidence and risk factors of PONV in transgender patients are poorly understood. This study investigated the rates of PONV in transgender patients receiving gender-affirming hormone therapy (GAHT) compared to cisgender patients. We postulate that exogenous testosterone GAHT reduces the risk of PONV while exogenous estrogen GAHT increases the risk of PONV.
Methods: This retrospective cohort study was conducted using the TriNetX database. Patients were divided into 2 groups: transgender and cisgender. Separate analyses were performed for hysterectomies (transgender male [assigned female at birth, AFAB] versus cisgender female), orchiectomies (transgender female [assigned male at birth, AMAB] versus cisgender male), and augmentation mammoplasties (transgender female [AMAB] versus cisgender female). Propensity score matching was performed for age, race, and ethnicity (White, Black, Hispanic, or Latino), which were treated as social and demographic variables as recorded in the database, nicotine dependence, and tobacco use. The primary outcome was the administration of a rescue antiemetic, defined as droperidol, promethazine, dimenhydrinate, metoclopramide, and prochlorperazine, on the day of or day following surgery.
Results: Following hysterectomy, there was a significant difference in the risk of rescue antiemetic use between transgender males (AFAB) taking testosterone GAHT (62.11%, 1031 of 1660) and cisgender females (65.90%, 1094 of 1660) (P = .0227). Following orchiectomy, there was a significant difference in the risk of rescue antiemetic use between transgender females (AMAB) taking estrogen GAHT (51.15%, 445 of 870) and cisgender males (36.78%, 320 of 870) (P < .0001). Following augmentation mammoplasty, there was a significant difference in the risk of rescue antiemetic use between transgender females (AMAB) taking estrogen GAHT (53.29%, 356 of 668) and cisgender females (43.71%, 292 of 668) (P = .0005).
Conclusions: Transgender female (AMAB) patients on estrogen GAHT required rescue antiemetics more often than cisgender males and cisgender females after orchiectomies and augmentation mammoplasties. Transgender male (AFAB) patients on testosterone GAHT required rescue antiemetics less often than cisgender females after hysterectomies. These findings underscore the need for individualized perioperative care and antiemetic prophylaxis to promote equitable anesthetic care for transgender patients. This study's retrospective design limits causal inference and is subject to coding errors and residual confounding. Prospective studies with detailed perioperative and hormonal data are needed to validate these findings and clarify how the timing, dosage, and duration of GAHT influence PONV risk.
{"title":"Exogenous Sex Hormones and Postoperative Nausea and Vomiting Risk in Transgender Patients.","authors":"Leonard J Soloniuk, Jasmine Sran, Christopher Baker, Andrew Kim, Blake Han, Sallie Canumay, Daniel Novak, Ashish C Sinha, Gary Stier","doi":"10.1213/ANE.0000000000007929","DOIUrl":"https://doi.org/10.1213/ANE.0000000000007929","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) remain a significant consideration in perioperative care; however, the incidence and risk factors of PONV in transgender patients are poorly understood. This study investigated the rates of PONV in transgender patients receiving gender-affirming hormone therapy (GAHT) compared to cisgender patients. We postulate that exogenous testosterone GAHT reduces the risk of PONV while exogenous estrogen GAHT increases the risk of PONV.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted using the TriNetX database. Patients were divided into 2 groups: transgender and cisgender. Separate analyses were performed for hysterectomies (transgender male [assigned female at birth, AFAB] versus cisgender female), orchiectomies (transgender female [assigned male at birth, AMAB] versus cisgender male), and augmentation mammoplasties (transgender female [AMAB] versus cisgender female). Propensity score matching was performed for age, race, and ethnicity (White, Black, Hispanic, or Latino), which were treated as social and demographic variables as recorded in the database, nicotine dependence, and tobacco use. The primary outcome was the administration of a rescue antiemetic, defined as droperidol, promethazine, dimenhydrinate, metoclopramide, and prochlorperazine, on the day of or day following surgery.</p><p><strong>Results: </strong>Following hysterectomy, there was a significant difference in the risk of rescue antiemetic use between transgender males (AFAB) taking testosterone GAHT (62.11%, 1031 of 1660) and cisgender females (65.90%, 1094 of 1660) (P = .0227). Following orchiectomy, there was a significant difference in the risk of rescue antiemetic use between transgender females (AMAB) taking estrogen GAHT (51.15%, 445 of 870) and cisgender males (36.78%, 320 of 870) (P < .0001). Following augmentation mammoplasty, there was a significant difference in the risk of rescue antiemetic use between transgender females (AMAB) taking estrogen GAHT (53.29%, 356 of 668) and cisgender females (43.71%, 292 of 668) (P = .0005).</p><p><strong>Conclusions: </strong>Transgender female (AMAB) patients on estrogen GAHT required rescue antiemetics more often than cisgender males and cisgender females after orchiectomies and augmentation mammoplasties. Transgender male (AFAB) patients on testosterone GAHT required rescue antiemetics less often than cisgender females after hysterectomies. These findings underscore the need for individualized perioperative care and antiemetic prophylaxis to promote equitable anesthetic care for transgender patients. This study's retrospective design limits causal inference and is subject to coding errors and residual confounding. Prospective studies with detailed perioperative and hormonal data are needed to validate these findings and clarify how the timing, dosage, and duration of GAHT influence PONV risk.</p>","PeriodicalId":7784,"journal":{"name":"Anesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}